WO2003009783A1 - Laminates for treating cornea and process for producing the same - Google Patents

Laminates for treating cornea and process for producing the same Download PDF

Info

Publication number
WO2003009783A1
WO2003009783A1 PCT/JP2002/007491 JP0207491W WO03009783A1 WO 2003009783 A1 WO2003009783 A1 WO 2003009783A1 JP 0207491 W JP0207491 W JP 0207491W WO 03009783 A1 WO03009783 A1 WO 03009783A1
Authority
WO
WIPO (PCT)
Prior art keywords
cornea
laminates
face
contact
treating
Prior art date
Application number
PCT/JP2002/007491
Other languages
French (fr)
Japanese (ja)
Inventor
Minoru Ueda
Ken-Ichiro Hata
Koji Hirano
Kazuhiro Kito
Original Assignee
Japan Tissue Engineering Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tissue Engineering Co., Ltd. filed Critical Japan Tissue Engineering Co., Ltd.
Priority to KR10-2003-7016445A priority Critical patent/KR20040024859A/en
Priority to JP2003515179A priority patent/JPWO2003009783A1/en
Publication of WO2003009783A1 publication Critical patent/WO2003009783A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Abstract

It is intended to provide laminates for treating cornea which are efficacious in treating cornea and excellent in convenience and thus can facilitate the treatment of cornea. These laminates are composed of a base material having a curved face allowing the loading thereof on the cornea and a cell layer provided directly or indirectly at least on the face of the base material to be in contact with the cornea and/or the face not to be in contact with the cornea. These laminates having a cell layer on the face to be in contact with the cornea are prepared by inoculating oral mucosa epithelial cells into the inside of a collagen shield, culturing the cells for 14 days and thus forming a cell layer consisting of the oral mucosa epithelial cells on the face to be in contact with the cornea.
PCT/JP2002/007491 2001-07-25 2002-07-24 Laminates for treating cornea and process for producing the same WO2003009783A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR10-2003-7016445A KR20040024859A (en) 2001-07-25 2002-07-24 Laminates for treating cornea and process for producing the same
JP2003515179A JPWO2003009783A1 (en) 2001-07-25 2002-07-24 Laminate for corneal treatment and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-224699 2001-07-25
JP2001224699 2001-07-25

Publications (1)

Publication Number Publication Date
WO2003009783A1 true WO2003009783A1 (en) 2003-02-06

Family

ID=19057815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007491 WO2003009783A1 (en) 2001-07-25 2002-07-24 Laminates for treating cornea and process for producing the same

Country Status (3)

Country Link
JP (1) JPWO2003009783A1 (en)
KR (1) KR20040024859A (en)
WO (1) WO2003009783A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006003818A1 (en) * 2004-06-30 2006-01-12 Alblast Co., Ltd. Corneal epithelial sheet and process for producing the same
JPWO2005047496A1 (en) * 2003-11-14 2007-05-31 学校法人慶應義塾 Cell culture method, cell three-dimensional culture method, three-dimensional tissue, artificial organ, and tissue transplantation method
CN100333702C (en) * 2004-04-28 2007-08-29 浙江大学医学院附属邵逸夫医院 Exogenous cornea substrate without cells and its preparation method and use
WO2008105454A1 (en) 2007-02-28 2008-09-04 Senju Pharmaceutical Co., Ltd. Cell capable of expressing lacritin at high level
EP2417933A3 (en) * 2010-08-11 2012-08-22 Body Organ Biomedical Corp. Bio-sheet for eye tissue repair
US10457913B2 (en) 2015-01-13 2019-10-29 Osaka University Corneal epithelioid cells derived from surface ectodermal cells
JP2021518136A (en) * 2018-03-22 2021-08-02 クイーン メアリー ユニバーシティ オブ ロンドン Implant-type cell dressing to treat diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192316A (en) * 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US5374515A (en) * 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5836313A (en) * 1993-02-08 1998-11-17 Massachusetts Institute Of Technology Methods for making composite hydrogels for corneal prostheses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192316A (en) * 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US5374515A (en) * 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5836313A (en) * 1993-02-08 1998-11-17 Massachusetts Institute Of Technology Methods for making composite hydrogels for corneal prostheses

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005047496A1 (en) * 2003-11-14 2007-05-31 学校法人慶應義塾 Cell culture method, cell three-dimensional culture method, three-dimensional tissue, artificial organ, and tissue transplantation method
CN100333702C (en) * 2004-04-28 2007-08-29 浙江大学医学院附属邵逸夫医院 Exogenous cornea substrate without cells and its preparation method and use
WO2006003818A1 (en) * 2004-06-30 2006-01-12 Alblast Co., Ltd. Corneal epithelial sheet and process for producing the same
WO2008105454A1 (en) 2007-02-28 2008-09-04 Senju Pharmaceutical Co., Ltd. Cell capable of expressing lacritin at high level
EP2417933A3 (en) * 2010-08-11 2012-08-22 Body Organ Biomedical Corp. Bio-sheet for eye tissue repair
US10457913B2 (en) 2015-01-13 2019-10-29 Osaka University Corneal epithelioid cells derived from surface ectodermal cells
JP2021518136A (en) * 2018-03-22 2021-08-02 クイーン メアリー ユニバーシティ オブ ロンドン Implant-type cell dressing to treat diseases

Also Published As

Publication number Publication date
KR20040024859A (en) 2004-03-22
JPWO2003009783A1 (en) 2004-11-11

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