WO2003011354A2 - Membrane for use with implantable devices - Google Patents
Membrane for use with implantable devices Download PDFInfo
- Publication number
- WO2003011354A2 WO2003011354A2 PCT/US2002/023902 US0223902W WO03011354A2 WO 2003011354 A2 WO2003011354 A2 WO 2003011354A2 US 0223902 W US0223902 W US 0223902W WO 03011354 A2 WO03011354 A2 WO 03011354A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biointerface membrane
- membrane according
- biointerface
- cell
- domain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
- A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/076—Permanent implantations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
Definitions
- the present invention relates generally to biointerface membranes that may be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample, cell transplantation devices, drug delivery devices and electrical signal delivering or measuring devices.
- implantable devices such as devices for the detection of analyte concentrations in a biological sample, cell transplantation devices, drug delivery devices and electrical signal delivering or measuring devices.
- the present invention further relates to methods for determining analyte levels using implantable devices including these membranes. More particularly, the invention relates to novel biointerface membranes, to sensors and implantable devices including these membranes, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.
- analyte sensing devices is an implantable glucose sensor for detecting glucose levels in patients with diabetes.
- implantable glucose sensing devices There are two commonly used types of implantable glucose sensing devices. These types are those which are implanted intravascularly and those implanted in tissue.
- Some medical devices including implanted analyte sensors, drug delivery devices and cell transplantation devices require transport of solutes across the device-tissue interface for proper function.
- These devices generally include a membrane, herein referred to as a cell-impermeable membrane that encases the device or a portion of the device to prevent access by host inflammatory or immune cells to sensitive regions of the device.
- FBR foreign body response
- the FBR has been well described in the literature and is composed of three main layers, as illustrated in FIG. 1.
- the innermost FBR layer 40 adjacent to the device, is composed generally of macrophages and foreign body giant cells 41 (herein referred to as the barrier cell layer). These cells form a monolayer 40 of closely opposed cells over the entire surface 48a of a smooth or microporous .( ⁇ 1.0 ⁇ m) membrane 48.
- the intermediate FBR layer 42 (herein referred to as the fibrous zone), lying distal to the first layer with respect to the device, is a wide zone (30-100 microns) composed primarily of fibroblasts 43 and fibrous matrix 44.
- the outermost FBR layer 46 is loose connective granular tissue containing new blood vessels 45 (herein referred to as the vascular zone 46).
- a consistent feature of the innermost layers 40 and 42 is that they are devoid of blood vessels. This has led to widely supported speculation that poor transport of molecules across the device- tissue interface 47 is due to a lack of vascularization near interface 47 (Scharp et ah, World J. Sure. 8:221-229 (1984), Colton and Avgoustiniatos J. Biomech. Eng. 113:152-170
- FIG. 2 illustrates a situation in which some blood vessels 45 are brought close to an implant membrane 48, but the primary layer 40 of cells adherent to the cell-impermeable membrane blocks glucose. This phenomenon is described in further detail below.
- bilayer membranes that have cell impermeable layers that are porous and adhesive to cells.
- Cells are able to enter into the interstices of these membranes, and form monolayers on the innermost layer, which is aimed at preventing cell access to the interior of the implanted device (cell impenetrable layers). Because the cell impenetrable layers are porous, cells are able to reach pseudopodia into the interstices of the membrane to adhere to and flatten on the membrane, as shown in FIGS. 1 and 2, thereby blocking transport of molecules across the membrane-tissue interface.
- the barrier cell layer prevents the passage of molecules that cannot diffuse through the layer. Again, this is illustrated in FIG. 2 where blood vessels 45 lie adjacent to the membrane but glucose transport is significantly reduced due to the impermeable nature of the barrier cell layer 40. For example, both glucose and its phosphorylated form do not readily transit the cell membrane and consequently little glucose reaches the implant membrane through the barrier layer cells .
- biointerface membranes of the present invention interfere with the formation of a monolayer of cells adjacent to the membrane, henceforth referred to herein as a barrier cell layer, which interferes with the transport of oxygen and glucose across a device-tissue interface.
- biointerface membrane architectures e.g., variations of those described below are contemplated by the present invention and are within the scope thereof.
- a biointerface membrane for use with an implantable device including; a first domain distal to the implantable device wherein the first domain supports tissue ingrowth and interferes with barrier-cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes.
- a biointerface membrane including the properties of: promoting tissue ingrowth into; interfering with barrier cell formation on or within; resisting barrier-cell attachment to; and blocking cell penetration into the membrane.
- a sensor head for use in an implantable device is provided which includes a biointerface membrane of the present invention.
- a sensor for use in an implantable device that measures the concentration of an analyte in a biological fluid is provided including the biointerface membrane of the present invention.
- a device for measuring an analyte in a biological fluid including the biointerface membrane of the present invention, a housing which includes electronic circuitry, and at least one sensor as provided above operably connected to the electronic circuitry of the housing.
- the present invention further provides a method of monitoring analyte levels including the steps of: providing a host and an implantable device as provided above; and implanting the device in the host. In one embodiment, the device is implanted subcutaneously.
- a method of measuring analyte in a biological fluid including the steps of: providing i) a host, and ii) a implantable device as provided above capable of accurate continuous analyte sensing; and implanting the device in the host.
- the device is implanted subcutaneously.
- an implantable drug delivery device including a biointerface membrane as provided above.
- the implantable drug delivery device is a pump, a microcapsule or a macrocapsule.
- the present invention further provides a device for implantation of cells, which includes a biointerface membrane as provided above.
- an electrical pulse delivering or measuring device including a biointerface membrane according to that provided above.
- the biointerface membranes, devices including these membranes and methods of use of these membranes provided by the invention allow for long term protection of implanted cells or drugs, as well as continuous information regarding, for example, glucose levels of a host over extended periods of time. Because of these abilities, the biointerface membranes of the present invention can be extremely important in the management of transplant patients, diabetic patients and patients requiring frequent drug treatment.
- biointerface membrane is a broad term and is used in its ordinary sense, including, without limitation, a permeable membrane that functions as a device-tissue interface comprised of two or more domains.
- the biointerface membrane is composed of two domains.
- the first domain supports tissue ingrowth, interferes with barrier cell layer formation and includes an open cell configuration having cavities and a solid portion.
- the second domain is resistant to cellular attachment and impermeable to cells (e.g., macrophages).
- the biointerface membrane is made of biostable materials and may be constructed in layers, uniform or non-uniform gradients (i.e.
- domain is a broad term and is used in its ordinary sense, including, without limitation, regions of the biointerface membrane that may be layers, uniform or non-uniform gradients (e.g. anisotropic) or provided as portions of the membrane.
- barrier cell layer is a broad term and is used in its ordinary sense, including, without limitation, a cohesive monolayer of closely opposed cells (e.g. macrophages and foreign body giant cells) that may adhere to implanted membranes and interfere with the transport of molecules across the membrane.
- distal to is a broad term and is used in its ordinary sense, including, without limitation, the spatial relationship between various elements in comparison to a particular point of reference.
- some embodiments of a device include a biointerface membrane having a cell disruptive domain and a cell impermeable domain. If the sensor is deemed to be the point of reference and the cell disruptive domain is positioned farther from the sensor, then that domain is distal to the sensor.
- proximal to is a broad term and is used in its ordinary sense, including, without limitation, the spatial relationship between various elements in comparison to a particular point of reference.
- some embodiments of a device include a biointerface membrane having a cell disruptive domain and a cell impermeable domain. If the sensor is deemed to be the point of reference and the cell impermeable domain is positioned nearer to the sensor, then that domain is proximal to the sensor.
- cell processes is a broad term and is used in its ordinary sense, including, without limitation, pseudopodia of a cell.
- solid portions is a broad term and is used in its ordinary sense, including, without limitation, a material having a structure that may or may not have an open-cell configuration, but in either case prohibits whole cells from traveling through or residing within the material.
- substantially number is a broad term and is used in its ordinary sense, including, without limitation, the number of linear dimensions within a domain (e.g.
- pores or solid portions in which greater than 50 percent of all dimensions are of the specified size, preferably greater than 75 percent and, most preferably, greater than 90 percent of the dimensions have the specified size.
- co-continuous is a broad term and is used in its ordinary sense, including, without limitation, a solid portion wherein an unbroken curved line in three dimensions exists between any two points of the solid portion.
- biostable is a broad term and is used in its ordinary sense, including, without limitation, materials that are relatively resistant to degradation by processes that are encountered in vivo.
- sensor is a broad term and is used in its ordinary sense, including, without limitation, the component or region of a device by which an analyte can be quantitated.
- analyte is a broad term and is used in its ordinary sense, including, without limitation, a substance or chemical constituent in a biological fluid (e.g., blood or urine) that is intended to be analyzed.
- a preferred analyte for measurement by analyte detection devices including the biointerface membranes of the present invention is glucose.
- operably connected and “operably linked,”as used herein, are broad terms and are used in their ordinary sense, including, without limitation, one or more components being linked to another component(s) in a manner that allows transmission of signals between the components.
- one or more electrodes may be used to detect the amount of analyte in a sample and convert that information into a signal; the signal may then be transmitted to an electronic circuit means.
- the electrode is "operably linked" to the electronic circuitry.
- electrosenor circuitry is a broad term and is used in its ordinary sense, including, without limitation, the components of a device required to process biological information obtained from a host.
- the biological information is obtained by a sensor regarding a particular analyte in a biological fluid, thereby providing data regarding the amount of that analyte in the fluid.
- U.S. Patent Nos. 4,757,022, 5,497,772 and 4,787,398 describe suitable electronic circuit means that may be utilized with devices including the biointerface membrane of the present invention.
- the phrase "member for determining the amount of glucose in a biological sample,”as used herein, is a broad term and is used in its ordinary sense, including, without limitation, any mechanism (e.g., enzymatic or non-enzymatic) by which glucose can be quantitated.
- the term "host,”as used herein, is a broad term and is used in its ordinary sense, including, without limitation, mammals, particularly humans.
- the term "accurately,”as used herein, is a broad term and is used in its ordinary sense, including, without limitation, for example, 90% of measured glucose values are within the "A" and "B" region of a standard Clarke error grid when the sensor measurements are compared to a standard reference measurement. It is understood that like any analytical device, calibration, calibration validation, and recalibration are required for the most accurate operation of the device.
- continuous glucose sensing is a broad term and is used in its ordinary sense, including, without limitation, the period in which monitoring of plasma glucose concentration is continuously performed, for example, about every 10 minutes.
- FIG. 1 is an illustration of classical three-layered foreign body response to a synthetic membrane implanted under the skin.
- FIG. 2 is an illustration of a device having increased neovascularization within the intermediary layer of the foreign body response.
- FIG. 3 is an illustration of a membrane of the present invention including a barrier-cell disruptive domain composed of fibers and a cell impermeable domain.
- FIG. 4 is an illustration of a three dimensional section of the first domain showing the solid portions and cavities.
- FIG. 5 is an illustration of a cross-section of the first domain in FIG. 4 showing solid portions and cavities.
- FIG. 6A depicts a cross-sectional drawing of one embodiment of an implantable analyte-measuring device for use in combination with a membrane according to the present invention.
- FIG. 6B depicts a cross-sectional exploded view of the sensor head shown in
- FIG. 6A is a diagrammatic representation of FIG. 6A.
- FIG. 6C depicts a cross-sectional exploded view of the electrode-membrane region set forth in FIG. 6B.
- FIG. 7 is a graphical representation of the number of functional sensors versus time (i.e. weeks) comparing control devices including only a cell-impermeable domain ("Control"), with devices including a cell-impermeable domain and a barrier-cell domain, in particular, wherein the barrier-cell disruptive domain includes non-woven fiber ("Non- Woven Fibers") and wherein the barrier-cell disruptive domain includes porous silicone ("Porous Silicone”).
- the present invention relates generally to novel biointerface membranes, their uses with implantable devices and methods for determining analyte levels in a biological fluid. More particularly, the invention provides biointerface membranes that may be utilized with implantable devices and methods for monitoring and determining glucose levels in a biological fluid, a particularly important measurement for individuals having diabetes.
- biointerface membranes of the present invention are not limited to use in devices that measure or monitor glucose. Rather, these biointerface membranes may be applied to a variety of devices, including for example, those that detect and quantify other analytes present in biological fluids (including, but not limited to, cholesterol, amino acids and lactate), especially those analytes that are substrates for oxidase enzymes [see, e.g., U.S. Patent No. 4,703,756 to Gough et ah, hereby incorporated by reference] cell transplantation devices (U.S. Pat.
- Implantable devices for detecting analyte concentrations in a biological system may utilize the biointerface membranes of the present invention to interfere with the formation of a barrier cell layer, thereby assuring that the sensor receives analyte concentrations representative of that in the vasculature.
- Drug delivery devices may utilize the biointerface membranes of the present invention to protect the drug housed within the device from host inflammatory or immune cells that might potentially damage or destroy the drug.
- the biointerface membrane prevents the formation of a barrier cell layer that might interfere with proper dispensing of drug from the device for treatment of the host.
- cell transplantation devices may utilize the biointerface membranes of the present invention to protect the transplanted cells from attack by the host inflammatory or immune response cells while simultaneously allowing nutrients as well as other biologically active molecules needed by the cells for survival to diffuse through the membrane.
- the materials contemplated for use in preparing the biointerface membrane also eliminate or significantly delay biodegradation. This is particularly important for devices that continuously measure analyte concentrations.
- the electrode surfaces of the glucose sensor are in contact with (or operably connected with) a thin electrolyte phase, which in turn is covered by a membrane that contains an enzyme, e.g., glucose oxidase, and a polymer system.
- the biointerface membrane covers this enzyme membrane and serves, in part, to protect the sensor from external forces and factors that may result in biodegradation. By significantly delaying biodegradation at the sensor, accurate data may be collected over long periods of time (e.g. months to years).
- biodegradation of the biointerface membrane of implantable cell transplantation devices and drug delivery devices could allow host inflammatory and immune cells to enter these devices, thereby compromising long-term function.
- FBC foreign body capsule
- a FBC has precluded the collection of reliable, continuous information because it was previously believed to isolate the sensor of the implanted device in a capsule containing fluid that did not mimic the levels of analytes (e.g. glucose and oxygen) in the body's vasculature.
- analytes e.g. glucose and oxygen
- the composition of a FBC has prevented stabilization of the implanted device, contributing to motion artifact that also renders unreliable results.
- the teachings of the present invention recognize that FBC formation is the dominant event surrounding long-term implantation of any sensor and must be managed to support rather than hinder or block sensor performance. It has been observed that during the early periods following implantation of an analyte-sensing device, particularly a glucose sensing device, glucose sensors function well. However, after a few days to two or more weeks of implantation, these devices lose their function. For example, U.S. Pat. No. 5,791,344 and Gross et al. Performance Evaluation of the Minimed Continuous Monitoring System During Patient home Use", Diabetes Technology and Therapuetics, Vol.
- the present invention contemplates the use of particular biointerface membrane architectures that interfere with barrier cell layer formation on the membrane's surface.
- the present invention also contemplates the use of these membranes with a variety of implantable devices (e.g. analyte measuring devices, particularly glucose measuring devices, cell transplantation devices, drug delivery devices and electrical signal delivery and measuring devices).
- implantable devices e.g. analyte measuring devices, particularly glucose measuring devices, cell transplantation devices, drug delivery devices and electrical signal delivery and measuring devices.
- the sensor interface region refers to the region of a monitoring device responsible for the detection of a particular analyte.
- the sensor interface refers to that region where a biological sample contacts (directly or after passage through one or more membranes or layers) an enzyme (e.g., glucose oxidase).
- the sensor interface region may include a biointerface membrane according to the present invention having different domains and/or layers that can cover and protect an underlying enzyme membrane and the electrodes of an implantable analyte-measuring device.
- the biointerface membranes of the present invention prevent direct contact of the biological fluid sample with the sensor.
- the membranes only permit selected substances (e.g., analytes) of the fluid to pass therethrough for reaction in the immobilized enzyme domain.
- the biointerface membranes of the present invention are biostable and prevent barrier cell formation. The characteristics of this biointerface membrane are now discussed in more detail. I. Biointerface Membrane
- the biointerface membrane is constructed of two or more domains.
- the membrane includes a cell impermeable domain 50 proximal to an implantable device, also referred to as the second domain; and a cell disruptive domain, which in the embodiment illustrated includes non-woven fibers 49 distal to an implantable device, also referred to as the first domain.
- A. Barrier-Cell Disruptive (First) Domain As described above, the outermost domain of the inventive membrane includes a material that supports tissue ingrowth.
- the barrier-cell disruptive domain may be composed of an open-cell configuration having cavities and solid portions.
- FIG. 4 is an illustration of a three-dimensional section 60 of a barrier-cell disruptive domain having solid portions 62 and cavities 64.
- Cells may enter into the cavities. However, they can not travel through or wholly exist within the solid portions.
- the cavities allow most substances to pass through, including, e.g., macrophages.
- the open-cell configuration yields a co-continuous solid domain that contains greater than one cavity in three dimensions substantially throughout the entirety of the membrane.
- the cavities and cavity interconnections may be formed in layers having different cavity dimensions.
- a two dimensional plane 66 cut through the barrier-cell disruptive domain can be utilized (FIG. 5).
- a dimension across a cavity 64 or solid portion 62 can be described as a linear line.
- the length of the linear line is the distance between two points lying at the interface of the cavity and solid portion.
- a substantial number of the cavities are not less than 20 microns in the shortest dimension and not more than 1000 microns in the longest dimension.
- a substantial number of the cavities are not less than 25 microns in the shortest dimension and not more than 500 microns in the longest dimension.
- the solid portion has not less than 5 microns in a substantial number of the shortest dimensions and not more than 2000 microns in a substantial number of the longest dimensions.
- the solid portion is not less than 10 microns in a substantial number of the shortest dimensions and not more than 1000 microns in a substantial number of the longest dimensions and, most preferably, not less than 10 microns in a substantial number of the shortest dimensions and not more than 400 microns in' a substantial number of the longest dimensions.
- the solid portion may be comprised of polytetrafluoroethylene or polyethylene-co-tetrafluoroethylene.
- the solid portion includes polyurethanes or block copolymers and, most preferably, is comprised of silicone.
- the solid portion is composed of porous silicone or non- woven fibers. Non- woven fibers are preferably made from polyester or polypropylene.
- FIG. 3 illustrates how the non- woven fibers 49 serve to disrupt the continuity of cells, such that they are not able to form a classical foreign body response. All the cell types that are involved in the formation of a FBR may be present.
- the 10- micron dimension provides a suitable surface for foreign body giant cells, but the fibers are in such proximity to allow and foster in growth of blood vessels 45 and vascularize the biointerface region (FIG. 3).
- Devices with smaller fibers have been used in previous inventions, but such membranes are prone to delamination due to the forces applied by cells in the interstices of the membrane. After delamination, cells are able to form barrier layers on the smooth or microporous surface of the bioprotective layer if it is adhesive to cells or has pores of sufficient size for physical penetration of cell processes, but not of whole cells.
- the non-woven fibers may be greater than 5 microns in the shortest dimension.
- the non-woven fibers are about 10 microns in the shortest dimension and, most preferably, the non- woven fibers are greater than or equal to 10 microns in the shortest dimension.
- the non-woven fibers may be constructed of polypropylene (PP), polyvinylchloride (PVC), polyvinylidene fluoride (PVDF), polybutylene terephthalate (PBT), polymethylmethacrylate (PMMA), polyether ether ketone (PEEK), polyurethanes, cellulosic polymers, polysulfones, and block copolymers thereof including, for example, di- block, tri-block, alternating, random and graft copolymers (block copolymers are discussed in U.S. Patent Nos. 4,803,243 and 4,686,044, hereby incorporated by reference).
- the non- woven fibers are comprised of polyolefins or polyester or polycarbonates or polytetrafluoroethylene.
- the thickness of the cell disruptive domain is not less than about 20 microns and not more than about 2000 microns.
- inflammatory response cells e.g. macrophages
- barrier cell layers which may block transport across the biointerface membrane.
- These inflammatory cells may also biodegrade many artificial biomaterials (some of which were, until recently, considered nonbiodegradable).
- tissue macrophages When activated by a foreign body, tissue macrophages degranulate, releasing from their cytoplasmic myeloperoxidase system hypochlorite (bleach) and other oxidative species. Hypochlorite and other oxidative species are known to break down a variety of polymers. However, polycarbonate based polyurethanes are believed to be resistant to the effects of these oxidative species and have been termed biodurable.
- the present invention contemplates the use of cell impermeable biomaterials of a few microns thickness or more (i.e., a cell impermeable domain) in most of its membrane architectures. Desirably, the thickness of the cell impermeable domain is not less than about 10 microns and not more than about 100 microns.
- This domain of the biointerface membrane is permeable to oxygen and may or may not be permeable to glucose and is constructed of biodurable materials (e.g. for period of several years in vivo) that are impermeable by host cells (e.g. macrophages) such as, for example, polymer blends of polycarbonate based polyurethane and PVP.
- the innermost domain of the inventive membrane is non-adhesive for cells
- the second domain is resistant to cellular attachment and is impermeable to cells and preferably composed of a biostable material.
- the second domain may be formed from materials such as those previously listed for the first domain and as copolymers or blends with hydrophilic polymers such as polyvinylpyrrolidone (PVP), polyhydroxyethyl methacrylate, polyvinylalcohol, polyacrylic acid, polyethers, such as polyethylene glycol, and block copolymers thereof including, for example, di-block, tri-block, alternating, random and graft copolymers (block copolymers are discussed in U.S. Patent Nos. 4,803,243 and 4,686,044, hereby incorporated by reference).
- hydrophilic polymers such as polyvinylpyrrolidone (PVP), polyhydroxyethyl methacrylate, polyvinylalcohol, polyacrylic acid, polyethers, such as polyethylene glycol, and block copolymers thereof including, for example, di-block, tri-block, alternating, random and graft copolymers (block copolymers are discussed in U.S. Patent Nos.
- the second domain is comprised of a polyurethane and a hydrophilic polymer.
- the hydrophilic polymer is polyvinylpyrrolidone.
- the second domain is polyurethane comprising not less than 5 weight percent polyvinylpyrrolidone and not more than 45 weight percent polyvinylpyrrolidone.
- the second domain comprises not less than 20 weight percent polyvinylpyrrolidone and not more than 35 weight percent polyvinylpyrrolidone and, most preferably, polyurethane comprising about 27 weight percent polyvinylpyrrolidone.
- the cell impermeable domain is comprised of a polymer blend comprised of a non-biodegradable polyurethane comprising polyvinylpyrrolidone.
- a polymer blend comprised of a non-biodegradable polyurethane comprising polyvinylpyrrolidone.
- the present invention contemplates the use of unique membrane architectures around the sensor interface of an implantable device.
- the present invention does not require a device including particular electronic components (e.g., electrodes, circuitry, etc).
- suitable devices include, analyte measuring devices, cell transplantation devices, drug delivery devices, electrical signal delivery and measurement devices and other devices such as those described in U.S. Patent Nos. 4,703,756 and 4,994,167 to Shults et ah; U.S. Patent No. 4,703,756 to Gough et ah, and U.S. Patent No.
- FIG. 6A shows a preferred embodiment of an analyte-measuring device for use in combination with a membrane according to the present invention.
- a ceramic body 1 and ceramic head 10 houses the sensor electronics that include a circuit board 2, a microprocessor 3, a battery 4, and an antenna 5. Furthermore, the ceramic body 1 and head 10 possess a matching taper joint 6 that is sealed with epoxy. The electrodes are subsequently connected to the circuit board via a socket 8.
- three electrodes protrude through the ceramic head 10, a platinum working electrode 21, a platinum counter electrode 22, and a silver/silver chloride reference electrode 20.
- Each of these is hermetically brazed 26 to the ceramic head 10 and further affixed with epoxy 28.
- the sensing region 24 is covered with the sensing membrane described below and the ceramic head 10 contains a groove 29 so that the membrane may be affixed into place with an o-ring.
- FIG. 6C depicts a cross-sectional exploded view of the electrode-membrane region 24 set forth in FIG. 6B detailing the sensor tip and the functional membrane layers.
- the electrode-membrane region includes the inventive biointerface membrane 33 and a sensing membrane 32.
- the top ends of the electrodes are in contact with the electrolyte phase 30, a free-flowing fluid phase.
- the electrolyte phase is covered by the sensing membrane 32 that includes an enzyme, e.g., glucose oxidase.
- the inventive interface membrane 33 covers the enzyme membrane 32 and serves, in part, to protect the sensor from external forces that may result in environmental stress cracking of the sensing membrane 32.
- Eq and Eqs (equivalents); mEq (milliequivalents); M (molar); mM (millimolar) ⁇ M (micromolar); N (Normal); mol (moles); mmol (millimoles); ⁇ mol (micromoles); nmol (nanomoles); g (grams); mg (milligrams); ⁇ g (micrograms); Kg (kilograms); L (liters); mL (miUiliters); dL (deciliters); ⁇ L(microliters); cm (centimeters); mm (millimeters); ⁇ m (micrometers); nm (nanometers); h and hr (hours); min.
- Example 1 (minutes); s and sec. (seconds); °C (degrees Centigrade); Astor Wax (Titusville, PA); BASF Wyandotte Corporation (Parsippany, NJ); Data Sciences, Inc. (St. Paul, MN); Douglas Hansen Co., Inc. (Minneapolis, MN); DuPont (DuPont Co., Wilmington, DE); Exxon Chemical (Houston, TX); GAF Corporation (New York, NY); Markwell Medical (Racine, WI); Meadox Medical, Inc. (Oakland, NJ); Mobay (Mobay Corporation, Pittsburgh, PA); Sandoz (East Hanover, NJ); and Union Carbide (Union Carbide Corporation; Chicago, IL).
- Example 1 Example 1
- the barrier-cell disruptive domain may be prepared from a non-woven polyester fiber filtration membrane.
- the cell-impermeable domain may then be coated on this domain layer.
- the cell-impermeable domain was prepared by placing approximately 706 g of dimethylacetamide (DMAC) into a 3L stainless steel bowl to which a polycarbonateurethane solution (1325g, Chronoflex AR 25% solids in DMAC and a viscosity of 5100cp) and polyvinylpyrrolidone (125g, Plasdone K-90D) were added.
- DMAC dimethylacetamide
- a polycarbonateurethane solution 1325g, Chronoflex AR 25% solids in DMAC and a viscosity of 5100cp
- polyvinylpyrrolidone 125g, Plasdone K-90D
- the barrier-cell disruptive domain can be comprised of a porous silicone sheet.
- the porous silicone was purchased from Seare Biomatrix Systems, Inc.
- the cell- impermeable domain was prepared by placing approximately 706 gm of dimethylacetamide (DMAC) into a 3L stainless steel bowl to which a polycarbonateurethane solution (1325 g, Chronoflex AR 25% solids in DMAC and a viscosity of 5100cp) and polyvinylpyrrolidone (125 g, Plasdone K-90D) were added.
- the bowl was then fitted to a planetary mixer with a paddle type blade and the contents were stirred for 1 hour at room temperature.
- the cell- impermeable domain coating solution was then coated onto a PET release liner (Douglas
- biointerface membrane was prepared by pressing the porous silicone onto the cast cell- impermeable domain. The membrane is then mechanically secured to the sensing device by
- In vivo sensor function was determined by correlating the sensor output to blood glucose values derived from an external blood glucose meter. We have found that non-diabetic dogs do not experience rapid blood glucose changes, even after ingestion of a high sugar meal. Thus, a 10% dextrose solution was infused into the sensor-implanted dog. A second catheter is placed in the opposite leg for the purpose of blood collection. The implanted sensor was programmed to transmit at 30-second intervals using a pulsed electromagnet. A dextrose solution was infused at a rate of 9.3 ml/minute for the first 25 minutes, 3.5 ml/minute for the next 20 minutes, 1.5 ml/minute for the next 20 minutes, and then the infusion pump was powered off.
- Blood glucose values were measured in duplicate every five minutes on a blood glucose meter (LXN Inc., San Diego, CA) for the duration of the study.
- a computer collected the sensor output. The data was then compiled and graphed in a spreadsheet, time-aligned, and time-shifted until an optimal R-squared value was achieved.
- the R-squared value reflects how well the sensor tracks with the blood glucose values.
- Implantable glucose sensors comprising the biointerface membranes of the present invention were implanted into dogs in the subcutaneous tissues and monitored for glucose response on a weekly basis.
- Control devices comprising only a cell-impermeable domain (“Control") were compared with devices comprising a cell-impermeable domain and a barrier-cell disruptive domain, in particular, wherein the barrier-cell disruptive domain was either a non-woven fiber ("Non- Woven Fibers”) or porous silicone ("Porous Silicone").
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003516584A JP2004538455A (en) | 2001-07-27 | 2002-07-26 | Membrane for use with implantable devices |
EP02747094A EP1414504B1 (en) | 2001-07-27 | 2002-07-26 | Membrane for use with implantable devices |
DE60209498T DE60209498T2 (en) | 2001-07-27 | 2002-07-26 | MEMBRANE FOR USE WITH IMPLANTABLE DEVICES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/916,386 | 2001-07-27 | ||
US09/916,386 US6702857B2 (en) | 2001-07-27 | 2001-07-27 | Membrane for use with implantable devices |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003011354A2 true WO2003011354A2 (en) | 2003-02-13 |
WO2003011354A3 WO2003011354A3 (en) | 2003-08-14 |
Family
ID=25437184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/023902 WO2003011354A2 (en) | 2001-07-27 | 2002-07-26 | Membrane for use with implantable devices |
Country Status (8)
Country | Link |
---|---|
US (6) | US6702857B2 (en) |
EP (2) | EP1656958A1 (en) |
JP (1) | JP2004538455A (en) |
AT (1) | ATE318622T1 (en) |
DE (1) | DE60209498T2 (en) |
DK (1) | DK1414504T3 (en) |
ES (1) | ES2259091T3 (en) |
WO (1) | WO2003011354A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007514460A (en) * | 2003-09-30 | 2007-06-07 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | Sensor showing increased biocompatibility |
WO2020243666A1 (en) * | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243665A1 (en) * | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
US11623023B2 (en) | 2016-11-10 | 2023-04-11 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
Families Citing this family (478)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
SE9700384D0 (en) * | 1997-02-04 | 1997-02-04 | Biacore Ab | Analytical method and apparatus |
US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
US7657297B2 (en) | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US6134461A (en) * | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
WO2002078512A2 (en) | 2001-04-02 | 2002-10-10 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
US20030032874A1 (en) * | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US8260393B2 (en) * | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US7828728B2 (en) * | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
US9282925B2 (en) * | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7226978B2 (en) * | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US20060258761A1 (en) * | 2002-05-22 | 2006-11-16 | Robert Boock | Silicone based membranes for use in implantable glucose sensors |
US7993108B2 (en) * | 2002-10-09 | 2011-08-09 | Abbott Diabetes Care Inc. | Variable volume, shape memory actuated insulin dispensing pump |
EP2386758A1 (en) * | 2002-10-09 | 2011-11-16 | Abbott Diabetes Care Inc. | A method of pumping a predetermined dose of a medical fluid |
US7727181B2 (en) * | 2002-10-09 | 2010-06-01 | Abbott Diabetes Care Inc. | Fluid delivery device with autocalibration |
US7381184B2 (en) | 2002-11-05 | 2008-06-03 | Abbott Diabetes Care Inc. | Sensor inserter assembly |
US7025791B2 (en) | 2002-12-02 | 2006-04-11 | Gi Dynamics, Inc. | Bariatric sleeve |
US7811231B2 (en) | 2002-12-31 | 2010-10-12 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
US7587287B2 (en) * | 2003-04-04 | 2009-09-08 | Abbott Diabetes Care Inc. | Method and system for transferring analyte test data |
US7134999B2 (en) * | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
US7679407B2 (en) * | 2003-04-28 | 2010-03-16 | Abbott Diabetes Care Inc. | Method and apparatus for providing peak detection circuitry for data communication systems |
US7875293B2 (en) * | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
US7258673B2 (en) * | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US20040249254A1 (en) * | 2003-06-06 | 2004-12-09 | Joel Racchini | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
US8460243B2 (en) * | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
US8071028B2 (en) * | 2003-06-12 | 2011-12-06 | Abbott Diabetes Care Inc. | Method and apparatus for providing power management in data communication systems |
US7695239B2 (en) * | 2003-07-14 | 2010-04-13 | Fortrend Engineering Corporation | End effector gripper arms having corner grippers which reorient reticle during transfer |
US7722536B2 (en) * | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
US20050051427A1 (en) * | 2003-07-23 | 2005-03-10 | Brauker James H. | Rolled electrode array and its method for manufacture |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
WO2005012871A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Increasing bias for oxygen production in an electrode system |
US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
US8423113B2 (en) * | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
US7761130B2 (en) * | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
EP1648298A4 (en) | 2003-07-25 | 2010-01-13 | Dexcom Inc | Oxygen enhancing membrane systems for implantable devices |
US7108778B2 (en) * | 2003-07-25 | 2006-09-19 | Dexcom, Inc. | Electrochemical sensors including electrode systems with increased oxygen generation |
US7074307B2 (en) | 2003-07-25 | 2006-07-11 | Dexcom, Inc. | Electrode systems for electrochemical sensors |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US7774145B2 (en) * | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7519408B2 (en) * | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US8369919B2 (en) * | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7959569B2 (en) | 2003-08-01 | 2011-06-14 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US7494465B2 (en) * | 2004-07-13 | 2009-02-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
US6931327B2 (en) * | 2003-08-01 | 2005-08-16 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US20100168542A1 (en) * | 2003-08-01 | 2010-07-01 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US7972628B2 (en) | 2003-10-01 | 2011-07-05 | University Of Washington | Porous biomaterials |
US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
US7299082B2 (en) * | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
USD914881S1 (en) | 2003-11-05 | 2021-03-30 | Abbott Diabetes Care Inc. | Analyte sensor electronic mount |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
WO2005057168A2 (en) | 2003-12-05 | 2005-06-23 | Dexcom, Inc. | Calibration techniques for a continuous analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
EP1711802B1 (en) * | 2003-12-08 | 2010-07-14 | DexCom, Inc. | Systems and methods for improving electrochemical analyte sensors |
WO2005057175A2 (en) * | 2003-12-09 | 2005-06-23 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US7637868B2 (en) * | 2004-01-12 | 2009-12-29 | Dexcom, Inc. | Composite material for implantable device |
US20050182451A1 (en) * | 2004-01-12 | 2005-08-18 | Adam Griffin | Implantable device with improved radio frequency capabilities |
US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
US7699964B2 (en) * | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
US7364592B2 (en) * | 2004-02-12 | 2008-04-29 | Dexcom, Inc. | Biointerface membrane with macro-and micro-architecture |
WO2005089103A2 (en) | 2004-02-17 | 2005-09-29 | Therasense, Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
AU2005233602B2 (en) * | 2004-04-12 | 2010-02-18 | Baker Hughes Incorporated | Completion with telescoping perforation & fracturing tool |
US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
US8277713B2 (en) * | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
JP2008501037A (en) * | 2004-06-01 | 2008-01-17 | マイクロチップス・インコーポレーテッド | Devices and methods for measuring and enhancing transport of drugs or analytes to / from medical implants |
US20060010098A1 (en) * | 2004-06-04 | 2006-01-12 | Goodnow Timothy T | Diabetes care host-client architecture and data management system |
US20060001538A1 (en) * | 2004-06-30 | 2006-01-05 | Ulrich Kraft | Methods of monitoring the concentration of an analyte |
US20060001551A1 (en) * | 2004-06-30 | 2006-01-05 | Ulrich Kraft | Analyte monitoring system with wireless alarm |
US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP3524151B1 (en) | 2004-07-13 | 2022-03-16 | DexCom, Inc. | Transcutaneous analyte sensor |
US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US20060020192A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8565848B2 (en) * | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20060270922A1 (en) * | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
WO2006015299A2 (en) * | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
US7604628B2 (en) * | 2004-09-01 | 2009-10-20 | Microchips, Inc. | Multi-cap reservoir devices for controlled release or exposure of reservoir contents |
US9398882B2 (en) | 2005-09-30 | 2016-07-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor and data processing device |
US9743862B2 (en) | 2011-03-31 | 2017-08-29 | Abbott Diabetes Care Inc. | Systems and methods for transcutaneously implanting medical devices |
US8512243B2 (en) | 2005-09-30 | 2013-08-20 | Abbott Diabetes Care Inc. | Integrated introducer and transmitter assembly and methods of use |
US20110073475A1 (en) * | 2009-08-29 | 2011-03-31 | Abbott Diabetes Care Inc. | Analyte Sensor |
US7883464B2 (en) | 2005-09-30 | 2011-02-08 | Abbott Diabetes Care Inc. | Integrated transmitter unit and sensor introducer mechanism and methods of use |
US20110190603A1 (en) * | 2009-09-29 | 2011-08-04 | Stafford Gary A | Sensor Inserter Having Introducer |
US8029441B2 (en) | 2006-02-28 | 2011-10-04 | Abbott Diabetes Care Inc. | Analyte sensor transmitter unit configuration for a data monitoring and management system |
US9351669B2 (en) | 2009-09-30 | 2016-05-31 | Abbott Diabetes Care Inc. | Interconnect for on-body analyte monitoring device |
US20070027381A1 (en) * | 2005-07-29 | 2007-02-01 | Therasense, Inc. | Inserter and methods of use |
US9259175B2 (en) * | 2006-10-23 | 2016-02-16 | Abbott Diabetes Care, Inc. | Flexible patch for fluid delivery and monitoring body analytes |
US7697967B2 (en) | 2005-12-28 | 2010-04-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
US9788771B2 (en) | 2006-10-23 | 2017-10-17 | Abbott Diabetes Care Inc. | Variable speed sensor insertion devices and methods of use |
US20090105569A1 (en) * | 2006-04-28 | 2009-04-23 | Abbott Diabetes Care, Inc. | Introducer Assembly and Methods of Use |
US8571624B2 (en) | 2004-12-29 | 2013-10-29 | Abbott Diabetes Care Inc. | Method and apparatus for mounting a data transmission device in a communication system |
US9636450B2 (en) | 2007-02-19 | 2017-05-02 | Udo Hoss | Pump system modular components for delivering medication and analyte sensing at seperate insertion sites |
US7731657B2 (en) * | 2005-08-30 | 2010-06-08 | Abbott Diabetes Care Inc. | Analyte sensor introducer and methods of use |
US20090082693A1 (en) * | 2004-12-29 | 2009-03-26 | Therasense, Inc. | Method and apparatus for providing temperature sensor module in a data communication system |
US9572534B2 (en) | 2010-06-29 | 2017-02-21 | Abbott Diabetes Care Inc. | Devices, systems and methods for on-skin or on-body mounting of medical devices |
US10226207B2 (en) | 2004-12-29 | 2019-03-12 | Abbott Diabetes Care Inc. | Sensor inserter having introducer |
US8613703B2 (en) * | 2007-05-31 | 2013-12-24 | Abbott Diabetes Care Inc. | Insertion devices and methods |
US8333714B2 (en) | 2006-09-10 | 2012-12-18 | Abbott Diabetes Care Inc. | Method and system for providing an integrated analyte sensor insertion device and data processing unit |
US20060166629A1 (en) * | 2005-01-24 | 2006-07-27 | Therasense, Inc. | Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems |
EP1843783B1 (en) * | 2005-01-25 | 2012-05-30 | MicroCHIPS, Inc. | Control of drug release by transient modification of local microenvironments |
US7545272B2 (en) | 2005-02-08 | 2009-06-09 | Therasense, Inc. | RF tag on test strips, test strip vials and boxes |
US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
CN101180093B (en) * | 2005-03-21 | 2012-07-18 | 雅培糖尿病护理公司 | Method and system for providing integrated medication infusion and analyte monitoring system |
US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
WO2006110193A2 (en) | 2005-04-08 | 2006-10-19 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
US8060174B2 (en) | 2005-04-15 | 2011-11-15 | Dexcom, Inc. | Analyte sensing biointerface |
US8112240B2 (en) * | 2005-04-29 | 2012-02-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing leak detection in data monitoring and management systems |
WO2006121661A2 (en) * | 2005-05-05 | 2006-11-16 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
US7768408B2 (en) | 2005-05-17 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing data management in data monitoring system |
US7620437B2 (en) * | 2005-06-03 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and apparatus for providing rechargeable power in data monitoring and management systems |
CN101365374B (en) | 2005-08-31 | 2011-11-16 | 弗吉尼亚大学专利基金委员会 | Improving accuracy of continuous glucose sensors |
US9521968B2 (en) | 2005-09-30 | 2016-12-20 | Abbott Diabetes Care Inc. | Analyte sensor retention mechanism and methods of use |
US7756561B2 (en) | 2005-09-30 | 2010-07-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing rechargeable power in data monitoring and management systems |
US8880138B2 (en) * | 2005-09-30 | 2014-11-04 | Abbott Diabetes Care Inc. | Device for channeling fluid and methods of use |
EP1948296B2 (en) | 2005-10-14 | 2017-10-11 | Pacesetter, Inc. | Leadless cardiac pacemaker and system |
US9168383B2 (en) | 2005-10-14 | 2015-10-27 | Pacesetter, Inc. | Leadless cardiac pacemaker with conducted communication |
US7583190B2 (en) | 2005-10-31 | 2009-09-01 | Abbott Diabetes Care Inc. | Method and apparatus for providing data communication in data monitoring and management systems |
US20090054747A1 (en) * | 2005-10-31 | 2009-02-26 | Abbott Diabetes Care, Inc. | Method and system for providing analyte sensor tester isolation |
US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
US8515518B2 (en) | 2005-12-28 | 2013-08-20 | Abbott Diabetes Care Inc. | Analyte monitoring |
EP1968432A4 (en) * | 2005-12-28 | 2009-10-21 | Abbott Diabetes Care Inc | Medical device insertion |
US8353881B2 (en) | 2005-12-28 | 2013-01-15 | Abbott Diabetes Care Inc. | Infusion sets for the delivery of a therapeutic substance to a patient |
US8160670B2 (en) | 2005-12-28 | 2012-04-17 | Abbott Diabetes Care Inc. | Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent |
US11298058B2 (en) | 2005-12-28 | 2022-04-12 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
WO2007084130A1 (en) | 2006-01-17 | 2007-07-26 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
EP2004796B1 (en) * | 2006-01-18 | 2015-04-08 | DexCom, Inc. | Membranes for an analyte sensor |
US7736310B2 (en) * | 2006-01-30 | 2010-06-15 | Abbott Diabetes Care Inc. | On-body medical device securement |
US8344966B2 (en) * | 2006-01-31 | 2013-01-01 | Abbott Diabetes Care Inc. | Method and system for providing a fault tolerant display unit in an electronic device |
ES2871822T3 (en) | 2006-02-22 | 2021-11-02 | Dexcom Inc | Analyte sensor |
US7981034B2 (en) | 2006-02-28 | 2011-07-19 | Abbott Diabetes Care Inc. | Smart messages and alerts for an infusion delivery and management system |
US7826879B2 (en) * | 2006-02-28 | 2010-11-02 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
EP1991110B1 (en) * | 2006-03-09 | 2018-11-07 | DexCom, Inc. | Systems and methods for processing analyte sensor data |
EP4218548A1 (en) | 2006-03-09 | 2023-08-02 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
WO2007106351A2 (en) * | 2006-03-10 | 2007-09-20 | The University Of Rochester | Porous silicon materials and devices |
US8346335B2 (en) * | 2008-03-28 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte sensor calibration management |
US9326709B2 (en) | 2010-03-10 | 2016-05-03 | Abbott Diabetes Care Inc. | Systems, devices and methods for managing glucose levels |
US7653425B2 (en) | 2006-08-09 | 2010-01-26 | Abbott Diabetes Care Inc. | Method and system for providing calibration of an analyte sensor in an analyte monitoring system |
US9675290B2 (en) | 2012-10-30 | 2017-06-13 | Abbott Diabetes Care Inc. | Sensitivity calibration of in vivo sensors used to measure analyte concentration |
US7630748B2 (en) | 2006-10-25 | 2009-12-08 | Abbott Diabetes Care Inc. | Method and system for providing analyte monitoring |
US9392969B2 (en) * | 2008-08-31 | 2016-07-19 | Abbott Diabetes Care Inc. | Closed loop control and signal attenuation detection |
US8224415B2 (en) | 2009-01-29 | 2012-07-17 | Abbott Diabetes Care Inc. | Method and device for providing offset model based calibration for analyte sensor |
US8219173B2 (en) | 2008-09-30 | 2012-07-10 | Abbott Diabetes Care Inc. | Optimizing analyte sensor calibration |
US7618369B2 (en) | 2006-10-02 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for dynamically updating calibration parameters for an analyte sensor |
US8226891B2 (en) | 2006-03-31 | 2012-07-24 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
US8140312B2 (en) | 2007-05-14 | 2012-03-20 | Abbott Diabetes Care Inc. | Method and system for determining analyte levels |
US7620438B2 (en) | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
US8473022B2 (en) | 2008-01-31 | 2013-06-25 | Abbott Diabetes Care Inc. | Analyte sensor with time lag compensation |
US7801582B2 (en) | 2006-03-31 | 2010-09-21 | Abbott Diabetes Care Inc. | Analyte monitoring and management system and methods therefor |
US8374668B1 (en) | 2007-10-23 | 2013-02-12 | Abbott Diabetes Care Inc. | Analyte sensor with lag compensation |
US8478557B2 (en) | 2009-07-31 | 2013-07-02 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte monitoring system calibration accuracy |
US20090054749A1 (en) * | 2006-05-31 | 2009-02-26 | Abbott Diabetes Care, Inc. | Method and System for Providing Data Transmission in a Data Management System |
US20080071158A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
US20080004601A1 (en) * | 2006-06-28 | 2008-01-03 | Abbott Diabetes Care, Inc. | Analyte Monitoring and Therapy Management System and Methods Therefor |
US20090171269A1 (en) * | 2006-06-29 | 2009-07-02 | Abbott Diabetes Care, Inc. | Infusion Device and Methods Therefor |
US20090105571A1 (en) * | 2006-06-30 | 2009-04-23 | Abbott Diabetes Care, Inc. | Method and System for Providing Data Communication in Data Management Systems |
US9119582B2 (en) | 2006-06-30 | 2015-09-01 | Abbott Diabetes Care, Inc. | Integrated analyte sensor and infusion device and methods therefor |
US8932216B2 (en) * | 2006-08-07 | 2015-01-13 | Abbott Diabetes Care Inc. | Method and system for providing data management in integrated analyte monitoring and infusion system |
US8206296B2 (en) | 2006-08-07 | 2012-06-26 | Abbott Diabetes Care Inc. | Method and system for providing integrated analyte monitoring and infusion system therapy management |
CN102772212A (en) | 2006-10-26 | 2012-11-14 | 雅培糖尿病护理公司 | Method, device and system for detection of sensitivity decline in analyte sensors |
US20080119710A1 (en) * | 2006-10-31 | 2008-05-22 | Abbott Diabetes Care, Inc. | Medical devices and methods of using the same |
US8579853B2 (en) | 2006-10-31 | 2013-11-12 | Abbott Diabetes Care Inc. | Infusion devices and methods |
US8121857B2 (en) | 2007-02-15 | 2012-02-21 | Abbott Diabetes Care Inc. | Device and method for automatic data acquisition and/or detection |
US20080199894A1 (en) * | 2007-02-15 | 2008-08-21 | Abbott Diabetes Care, Inc. | Device and method for automatic data acquisition and/or detection |
US8732188B2 (en) | 2007-02-18 | 2014-05-20 | Abbott Diabetes Care Inc. | Method and system for providing contextual based medication dosage determination |
US8930203B2 (en) | 2007-02-18 | 2015-01-06 | Abbott Diabetes Care Inc. | Multi-function analyte test device and methods therefor |
US8123686B2 (en) | 2007-03-01 | 2012-02-28 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
CA2681412A1 (en) | 2007-03-26 | 2008-10-02 | Dexcom, Inc. | Analyte sensor |
CA2683962C (en) | 2007-04-14 | 2017-06-06 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in medical communication system |
WO2008128210A1 (en) | 2007-04-14 | 2008-10-23 | Abbott Diabetes Care, Inc. | Method and apparatus for providing data processing and control in medical communication system |
EP2146624B1 (en) * | 2007-04-14 | 2020-03-25 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in medical communication system |
CA2683953C (en) * | 2007-04-14 | 2016-08-02 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in medical communication system |
CA2683721C (en) | 2007-04-14 | 2017-05-23 | Abbott Diabetes Care Inc. | Method and apparatus for providing dynamic multi-stage signal amplification in a medical device |
WO2009096992A1 (en) * | 2007-04-14 | 2009-08-06 | Abbott Diabetes Care, Inc. | Method and apparatus for providing data processing and control in medical communication system |
US8456301B2 (en) | 2007-05-08 | 2013-06-04 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US8461985B2 (en) * | 2007-05-08 | 2013-06-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US20080281179A1 (en) * | 2007-05-08 | 2008-11-13 | Abbott Diabetes Care, Inc. | Analyte monitoring system and methods |
US8665091B2 (en) | 2007-05-08 | 2014-03-04 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US7996158B2 (en) | 2007-05-14 | 2011-08-09 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US10002233B2 (en) * | 2007-05-14 | 2018-06-19 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8560038B2 (en) | 2007-05-14 | 2013-10-15 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8239166B2 (en) | 2007-05-14 | 2012-08-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US20080312845A1 (en) * | 2007-05-14 | 2008-12-18 | Abbott Diabetes Care, Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8600681B2 (en) | 2007-05-14 | 2013-12-03 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US9125548B2 (en) | 2007-05-14 | 2015-09-08 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8260558B2 (en) | 2007-05-14 | 2012-09-04 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8103471B2 (en) | 2007-05-14 | 2012-01-24 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8444560B2 (en) | 2007-05-14 | 2013-05-21 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8649840B2 (en) * | 2007-06-07 | 2014-02-11 | Microchips, Inc. | Electrochemical biosensors and arrays |
US20080306444A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US20080319294A1 (en) * | 2007-06-21 | 2008-12-25 | Abbott Diabetes Care, Inc. | Health management devices and methods |
CN101686804B (en) * | 2007-06-21 | 2013-05-08 | 雅培糖尿病护理公司 | Health monitor |
AU2008265541B2 (en) | 2007-06-21 | 2014-07-17 | Abbott Diabetes Care, Inc. | Health management devices and methods |
US8641618B2 (en) * | 2007-06-27 | 2014-02-04 | Abbott Diabetes Care Inc. | Method and structure for securing a monitoring device element |
US8085151B2 (en) * | 2007-06-28 | 2011-12-27 | Abbott Diabetes Care Inc. | Signal converting cradle for medical condition monitoring and management system |
US8160900B2 (en) | 2007-06-29 | 2012-04-17 | Abbott Diabetes Care Inc. | Analyte monitoring and management device and method to analyze the frequency of user interaction with the device |
US20090036760A1 (en) * | 2007-07-31 | 2009-02-05 | Abbott Diabetes Care, Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US7768386B2 (en) * | 2007-07-31 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and apparatus for providing data processing and control in a medical communication system |
US8834366B2 (en) | 2007-07-31 | 2014-09-16 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor calibration |
US9968742B2 (en) | 2007-08-29 | 2018-05-15 | Medtronic Minimed, Inc. | Combined sensor and infusion set using separated sites |
US20120046533A1 (en) | 2007-08-29 | 2012-02-23 | Medtronic Minimed, Inc. | Combined sensor and infusion sets |
JP2010540037A (en) * | 2007-09-20 | 2010-12-24 | ナノスティム インコーポレイテッド | Leadless cardiac pacemaker with secondary fixation capability |
EP2227132B1 (en) | 2007-10-09 | 2023-03-08 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8377031B2 (en) | 2007-10-23 | 2013-02-19 | Abbott Diabetes Care Inc. | Closed loop control system with safety parameters and methods |
US8216138B1 (en) | 2007-10-23 | 2012-07-10 | Abbott Diabetes Care Inc. | Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration |
US8409093B2 (en) * | 2007-10-23 | 2013-04-02 | Abbott Diabetes Care Inc. | Assessing measures of glycemic variability |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
AU2008316630A1 (en) | 2007-10-25 | 2009-04-30 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8313527B2 (en) | 2007-11-05 | 2012-11-20 | Allergan, Inc. | Soft prosthesis shell texturing method |
GB0723169D0 (en) * | 2007-11-27 | 2008-01-02 | Invibio Ltd | Housing |
US20090164239A1 (en) | 2007-12-19 | 2009-06-25 | Abbott Diabetes Care, Inc. | Dynamic Display Of Glucose Information |
US20090164190A1 (en) * | 2007-12-19 | 2009-06-25 | Abbott Diabetes Care, Inc. | Physiological condition simulation device and method |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
US20090242399A1 (en) * | 2008-03-25 | 2009-10-01 | Dexcom, Inc. | Analyte sensor |
EP3387993A3 (en) | 2008-03-28 | 2018-11-14 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8682408B2 (en) * | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US20090259118A1 (en) * | 2008-03-31 | 2009-10-15 | Abbott Diabetes Care Inc. | Shallow Implantable Analyte Sensor with Rapid Physiological Response |
EP3659628A1 (en) * | 2008-04-10 | 2020-06-03 | Abbott Diabetes Care, Inc. | Method and system for sterilizing an analyte sensor |
US8924159B2 (en) | 2008-05-30 | 2014-12-30 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
US7826382B2 (en) | 2008-05-30 | 2010-11-02 | Abbott Diabetes Care Inc. | Close proximity communication device and methods |
US8591410B2 (en) | 2008-05-30 | 2013-11-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing glycemic control |
US8876755B2 (en) | 2008-07-14 | 2014-11-04 | Abbott Diabetes Care Inc. | Closed loop control system interface and methods |
WO2010019781A1 (en) | 2008-08-13 | 2010-02-18 | Smed-Ta/Td, Llc | Drug delivery implants |
JP5774989B2 (en) | 2008-08-13 | 2015-09-09 | スメド−ティーエイ/ティーディー・エルエルシー | Orthopedic screw |
US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
US10842645B2 (en) | 2008-08-13 | 2020-11-24 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
US8506627B2 (en) | 2008-08-13 | 2013-08-13 | Allergan, Inc. | Soft filled prosthesis shell with discrete fixation surfaces |
US9700431B2 (en) | 2008-08-13 | 2017-07-11 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
US9050184B2 (en) | 2008-08-13 | 2015-06-09 | Allergan, Inc. | Dual plane breast implant |
US9603558B2 (en) | 2008-08-15 | 2017-03-28 | Theranova, Llc | Methods and devices for the diagnosis and treatment of diabetes |
US8900431B2 (en) | 2008-08-27 | 2014-12-02 | Edwards Lifesciences Corporation | Analyte sensor |
ES2686906T3 (en) | 2008-08-29 | 2018-10-22 | Smed-Ta/Td, Llc | Orthopedic implant |
US8622988B2 (en) | 2008-08-31 | 2014-01-07 | Abbott Diabetes Care Inc. | Variable rate closed loop control and methods |
US8734422B2 (en) | 2008-08-31 | 2014-05-27 | Abbott Diabetes Care Inc. | Closed loop control with improved alarm functions |
US9943644B2 (en) * | 2008-08-31 | 2018-04-17 | Abbott Diabetes Care Inc. | Closed loop control with reference measurement and methods thereof |
US20100057040A1 (en) * | 2008-08-31 | 2010-03-04 | Abbott Diabetes Care, Inc. | Robust Closed Loop Control And Methods |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
US8560039B2 (en) | 2008-09-19 | 2013-10-15 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
US20100082364A1 (en) * | 2008-09-30 | 2010-04-01 | Abbott Diabetes Care, Inc. | Medical Information Management |
US8986208B2 (en) | 2008-09-30 | 2015-03-24 | Abbott Diabetes Care Inc. | Analyte sensor sensitivity attenuation mitigation |
US9326707B2 (en) | 2008-11-10 | 2016-05-03 | Abbott Diabetes Care Inc. | Alarm characterization for analyte monitoring devices and systems |
JP2012508584A (en) | 2008-11-14 | 2012-04-12 | ヴィアサイト,インコーポレイテッド | Encapsulation of human pluripotent stem cell-derived pancreatic cells |
US8103456B2 (en) | 2009-01-29 | 2012-01-24 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
US8560082B2 (en) | 2009-01-30 | 2013-10-15 | Abbott Diabetes Care Inc. | Computerized determination of insulin pump therapy parameters using real time and retrospective data processing |
US20100198196A1 (en) * | 2009-01-30 | 2010-08-05 | Abbott Diabetes Care, Inc. | Therapy Delivery Device Programming Tool |
WO2010088687A1 (en) | 2009-02-02 | 2010-08-05 | Nanostim, Inc. | Leadless cardiac pacemaker with secondary fixation capability |
US9402544B2 (en) | 2009-02-03 | 2016-08-02 | Abbott Diabetes Care Inc. | Analyte sensor and apparatus for insertion of the sensor |
DK3912551T3 (en) * | 2009-02-26 | 2023-10-30 | Abbott Diabetes Care Inc | Procedure for calibrating an analyte sensor |
WO2010111660A1 (en) | 2009-03-27 | 2010-09-30 | Dexcom, Inc. | Methods and systems for promoting glucose management |
WO2010114942A1 (en) * | 2009-03-31 | 2010-10-07 | Abbott Diabetes Care Inc. | Precise fluid dispensing method and device |
US8497777B2 (en) * | 2009-04-15 | 2013-07-30 | Abbott Diabetes Care Inc. | Analyte monitoring system having an alert |
EP2419015A4 (en) | 2009-04-16 | 2014-08-20 | Abbott Diabetes Care Inc | Analyte sensor calibration management |
WO2010127050A1 (en) * | 2009-04-28 | 2010-11-04 | Abbott Diabetes Care Inc. | Error detection in critical repeating data in a wireless sensor system |
US20100274515A1 (en) * | 2009-04-28 | 2010-10-28 | Abbott Diabetes Care Inc. | Dynamic Analyte Sensor Calibration Based On Sensor Stability Profile |
US8467972B2 (en) * | 2009-04-28 | 2013-06-18 | Abbott Diabetes Care Inc. | Closed loop blood glucose control algorithm analysis |
EP2425209A4 (en) | 2009-04-29 | 2013-01-09 | Abbott Diabetes Care Inc | Method and system for providing real time analyte sensor calibration with retrospective backfill |
WO2010127187A1 (en) | 2009-04-29 | 2010-11-04 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
US20100278738A1 (en) * | 2009-05-04 | 2010-11-04 | Sitzman Thomas J | Method to detect and monitor ischemia in transplanted organs and tissues |
PT2295132T (en) | 2009-05-15 | 2016-11-15 | Interface Biologics Inc | Antithrombogenic hollow fiber membranes, potting material and blood tubing |
WO2010138856A1 (en) | 2009-05-29 | 2010-12-02 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
US9517023B2 (en) | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
US8613892B2 (en) | 2009-06-30 | 2013-12-24 | Abbott Diabetes Care Inc. | Analyte meter with a moveable head and methods of using the same |
LT3689237T (en) | 2009-07-23 | 2021-09-27 | Abbott Diabetes Care, Inc. | Method of manufacturing and system for continuous analyte measurement |
WO2011011739A2 (en) | 2009-07-23 | 2011-01-27 | Abbott Diabetes Care Inc. | Real time management of data relating to physiological control of glucose levels |
EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
US20110106126A1 (en) * | 2009-08-31 | 2011-05-05 | Michael Love | Inserter device including rotor subassembly |
US9314195B2 (en) | 2009-08-31 | 2016-04-19 | Abbott Diabetes Care Inc. | Analyte signal processing device and methods |
DK3988470T3 (en) | 2009-08-31 | 2023-08-28 | Abbott Diabetes Care Inc | Display devices for a medical device |
EP2473099A4 (en) | 2009-08-31 | 2015-01-14 | Abbott Diabetes Care Inc | Analyte monitoring system and methods for managing power and noise |
JP5795584B2 (en) | 2009-08-31 | 2015-10-14 | アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. | Medical device |
WO2011041469A1 (en) | 2009-09-29 | 2011-04-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
US20110082356A1 (en) | 2009-10-01 | 2011-04-07 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having interference rejection membranes and methods for making and using them |
US20110093069A1 (en) | 2009-10-16 | 2011-04-21 | Allergan, Inc. | Implants and methdos for manufacturing same |
US8185181B2 (en) | 2009-10-30 | 2012-05-22 | Abbott Diabetes Care Inc. | Method and apparatus for detecting false hypoglycemic conditions |
US20110288388A1 (en) | 2009-11-20 | 2011-11-24 | Medtronic Minimed, Inc. | Multi-conductor lead configurations useful with medical device systems and methods for making and using them |
CA2781518C (en) | 2009-11-25 | 2016-08-23 | Healionics Corporation | Granules of porous biocompatible materials |
US8660628B2 (en) | 2009-12-21 | 2014-02-25 | Medtronic Minimed, Inc. | Analyte sensors comprising blended membrane compositions and methods for making and using them |
US20110184258A1 (en) * | 2010-01-28 | 2011-07-28 | Abbott Diabetes Care Inc. | Balloon Catheter Analyte Measurement Sensors and Methods for Using the Same |
WO2011094155A2 (en) | 2010-01-28 | 2011-08-04 | Allergan, Inc. | Open celled foams, implants including them and processes for making same |
USD924406S1 (en) | 2010-02-01 | 2021-07-06 | Abbott Diabetes Care Inc. | Analyte sensor inserter |
US9072821B2 (en) | 2010-02-05 | 2015-07-07 | Allergan, Inc. | Biocompatible structures and compositions |
US8685296B2 (en) | 2010-05-11 | 2014-04-01 | Allergan, Inc. | Porogen compositions, method of making and uses |
US8877822B2 (en) | 2010-09-28 | 2014-11-04 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US8889751B2 (en) | 2010-09-28 | 2014-11-18 | Allergan, Inc. | Porous materials, methods of making and uses |
US9044897B2 (en) | 2010-09-28 | 2015-06-02 | Allergan, Inc. | Porous materials, methods of making and uses |
US9138308B2 (en) | 2010-02-03 | 2015-09-22 | Apollo Endosurgery, Inc. | Mucosal tissue adhesion via textured surface |
US9205577B2 (en) | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
US10448872B2 (en) | 2010-03-16 | 2019-10-22 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having improved electrode configurations and methods for making and using them |
JP5904500B2 (en) | 2010-03-24 | 2016-04-13 | アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. | Apparatus and system for inserting sharp member under skin surface |
KR101813300B1 (en) | 2010-04-08 | 2017-12-28 | 힐리오닉스 코포레이션 | Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same |
EP2563851A1 (en) | 2010-04-27 | 2013-03-06 | Allergan, Inc. | Foam-like materials and methods for producing same |
US11202853B2 (en) | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
US9215995B2 (en) | 2010-06-23 | 2015-12-22 | Medtronic Minimed, Inc. | Sensor systems having multiple probes and electrode arrays |
US8635046B2 (en) | 2010-06-23 | 2014-01-21 | Abbott Diabetes Care Inc. | Method and system for evaluating analyte sensor response characteristics |
US11064921B2 (en) | 2010-06-29 | 2021-07-20 | Abbott Diabetes Care Inc. | Devices, systems and methods for on-skin or on-body mounting of medical devices |
US10092229B2 (en) | 2010-06-29 | 2018-10-09 | Abbott Diabetes Care Inc. | Calibration of analyte measurement system |
US9357968B2 (en) * | 2010-07-14 | 2016-06-07 | Dyconex Ag | Self-cleaning sensor surfaces for implantable sensor systems |
US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
CN103260501B (en) | 2010-10-06 | 2015-09-02 | 普罗弗萨股份有限公司 | Tissue integration sensor |
US11213226B2 (en) | 2010-10-07 | 2022-01-04 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods |
US9060692B2 (en) | 2010-10-12 | 2015-06-23 | Pacesetter, Inc. | Temperature sensor for a leadless cardiac pacemaker |
CN103249452A (en) | 2010-10-12 | 2013-08-14 | 内诺斯蒂姆股份有限公司 | Temperature sensor for a leadless cardiac pacemaker |
EP2627406A1 (en) | 2010-10-13 | 2013-08-21 | Nanostim, Inc. | Leadless cardiac pacemaker with anti-unscrewing feature |
US8679279B2 (en) | 2010-11-16 | 2014-03-25 | Allergan, Inc. | Methods for creating foam-like texture |
US8546458B2 (en) | 2010-12-07 | 2013-10-01 | Allergan, Inc. | Process for texturing materials |
CN103429296A (en) | 2010-12-13 | 2013-12-04 | 内诺斯蒂姆股份有限公司 | Delivery catheter systems and methods |
US9126032B2 (en) | 2010-12-13 | 2015-09-08 | Pacesetter, Inc. | Pacemaker retrieval systems and methods |
US9242102B2 (en) | 2010-12-20 | 2016-01-26 | Pacesetter, Inc. | Leadless pacemaker with radial fixation mechanism |
EP2680754B1 (en) | 2011-02-28 | 2019-04-24 | Abbott Diabetes Care, Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
US9028410B2 (en) | 2011-04-08 | 2015-05-12 | Dexcom, Inc. | Systems and methods for processing and transmitting sensor data |
DK3575796T3 (en) | 2011-04-15 | 2021-01-18 | Dexcom Inc | ADVANCED ANALYZE SENSOR CALIBRATION AND ERROR DETECTION |
US9008744B2 (en) | 2011-05-06 | 2015-04-14 | Medtronic Minimed, Inc. | Method and apparatus for continuous analyte monitoring |
EP3505064B8 (en) | 2011-09-23 | 2020-08-12 | Dexcom, Inc. | Systems and methods for processing and transmitting sensor data |
US9381112B1 (en) | 2011-10-06 | 2016-07-05 | William Eric Sponsell | Bleb drainage device, ophthalmological product and methods |
US9069536B2 (en) | 2011-10-31 | 2015-06-30 | Abbott Diabetes Care Inc. | Electronic devices having integrated reset systems and methods thereof |
US9622691B2 (en) | 2011-10-31 | 2017-04-18 | Abbott Diabetes Care Inc. | Model based variable risk false glucose threshold alarm prevention mechanism |
EP2773416B1 (en) | 2011-11-04 | 2019-04-24 | Pacesetter, Inc. | Leadless cardiac pacemaker with integral battery and redundant welds |
WO2013070794A2 (en) | 2011-11-07 | 2013-05-16 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods |
US9317656B2 (en) | 2011-11-23 | 2016-04-19 | Abbott Diabetes Care Inc. | Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof |
US8710993B2 (en) | 2011-11-23 | 2014-04-29 | Abbott Diabetes Care Inc. | Mitigating single point failure of devices in an analyte monitoring system and methods thereof |
WO2013078426A2 (en) | 2011-11-25 | 2013-05-30 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods of use |
US9402570B2 (en) | 2011-12-11 | 2016-08-02 | Abbott Diabetes Care Inc. | Analyte sensor devices, connections, and methods |
US8801782B2 (en) | 2011-12-15 | 2014-08-12 | Allergan, Inc. | Surgical methods for breast reconstruction or augmentation |
US8632489B1 (en) | 2011-12-22 | 2014-01-21 | A. Mateen Ahmed | Implantable medical assembly and methods |
WO2013138369A1 (en) | 2012-03-16 | 2013-09-19 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US20130267812A1 (en) | 2012-04-04 | 2013-10-10 | Dexcom, Inc. | Transcutaneous analyte sensors, applicators therefor, and associated methods |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
US10980919B2 (en) | 2016-04-14 | 2021-04-20 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
US9493807B2 (en) | 2012-05-25 | 2016-11-15 | Medtronic Minimed, Inc. | Foldover sensors and methods for making and using them |
US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US20130325352A1 (en) | 2012-06-05 | 2013-12-05 | Dexcom, Inc. | Calculation engine based on histograms |
US10598627B2 (en) | 2012-06-29 | 2020-03-24 | Dexcom, Inc. | Devices, systems, and methods to compensate for effects of temperature on implantable sensors |
US10881339B2 (en) | 2012-06-29 | 2021-01-05 | Dexcom, Inc. | Use of sensor redundancy to detect sensor failures |
US20140012115A1 (en) | 2012-07-03 | 2014-01-09 | Medtronic Minimed, Inc. | Plasma deposited adhesion promoter layers for use with analyte sensors |
US20140012511A1 (en) | 2012-07-09 | 2014-01-09 | Dexcom, Inc. | Systems and methods for leveraging smartphone features in continuous glucose monitoring |
WO2014022661A1 (en) | 2012-08-01 | 2014-02-06 | Nanostim, Inc. | Biostimulator circuit with flying cell |
EP2890297B1 (en) | 2012-08-30 | 2018-04-11 | Abbott Diabetes Care, Inc. | Dropout detection in continuous analyte monitoring data during data excursions |
US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
EP2901153A4 (en) | 2012-09-26 | 2016-04-27 | Abbott Diabetes Care Inc | Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data |
US9788765B2 (en) | 2012-09-28 | 2017-10-17 | Dexcom, Inc. | Zwitterion surface modifications for continuous sensors |
US20140129151A1 (en) | 2012-11-07 | 2014-05-08 | Dexcom, Inc. | Systems and methods for managing glycemic variability |
US10194840B2 (en) | 2012-12-06 | 2019-02-05 | Medtronic Minimed, Inc. | Microarray electrodes useful with analyte sensors and methods for making and using them |
US9907654B2 (en) * | 2012-12-11 | 2018-03-06 | Dr. H.C. Robert Mathys Stiftung | Bone substitute and method for producing the same |
EP2962662A1 (en) | 2012-12-13 | 2016-01-06 | Allergan, Inc. | Variable surface breast implant |
US9427181B2 (en) * | 2012-12-28 | 2016-08-30 | Senseonics, Incorporated | Analyte permeable membrane systems for oxidative and optical stability |
US11109779B2 (en) | 2012-12-28 | 2021-09-07 | Senseonics, Incorporated | Chemical modification of analyte permeable membrane for enhanced oxidative stability |
US9730621B2 (en) | 2012-12-31 | 2017-08-15 | Dexcom, Inc. | Remote monitoring of analyte measurements |
US9801541B2 (en) | 2012-12-31 | 2017-10-31 | Dexcom, Inc. | Remote monitoring of analyte measurements |
US10426383B2 (en) | 2013-01-22 | 2019-10-01 | Medtronic Minimed, Inc. | Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating |
US9592475B2 (en) | 2013-03-12 | 2017-03-14 | Lockheed Martin Corporation | Method for forming perforated graphene with uniform aperture size |
CA2904031A1 (en) | 2013-03-14 | 2014-10-02 | Profusa, Inc. | Method and device for correcting optical signals |
US9445445B2 (en) | 2013-03-14 | 2016-09-13 | Dexcom, Inc. | Systems and methods for processing and transmitting sensor data |
US10335075B2 (en) | 2013-03-14 | 2019-07-02 | Dexcom, Inc. | Advanced calibration for analyte sensors |
US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
WO2014158405A2 (en) | 2013-03-14 | 2014-10-02 | Dexcom, Inc. | Systems and methods for processing and transmitting sensor data |
US9182368B2 (en) | 2013-03-14 | 2015-11-10 | Sano Intelligence, Inc. | Method of manufacturing a sensor for sensing analytes |
US10076285B2 (en) | 2013-03-15 | 2018-09-18 | Abbott Diabetes Care Inc. | Sensor fault detection using analyte sensor data pattern comparison |
US10433773B1 (en) | 2013-03-15 | 2019-10-08 | Abbott Diabetes Care Inc. | Noise rejection methods and apparatus for sparsely sampled analyte sensor data |
US9724203B2 (en) | 2013-03-15 | 2017-08-08 | Smed-Ta/Td, Llc | Porous tissue ingrowth structure |
US9681966B2 (en) | 2013-03-15 | 2017-06-20 | Smed-Ta/Td, Llc | Method of manufacturing a tubular medical implant |
US9408699B2 (en) | 2013-03-15 | 2016-08-09 | Smed-Ta/Td, Llc | Removable augment for medical implant |
US9474475B1 (en) | 2013-03-15 | 2016-10-25 | Abbott Diabetes Care Inc. | Multi-rate analyte sensor data collection with sample rate configurable signal processing |
WO2014186727A1 (en) * | 2013-05-17 | 2014-11-20 | Senseonics, Incorporated | Opacity consistent polymer graft for optical sensor |
CN105307559B (en) | 2013-06-06 | 2020-06-05 | 普罗菲尤萨股份有限公司 | Apparatus and method for detecting optical signals from implanted sensors |
US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
US20150122647A1 (en) | 2013-11-07 | 2015-05-07 | Medtronic Minimed, Inc. | Enzyme matrices for use with ethylene oxide sterilization |
US11229382B2 (en) | 2013-12-31 | 2022-01-25 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
SG11201606287VA (en) | 2014-01-31 | 2016-08-30 | Lockheed Corp | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
EP3100297A4 (en) | 2014-01-31 | 2017-12-13 | Lockheed Martin Corporation | Perforating two-dimensional materials using broad ion field |
JP2017512129A (en) | 2014-03-12 | 2017-05-18 | ロッキード・マーチン・コーポレーション | Separation membranes formed from perforated graphene |
US10595754B2 (en) | 2014-03-13 | 2020-03-24 | Sano Intelligence, Inc. | System for monitoring body chemistry |
CN106102578A (en) | 2014-03-13 | 2016-11-09 | 萨诺智能公司 | For monitoring the system of body chemistry |
EP3865063A1 (en) | 2014-03-30 | 2021-08-18 | Abbott Diabetes Care, Inc. | Method and apparatus for determining meal start and peak events in analyte monitoring systems |
WO2015156966A1 (en) | 2014-04-10 | 2015-10-15 | Dexcom, Inc. | Sensors for continuous analyte monitoring, and related methods |
AU2015258842B2 (en) | 2014-05-16 | 2020-01-02 | Allergan, Inc. | Soft filled prosthesis shell with variable texture |
US10092392B2 (en) | 2014-05-16 | 2018-10-09 | Allergan, Inc. | Textured breast implant and methods of making same |
US10159943B2 (en) * | 2014-07-24 | 2018-12-25 | Toray Industries, Inc. | Carbon membrane for fluid separation, fluid separation membrane module, and method for producing carbon membrane for fluid separation |
WO2016014987A2 (en) | 2014-07-24 | 2016-01-28 | Thomas Jefferson University | Long-term implantable monitoring system & methods of use |
EP2979623A1 (en) * | 2014-07-28 | 2016-02-03 | Roche Diagnostics GmbH | Medical sensor assembly |
WO2016036888A1 (en) | 2014-09-02 | 2016-03-10 | Lockheed Martin Corporation | Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same |
WO2016109163A1 (en) | 2014-12-31 | 2016-07-07 | Theranova, Llc | Methods and devices for analyte sensing in potential spaces |
US10213139B2 (en) | 2015-05-14 | 2019-02-26 | Abbott Diabetes Care Inc. | Systems, devices, and methods for assembling an applicator and sensor control device |
US10674944B2 (en) | 2015-05-14 | 2020-06-09 | Abbott Diabetes Care Inc. | Compact medical device inserters and related systems and methods |
CN113349766A (en) | 2015-07-10 | 2021-09-07 | 雅培糖尿病护理公司 | System, device and method for dynamic glucose curve response to physiological parameters |
JP2018528144A (en) | 2015-08-05 | 2018-09-27 | ロッキード・マーチン・コーポレーション | Perforable sheet of graphene-based material |
MX2018001559A (en) | 2015-08-06 | 2018-09-27 | Lockheed Corp | Nanoparticle modification and perforation of graphene. |
US20170112534A1 (en) | 2015-10-21 | 2017-04-27 | Dexcom, Inc. | Transcutaneous analyte sensors, applicators therefor, and associated methods |
AU2016380858B2 (en) | 2015-12-28 | 2019-08-08 | Dexcom, Inc. | Systems and methods for remote and host monitoring communications |
WO2017117472A1 (en) | 2015-12-30 | 2017-07-06 | Dexcom, Inc. | Biointerface layer for analyte sensors |
ES2837390T3 (en) | 2016-03-31 | 2021-06-30 | Dexcom Inc | Analyte monitoring system |
JP2019521055A (en) | 2016-04-14 | 2019-07-25 | ロッキード・マーチン・コーポレーション | Selective interface relaxation of graphene defects |
JP2019519756A (en) | 2016-04-14 | 2019-07-11 | ロッキード・マーチン・コーポレーション | In-situ monitoring and control of defect formation or defect repair |
JP2019517909A (en) | 2016-04-14 | 2019-06-27 | ロッキード・マーチン・コーポレーション | Two-dimensional membrane structure having a flow path |
EP3442739A4 (en) | 2016-04-14 | 2020-03-04 | Lockheed Martin Corporation | Method for treating graphene sheets for large-scale transfer using free-float method |
US10324058B2 (en) | 2016-04-28 | 2019-06-18 | Medtronic Minimed, Inc. | In-situ chemistry stack for continuous glucose sensors |
DK3455269T3 (en) * | 2016-05-10 | 2023-12-18 | Evonik Canada Inc | IMPLANTABLE GLUCOSE SENSORS WITH A BIOSTABLE SURFACE |
US11179078B2 (en) | 2016-06-06 | 2021-11-23 | Medtronic Minimed, Inc. | Polycarbonate urea/urethane polymers for use with analyte sensors |
EP3529300A4 (en) | 2016-10-18 | 2020-03-18 | Evonik Canada Inc. | Plasticized pvc admixtures with surface modifying macromolecules and articles made therefrom |
US11067527B2 (en) | 2016-12-16 | 2021-07-20 | Siemens Healthcare Diagnostics Inc. | Sensor assembly having microsensors |
US11331018B2 (en) | 2016-12-22 | 2022-05-17 | Profusa, Inc. | System and single-channel biosensor for and method of determining analyte value |
US11071478B2 (en) | 2017-01-23 | 2021-07-27 | Abbott Diabetes Care Inc. | Systems, devices and methods for analyte sensor insertion |
US11134868B2 (en) | 2017-03-17 | 2021-10-05 | Medtronic Minimed, Inc. | Metal pillar device structures and methods for making and using them in electrochemical and/or electrocatalytic applications |
EP3600014A4 (en) | 2017-03-21 | 2020-10-21 | Abbott Diabetes Care Inc. | Methods, devices and system for providing diabetic condition diagnosis and therapy |
US10413658B2 (en) | 2017-03-31 | 2019-09-17 | Capillary Biomedical, Inc. | Helical insertion infusion device |
EP4154800A1 (en) | 2017-06-23 | 2023-03-29 | Dexcom, Inc. | Transcutaneous analyte sensors, applicators therefor, and associated methods |
US10856784B2 (en) | 2017-06-30 | 2020-12-08 | Medtronic Minimed, Inc. | Sensor initialization methods for faster body sensor response |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
AU2018354120A1 (en) | 2017-10-24 | 2020-04-23 | Dexcom, Inc. | Pre-connected analyte sensors |
CN109717876B (en) * | 2017-10-31 | 2023-12-26 | 心脏起搏器股份公司 | Structural diffusion membrane for chemical sensors |
US20190223771A1 (en) | 2018-01-23 | 2019-07-25 | Medtronic Minimed, Inc. | Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses |
US11186859B2 (en) | 2018-02-07 | 2021-11-30 | Medtronic Minimed, Inc. | Multilayer electrochemical analyte sensors and methods for making and using them |
US11220735B2 (en) | 2018-02-08 | 2022-01-11 | Medtronic Minimed, Inc. | Methods for controlling physical vapor deposition metal film adhesion to substrates and surfaces |
US11583213B2 (en) | 2018-02-08 | 2023-02-21 | Medtronic Minimed, Inc. | Glucose sensor electrode design |
CN112088217A (en) | 2018-05-16 | 2020-12-15 | 美敦力泌力美公司 | Thermostable glucose limiting membrane for glucose sensors |
US11786153B2 (en) * | 2018-11-02 | 2023-10-17 | The Johns Hopkins University | Wearable sensor |
USD1002852S1 (en) | 2019-06-06 | 2023-10-24 | Abbott Diabetes Care Inc. | Analyte sensor device |
US11718865B2 (en) | 2019-07-26 | 2023-08-08 | Medtronic Minimed, Inc. | Methods to improve oxygen delivery to implantable sensors |
US11523757B2 (en) | 2019-08-01 | 2022-12-13 | Medtronic Minimed, Inc. | Micro-pillar working electrodes design to reduce backflow of hydrogen peroxide in glucose sensor |
EP4048152B1 (en) | 2020-07-29 | 2023-12-20 | Biolinq Incorporated | Continuous analyte monitoring system with microneedle array |
US20220031205A1 (en) | 2020-07-31 | 2022-02-03 | Medtronic Minimed, Inc. | Sensor identification and integrity check design |
US20220133190A1 (en) | 2020-10-29 | 2022-05-05 | Medtronic Minimed, Inc. | Glucose biosensors comprising direct electron transfer enzymes and methods of making and using them |
USD999913S1 (en) | 2020-12-21 | 2023-09-26 | Abbott Diabetes Care Inc | Analyte sensor inserter |
US20220240823A1 (en) | 2021-01-29 | 2022-08-04 | Medtronic Minimed, Inc. | Interference rejection membranes useful with analyte sensors |
US20220338768A1 (en) | 2021-04-09 | 2022-10-27 | Medtronic Minimed, Inc. | Hexamethyldisiloxane membranes for analyte sensors |
USD988882S1 (en) | 2021-04-21 | 2023-06-13 | Informed Data Systems Inc. | Sensor assembly |
CN116113454A (en) | 2021-05-08 | 2023-05-12 | 比奥林股份有限公司 | Continuous analyte monitoring device fault detection based on microneedle arrays |
US20230113175A1 (en) | 2021-10-08 | 2023-04-13 | Medtronic Minimed, Inc. | Immunosuppressant releasing coatings |
US20230123613A1 (en) | 2021-10-14 | 2023-04-20 | Medtronic Minimed, Inc. | Sensors for 3-hydroxybutyrate detection |
US20230172497A1 (en) | 2021-12-02 | 2023-06-08 | Medtronic Minimed, Inc. | Ketone limiting membrane and dual layer membrane approach for ketone sensing |
CN114748208B (en) * | 2022-04-15 | 2024-01-12 | 柔脉医疗(深圳)有限公司 | Tissue engineering scaffold capable of in-situ detecting multiple chemical and biological components |
US20240023849A1 (en) | 2022-07-20 | 2024-01-25 | Medtronic Minimed, Inc. | Acrylate hydrogel membrane for dual function of diffusion limiting membrane as well as attenuation to the foreign body response |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007525A1 (en) * | 1990-10-31 | 1992-05-14 | Baxter International Inc. | Close vascularization implant material |
WO1997043633A1 (en) * | 1996-05-17 | 1997-11-20 | Encelle, Inc. | Electrochemical biosensors |
WO2000013003A1 (en) * | 1998-08-26 | 2000-03-09 | Sensors For Medicine And Science, Inc. | Optical-based sensing devices |
WO2001012158A1 (en) * | 1999-08-16 | 2001-02-22 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
WO2001043660A2 (en) * | 1999-12-08 | 2001-06-21 | Baxter International Inc. | Porous three dimensional structure |
Family Cites Families (447)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19852258A1 (en) | 1998-11-11 | 2000-05-18 | Agfa Gevaert Ag | Radiation-sensitive recording material for the production of waterless offset printing plates |
USRE31916E (en) | 1970-11-10 | 1985-06-18 | Becton Dickinson & Company | Electrochemical detection cell |
GB1412983A (en) | 1971-11-30 | 1975-11-05 | Debell & Richardson | Method of producing porous plastic materials |
US3943918A (en) | 1971-12-02 | 1976-03-16 | Tel-Pac, Inc. | Disposable physiological telemetric device |
US3775182A (en) | 1972-02-25 | 1973-11-27 | Du Pont | Tubular electrochemical cell with coiled electrodes and compressed central spindle |
GB1442303A (en) | 1972-09-08 | 1976-07-14 | Radiometer As | Cell for electro-chemical analysis |
CS164231B2 (en) | 1972-09-28 | 1975-11-07 | ||
US3929971A (en) | 1973-03-30 | 1975-12-30 | Research Corp | Porous biomaterials and method of making same |
US3898984A (en) | 1974-02-04 | 1975-08-12 | Us Navy | Ambulatory patient monitoring system |
US3966580A (en) | 1974-09-16 | 1976-06-29 | The University Of Utah | Novel protein-immobilizing hydrophobic polymeric membrane, process for producing same and apparatus employing same |
US3979274A (en) | 1975-09-24 | 1976-09-07 | The Yellow Springs Instrument Company, Inc. | Membrane for enzyme electrodes |
CH591237A5 (en) | 1975-11-06 | 1977-09-15 | Bbc Brown Boveri & Cie | |
US4040908A (en) | 1976-03-12 | 1977-08-09 | Children's Hospital Medical Center | Polarographic analysis of cholesterol and other macromolecular substances |
US4024312A (en) | 1976-06-23 | 1977-05-17 | Johnson & Johnson | Pressure-sensitive adhesive tape having extensible and elastic backing composed of a block copolymer |
US4273636A (en) | 1977-05-26 | 1981-06-16 | Kiyoo Shimada | Selective chemical sensitive field effect transistor transducers |
CS200909B1 (en) | 1977-12-23 | 1980-10-31 | Petr Slovak | Haemodlialysation device |
JPS5921500B2 (en) | 1978-01-28 | 1984-05-21 | 東洋紡績株式会社 | Enzyme membrane for oxygen electrode |
US4172770A (en) | 1978-03-27 | 1979-10-30 | Technicon Instruments Corporation | Flow-through electrochemical system analytical method |
US4259540A (en) | 1978-05-30 | 1981-03-31 | Bell Telephone Laboratories, Incorporated | Filled cables |
US4215703A (en) | 1978-08-29 | 1980-08-05 | Willson James K V | Variable stiffness guide wire |
US4225410A (en) | 1978-12-04 | 1980-09-30 | Technicon Instruments Corporation | Integrated array of electrochemical sensors |
US4255500A (en) | 1979-03-29 | 1981-03-10 | General Electric Company | Vibration resistant electrochemical cell having deformed casing and method of making same |
US4253469A (en) | 1979-04-20 | 1981-03-03 | The Narda Microwave Corporation | Implantable temperature probe |
DE2932761A1 (en) | 1979-08-13 | 1981-02-26 | Akzo Gmbh | POLYCARBONATE-POLYAETHER-COPOLYMER MEMBRANE |
JPS5627643A (en) | 1979-08-14 | 1981-03-18 | Toshiba Corp | Electrochemical measuring device |
US4260725A (en) * | 1979-12-10 | 1981-04-07 | Bausch & Lomb Incorporated | Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains |
US4403984A (en) | 1979-12-28 | 1983-09-13 | Biotek, Inc. | System for demand-based adminstration of insulin |
US4861830A (en) | 1980-02-29 | 1989-08-29 | Th. Goldschmidt Ag | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
SE419903B (en) | 1980-03-05 | 1981-08-31 | Enfors Sven Olof | enzyme electrode |
US4340458A (en) | 1980-06-02 | 1982-07-20 | Joslin Diabetes Center, Inc. | Glucose sensor |
JPS625174Y2 (en) | 1980-09-02 | 1987-02-05 | ||
IE51643B1 (en) | 1980-10-15 | 1987-01-21 | Smith & Nephew Ass | Coated articles and materials suitable for coating |
US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
US4436094A (en) | 1981-03-09 | 1984-03-13 | Evreka, Inc. | Monitor for continuous in vivo measurement of glucose concentration |
US4442841A (en) | 1981-04-30 | 1984-04-17 | Mitsubishi Rayon Company Limited | Electrode for living bodies |
US4453537A (en) | 1981-08-04 | 1984-06-12 | Spitzer Daniel E | Apparatus for powering a body implant device |
US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
US4418148A (en) | 1981-11-05 | 1983-11-29 | Miles Laboratories, Inc. | Multilayer enzyme electrode membrane |
US4415666A (en) | 1981-11-05 | 1983-11-15 | Miles Laboratories, Inc. | Enzyme electrode membrane |
US4494950A (en) | 1982-01-19 | 1985-01-22 | The Johns Hopkins University | Plural module medication delivery system |
EP0098592A3 (en) | 1982-07-06 | 1985-08-21 | Fujisawa Pharmaceutical Co., Ltd. | Portable artificial pancreas |
DE3228551A1 (en) | 1982-07-30 | 1984-02-02 | Siemens AG, 1000 Berlin und 8000 München | METHOD FOR DETERMINING SUGAR CONCENTRATION |
US4571292A (en) | 1982-08-12 | 1986-02-18 | Case Western Reserve University | Apparatus for electrochemical measurements |
EP0107634B1 (en) | 1982-10-25 | 1989-04-12 | Lars Gustav Inge Hellgren | Enzyme composition for cleaning, the use thereof and preparation of the composition |
US4603152A (en) | 1982-11-05 | 1986-07-29 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
US5059654A (en) | 1983-02-14 | 1991-10-22 | Cuno Inc. | Affinity matrices of modified polysaccharide supports |
US4506680A (en) | 1983-03-17 | 1985-03-26 | Medtronic, Inc. | Drug dispensing body implantable lead |
CA1226036A (en) | 1983-05-05 | 1987-08-25 | Irving J. Higgins | Analytical equipment and sensor electrodes therefor |
US4484987A (en) | 1983-05-19 | 1984-11-27 | The Regents Of The University Of California | Method and membrane applicable to implantable sensor |
US4650547A (en) | 1983-05-19 | 1987-03-17 | The Regents Of The University Of California | Method and membrane applicable to implantable sensor |
WO1985000463A1 (en) | 1983-07-05 | 1985-01-31 | Matsushita Electric Industrial Co., Ltd. | Aluminum electrolytic capacitor and method of manufacture thereof |
US4554927A (en) | 1983-08-30 | 1985-11-26 | Thermometrics Inc. | Pressure and temperature sensor |
GB2149918A (en) | 1983-11-03 | 1985-06-19 | John Anderson | Sudden infant death syndrome monitor |
US4753652A (en) | 1984-05-04 | 1988-06-28 | Children's Medical Center Corporation | Biomaterial implants which resist calcification |
US4883057A (en) | 1984-05-09 | 1989-11-28 | Research Foundation, The City University Of New York | Cathodic electrochemical current arrangement with telemetric application |
US5464013A (en) | 1984-05-25 | 1995-11-07 | Lemelson; Jerome H. | Medical scanning and treatment system and method |
US5171689A (en) | 1984-11-08 | 1992-12-15 | Matsushita Electric Industrial Co., Ltd. | Solid state bio-sensor |
US4702732A (en) | 1984-12-24 | 1987-10-27 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands |
US4963595A (en) | 1985-01-04 | 1990-10-16 | Thoratec Laboratories Corporation | Polysiloxane-polylactone block copolymers |
US5235003A (en) | 1985-01-04 | 1993-08-10 | Thoratec Laboratories Corporation | Polysiloxane-polylactone block copolymers |
US4577642A (en) | 1985-02-27 | 1986-03-25 | Medtronic, Inc. | Drug dispensing body implantable lead employing molecular sieves and methods of fabrication |
US4787398A (en) | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
US4781798A (en) | 1985-04-19 | 1988-11-01 | The Regents Of The University Of California | Transparent multi-oxygen sensor array and method of using same |
US4671288A (en) | 1985-06-13 | 1987-06-09 | The Regents Of The University Of California | Electrochemical cell sensor for continuous short-term use in tissues and blood |
US5364770A (en) | 1985-08-29 | 1994-11-15 | Genencor International Inc. | Heterologous polypeptides expressed in aspergillus |
US4805624A (en) | 1985-09-09 | 1989-02-21 | The Montefiore Hospital Association Of Western Pa | Low-potential electrochemical redox sensors |
US4680268A (en) | 1985-09-18 | 1987-07-14 | Children's Hospital Medical Center | Implantable gas-containing biosensor and method for measuring an analyte such as glucose |
US4890620A (en) | 1985-09-20 | 1990-01-02 | The Regents Of The University Of California | Two-dimensional diffusion glucose substrate sensing electrode |
US4689309A (en) | 1985-09-30 | 1987-08-25 | Miles Laboratories, Inc. | Test device, method of manufacturing same and method of determining a component in a sample |
JPS6283849A (en) | 1985-10-04 | 1987-04-17 | Reiji Yoshinaka | Method of purifying collagen |
US4839296A (en) | 1985-10-18 | 1989-06-13 | Chem-Elec, Inc. | Blood plasma test method |
JPS6283849U (en) | 1985-11-12 | 1987-05-28 | ||
US4776944A (en) | 1986-03-20 | 1988-10-11 | Jiri Janata | Chemical selective sensors utilizing admittance modulated membranes |
JPS62225513A (en) | 1986-03-26 | 1987-10-03 | Shin Etsu Chem Co Ltd | Block-graft copolymer and production thereof |
US4757022A (en) | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4994167A (en) | 1986-04-15 | 1991-02-19 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
US4731726A (en) | 1986-05-19 | 1988-03-15 | Healthware Corporation | Patient-operated glucose monitor and diabetes management system |
GB8612861D0 (en) * | 1986-05-27 | 1986-07-02 | Cambridge Life Sciences | Immobilised enzyme biosensors |
US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
US5002572A (en) | 1986-09-11 | 1991-03-26 | Picha George J | Biological implant with textured surface |
US5007929B1 (en) | 1986-11-04 | 1994-08-30 | Medical Products Dev | Open-cell silicone-elastomer medical implant |
AU617667B2 (en) | 1986-11-04 | 1991-12-05 | Allergan, Inc. | Open-cell, silicone-elastomer medical implant and method for making |
FR2607696B1 (en) | 1986-12-03 | 1995-08-11 | Gosserez Olivier | IMPLANTABLE BREAST PROSTHESIS CONTRARY TO THE FORMATION OF A RETRACTILE SHELL |
AT391063B (en) | 1987-01-08 | 1990-08-10 | Blum Gmbh Julius | CONNECTING FITTING FOR FASTENING THE RAILING OF A DRAWER |
US4935345A (en) | 1987-04-07 | 1990-06-19 | Arizona Board Of Regents | Implantable microelectronic biochemical sensor incorporating thin film thermopile |
US4759828A (en) | 1987-04-09 | 1988-07-26 | Nova Biomedical Corporation | Glucose electrode and method of determining glucose |
US5540828A (en) | 1987-06-08 | 1996-07-30 | Yacynych; Alexander | Method for making electrochemical sensors and biosensors having a polymer modified surface |
US4810470A (en) | 1987-06-19 | 1989-03-07 | Miles Inc. | Volume independent diagnostic device |
JPH07122624B2 (en) | 1987-07-06 | 1995-12-25 | ダイキン工業株式会社 | Biosensor |
US4823808A (en) | 1987-07-06 | 1989-04-25 | Clegg Charles T | Method for control of obesity, overweight and eating disorders |
US4805625A (en) | 1987-07-08 | 1989-02-21 | Ad-Tech Medical Instrument Corporation | Sphenoidal electrode and insertion method |
FI77569C (en) | 1987-07-13 | 1989-04-10 | Huhtamaeki Oy | ANORDINATION FOR THE PURPOSE OF THE OPERATIONS AND THE OPERATIONS OF ELLER EN VAEVNAD. |
NL8702370A (en) | 1987-10-05 | 1989-05-01 | Groningen Science Park | METHOD AND SYSTEM FOR GLUCOSE DETERMINATION AND USEABLE MEASURING CELL ASSEMBLY. |
GB8725936D0 (en) | 1987-11-05 | 1987-12-09 | Genetics Int Inc | Sensing system |
US4852573A (en) | 1987-12-04 | 1989-08-01 | Kennedy Philip R | Implantable neural electrode |
US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
CA1299653C (en) | 1988-07-07 | 1992-04-28 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
GB8817997D0 (en) | 1988-07-28 | 1988-09-01 | Cambridge Life Sciences | Enzyme electrodes & improvements in manufacture thereof |
EP0353328A1 (en) | 1988-08-03 | 1990-02-07 | Dräger Nederland B.V. | A polarographic-amperometric three-electrode sensor |
US5458631A (en) | 1989-01-06 | 1995-10-17 | Xavier; Ravi | Implantable catheter with electrical pulse nerve stimulators and drug delivery system |
US5269891A (en) | 1989-03-09 | 1993-12-14 | Novo Nordisk A/S | Method and apparatus for determination of a constituent in a fluid |
JPH02298855A (en) | 1989-03-20 | 1990-12-11 | Assoc Univ Inc | Electrochemical biosensor using immobilized enzyme and redox polymer |
US4986671A (en) | 1989-04-12 | 1991-01-22 | Luxtron Corporation | Three-parameter optical fiber sensor and system |
US4953552A (en) | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
US4988341A (en) | 1989-06-05 | 1991-01-29 | Eastman Kodak Company | Sterilizing dressing device and method for skin puncture |
US4927407A (en) | 1989-06-19 | 1990-05-22 | Regents Of The University Of Minnesota | Cardiac assist pump with steady rate supply of fluid lubricant |
CH677149A5 (en) | 1989-07-07 | 1991-04-15 | Disetronic Ag | |
US5431160A (en) | 1989-07-19 | 1995-07-11 | University Of New Mexico | Miniature implantable refillable glucose sensor and material therefor |
US4986271A (en) | 1989-07-19 | 1991-01-22 | The University Of New Mexico | Vivo refillable glucose sensor |
US5264104A (en) | 1989-08-02 | 1993-11-23 | Gregg Brian A | Enzyme electrodes |
US5101814A (en) | 1989-08-11 | 1992-04-07 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5190041A (en) | 1989-08-11 | 1993-03-02 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5050612A (en) | 1989-09-12 | 1991-09-24 | Matsumura Kenneth N | Device for computer-assisted monitoring of the body |
JPH03133440A (en) | 1989-10-18 | 1991-06-06 | Nishitomo:Kk | Clinical thermometer for ladies |
US5067491A (en) | 1989-12-08 | 1991-11-26 | Becton, Dickinson And Company | Barrier coating on blood contacting devices |
US5985129A (en) | 1989-12-14 | 1999-11-16 | The Regents Of The University Of California | Method for increasing the service life of an implantable sensor |
FR2656423A1 (en) | 1989-12-22 | 1991-06-28 | Rhone Poulenc Chimie | Electrochemical biosensor |
US5108819A (en) | 1990-02-14 | 1992-04-28 | Eli Lilly And Company | Thin film electrical component |
CA2011298C (en) | 1990-03-01 | 1999-05-25 | Adrian William Alden | Dual polarization dipole array antenna |
US5031618A (en) | 1990-03-07 | 1991-07-16 | Medtronic, Inc. | Position-responsive neuro stimulator |
US5316008A (en) | 1990-04-06 | 1994-05-31 | Casio Computer Co., Ltd. | Measurement of electrocardiographic wave and sphygmus |
US5165407A (en) | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
US5713926A (en) | 1990-04-25 | 1998-02-03 | Cardiac Pacemakers, Inc. | Implantable intravenous cardiac stimulation system with pulse generator housing serving as optional additional electrode |
US5331555A (en) | 1990-05-11 | 1994-07-19 | Sharp Kabushiki Kaisha | Electronic apparatus |
IT1248934B (en) | 1990-06-01 | 1995-02-11 | Fidia Spa | BIOCOMPATIBLE PERFORATED MEMBRANES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS A SUPPORT FOR THE IN VITRO GROWTH OF EPITHELIAL CELLS, ARTIFICIAL LEATHER THUS OBTAINED AND THEIR USE IN LEATHER TRANSPLANTS |
ES2081490T3 (en) | 1990-08-28 | 1996-03-16 | Meadox Medicals Inc | VASCULAR GRAFT SELF-SUPPORTING FABRIC. |
US5380536A (en) | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
US5713888A (en) | 1990-10-31 | 1998-02-03 | Baxter International, Inc. | Tissue implant systems |
US5344454A (en) | 1991-07-24 | 1994-09-06 | Baxter International Inc. | Closed porous chambers for implanting tissue in a host |
US5545223A (en) | 1990-10-31 | 1996-08-13 | Baxter International, Inc. | Ported tissue implant systems and methods of using same |
US5314471A (en) | 1991-07-24 | 1994-05-24 | Baxter International Inc. | Tissue inplant systems and methods for sustaining viable high cell densities within a host |
AU1356792A (en) | 1991-01-25 | 1992-08-27 | Markwell Medical Institute, Inc. | Implantable biological fluid measuring device |
US5348788A (en) | 1991-01-30 | 1994-09-20 | Interpore Orthopaedics, Inc. | Mesh sheet with microscopic projections and holes |
CA2050057A1 (en) | 1991-03-04 | 1992-09-05 | Adam Heller | Interferant eliminating biosensors |
US5593852A (en) * | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
US5397848A (en) * | 1991-04-25 | 1995-03-14 | Allergan, Inc. | Enhancing the hydrophilicity of silicone polymers |
US5271736A (en) * | 1991-05-13 | 1993-12-21 | Applied Medical Research | Collagen disruptive morphology for implants |
JP3118015B2 (en) * | 1991-05-17 | 2000-12-18 | アークレイ株式会社 | Biosensor and separation and quantification method using the same |
FI88223C (en) * | 1991-05-22 | 1993-04-13 | Polar Electro Oy | Telemetric transmitter unit |
JP3084642B2 (en) | 1991-05-30 | 2000-09-04 | 株式会社ジェルテック | Pad for dressing and method of manufacturing the same |
US5453278A (en) | 1991-07-24 | 1995-09-26 | Baxter International Inc. | Laminated barriers for tissue implants |
US5328451A (en) | 1991-08-15 | 1994-07-12 | Board Of Regents, The University Of Texas System | Iontophoretic device and method for killing bacteria and other microbes |
DE4130742A1 (en) | 1991-09-16 | 1993-03-18 | Inst Diabetestechnologie Gemei | METHOD AND ARRANGEMENT FOR DETERMINING THE CONCENTRATION OF INGREDIENTS IN BODY LIQUIDS |
US5222980A (en) * | 1991-09-27 | 1993-06-29 | Medtronic, Inc. | Implantable heart-assist device |
US5322063A (en) | 1991-10-04 | 1994-06-21 | Eli Lilly And Company | Hydrophilic polyurethane membranes for electrochemical glucose sensors |
US5605162A (en) | 1991-10-15 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Method for using a variable stiffness guidewire |
US5249576A (en) | 1991-10-24 | 1993-10-05 | Boc Health Care, Inc. | Universal pulse oximeter probe |
US5866217A (en) | 1991-11-04 | 1999-02-02 | Possis Medical, Inc. | Silicone composite vascular graft |
US5310469A (en) | 1991-12-31 | 1994-05-10 | Abbott Laboratories | Biosensor with a membrane containing biologically active material |
DE69215204T2 (en) | 1992-01-29 | 1997-03-13 | Hewlett Packard Gmbh | Process and system for monitoring vital functions |
JPH07508183A (en) | 1992-02-01 | 1995-09-14 | ザ ヴィクトリア ユニヴァーシティ オヴ マンチェスター | Improvements regarding monitoring system |
NL9200207A (en) | 1992-02-05 | 1993-09-01 | Nedap Nv | IMPLANTABLE BIOMEDICAL SENSOR DEVICE, IN PARTICULAR FOR MEASUREMENT OF THE GLUCOSE CONCENTRATION. |
US5284140A (en) | 1992-02-11 | 1994-02-08 | Eli Lilly And Company | Acrylic copolymer membranes for biosensors |
DE69319771T2 (en) | 1992-03-31 | 1999-04-22 | Dainippon Printing Co Ltd | Immobilized enzyme electrode, composition for its production and electrically conductive enzymes |
ATE208169T1 (en) | 1992-04-01 | 2001-11-15 | Baxter Int | SYSTEMS FOR PLANNING VASCULAR TISSUE |
US5324322A (en) | 1992-04-20 | 1994-06-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
WO1993022360A1 (en) | 1992-04-24 | 1993-11-11 | The Polymer Technology Group, Inc. | Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range |
US5589563A (en) | 1992-04-24 | 1996-12-31 | The Polymer Technology Group | Surface-modifying endgroups for biomedical polymers |
GB9211402D0 (en) | 1992-05-29 | 1992-07-15 | Univ Manchester | Sensor devices |
US5330521A (en) | 1992-06-29 | 1994-07-19 | Cohen Donald M | Low resistance implantable electrical leads |
JPH0634596A (en) | 1992-07-20 | 1994-02-08 | Fujitsu Ltd | Oxygen electrode, biosensor and manufacture thereof |
JP2541081B2 (en) * | 1992-08-28 | 1996-10-09 | 日本電気株式会社 | Biosensor and method of manufacturing and using biosensor |
EP1104883A3 (en) | 1992-10-01 | 2001-07-18 | Australian Membrane And Biotechnology Research Institute | Improved sensor membranes |
GB9221099D0 (en) | 1992-10-07 | 1992-11-18 | Ecossensors Ltd | Improvements in and relating to gas permeable membranes for amperometric gas electrodes |
US5387327A (en) * | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
US6256522B1 (en) | 1992-11-23 | 2001-07-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Sensors for continuous monitoring of biochemicals and related method |
ZA938555B (en) | 1992-11-23 | 1994-08-02 | Lilly Co Eli | Technique to improve the performance of electrochemical sensors |
US5285513A (en) | 1992-11-30 | 1994-02-08 | At&T Bell Laboratories | Optical fiber cable provided with stabilized waterblocking material |
US5299571A (en) | 1993-01-22 | 1994-04-05 | Eli Lilly And Company | Apparatus and method for implantation of sensors |
WO1994022367A1 (en) | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Radiotelemetry impedance plethysmography device |
US5387329A (en) | 1993-04-09 | 1995-02-07 | Ciba Corning Diagnostics Corp. | Extended use planar sensors |
US5906817A (en) | 1993-04-21 | 1999-05-25 | Institut Pasteur | Biocompatible implant for the expression and in vivo secretion of a therapeutic substance |
US5417395A (en) | 1993-06-30 | 1995-05-23 | Medex, Inc. | Modular interconnecting component support plate |
AU692786B2 (en) | 1993-07-02 | 1998-06-18 | Materials Evolution And Development Usa, Inc. | Implantable system for cell growth control |
US5508030A (en) | 1993-08-05 | 1996-04-16 | Bierman; Howard R. | Creating new capillary blood pools for practicing bidirectional medicine |
DE4329898A1 (en) | 1993-09-04 | 1995-04-06 | Marcus Dr Besson | Wireless medical diagnostic and monitoring device |
AU7607494A (en) | 1993-09-10 | 1995-03-27 | Ottawa Heart Institute Research Corporation | Electrohydraulic ventricular assist device |
EP0670738A1 (en) | 1993-09-24 | 1995-09-13 | Baxter International Inc. | Methods for enhancing vascularization of implant devices |
US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
KR970010981B1 (en) | 1993-11-04 | 1997-07-05 | 엘지전자 주식회사 | Alcohol concentration measuring bio-sensor, manufacturing method and related apparatus |
US5545220A (en) | 1993-11-04 | 1996-08-13 | Lipomatrix Incorporated | Implantable prosthesis with open cell textured surface and method for forming same |
US5791344A (en) | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
US5497772A (en) | 1993-11-19 | 1996-03-12 | Alfred E. Mann Foundation For Scientific Research | Glucose monitoring system |
US5421923A (en) | 1993-12-03 | 1995-06-06 | Baxter International, Inc. | Ultrasonic welding horn with sonics dampening insert |
US5443080A (en) | 1993-12-22 | 1995-08-22 | Americate Transtech, Inc. | Integrated system for biological fluid constituent analysis |
US5437824A (en) | 1993-12-23 | 1995-08-01 | Moghan Medical Corp. | Method of forming a molded silicone foam implant having open-celled interstices |
US5549675A (en) | 1994-01-11 | 1996-08-27 | Baxter International, Inc. | Method for implanting tissue in a host |
DE4401400A1 (en) | 1994-01-19 | 1995-07-20 | Ernst Prof Dr Pfeiffer | Method and arrangement for continuously monitoring the concentration of a metabolite |
US5391250A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
US5390671A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Transcutaneous sensor insertion set |
US5505713A (en) | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
US5569186A (en) | 1994-04-25 | 1996-10-29 | Minimed Inc. | Closed loop infusion pump system with removable glucose sensor |
US5584876A (en) * | 1994-04-29 | 1996-12-17 | W. L. Gore & Associates, Inc. | Cell excluding sheath for vascular grafts |
US5466356A (en) | 1994-04-29 | 1995-11-14 | Mine Safety Appliances Company | Potentiostat circuit for electrochemical cells |
DE4415896A1 (en) | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysis system for monitoring the concentration of an analyte in the blood of a patient |
US5484404A (en) * | 1994-05-06 | 1996-01-16 | Alfred E. Mann Foundation For Scientific Research | Replaceable catheter system for physiological sensors, tissue stimulating electrodes and/or implantable fluid delivery systems |
EP0685735B1 (en) | 1994-06-03 | 2002-01-16 | Metrohm Ag | Voltammetric apparaus, indicating electrode arrangement for such apparatus, especially as a part of a tape cassette, and voltammetric method for serial analysis |
DE4422068A1 (en) * | 1994-06-23 | 1996-01-04 | Siemens Ag | Electro-catalytic glucose sensor in catheter form |
US5529066A (en) | 1994-06-27 | 1996-06-25 | Cb-Carmel Biotechnology Ltd. | Implantable capsule for enhancing cell electric signals |
US5494562A (en) * | 1994-06-27 | 1996-02-27 | Ciba Corning Diagnostics Corp. | Electrochemical sensors |
US5429735A (en) | 1994-06-27 | 1995-07-04 | Miles Inc. | Method of making and amperometric electrodes |
CN1157560A (en) | 1994-07-08 | 1997-08-20 | 巴克斯特国际有限公司 | Implanted device containing tumor cells for treatment of cancer |
US5480711A (en) * | 1994-07-12 | 1996-01-02 | Ruefer; Bruce G. | Nano-porous PTFE biomaterial |
US5513636A (en) | 1994-08-12 | 1996-05-07 | Cb-Carmel Biotechnology Ltd. | Implantable sensor chip |
US5462051A (en) | 1994-08-31 | 1995-10-31 | Colin Corporation | Medical communication system |
AT402452B (en) | 1994-09-14 | 1997-05-26 | Avl Verbrennungskraft Messtech | PLANAR SENSOR FOR DETECTING A CHEMICAL PARAMETER OF A SAMPLE |
US5624537A (en) | 1994-09-20 | 1997-04-29 | The University Of British Columbia - University-Industry Liaison Office | Biosensor and interface membrane |
US5807406A (en) | 1994-10-07 | 1998-09-15 | Baxter International Inc. | Porous microfabricated polymer membrane structures |
CA2159052C (en) | 1994-10-28 | 2007-03-06 | Rainer Alex | Injection device |
IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5590651A (en) * | 1995-01-17 | 1997-01-07 | Temple University - Of The Commonwealth System Of Higher Education | Breathable liquid elimination analysis |
US5837728A (en) | 1995-01-27 | 1998-11-17 | Molecular Design International | 9-cis retinoic acid esters and amides and uses thereof |
US5741319A (en) | 1995-01-27 | 1998-04-21 | Medtronic, Inc. | Biocompatible medical lead |
US5697366A (en) | 1995-01-27 | 1997-12-16 | Optical Sensors Incorporated | In situ calibration system for sensors located in a physiologic line |
US5568806A (en) | 1995-02-16 | 1996-10-29 | Minimed Inc. | Transcutaneous sensor insertion set |
US5586553A (en) | 1995-02-16 | 1996-12-24 | Minimed Inc. | Transcutaneous sensor insertion set |
US5882494A (en) | 1995-03-27 | 1999-03-16 | Minimed, Inc. | Polyurethane/polyurea compositions containing silicone for biosensor membranes |
WO1996032076A1 (en) | 1995-04-11 | 1996-10-17 | Baxter Internatonal Inc. | Tissue implant systems |
US5620579A (en) | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
US5626561A (en) * | 1995-06-07 | 1997-05-06 | Gore Hybrid Technologies, Inc. | Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
WO1996039993A1 (en) * | 1995-06-07 | 1996-12-19 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
US5584813A (en) | 1995-06-07 | 1996-12-17 | Minimed Inc. | Subcutaneous injection set |
US5743262A (en) | 1995-06-07 | 1998-04-28 | Masimo Corporation | Blood glucose monitoring system |
US5656707A (en) | 1995-06-16 | 1997-08-12 | Regents Of The University Of Minnesota | Highly cross-linked polymeric supports |
US5995860A (en) | 1995-07-06 | 1999-11-30 | Thomas Jefferson University | Implantable sensor and system for measurement and control of blood constituent levels |
US6001471A (en) | 1995-08-11 | 1999-12-14 | 3M Innovative Properties Company | Removable adhesive tape with controlled sequential release |
US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
US5855613A (en) | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
JP3592416B2 (en) | 1995-10-31 | 2004-11-24 | 晃敏 吉田 | Measuring device for intraocular substances |
US5711861A (en) * | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
AU1058297A (en) | 1995-11-22 | 1997-06-11 | Minimed, Inc. | Detection of biological molecules using chemical amplification and optical sensors |
US6063637A (en) | 1995-12-13 | 2000-05-16 | California Institute Of Technology | Sensors for sugars and other metal binding analytes |
WO1997024059A1 (en) | 1995-12-28 | 1997-07-10 | Cygnus, Inc. | Continuous monitoring of physiological analyte |
US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
GB2311157B (en) | 1996-03-14 | 1999-11-03 | Autoliv Dev | Improvements in or relating to a crash detector |
US5964261A (en) | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
EP0923335B1 (en) | 1996-07-08 | 2006-08-23 | Animas Corporation | Implantable sensor and system for in vivo measurement and control of fluid constituent levels |
JP2943700B2 (en) | 1996-07-10 | 1999-08-30 | 日本電気株式会社 | Biosensor |
US6325978B1 (en) | 1998-08-04 | 2001-12-04 | Ntc Technology Inc. | Oxygen monitoring and apparatus |
US6054142A (en) | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
US5804048A (en) * | 1996-08-15 | 1998-09-08 | Via Medical Corporation | Electrode assembly for assaying glucose |
DE19642453C2 (en) | 1996-10-15 | 1998-07-23 | Bosch Gmbh Robert | Arrangement for gas sensor electrodes |
WO1998024358A2 (en) | 1996-12-04 | 1998-06-11 | Enact Health Management Systems | System for downloading and reporting medical information |
US5811487A (en) | 1996-12-16 | 1998-09-22 | Dow Corning Corporation | Thickening silicones with elastomeric silicone polyethers |
US5964993A (en) | 1996-12-19 | 1999-10-12 | Implanted Biosystems Inc. | Glucose sensor |
US5914026A (en) | 1997-01-06 | 1999-06-22 | Implanted Biosystems Inc. | Implantable sensor employing an auxiliary electrode |
US6607509B2 (en) | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US6093172A (en) | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
US7329239B2 (en) | 1997-02-05 | 2008-02-12 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US5851197A (en) | 1997-02-05 | 1998-12-22 | Minimed Inc. | Injector for a subcutaneous infusion set |
US6891317B2 (en) * | 2001-05-22 | 2005-05-10 | Sri International | Rolled electroactive polymers |
US6208894B1 (en) | 1997-02-26 | 2001-03-27 | Alfred E. Mann Foundation For Scientific Research And Advanced Bionics | System of implantable devices for monitoring and/or affecting body parameters |
US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
US7657297B2 (en) | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US6558321B1 (en) | 1997-03-04 | 2003-05-06 | Dexcom, Inc. | Systems and methods for remote monitoring and modulation of medical devices |
US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
US6741877B1 (en) * | 1997-03-04 | 2004-05-25 | Dexcom, Inc. | Device and method for determining analyte levels |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
FR2760962B1 (en) | 1997-03-20 | 1999-05-14 | Sillonville Francis Klefstad | REMOTE MEDICAL ASSISTANCE AND SURVEILLANCE SYSTEM |
US6270455B1 (en) | 1997-03-28 | 2001-08-07 | Health Hero Network, Inc. | Networked system for interactive communications and remote monitoring of drug delivery |
US5961451A (en) | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US6059946A (en) | 1997-04-14 | 2000-05-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
US5944661A (en) | 1997-04-16 | 1999-08-31 | Giner, Inc. | Potential and diffusion controlled solid electrolyte sensor for continuous measurement of very low levels of transdermal alcohol |
AT404992B (en) | 1997-04-17 | 1999-04-26 | Avl List Gmbh | SENSOR FOR DETERMINING AN ENZYME SUBSTRATE |
US6115634A (en) | 1997-04-30 | 2000-09-05 | Medtronic, Inc. | Implantable medical device and method of manufacture |
US5779665A (en) | 1997-05-08 | 1998-07-14 | Minimed Inc. | Transdermal introducer assembly |
US6558351B1 (en) | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
US7267665B2 (en) | 1999-06-03 | 2007-09-11 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
US6093167A (en) | 1997-06-16 | 2000-07-25 | Medtronic, Inc. | System for pancreatic stimulation and glucose measurement |
CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
US6013711A (en) | 1997-06-18 | 2000-01-11 | Ck Witco Corporation | Hydrophilic polysiloxane compositions |
US5861019A (en) * | 1997-07-25 | 1999-01-19 | Medtronic Inc. | Implantable medical device microstrip telemetry antenna |
US5871514A (en) | 1997-08-01 | 1999-02-16 | Medtronic, Inc. | Attachment apparatus for an implantable medical device employing ultrasonic energy |
GB9717906D0 (en) | 1997-08-23 | 1997-10-29 | Univ Manchester | Sensor Devices And Analytical Methods |
US6731976B2 (en) | 1997-09-03 | 2004-05-04 | Medtronic, Inc. | Device and method to measure and communicate body parameters |
US6259937B1 (en) | 1997-09-12 | 2001-07-10 | Alfred E. Mann Foundation | Implantable substrate sensor |
US5917346A (en) | 1997-09-12 | 1999-06-29 | Alfred E. Mann Foundation | Low power current to frequency converter circuit for use in implantable sensors |
US5999848A (en) | 1997-09-12 | 1999-12-07 | Alfred E. Mann Foundation | Daisy chainable sensors and stimulators for implantation in living tissue |
US6117290A (en) | 1997-09-26 | 2000-09-12 | Pepex Biomedical, Llc | System and method for measuring a bioanalyte such as lactate |
EP1029229A1 (en) | 1997-09-30 | 2000-08-23 | M- Biotech, Inc. | Biosensor |
US5967986A (en) | 1997-11-25 | 1999-10-19 | Vascusense, Inc. | Endoluminal implant with fluid flow sensing capability |
US6296615B1 (en) | 1999-03-05 | 2001-10-02 | Data Sciences International, Inc. | Catheter with physiological sensor |
US6409674B1 (en) | 1998-09-24 | 2002-06-25 | Data Sciences International, Inc. | Implantable sensor with wireless communication |
US6585763B1 (en) | 1997-10-14 | 2003-07-01 | Vascusense, Inc. | Implantable therapeutic device and method |
US6104280A (en) * | 1997-10-20 | 2000-08-15 | Micron Technology, Inc. | Method of manufacturing and testing an electronic device, and an electronic device |
US6081736A (en) | 1997-10-20 | 2000-06-27 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems adapted for long term use |
US6119028A (en) | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
US6088608A (en) | 1997-10-20 | 2000-07-11 | Alfred E. Mann Foundation | Electrochemical sensor and integrity tests therefor |
CA2575064C (en) | 1997-12-31 | 2010-02-02 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
US6134461A (en) | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
US6013113A (en) * | 1998-03-06 | 2000-01-11 | Wilson Greatbatch Ltd. | Slotted insulator for unsealed electrode edges in electrochemical cells |
CA2265119C (en) | 1998-03-13 | 2002-12-03 | Cygnus, Inc. | Biosensor, iontophoretic sampling system, and methods of use thereof |
US5904708A (en) | 1998-03-19 | 1999-05-18 | Medtronic, Inc. | System and method for deriving relative physiologic signals |
GB9805896D0 (en) | 1998-03-20 | 1998-05-13 | Eglise David | Remote analysis system |
JP3104672B2 (en) | 1998-03-31 | 2000-10-30 | 日本電気株式会社 | Current detection type sensor element and method of manufacturing the same |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6537318B1 (en) * | 1998-04-06 | 2003-03-25 | Konjac Technologies, Llc | Use of glucomannan hydrocolloid as filler material in prostheses |
US6241863B1 (en) | 1998-04-27 | 2001-06-05 | Harold G. Monbouquette | Amperometric biosensors based on redox enzymes |
US6223080B1 (en) | 1998-04-29 | 2001-04-24 | Medtronic, Inc. | Power consumption reduction in medical devices employing multiple digital signal processors and different supply voltages |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
JP2002514452A (en) | 1998-05-13 | 2002-05-21 | シグナス, インコーポレイテッド | Signal processing for measurement of physiological analytes |
US6272364B1 (en) | 1998-05-13 | 2001-08-07 | Cygnus, Inc. | Method and device for predicting physiological values |
PT1077634E (en) | 1998-05-13 | 2003-12-31 | Cygnus Therapeutic Systems | MONITORING OF PHYSIOLOGICAL SUBSTANCES TO BE ANALYZED |
US6129757A (en) | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
US7540875B2 (en) * | 1998-06-01 | 2009-06-02 | Avatar Design & Development, Inc. | Surgical cutting tool with automatically retractable blade assembly |
US6702972B1 (en) | 1998-06-09 | 2004-03-09 | Diametrics Medical Limited | Method of making a kink-resistant catheter |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
US6187062B1 (en) * | 1998-06-16 | 2001-02-13 | Alcatel | Current collection through thermally sprayed tabs at the ends of a spirally wound electrochemical cell |
US6272382B1 (en) | 1998-07-31 | 2001-08-07 | Advanced Bionics Corporation | Fully implantable cochlear implant system |
US6248067B1 (en) | 1999-02-05 | 2001-06-19 | Minimed Inc. | Analyte sensor and holter-type monitor system and method of using the same |
US6254586B1 (en) | 1998-09-25 | 2001-07-03 | Minimed Inc. | Method and kit for supplying a fluid to a subcutaneous placement site |
JP3537136B2 (en) | 1998-09-30 | 2004-06-14 | シグナス, インコーポレイテッド | Method and apparatus for predicting physiological values |
US6180416B1 (en) | 1998-09-30 | 2001-01-30 | Cygnus, Inc. | Method and device for predicting physiological values |
US6201980B1 (en) | 1998-10-05 | 2001-03-13 | The Regents Of The University Of California | Implantable medical sensor system |
US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6591125B1 (en) | 2000-06-27 | 2003-07-08 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
DK1413245T3 (en) | 1998-10-08 | 2011-10-10 | Medtronic Minimed Inc | Installations for monitoring a characteristic of remote sensing |
US6016448A (en) * | 1998-10-27 | 2000-01-18 | Medtronic, Inc. | Multilevel ERI for implantable medical devices |
US6156013A (en) * | 1998-11-04 | 2000-12-05 | Mahurkar; Sakharam D. | Safety syringe |
JP2002529204A (en) * | 1998-11-13 | 2002-09-10 | エラン・フアルマ・インターナシヨナル・リミテツド | System and method for delivering chemicals |
EP1131114B1 (en) | 1998-11-20 | 2004-06-16 | The University of Connecticut | Apparatus and method for control of tissue/implant interactions |
US6066083A (en) | 1998-11-27 | 2000-05-23 | Syntheon Llc | Implantable brachytherapy device having at least partial deactivation capability |
EP1135677A1 (en) | 1998-12-02 | 2001-09-26 | UT-Battelle, LLC | In vivo biosensor apparatus and method of use |
US6447448B1 (en) | 1998-12-31 | 2002-09-10 | Ball Semiconductor, Inc. | Miniature implanted orthopedic sensors |
US6309384B1 (en) | 1999-02-01 | 2001-10-30 | Adiana, Inc. | Method and apparatus for tubal occlusion |
US6424847B1 (en) | 1999-02-25 | 2002-07-23 | Medtronic Minimed, Inc. | Glucose monitor calibration methods |
US6360888B1 (en) | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
US6230059B1 (en) | 1999-03-17 | 2001-05-08 | Medtronic, Inc. | Implantable monitor |
US6285897B1 (en) | 1999-04-07 | 2001-09-04 | Endonetics, Inc. | Remote physiological monitoring system |
JP2002541441A (en) | 1999-04-07 | 2002-12-03 | スペクトルクス,インコーポレイティド | Analytical device for continuous measurement of fluid properties |
US6189536B1 (en) * | 1999-04-15 | 2001-02-20 | Medtronic Inc. | Method for protecting implantable devices |
US6223083B1 (en) | 1999-04-16 | 2001-04-24 | Medtronic, Inc. | Receiver employing digital filtering for use with an implantable medical device |
EP1064046A1 (en) | 1999-04-22 | 2001-01-03 | Cygnus, Inc. | Methods and devices for removing interfering species |
US7371400B2 (en) | 2001-01-02 | 2008-05-13 | The General Hospital Corporation | Multilayer device for tissue engineering |
US6475750B1 (en) | 1999-05-11 | 2002-11-05 | M-Biotech, Inc. | Glucose biosensor |
US6300002B1 (en) | 1999-05-13 | 2001-10-09 | Moltech Power Systems, Inc. | Notched electrode and method of making same |
US6546268B1 (en) | 1999-06-02 | 2003-04-08 | Ball Semiconductor, Inc. | Glucose sensor |
EP2322645A1 (en) | 1999-06-18 | 2011-05-18 | Abbott Diabetes Care Inc. | Mass transport limited in vivo analyte sensor |
US6991643B2 (en) | 2000-12-20 | 2006-01-31 | Usgi Medical Inc. | Multi-barbed device for retaining tissue in apposition and methods of use |
US7247138B2 (en) | 1999-07-01 | 2007-07-24 | Medtronic Minimed, Inc. | Reusable analyte sensor site and method of using the same |
US6368274B1 (en) | 1999-07-01 | 2002-04-09 | Medtronic Minimed, Inc. | Reusable analyte sensor site and method of using the same |
US6413393B1 (en) | 1999-07-07 | 2002-07-02 | Minimed, Inc. | Sensor including UV-absorbing polymer and method of manufacture |
US6346583B1 (en) | 1999-08-25 | 2002-02-12 | General Electric Company | Polar solvent compatible polyethersiloxane elastomers |
US6312469B1 (en) | 1999-09-13 | 2001-11-06 | Medtronic Inc. | Lamina prosthesis for delivery of medical treatment |
US6343225B1 (en) | 1999-09-14 | 2002-01-29 | Implanted Biosystems, Inc. | Implantable glucose sensor |
WO2001020334A1 (en) | 1999-09-15 | 2001-03-22 | The Regents Of The University Of California | Glucose sensing molecules having selected fluorescent properties |
US6541107B1 (en) | 1999-10-25 | 2003-04-01 | Dow Corning Corporation | Nanoporous silicone resins having low dielectric constants |
US6527729B1 (en) * | 1999-11-10 | 2003-03-04 | Pacesetter, Inc. | Method for monitoring patient using acoustic sensor |
SE9904087D0 (en) | 1999-11-11 | 1999-11-11 | Pacesetter Ab | Recommended replacement time of an implantable medical device |
JP3426549B2 (en) | 1999-11-12 | 2003-07-14 | 本田技研工業株式会社 | Exhaust pipe connection structure |
GB9928071D0 (en) * | 1999-11-29 | 2000-01-26 | Polybiomed Ltd | Blood compatible medical articles |
US6873268B2 (en) | 2000-01-21 | 2005-03-29 | Medtronic Minimed, Inc. | Microprocessor controlled ambulatory medical apparatus with hand held communication device |
CA2395868C (en) | 2000-02-10 | 2009-07-14 | Medtronic Minimed, Inc. | Improved analyte sensor and method of making the same |
US6895263B2 (en) | 2000-02-23 | 2005-05-17 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
US6551496B1 (en) | 2000-03-03 | 2003-04-22 | Ysi Incorporated | Microstructured bilateral sensor |
US6365670B1 (en) | 2000-03-10 | 2002-04-02 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
CA2406814A1 (en) | 2000-03-17 | 2001-09-20 | F. Hoffmann-La Roche Ag | Implantable analyte sensor |
US6405066B1 (en) | 2000-03-17 | 2002-06-11 | The Regents Of The University Of California | Implantable analyte sensor |
WO2001088524A1 (en) | 2000-05-12 | 2001-11-22 | Therasense, Inc. | Electrodes with multilayer membranes and methods of using and making the electrodes |
US6442413B1 (en) | 2000-05-15 | 2002-08-27 | James H. Silver | Implantable sensor |
WO2001088534A2 (en) | 2000-05-16 | 2001-11-22 | Cygnus, Inc. | Methods for improving performance and reliability of biosensors |
US6459917B1 (en) | 2000-05-22 | 2002-10-01 | Ashok Gowda | Apparatus for access to interstitial fluid, blood, or blood plasma components |
WO2001090733A1 (en) | 2000-05-23 | 2001-11-29 | Radiometer Medical A/S | A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor |
US6991652B2 (en) * | 2000-06-13 | 2006-01-31 | Burg Karen J L | Tissue engineering composite |
US6773565B2 (en) | 2000-06-22 | 2004-08-10 | Kabushiki Kaisha Riken | NOx sensor |
US6400974B1 (en) | 2000-06-29 | 2002-06-04 | Sensors For Medicine And Science, Inc. | Implanted sensor processing system and method for processing implanted sensor output |
US6569521B1 (en) | 2000-07-06 | 2003-05-27 | 3M Innovative Properties Company | Stretch releasing pressure sensitive adhesive tape and articles |
US6477392B1 (en) | 2000-07-14 | 2002-11-05 | Futrex Inc. | Calibration of near infrared quantitative measurement device using optical measurement cross-products |
US6683535B1 (en) * | 2000-08-09 | 2004-01-27 | Alderon Industries, Llc | Water detection system and method |
US7404819B1 (en) | 2000-09-14 | 2008-07-29 | C.R. Bard, Inc. | Implantable prosthesis |
DE60126325T2 (en) * | 2000-11-09 | 2007-11-08 | Insulet Corp., Beverly | DEVICE FOR THE TRANSCUTANEOUS DISPOSAL OF MEDICAMENTS |
US6695860B1 (en) * | 2000-11-13 | 2004-02-24 | Isense Corp. | Transcutaneous sensor insertion device |
US6642015B2 (en) | 2000-12-29 | 2003-11-04 | Minimed Inc. | Hydrophilic polymeric material for coating biosensors |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6793802B2 (en) | 2001-01-04 | 2004-09-21 | Tyson Bioresearch, Inc. | Biosensors having improved sample application and measuring properties and uses thereof |
US6666821B2 (en) | 2001-01-08 | 2003-12-23 | Medtronic, Inc. | Sensor system |
US6824521B2 (en) | 2001-01-22 | 2004-11-30 | Integrated Sensing Systems, Inc. | Sensing catheter system and method of fabrication |
US6547839B2 (en) | 2001-01-23 | 2003-04-15 | Skc Co., Ltd. | Method of making an electrochemical cell by the application of polysiloxane onto at least one of the cell components |
US7014610B2 (en) | 2001-02-09 | 2006-03-21 | Medtronic, Inc. | Echogenic devices and methods of making and using such devices |
WO2002064027A2 (en) | 2001-02-15 | 2002-08-22 | The Regents Of The University Of California | Membrane and electrode structure for implantable sensor |
FR2822383B1 (en) | 2001-03-23 | 2004-12-17 | Perouse Lab | PROSTHESIS FOR PLASTIC RECONSTRUCTION WITH IMPROVED HYDROPHILICITY PROPERTIES, AND METHOD FOR OBTAINING SAME |
US6454710B1 (en) | 2001-04-11 | 2002-09-24 | Motorola, Inc. | Devices and methods for monitoring an analyte |
US6528584B2 (en) * | 2001-04-12 | 2003-03-04 | The University Of Akron | Multi-component polymeric networks containing poly(ethylene glycol) |
US6613379B2 (en) | 2001-05-08 | 2003-09-02 | Isense Corp. | Implantable analyte sensor |
US6793632B2 (en) | 2001-06-12 | 2004-09-21 | Lifescan, Inc. | Percutaneous biological fluid constituent sampling and measurement devices and methods |
US6501976B1 (en) | 2001-06-12 | 2002-12-31 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
US20030032874A1 (en) * | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
US6913626B2 (en) * | 2001-08-14 | 2005-07-05 | Mcghan Jim J. | Medical implant having bioabsorbable textured surface |
US7025760B2 (en) | 2001-09-07 | 2006-04-11 | Medtronic Minimed, Inc. | Method and system for non-vascular sensor implantation |
US6809507B2 (en) | 2001-10-23 | 2004-10-26 | Medtronic Minimed, Inc. | Implantable sensor electrodes and electronic circuitry |
US6705833B2 (en) | 2001-11-15 | 2004-03-16 | Hewlett-Packard Development Company, L.P. | Airflow flapper valve |
US20040030294A1 (en) * | 2001-11-28 | 2004-02-12 | Mahurkar Sakharam D. | Retractable needle single use safety syringe |
US6952604B2 (en) | 2001-12-21 | 2005-10-04 | Becton, Dickinson And Company | Minimally-invasive system and method for monitoring analyte levels |
US7018336B2 (en) | 2001-12-27 | 2006-03-28 | Medtronic Minimed, Inc. | Implantable sensor flush sleeve |
CA2474359A1 (en) | 2002-01-29 | 2003-08-07 | Sicel Technologies, Inc. | Implantable sensor housing and fabrication methods |
US8010174B2 (en) * | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
DE60337038D1 (en) | 2002-03-22 | 2011-06-16 | Animas Technologies Llc | Performance improvement of an analyte monitoring device |
US6936006B2 (en) | 2002-03-22 | 2005-08-30 | Novo Nordisk, A/S | Atraumatic insertion of a subcutaneous device |
US7153265B2 (en) | 2002-04-22 | 2006-12-26 | Medtronic Minimed, Inc. | Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
AU2003240018A1 (en) | 2002-05-31 | 2003-12-19 | Dow Corning Toray Silicone Co., Ltd. | Cartridge for moisture-curable sealant |
JP2005531759A (en) | 2002-06-28 | 2005-10-20 | ノヴェンバー アクティエンゲゼルシャフト | Electrochemical detection apparatus and method |
US7233649B2 (en) * | 2002-07-12 | 2007-06-19 | Utstarcom, Inc. | Faster modem method and apparatus |
US20040010207A1 (en) * | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
US20040068230A1 (en) | 2002-07-24 | 2004-04-08 | Medtronic Minimed, Inc. | System for providing blood glucose measurements to an infusion device |
US7150975B2 (en) | 2002-08-19 | 2006-12-19 | Animas Technologies, Llc | Hydrogel composition for measuring glucose flux |
US7736309B2 (en) | 2002-09-27 | 2010-06-15 | Medtronic Minimed, Inc. | Implantable sensor method and system |
US7248912B2 (en) | 2002-10-31 | 2007-07-24 | The Regents Of The University Of California | Tissue implantable sensors for measurement of blood solutes |
US7811231B2 (en) | 2002-12-31 | 2010-10-12 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
US7875293B2 (en) * | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
US8454566B2 (en) | 2003-07-10 | 2013-06-04 | Medtronic Minimed, Inc. | Methods and compositions for the inhibition of biofilms on medical devices |
US20050051427A1 (en) * | 2003-07-23 | 2005-03-10 | Brauker James H. | Rolled electrode array and its method for manufacture |
US7074307B2 (en) | 2003-07-25 | 2006-07-11 | Dexcom, Inc. | Electrode systems for electrochemical sensors |
WO2005012871A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Increasing bias for oxygen production in an electrode system |
EP1648298A4 (en) * | 2003-07-25 | 2010-01-13 | Dexcom Inc | Oxygen enhancing membrane systems for implantable devices |
US7108778B2 (en) | 2003-07-25 | 2006-09-19 | Dexcom, Inc. | Electrochemical sensors including electrode systems with increased oxygen generation |
US6931327B2 (en) | 2003-08-01 | 2005-08-16 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US20050090607A1 (en) | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
EP1711802B1 (en) | 2003-12-08 | 2010-07-14 | DexCom, Inc. | Systems and methods for improving electrochemical analyte sensors |
US7364592B2 (en) | 2004-02-12 | 2008-04-29 | Dexcom, Inc. | Biointerface membrane with macro-and micro-architecture |
US20050245799A1 (en) | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
US20060015020A1 (en) * | 2004-07-06 | 2006-01-19 | Dexcom, Inc. | Systems and methods for manufacture of an analyte-measuring device including a membrane system |
US20080242961A1 (en) | 2004-07-13 | 2008-10-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20060270922A1 (en) | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
US8060174B2 (en) | 2005-04-15 | 2011-11-15 | Dexcom, Inc. | Analyte sensing biointerface |
WO2006113618A1 (en) | 2005-04-15 | 2006-10-26 | Dexcom, Inc. | Analyte sensing biointerface |
WO2006130854A2 (en) | 2005-06-02 | 2006-12-07 | Isense Corporation | Use of multiple data points and filtering in an analyte sensor |
ATE514755T1 (en) | 2006-07-25 | 2011-07-15 | Glumetrics Inc | FLUORESCENT DYES FOR USE IN GLUCOSE DETECTION |
US7751863B2 (en) | 2007-02-06 | 2010-07-06 | Glumetrics, Inc. | Optical determination of ph and glucose |
US7824918B2 (en) | 2007-08-06 | 2010-11-02 | Glumetrics, Inc. | HPTS-Mono and BIS Cys-Ma polymerizable fluorescent dyes for use in analyte sensors |
US8088097B2 (en) | 2007-11-21 | 2012-01-03 | Glumetrics, Inc. | Use of an equilibrium intravascular sensor to achieve tight glycemic control |
US20090018426A1 (en) | 2007-05-10 | 2009-01-15 | Glumetrics, Inc. | Device and methods for calibrating analyte sensors |
EP2989975B1 (en) | 2007-02-06 | 2018-06-13 | Medtronic MiniMed, Inc. | Optical systems and methods for rationmetric measurement of blood glucose concentration |
EP2122334B1 (en) | 2007-02-06 | 2018-01-24 | Medtronic Minimed, Inc. | Method for polymerizing a monomer solution within a cavity to generate a smooth polymer surface |
WO2008137604A1 (en) | 2007-05-01 | 2008-11-13 | Glumetrics, Inc. | Pyridinium boronic acid quenchers for use in analyte sensors |
WO2008141241A1 (en) | 2007-05-10 | 2008-11-20 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
WO2009009756A2 (en) | 2007-07-11 | 2009-01-15 | Glumetrics, Inc. | Polyviologen boronic acid quenchers for use in analyte sensors |
WO2009129186A2 (en) | 2008-04-17 | 2009-10-22 | Glumetrics, Inc. | Sensor for percutaneous intravascular deployment without an indwelling cannula |
-
2001
- 2001-07-27 US US09/916,386 patent/US6702857B2/en not_active Expired - Lifetime
-
2002
- 2002-07-26 JP JP2003516584A patent/JP2004538455A/en active Pending
- 2002-07-26 AT AT02747094T patent/ATE318622T1/en not_active IP Right Cessation
- 2002-07-26 EP EP05111808A patent/EP1656958A1/en not_active Withdrawn
- 2002-07-26 WO PCT/US2002/023902 patent/WO2003011354A2/en active IP Right Grant
- 2002-07-26 EP EP02747094A patent/EP1414504B1/en not_active Expired - Lifetime
- 2002-07-26 ES ES02747094T patent/ES2259091T3/en not_active Expired - Lifetime
- 2002-07-26 DE DE60209498T patent/DE60209498T2/en not_active Expired - Lifetime
- 2002-07-26 DK DK02747094T patent/DK1414504T3/en active
-
2004
- 2004-01-29 US US10/768,889 patent/US7632228B2/en active Active
-
2009
- 2009-12-08 US US12/633,578 patent/US8840552B2/en active Active
-
2014
- 2014-07-25 US US14/341,468 patent/US9532741B2/en not_active Expired - Lifetime
-
2015
- 2015-02-11 US US14/619,651 patent/US10039480B2/en not_active Expired - Lifetime
-
2018
- 2018-07-05 US US16/028,110 patent/US20180317827A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007525A1 (en) * | 1990-10-31 | 1992-05-14 | Baxter International Inc. | Close vascularization implant material |
WO1997043633A1 (en) * | 1996-05-17 | 1997-11-20 | Encelle, Inc. | Electrochemical biosensors |
WO2000013003A1 (en) * | 1998-08-26 | 2000-03-09 | Sensors For Medicine And Science, Inc. | Optical-based sensing devices |
WO2001012158A1 (en) * | 1999-08-16 | 2001-02-22 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
WO2001043660A2 (en) * | 1999-12-08 | 2001-06-21 | Baxter International Inc. | Porous three dimensional structure |
Non-Patent Citations (1)
Title |
---|
SIEMINSKI A L ET AL: "Biomaterial-microvasculature interactions" BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 22, 15 November 2000 (2000-11-15), pages 2233-2241, XP004210280 ISSN: 0142-9612 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007514460A (en) * | 2003-09-30 | 2007-06-07 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | Sensor showing increased biocompatibility |
US11623023B2 (en) | 2016-11-10 | 2023-04-11 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
WO2020243666A1 (en) * | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
WO2020243665A1 (en) * | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
Also Published As
Publication number | Publication date |
---|---|
ES2259091T3 (en) | 2006-09-16 |
WO2003011354A3 (en) | 2003-08-14 |
DE60209498D1 (en) | 2006-04-27 |
US10039480B2 (en) | 2018-08-07 |
US20150157248A1 (en) | 2015-06-11 |
US20100087724A1 (en) | 2010-04-08 |
EP1656958A1 (en) | 2006-05-17 |
US7632228B2 (en) | 2009-12-15 |
EP1414504B1 (en) | 2006-03-01 |
DK1414504T3 (en) | 2006-07-10 |
US9532741B2 (en) | 2017-01-03 |
EP1414504A2 (en) | 2004-05-06 |
US8840552B2 (en) | 2014-09-23 |
US6702857B2 (en) | 2004-03-09 |
DE60209498T2 (en) | 2006-08-03 |
US20180317827A1 (en) | 2018-11-08 |
JP2004538455A (en) | 2004-12-24 |
US20030023317A1 (en) | 2003-01-30 |
US20140335343A1 (en) | 2014-11-13 |
US20040186362A1 (en) | 2004-09-23 |
ATE318622T1 (en) | 2006-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20180317827A1 (en) | Membrane for use with implantable devices | |
US9931067B2 (en) | Device and method for determining analyte levels | |
JP4124827B2 (en) | Apparatus and method for measuring an analyte level | |
US7136689B2 (en) | Device and method for determining analyte levels | |
Gilligan et al. | Feasibility of continuous long-term glucose monitoring from a subcutaneous glucose sensor in humans |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EC EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GE GH GM HR HU ID IL IN IS JP KE KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG US Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003516584 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002747094 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002747094 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002747094 Country of ref document: EP |