WO2003017874A1 - Self-molding annuloplasty ring - Google Patents
Self-molding annuloplasty ring Download PDFInfo
- Publication number
- WO2003017874A1 WO2003017874A1 PCT/US2002/026452 US0226452W WO03017874A1 WO 2003017874 A1 WO2003017874 A1 WO 2003017874A1 US 0226452 W US0226452 W US 0226452W WO 03017874 A1 WO03017874 A1 WO 03017874A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diameter
- resilient
- attachment
- annuloplasty ring
- ring
- Prior art date
Links
- 238000000465 moulding Methods 0.000 title claims abstract description 11
- 238000002513 implantation Methods 0.000 claims abstract description 24
- 238000004513 sizing Methods 0.000 claims description 26
- 229920001971 elastomer Polymers 0.000 claims description 7
- 239000000806 elastomer Substances 0.000 claims description 6
- 229920004934 Dacron® Polymers 0.000 claims description 4
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims description 4
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 230000008467 tissue growth Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 23
- 210000001519 tissue Anatomy 0.000 description 14
- 210000004115 mitral valve Anatomy 0.000 description 12
- -1 without limitation Substances 0.000 description 8
- 238000003780 insertion Methods 0.000 description 7
- 230000037431 insertion Effects 0.000 description 7
- 230000008602 contraction Effects 0.000 description 5
- 210000005246 left atrium Anatomy 0.000 description 5
- 210000000591 tricuspid valve Anatomy 0.000 description 5
- 210000003709 heart valve Anatomy 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000003698 chordae tendineae Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003540 papillary muscle Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
- A61F2/2448—D-shaped rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
Definitions
- the human heart is hollow muscular organ having four pumping chambers separated by four heart valves.
- the mitral and tricuspid valves present at the left and right atrio-ventricular junctions, open and close in response to a pressure gradient during each cardiac cycle of relaxation and contraction to control the flow of blood to a particular region of the heart.
- valves are comprised of a dense fibrous ring known as the annulus, leaflets or cusps attached to the annulus, and a complex of chordae tendineae and papillary muscles securing the leaflets.
- the size of the leaflets or cusps is such that when the heart contracts the resulting increased blood pressure formed within the ventricular cavity forces the leaflets towards the arterial cavity. As a result, the leaflets or cusps come in apposition to each other thereby closing the atrio- ventricular passage.
- valvular dysfunction occurs when the annulus becomes excessively dilated or the valve geometry results in effective valve closure, which results in regurgitation. Due to the increased diameter of the annulus, the leaflets or cusps fail to meet during systolic contraction, thereby resulting in the regurgitation of blood during ventricular contractions. As such, sufficient back pressure exists within the chambers of the heart capable of forcing some blood flow to traverse the atrio-ventricular junction from the ventricle to the atria.
- One manner of repairing this problem involves surgically implanting a prosthetic ring (i.e. "annulolasty ring”) about the dilated annulus, thereby restoring the annulus to the normal size and shape and allowing the valve leaflets to function normally.
- a surgeon positions the annuloplasty ring near the valve annulus and sutures the device in place.
- a rigid annuloplasty ring having the desired internal diameter is positioned near the heart valve and sutured in place. As a result, the diameter of the valve is reduced to the diameter of the annuloplasty ring.
- This procedure utilizing current annuloplasty rings has several shortcomings.
- the tissue comprising the heart particularly in the area of the heart valves, is flexible.
- the implantation of a rigid annuloplasty ring restricts the natural flexibility of this tissue, and may impact the heart function.
- the dilated annulus is substantially larger in diameter than the annuloplasty ring, thereby making the implantation surgery unnecessarily time consuming.
- the surgeon is required to position the prosthesis near a portion of the tissue and suture the ring in place. Thereafter, the opposing tissue is forced to engage the ring and is attached to the annuloplasty ring with sutures. Consequently, the sutures may be under different stress loads, and could result in an increased risk of ring dehiscence.
- the present invention solves the aforementioned problems in that the resilient annuloplasty ring of the present invention may be stretched to the diameter of the dilated valve annulus prior to implantation, thereby simplifying the implantation process.
- the contractive force of the resilient annuloplasty ring of the present invention may controllably reduce the diameter of an incompetent dilated valve annulus to more competent diameter.
- the present invention is easy to manufacture and may be manufactured from a plurality of materials.
- the annuloplasty ring of the present invention comprises a resilient inner sizing member positioned within a resilient outer attachment sheath.
- the resilient inner sizing member applies a contractive force to the incompetent annulus tissue.
- the resilient outer attachment sheath permits the surgeon to attach the device to the annulus tissue in a plurality of manners including suturing and stapling.
- the annuloplasty ring of the present invention may be manufactured from a plurality of biologically compatible materials having sufficient resiliency to permit stretching during implantation and having sufficient contractive force to permit a reduction in the diameter of the incompetent valve annulus.
- the present invention further discloses an alternate embodiment of the self molding annuloplasty ring.
- the present embodiment comprises an resilient inner sizing member positioned within a resilient outer attachment sheath, the ring having a plurality of attachment member positioned thereon.
- the attachment members may comprise a plurality of devices, including, for example, needles, barbs, or hooks.
- the attachment members may be manufactured from a plurality of materials, including, without limitation, stainless steel, titanium, and Nitinol.
- a self molding annuloplasty ring having a predetermined contracted diameter is disclosed.
- the present embodiment comprises a resilient inner sizing member positioned within a series of individual sizing supports.
- a resilient outer attachment sheath is positioned on the exterior of the sizing supports.
- the present embodiment permits the surgeon to predetermine the inner diameter of a repaired valve annulus, thereby rendering an incompetent valve competent.
- the sizing support members may be manufactured from a plurality of biologically compatible materials, including, without limitation, plastic and elastomer.
- Figure 1 shows a top sectional view of the mitral and tricuspid valves and valve annuli within a heart
- Figure 2A shows a side view of the annuloplasty ring of the present invention
- Figure 2B shows a top view of the annuloplasty ring of the present invention
- Figure 2C shows a cross sectional view of the annuloplasty ring of the present invention
- Figure 2D shows an alternate embodiment of the annuloplasty ring of the present invention having a support member positioned therein;
- Figure 2E shows a perspective view of the annuloplasty ring of the present invention
- Figure 3 shows a top sectional view of the annuloplasty ring of the present invention positioned within the valve annulus of the mitral valve;
- Figure 3B shows a top view of an embodiment of the present embodiment having a plurality of attachment devices disposed thereon;
- Figure 3C shows a cross sectional view of the present embodiment having a plurality of attachment devices disposed thereon;
- Figure 3D shows a perspective view of the present embodiment having a plurality of attachment devices disposed thereon;
- Figure 4A shows a top view of the present embodiment of the present invention in a contracted state having a plurality of size support members positioned thereon;
- Figure 4B shows a top view of the present embodiment of the present invention in a stretched state having a plurality of size support members positioned thereon;
- Figure 4C shows a cross sectional view of the present embodiment of the present invention.
- the self-molding annuloplasty ring of the present invention is generally used in surgical procedures to repair an incompetent tissue annulus. More specifically, the present invention is used to render an otherwise incompetent heart valve competent by decreasing the diameter of the opening at the valvular junction. As those skilled in the art will appreciate, the present invention may be manufactured with varying degrees of pre-tension and contractive force, thereby permitting variation of the contraction of the anterior or posterior annuli. In addition, the present invention simplifies the implantation procedure by pre- stretching the annulus ring to the diameter of the dilated annulus, and thereafter reducing the annulus with the contractive force exerted by the self-molding annulus ring.
- Figure 1 shows a cross sectional view of the heart 10 having a bicuspid or mitral valve 12 positioned near the mitral valve annulus 14, and a tricuspid valve 16 positioned near the tricuspid valve annulus 18.
- the self-molding annulus ring 20 comprises a first planar surface 22 and an opposing second planar surface 24.
- Figure 2B shows the annulus ring 20 having a rectilinear segment 26 and an arcuate segment 28 connected by two curved ends 30 and 32, respectively.
- the annuloplasty ring 20 is generally "D" shaped to conform to the shape of a typical mitral valve annulus.
- the ring 20 may be manufactured in any shape suitable for implantation about an annulus.
- the present invention may be manufactured in a generally round or oval shape thereby permitting use of the present invention to remodel an otherwise incompetent tricuspid valve.
- Figure 2C shows a cross-section view of the annuloplasty ring 20 having an elastic sizing member 36 positioned within an attachment sheath 38.
- the elastic sizing member 36 may comprise a plurality of biologically-compatible materials including, without limitation, elastomer, silicon, or any other material having sufficient resiliency to permit pre-stretching of the annuloplasty ring 20 prior to and during implantation, while having sufficient contractive force to decrease the size of the valve annulus to a desired diameter.
- the attachment sheath 38 provides a suitable material for suturing or otherwise attaching the annulus ring 20 to the tissue forming the valve annulus and promoting tissue growth therein.
- the attachment sheath 38 may comprise a plurality of biologically-compatible materials having comparable resiliency, including, for example, dacron, polyester knit, PTFE knit, and ePTFE knit.
- the attachment sheath may further comprise material treated with a biologically- compatible tissue growth factor or other medicament to aid in treating the attachment area.
- SAM systolic anterior motion
- LVOT left ventricular outflow track
- FIG. 2D An alternate embodiment of the present invention is shown in Figure 2D having the support member 40 positioned between the sizing member 36 and the attachment sheath 36.
- the support member 40 may be fabricated from a plurality of biologically-compatible materials having a comparable modulus of resiliency, including, for example, elastomer, rubber, silicon, or other material having sufficient resiliency to permit pre-stretching prior to implantation while providing support to the valve annulus.
- the support member 40 provides additional support of the valve and valve annulus
- Figure 2E shows a perspective view of the annuloplasty ring of the present invention.
- the annulus ring may be attached to the annulus or surrounding tissue using a plurality of devices.
- the annulus ring 20 may be attached to the valve annulus, either 14 or 18, with sutures 42.
- Figure 3B shows an alternate embodiment of the present invention utilizing attachment devices positioned on the annuloplasty ring.
- the present embodiment of the ring 44 comprises a rectilinear segment 46 attached to an arcuate portion 48 with two curved ends 50 and 52 positioned therebetween.
- a number of attachment devices 54 are positioned around the ring 44 to facilitate attachment of the ring 44 to the annulus tissue.
- Figure 3C shows the internal materials of the present invention having a sizing member 56 and an tissue-engaging sheath 58 disposed thereon.
- the sizing member 56 may be manufactured from a plurality of materials, including, for example, elastomer, silicon, or any other material having sufficient resiliency to permit pre-stretching of the annuloplasty ring 44 prior to and during implantation, while having sufficient contractive force to decreasing the size of the valve annulus to a desired diameter.
- the tissue- engaging sheath 58 may be manufactured from a plurality of biologically- compatible materials having comparable resiliency, including, for example, dacron, polyester knit, PTFE knit, and ePTFE knit, or may incorporate tissue growth-enhancing materials.
- the attachment device 54 may comprise various tissue-engaging devices, including, for example, needles, barbs, or hooks.
- attachment devices 54 may be manufactured from a plurality of materials, including, without limitation, stainless steel, titanium, Nickel-Titanium alloy (Nitinol), or other biologically-compatible material.
- Figure 3D shows a perspective view of the annuloplasty ring of the present embodiment having a plurality of attachment devices 54 position about the device body 44.
- Figures 4A-4C show an alternative embodiment of the present invention which includes size retaining members.
- Figure 4A shows the annuloplasty ring 60 of the present embodiment in a contracted state, wherein the ring 60 comprises a rectilinear segment 62, an arcuate segment 64, and two curved ends 66 and 68 positioned therebetween.
- the resilient ring 60 is comprised of a series of size supports 70 positioned about the exterior of the device.
- Figure 4B shows the resilient ring 60 stretched prior to implantation, having a resilient sizing member 72 positioned within the sizing supports 70.
- the sizing support 70 has a receiving lumen 74 formed therein which is capable of receiving the sizing member 72.
- the attachment sheath 76 may be positioned on the exterior of the sizing support 70.
- the resilient ring 60 Prior to implantation the resilient ring 60 is pre- stretched to a diameter roughly equivalent to the diameter of the dilated valve annulus and attached to the tissue use, for example, sutures, staples, or barbs.
- the insertion device (not shown) is removed and the ring 60 contracts causing each size support 70 to engage the proximate size supports 70, thereby limiting the amount of contraction the resilient ring 60 may achieve.
- the size supports 70 may be manufactured from a plurality of biologically-compatible materials, including, without limitation, stainless steel, titanium, or plastic.
- the sizing member 72 may be manufactured from a plurality of biologically compatible materials, including, for example, elastomer, silicon, or any other material having sufficient resiliency to permit pre-stretching of the annuloplasty ring 44 prior to and during implantation, while having sufficient contractive force to decrease the size of the valve annulus to a desired diameter.
- the attachment sheath 58 may be manufactured from a plurality of resilient biologically-compatible materials, including, for example, dacron, polyester knit, PTFE knit, and ePTFE knit, or may incorporate tissue growth-enhancing materials.
- the present invention further discloses a method of repairing a dilated or otherwise incompetent annulus.
- An exemplary open-chest surgical repair of a mitral valve will be disclosed herein. It should be understood the method disclosed herein is not intended to limit the scope of the present invention in any way.
- the mitral valve partially forms the atrio-ventricular junction between the left atrium and left ventricle of the heart and is most easily reached through the wall of the left atrium.
- the wall of the left atrium is may be accessed through a medial sternotomy procedure.
- the surgeon rotates the heart to an anterior position, thereby providing access to the left atrium.
- An incision is made in the left atrium, thereby providing access to the mitral valve and the valve annulus.
- the ring 20 is stretched for positioning on an insertion device.
- the annuloplasty ring may be positioned on the insertion device at the time of manufacture or immediately prior to implantation.
- the annuloplasty ring should be stretched to a size commensurate with the diameter of the dilated valve annulus.
- the ring, positioned on the insertion device is proximate to the valve annulus and attached to surrounding tissue in a plurality of manners, including, suturing, stapling, or any other biologically- compatible attachment technique.
- the insertion device may be removed, resulting in the annuloplasty ring contracting to its pre-stretched diameter, thereby rendering the valve competent.
- the contractive force of the annuloplasty ring will determine the amount of post-implantation valvular dilation, thereby permitting the surgeon to accurately predict the post-implantation valve diameter.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT02759412T ATE446727T1 (en) | 2001-08-24 | 2002-08-20 | SELF-FORMABLE ANNULOPLASTY RING PROSTHESIS |
EP02759412A EP1418865B1 (en) | 2001-08-24 | 2002-08-20 | Self-moulding annuloplasty ring |
DE60234189T DE60234189D1 (en) | 2001-08-24 | 2002-08-20 | Selbst-formbare annuloplastie-ringprothese |
CA002456991A CA2456991A1 (en) | 2001-08-24 | 2002-08-20 | Self-molding annuloplasty ring |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/938,902 US6726716B2 (en) | 2001-08-24 | 2001-08-24 | Self-molding annuloplasty ring |
US09/938,902 | 2001-08-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003017874A1 true WO2003017874A1 (en) | 2003-03-06 |
Family
ID=25472169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/026452 WO2003017874A1 (en) | 2001-08-24 | 2002-08-20 | Self-molding annuloplasty ring |
Country Status (6)
Country | Link |
---|---|
US (3) | US6726716B2 (en) |
EP (2) | EP2133040A3 (en) |
AT (1) | ATE446727T1 (en) |
CA (1) | CA2456991A1 (en) |
DE (1) | DE60234189D1 (en) |
WO (1) | WO2003017874A1 (en) |
Cited By (23)
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US7942927B2 (en) | 2004-03-15 | 2011-05-17 | Baker Medical Research Institute | Treating valve failure |
WO2013130641A1 (en) | 2012-02-29 | 2013-09-06 | Valcare, Inc. | Percutaneous annuloplasty system with anterior-posterior adjustment |
US9180005B1 (en) | 2014-07-17 | 2015-11-10 | Millipede, Inc. | Adjustable endolumenal mitral valve ring |
US9180008B2 (en) | 2012-02-29 | 2015-11-10 | Valcare, Inc. | Methods, devices, and systems for percutaneously anchoring annuloplasty rings |
US9192471B2 (en) | 2007-01-08 | 2015-11-24 | Millipede, Inc. | Device for translumenal reshaping of a mitral valve annulus |
US9402721B2 (en) | 2011-06-01 | 2016-08-02 | Valcare, Inc. | Percutaneous transcatheter repair of heart valves via trans-apical access |
US9433503B2 (en) | 2010-08-04 | 2016-09-06 | Valcare, Inc. | Percutaneous transcatheter repair of heart valves |
US9795480B2 (en) | 2010-08-24 | 2017-10-24 | Millipede, Inc. | Reconfiguring tissue features of a heart annulus |
US9848983B2 (en) | 2015-02-13 | 2017-12-26 | Millipede, Inc. | Valve replacement using rotational anchors |
US10166100B2 (en) | 2013-03-15 | 2019-01-01 | Valcare, Inc. | Systems and methods for delivery of annuloplasty rings |
US10278819B2 (en) | 2015-06-01 | 2019-05-07 | Edwards Lifesciences Corporation | Cardiac valve repair devices configured for percutaneous delivery |
US10335275B2 (en) | 2015-09-29 | 2019-07-02 | Millipede, Inc. | Methods for delivery of heart valve devices using intravascular ultrasound imaging |
US10543088B2 (en) | 2012-09-14 | 2020-01-28 | Boston Scientific Scimed, Inc. | Mitral valve inversion prostheses |
US10548731B2 (en) | 2017-02-10 | 2020-02-04 | Boston Scientific Scimed, Inc. | Implantable device and delivery system for reshaping a heart valve annulus |
US10555813B2 (en) | 2015-11-17 | 2020-02-11 | Boston Scientific Scimed, Inc. | Implantable device and delivery system for reshaping a heart valve annulus |
US10813751B2 (en) | 2013-05-22 | 2020-10-27 | Valcare, Inc. | Transcatheter prosthetic valve for mitral or tricuspid valve replacement |
US10849755B2 (en) | 2012-09-14 | 2020-12-01 | Boston Scientific Scimed, Inc. | Mitral valve inversion prostheses |
US11058417B2 (en) | 2013-06-28 | 2021-07-13 | Valcare, Inc. | Device, system, and method to secure an article to a tissue |
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US11534300B2 (en) | 2018-12-03 | 2022-12-27 | Valcare, Inc. | Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system |
US11576779B2 (en) | 2017-03-17 | 2023-02-14 | Valcare, Inc. | Mitral or tricuspid repair systems with multi-directional anchors |
US11654018B2 (en) | 2013-05-24 | 2023-05-23 | Valcare, Inc. | Heart and peripheral vascular valve replacement in conjunction with a support ring |
US11793628B2 (en) | 2019-07-15 | 2023-10-24 | Valcare, Inc. | Transcatheter bio-prosthesis member and support structure |
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US6332893B1 (en) | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US6260552B1 (en) | 1998-07-29 | 2001-07-17 | Myocor, Inc. | Transventricular implant tools and devices |
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US7666204B2 (en) | 1999-04-09 | 2010-02-23 | Evalve, Inc. | Multi-catheter steerable guiding system and methods of use |
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US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US6752813B2 (en) | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US10327743B2 (en) * | 1999-04-09 | 2019-06-25 | Evalve, Inc. | Device and methods for endoscopic annuloplasty |
EP1113497A3 (en) * | 1999-12-29 | 2006-01-25 | Texas Instruments Incorporated | Semiconductor package with conductor impedance selected during assembly |
ITPC20000013A1 (en) * | 2000-04-13 | 2000-07-13 | Paolo Ferrazzi | INTROVENTRICULAR DEVICE AND RELATED METHOD FOR THE TREATMENT AND CORRECTION OF MYOCARDIOPATHIES. |
US6723038B1 (en) | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US6602286B1 (en) * | 2000-10-26 | 2003-08-05 | Ernst Peter Strecker | Implantable valve system |
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US7935145B2 (en) | 2001-05-17 | 2011-05-03 | Edwards Lifesciences Corporation | Annuloplasty ring for ischemic mitral valve insuffuciency |
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Also Published As
Publication number | Publication date |
---|---|
DE60234189D1 (en) | 2009-12-10 |
US20030040793A1 (en) | 2003-02-27 |
US7063722B2 (en) | 2006-06-20 |
US6726716B2 (en) | 2004-04-27 |
EP2133040A2 (en) | 2009-12-16 |
ATE446727T1 (en) | 2009-11-15 |
CA2456991A1 (en) | 2003-03-06 |
EP1418865B1 (en) | 2009-10-28 |
US20060184241A1 (en) | 2006-08-17 |
US20040162611A1 (en) | 2004-08-19 |
EP1418865A1 (en) | 2004-05-19 |
EP2133040A3 (en) | 2012-08-15 |
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