WO2003020359A3 - Microneedle arrays and methods of manufacturing the same - Google Patents

Microneedle arrays and methods of manufacturing the same Download PDF

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Publication number
WO2003020359A3
WO2003020359A3 PCT/US2002/022361 US0222361W WO03020359A3 WO 2003020359 A3 WO2003020359 A3 WO 2003020359A3 US 0222361 W US0222361 W US 0222361W WO 03020359 A3 WO03020359 A3 WO 03020359A3
Authority
WO
WIPO (PCT)
Prior art keywords
microneedles
microneedle arrays
microneedle
manufacturing
methods
Prior art date
Application number
PCT/US2002/022361
Other languages
French (fr)
Other versions
WO2003020359A2 (en
Inventor
Michael D Delmore
Patrick R Fleming
Douglas A Huntley
Jamieson C Keister
Cristina U Thomas
Richard H Ferber
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to EP02750036A priority Critical patent/EP1425062A2/en
Priority to JP2003524663A priority patent/JP2005501615A/en
Publication of WO2003020359A2 publication Critical patent/WO2003020359A2/en
Publication of WO2003020359A3 publication Critical patent/WO2003020359A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Abstract

The microneedles (20) in the microneedle arrays may be in the form of tapered structures that include at least one channel (22) formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures.
PCT/US2002/022361 2001-09-05 2002-07-15 Microneedle arrays and methods of manufacturing the same WO2003020359A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02750036A EP1425062A2 (en) 2001-09-05 2002-07-15 Microneedle arrays and methods of manufacturing the same
JP2003524663A JP2005501615A (en) 2001-09-05 2002-07-15 Microneedle array and manufacturing method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/947,195 US6881203B2 (en) 2001-09-05 2001-09-05 Microneedle arrays and methods of manufacturing the same
US09/947,195 2001-09-05

Publications (2)

Publication Number Publication Date
WO2003020359A2 WO2003020359A2 (en) 2003-03-13
WO2003020359A3 true WO2003020359A3 (en) 2003-07-31

Family

ID=25485700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022361 WO2003020359A2 (en) 2001-09-05 2002-07-15 Microneedle arrays and methods of manufacturing the same

Country Status (8)

Country Link
US (2) US6881203B2 (en)
EP (2) EP1652551B1 (en)
JP (1) JP2005501615A (en)
AT (1) ATE390167T1 (en)
DE (1) DE60225859T2 (en)
ES (1) ES2304758T3 (en)
TW (1) TW550101B (en)
WO (1) WO2003020359A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds

Families Citing this family (299)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
WO2002085447A2 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404234B1 (en) 2001-06-12 2011-02-09 Pelikan Technologies Inc. Apparatus for improving success rate of blood yield from a fingerstick
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
ATE485766T1 (en) 2001-06-12 2010-11-15 Pelikan Technologies Inc ELECTRICAL ACTUATING ELEMENT FOR A LANCET
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
DE60234598D1 (en) 2001-06-12 2010-01-14 Pelikan Technologies Inc SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
CA2480072A1 (en) 2002-03-26 2003-10-09 Becton, Dickinson And Company Multi-stage fluid delivery device and method
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
CA2492867C (en) 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
CA2493728C (en) * 2002-07-22 2013-10-29 Becton, Dickinson And Company Patch-like infusion device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
DK1633235T3 (en) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparatus for sampling body fluid and detecting analyte
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
WO2005018705A2 (en) 2003-08-12 2005-03-03 Becton, Dickinson And Company Patch-like infusion device
BRPI0413867A (en) * 2003-08-26 2006-10-24 Alza Corp device and method for intradermal cell implantation
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
EP1699524A4 (en) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Enhanced penetration system and method for sliding microneedles
EP1713533A4 (en) * 2003-11-21 2008-01-23 Univ California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
EP1706171A1 (en) 2003-12-29 2006-10-04 3M Innovative Properties Company Medical devices and kits including same
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
JP2005246595A (en) * 2004-03-05 2005-09-15 Ritsumeikan Microneedle array and method of producing the same
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
BRPI0509806A (en) * 2004-04-12 2007-09-18 Allergan Inc multi-site injection system
BRPI0509788A (en) 2004-05-13 2007-10-23 Alza Corp apparatus and method for transdermal delivery of parathyroid hormone agents
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
ES2650188T3 (en) 2004-06-10 2018-01-17 3M Innovative Properties Company Device and patch application kit
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
US8696619B2 (en) 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
US20070250018A1 (en) * 2004-08-12 2007-10-25 Hirotoshi Adachi Transdermal Drug Administration System with Microneedles
ATE490037T1 (en) 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
SE0402100D0 (en) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
GB0420256D0 (en) * 2004-09-13 2004-10-13 Cassells John M Method and apparatus for sampling and analysis of fluids
CA2587387C (en) 2004-11-18 2013-06-25 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
JP4927752B2 (en) 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array applicator and holding device
KR20130026511A (en) 2004-11-18 2013-03-13 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Low-profile microneedle array applicator
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
EP1814701A1 (en) * 2004-11-26 2007-08-08 Agency for Science, Technology and Research Method and apparatus for forming microstructures
JP2008522875A (en) * 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー Microneedle molding method
KR101288725B1 (en) * 2004-12-10 2013-07-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Medical Device
US7588705B2 (en) 2004-12-28 2009-09-15 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JPWO2006075689A1 (en) * 2005-01-14 2008-06-12 久光製薬株式会社 Medicinal product carrying device and method for producing the same
JP4793806B2 (en) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
CA2602259A1 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
JP5301985B2 (en) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー System and method for tool feedback sensing
GB0509863D0 (en) * 2005-05-16 2005-06-22 Cambridge Biostability Ltd Apparatus for administrating substances into a body
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
ATE477833T1 (en) 2005-06-27 2010-09-15 3M Innovative Properties Co MICRONEEDLE CARTRIDGE ASSEMBLY
JP5144510B2 (en) * 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array application device
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JPWO2007032446A1 (en) * 2005-09-15 2009-03-19 Ｔｔｉ・エルビュー株式会社 Rod iontophoresis device
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
WO2007041323A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic delivery of vesicle-encapsulated active agents
US7574256B2 (en) * 2005-09-30 2009-08-11 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
KR20080066712A (en) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 Functionalized microneedles transdermal drug delivery systems, devices, and methods
JP2009509685A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device and method for delivery of angiogenic factors to enhance healing of damaged tissue
US20070083186A1 (en) * 2005-09-30 2007-04-12 Darrick Carter Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
EP1928539A1 (en) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Functionalized microneedles transdermal drug delivery systems, devices, and methods
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US8554317B2 (en) * 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
CA2633071A1 (en) * 2005-12-14 2007-06-21 Rad Omid Chemical applicator
EP1962942A1 (en) * 2005-12-21 2008-09-03 3M Innovative Properties Company Microneedle devices
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
US7848801B2 (en) * 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) * 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
EP1992386B1 (en) * 2006-02-10 2011-11-09 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus having microneedles
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
GB0605003D0 (en) * 2006-03-13 2006-04-19 Microsample Ltd Method and apparatus for piercing the skin and delivery or collection of liquids
US8858807B2 (en) * 2006-03-24 2014-10-14 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
JP4908893B2 (en) * 2006-03-30 2012-04-04 久光製薬株式会社 Medicinal product carrying device, method for producing the same, and method for producing a mold for producing a medicinal product carrying device
CN100441388C (en) * 2006-04-06 2008-12-10 上海交通大学 Microneedle preparation method based on multiplayer processing technology
WO2007116959A1 (en) * 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and transdermal administration device provided with microneedles
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
JP4904964B2 (en) * 2006-07-24 2012-03-28 凸版印刷株式会社 Manufacturing method of needle-shaped body
DE102006036331A1 (en) 2006-08-03 2008-02-14 Stephan Hammelbacher Device and method for marking objects
EP2062611A4 (en) * 2006-08-18 2010-01-06 Toppan Printing Co Ltd Microneedle and microneedle patch
DE102006040642A1 (en) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Microneedles for placement in the skin for transdermal application of pharmaceuticals
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
MX2009002321A (en) * 2006-09-05 2009-03-23 Tti Ellebeau Inc Transdermal drug delivery systems, devices, and methods using inductive power supplies.
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
WO2008042902A2 (en) * 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
JP5383497B2 (en) 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 System and device for powering and / or controlling a device, for example a transdermal delivery device
WO2008091602A2 (en) * 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5090032B2 (en) * 2007-03-20 2012-12-05 凸版印刷株式会社 Needle-like body and method for producing needle-like body
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
EP2167301B1 (en) 2007-06-20 2013-07-31 3M Innovative Properties Company Ultrasonic injection molding on a web
JP2009039171A (en) * 2007-08-06 2009-02-26 Dai Ichi Kasei Kk Fine needle-shaped projection, its mold, and its manufacturing method
JP5173332B2 (en) * 2007-09-10 2013-04-03 凸版印刷株式会社 Microneedle and microneedle manufacturing method
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (en) * 2007-10-11 2013-04-10 キヤノン株式会社 Image processing system and image processing method
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009065078A1 (en) * 2007-11-14 2009-05-22 Pathway Medical Technologies, Inc. Delivery and administration of compositions using interventional catheters
WO2009079712A1 (en) 2007-12-24 2009-07-02 The University Of Queensland Coating method
WO2009097660A1 (en) * 2008-02-07 2009-08-13 The University Of Queensland Patch production
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US20090234322A1 (en) * 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
FR2929135A1 (en) * 2008-03-31 2009-10-02 Commissariat Energie Atomique DEVICE FOR ALIQUOTAGE AND EXEMPTION OF A LIQUID
US20110251602A1 (en) * 2008-04-01 2011-10-13 The General Hospital Corporation Method and apparatus for tissue expansion
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
KR101383285B1 (en) 2008-05-21 2014-04-08 테라젝트, 인코포레이티드 Method of manufacturing solid solution perforator patches and uses thereof
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
JP5521147B2 (en) * 2008-08-05 2014-06-11 国立大学法人 香川大学 Microneedle and its jig
US8906046B2 (en) * 2008-09-20 2014-12-09 Microkoll Inc. Apparatus and method for tissue adhesion
US20110213335A1 (en) * 2008-11-18 2011-09-01 Burton Scott A Hollow microneedle array and method
KR101004014B1 (en) 2008-12-18 2010-12-31 (주)마이티시스템 Structure of a Micro-needle with a Side Channel, and Manufacturing Method of the Same
US20110021996A1 (en) * 2008-12-18 2011-01-27 Miti Systems Inc. Structure of micro-needle with side channel and manufacturing method thereof
US8734697B2 (en) 2008-12-22 2014-05-27 The University Of Queensland Patch production
AU2010209763B2 (en) 2009-01-30 2016-05-12 Mycartis N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100256524A1 (en) * 2009-03-02 2010-10-07 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
JP4779084B2 (en) * 2009-03-25 2011-09-21 国立大学法人 香川大学 Microneedle, manufacturing method thereof and mold
CN101829396B (en) * 2009-03-27 2013-01-30 清华大学 Micro-needle array chip and percutaneous administration patch using same and preparation method thereof
FI20095433A0 (en) 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
CA2759850C (en) * 2009-04-24 2019-10-22 Corium International, Inc. Methods for manufacturing microprojection arrays
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
NO2491401T3 (en) 2009-10-21 2018-11-03
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
JP2013508119A (en) 2009-10-26 2013-03-07 エムキネティクス， インコーポレイテッド Method and apparatus for electromagnetic stimulation of nerves, muscles and body tissues
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
JP5894082B2 (en) 2009-12-16 2016-03-23 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Self-injection device
JP5650242B2 (en) 2009-12-16 2015-01-07 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Self injection device
ES2617145T3 (en) 2009-12-16 2017-06-15 Becton, Dickinson And Company Automatic injection device
EP2512551B1 (en) 2009-12-16 2019-03-20 Becton, Dickinson and Company Self-injection device
DK2512559T3 (en) 2009-12-16 2019-03-25 Becton Dickinson Co SELF-INJECTIVE DEVICE
ES2565405T3 (en) 2009-12-16 2016-04-04 Becton Dickinson And Company Auto injection device
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
DE102010000843A1 (en) * 2010-01-13 2011-07-14 Robert Bosch GmbH, 70469 Porous micro-needle assembly glucose sensor device, corresponding manufacturing method and glucose measurement method
CA2788760A1 (en) 2010-03-26 2011-09-29 Pronota N.V. Ltbp2 as a biomarker for renal dysfunction
JP2013524251A (en) 2010-04-13 2013-06-17 プロノタ エヌ．ヴェ． Biomarkers for pregnancy-induced hypertension
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
MX2012012567A (en) 2010-04-28 2012-11-21 Kimberly Clark Co Method for increasing permeability of an epithelial barrier.
EP2563450B1 (en) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
JP5871907B2 (en) 2010-04-28 2016-03-01 キンバリー クラーク ワールドワイド インコーポレイテッド Nanopatterned medical device with enhanced cell-cell interaction
RU2585138C2 (en) 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Medical devices for delivery of sirna
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
KR101815035B1 (en) 2010-05-07 2018-01-08 더 제너럴 하스피탈 코포레이션 Apparatus for tissue grafting and copying
CA2800253C (en) 2010-05-28 2022-07-12 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
DE102010030864A1 (en) * 2010-07-02 2012-01-05 Robert Bosch Gmbh Manufacturing method for a microneedle assembly and corresponding microneedle assembly and use
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
ES2561824T3 (en) * 2010-07-16 2016-03-01 Seventh Sense Biosystems, Inc. Low pressure environment for fluid transfer devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
CN101912663B (en) * 2010-08-18 2013-09-04 清华大学 Empty micropin array chip, percutaneous dosing paster, device and manufacture method thereof
CN103153360B (en) 2010-09-02 2016-04-06 贝克顿·迪金森公司 Have band activate interceptor pin lid from injection device
WO2012054518A1 (en) * 2010-10-18 2012-04-26 Lanco Biosciences, Inc. Delivery of copolymers by microinjection systems
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
EP2646218B1 (en) 2010-12-02 2016-04-06 3M Innovative Properties Company Liquid crystalline polymer microneedles
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
KR102058978B1 (en) 2011-03-07 2019-12-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle devices and methods
KR102058979B1 (en) 2011-03-07 2019-12-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle devices and methods
WO2012126784A1 (en) 2011-03-18 2012-09-27 Universite Libre De Bruxelles Devices for puncturing a human or animal body's membrane
KR102237667B1 (en) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. Delivering and/or receiving fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP2702406B1 (en) 2011-04-29 2017-06-21 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
JP2014521460A (en) * 2011-08-05 2014-08-28 ユニトラクト シリンジ プロプライエタリイ リミテッド Cannula with limited insertion depth
CN102319066B (en) * 2011-08-16 2014-05-07 中国人民解放军广州军区武汉总医院 Multi-channel matrix type spatial summation electrocardiogram detection system
KR102022574B1 (en) 2011-10-12 2019-09-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Integrated microneedle array delivery system
AU2012323782B2 (en) * 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
JP6535464B2 (en) 2011-10-27 2019-06-26 ソレント・セラピューティクス・インコーポレイテッド Implantable device for delivery of bioactive agents
US20170246439A9 (en) * 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
BR112014009713A2 (en) 2011-10-27 2017-04-18 Kimberly Clark Co transdermal administration of high viscosity bioactive agents
WO2013082418A1 (en) 2011-11-30 2013-06-06 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
CA3077452C (en) 2012-05-01 2022-08-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
EP3563772B1 (en) 2012-08-14 2022-01-12 The General Hospital Corporation Apparatus for tissue harvesting
EP2931356B1 (en) 2012-12-14 2019-03-06 Mindera Corporation Methods and devices for detection and acquisition of biomarkers
ES2743404T3 (en) 2012-12-21 2020-02-19 Corium Inc Matrix for therapeutic agent supply and manufacturing method
WO2014105458A1 (en) 2012-12-27 2014-07-03 3M Innovative Properties Company Article with hollow microneedles and method of making
CN105025976B (en) * 2013-01-21 2019-01-08 白雁美学公司 Microneedle, the manufacture mold of microneedle and manufacturing method
WO2014130359A1 (en) 2013-02-20 2014-08-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968119B1 (en) 2013-03-15 2019-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CA2903459C (en) 2013-03-15 2024-02-20 Corium International, Inc. Multiple impact microprojection applicators and methods of use
BR112016002695B1 (en) 2013-08-09 2022-09-20 Cytrellis Biosystems, Inc DEVICE WITH AN ABLATIVE DEVICE, A REMOVAL DEVICE AND A POSITIONING DEVICE
DE102013219432A1 (en) * 2013-09-26 2015-03-26 Peter Röhr Blood collection device and method for withdrawing blood
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
WO2015119906A1 (en) * 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
EP3169261B1 (en) 2014-07-15 2021-11-10 The General Hospital Corporation Apparatus for tissue copying and grafting
AU2015311618B2 (en) * 2014-09-03 2021-03-04 Davies, Graham James PROF Microfluidic devices and fabrication
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP2017533774A (en) 2014-11-14 2017-11-16 サイトレリス バイオシステムズ，インコーポレーテッド Device and method for skin ablation
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP2016195651A (en) * 2015-04-02 2016-11-24 日本写真印刷株式会社 Microneedle sheet
US10070886B2 (en) 2015-04-22 2018-09-11 Medline Industries, Inc. Method of harvesting tissue using sequential sections of a two dimensional array of needles
EP4039253A1 (en) 2015-04-29 2022-08-10 Radius Pharmaceuticals, Inc. Methods of treating cancer
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP6499598B2 (en) * 2015-10-06 2019-04-10 富士フイルム株式会社 Method for producing transdermal absorption sheet
ES2909043T3 (en) 2015-10-09 2022-05-05 Kindeva Drug Delivery Lp Zinc compositions for coated microneedle systems
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
KR101811513B1 (en) 2015-11-25 2017-12-20 주식회사 파이안에스테틱스 Micro spicule, Mold for Producing the Same and Method for Producing the Same
EP3285851B1 (en) * 2015-12-04 2021-01-20 Ascilion AB A microneedle and a chip
JP6799005B2 (en) * 2015-12-15 2020-12-09 久光製薬株式会社 Microneedle sheet
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
KR20180131554A (en) 2016-03-01 2018-12-10 키토테크 메디컬 인코포레이티드 Microstructure-based systems, devices, and methods for wound closure
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
JP2017176652A (en) * 2016-03-31 2017-10-05 花王株式会社 Minute hollow projection tool
CA3020333A1 (en) 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
US11464954B2 (en) 2016-09-21 2022-10-11 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
EP3558265A4 (en) * 2016-12-22 2020-11-04 Ohio State Innovation Foundation Interpentrating microstructures for nanochannel-based cargo delivery
KR102322802B1 (en) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic form of RAD1901-2HCL
US11642453B2 (en) 2017-01-10 2023-05-09 A.T. Still University Fluid infusion system
DK3606760T3 (en) 2017-03-31 2023-11-06 Vaxxas Pty Ltd ARRANGEMENT AND PROCEDURE FOR COATING SURFACES
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
JP1601442S (en) * 2017-07-28 2018-04-09
EP3661587A4 (en) 2017-08-04 2021-06-09 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
WO2019033361A1 (en) * 2017-08-17 2019-02-21 深圳华迈兴微医疗科技有限公司 Blood collection apparatus and control device thereof
JP7204748B2 (en) * 2017-10-16 2023-01-16 トラスティーズ オブ タフツ カレッジ Systems and methods for making microneedles
CN108744258B (en) * 2018-05-04 2024-03-08 陈彦彪 Microneedle device for bee sting therapy and preparation method thereof
US11318292B2 (en) 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
CN112423844A (en) 2018-07-04 2021-02-26 雷迪厄斯制药公司 Polymorphic forms of RAD1901-2HCL
US20210322746A1 (en) * 2018-08-28 2021-10-21 Nissha Co., Ltd. Skin quality-improving sheet
JP2020078363A (en) * 2018-11-10 2020-05-28 コスメディ製薬株式会社 Method of manufacturing microneedle arrays
EP3795358A1 (en) * 2019-09-20 2021-03-24 Axenoll Life Sciences AG Microneedle and method for manufacturing same
CN112618945B (en) * 2020-12-14 2022-06-21 北京航空航天大学 Hollow closed type microneedle, preparation method thereof and operating device comprising microneedle
CN113712547B (en) * 2021-09-07 2023-12-29 集美大学 Multi-groove microneedle array, preparation method thereof and biological detection microneedle sensor
CN114209975B (en) * 2021-12-14 2022-07-26 优微（珠海）生物科技有限公司 Microneedle patch with easily torn substrate
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
WO2000074763A2 (en) * 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2001036037A2 (en) * 1999-11-15 2001-05-25 Velcro Industries B.V. Skin attachment member
WO2002072189A2 (en) * 2001-03-14 2002-09-19 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4018938A (en) 1975-06-30 1977-04-19 International Business Machines Corporation Fabrication of high aspect ratio masks
US4165395A (en) 1977-06-30 1979-08-21 International Business Machines Corporation Process for forming a high aspect ratio structure by successive exposures with electron beam and actinic radiation
JPS5590931A (en) 1978-12-29 1980-07-10 Canon Inc Production of micro structure element array
US4568632A (en) 1982-10-07 1986-02-04 International Business Machines Corporation Patterning of polyimide films with far ultraviolet light
FR2535602B1 (en) * 1982-11-05 1986-06-13 Stallergenes Lab SCARIFIER DEVICE
US4508749A (en) 1983-12-27 1985-04-02 International Business Machines Corporation Patterning of polyimide films with ultraviolet light
US4822975A (en) 1984-01-30 1989-04-18 Canon Kabushiki Kaisha Method and apparatus for scanning exposure
DE3517729A1 (en) 1985-05-17 1986-11-20 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe METHOD FOR PRODUCING SPINNING NOZZLE PLATES
US4768358A (en) 1986-08-04 1988-09-06 Robert Viola Security handle lock
JPH01245993A (en) 1988-03-27 1989-10-02 Semiconductor Energy Lab Co Ltd Thin film working device
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3842354A1 (en) 1988-12-16 1990-06-21 Kernforschungsz Karlsruhe METHOD FOR THE LITHOGRAPHIC PRODUCTION OF GALVANIC MOLDABLE MICROSTRUCTURES WITH TRIANGULAR OR KEYSTONE SECTION
DE3842610C1 (en) 1988-12-17 1990-06-21 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe, De
CA2016900A1 (en) * 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
US5697901A (en) * 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
DE4010669C1 (en) 1990-04-03 1991-04-11 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe, De
US5389954A (en) 1990-11-21 1995-02-14 Canon Kabushiki Kaisha Laser process apparatus for forming holes in a workpiece
US5160823A (en) 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
DE4222856C1 (en) 1992-07-11 1993-05-27 Buerkert Gmbh
JP3211525B2 (en) 1993-04-22 2001-09-25 オムロン株式会社 Thin material mesh, its manufacturing method and its manufacturing apparatus
US6093520A (en) 1994-09-09 2000-07-25 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College High aspect ratio microstructures and methods for manufacturing microstructures
EP0822881B1 (en) 1995-04-26 2009-08-12 Minnesota Mining And Manufacturing Company Laser imaging ablation method
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
WO2000035530A1 (en) * 1998-12-18 2000-06-22 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP2002079499A (en) * 2000-09-08 2002-03-19 Terumo Corp Method of manufacturing needle-like article, and manufactured needle
BR0114628A (en) * 2000-10-13 2004-01-20 Alza Corp Impact applicator microprojection retention member
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
WO2000074763A2 (en) * 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
WO2001036037A2 (en) * 1999-11-15 2001-05-25 Velcro Industries B.V. Skin attachment member
WO2002072189A2 (en) * 2001-03-14 2002-09-19 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds

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