WO2003024316A3 - Pore-forming agents for orthopedic cements - Google Patents

Pore-forming agents for orthopedic cements Download PDF

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Publication number
WO2003024316A3
WO2003024316A3 PCT/US2002/029966 US0229966W WO03024316A3 WO 2003024316 A3 WO2003024316 A3 WO 2003024316A3 US 0229966 W US0229966 W US 0229966W WO 03024316 A3 WO03024316 A3 WO 03024316A3
Authority
WO
WIPO (PCT)
Prior art keywords
pore
bone
forming agent
composition
implant
Prior art date
Application number
PCT/US2002/029966
Other languages
French (fr)
Other versions
WO2003024316A2 (en
Inventor
Paresh S Dalal
Tracy J Landeryou
Carol Ann Toth
Shailesh C Kulkarni
Original Assignee
Stryker Corp
Paresh S Dalal
Tracy J Landeryou
Carol Ann Toth
Shailesh C Kulkarni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp, Paresh S Dalal, Tracy J Landeryou, Carol Ann Toth, Shailesh C Kulkarni filed Critical Stryker Corp
Priority to CA002460843A priority Critical patent/CA2460843A1/en
Priority to AU2002327007A priority patent/AU2002327007B2/en
Priority to JP2003528218A priority patent/JP2005508217A/en
Priority to EP02761768A priority patent/EP1446445A4/en
Publication of WO2003024316A2 publication Critical patent/WO2003024316A2/en
Publication of WO2003024316A3 publication Critical patent/WO2003024316A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Abstract

A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 νm. More preferably, the proportion of the pore-forming agent is 7-40% (w/w). The composition may further include a bioactive agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition can be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surface region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bone formation and delivering the bioactive agent are provided.
PCT/US2002/029966 2001-09-21 2002-09-20 Pore-forming agents for orthopedic cements WO2003024316A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002460843A CA2460843A1 (en) 2001-09-21 2002-09-20 Pore-forming agents for orthopedic cements
AU2002327007A AU2002327007B2 (en) 2001-09-21 2002-09-20 Pore-forming agents for orthopedic cements
JP2003528218A JP2005508217A (en) 2001-09-21 2002-09-20 Pore former for orthopedic cement
EP02761768A EP1446445A4 (en) 2001-09-21 2002-09-20 Pore-forming agents for orthopedic cements

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96042101A 2001-09-21 2001-09-21
US09/960,421 2001-09-21

Publications (2)

Publication Number Publication Date
WO2003024316A2 WO2003024316A2 (en) 2003-03-27
WO2003024316A3 true WO2003024316A3 (en) 2003-12-31

Family

ID=25503137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029966 WO2003024316A2 (en) 2001-09-21 2002-09-20 Pore-forming agents for orthopedic cements

Country Status (5)

Country Link
EP (1) EP1446445A4 (en)
JP (1) JP2005508217A (en)
AU (1) AU2002327007B2 (en)
CA (1) CA2460843A1 (en)
WO (1) WO2003024316A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9446170B2 (en) 2013-12-13 2016-09-20 Agnovos Healthcare, Llc Multiphasic bone graft substitute material

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US7524335B2 (en) 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US7857860B2 (en) 2003-04-30 2010-12-28 Therics, Llc Bone void filler and method of manufacture
ATE490745T1 (en) 2002-03-29 2010-12-15 Wright Medical Tech Inc BONE TRANSPLANT REPLACEMENT COMPOSITION
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
PL1680089T3 (en) 2003-10-22 2014-03-31 Lidds Ab Composition comprising biodegradable hydrating ceramics for controlled drug delivery
FR2869544B1 (en) * 2004-05-03 2006-07-21 Centre Nat Rech Scient Cnrse COMPOSITION FOR INJECTION CEMENT, USEFUL AS BONE SUBSTITUTE
US7749268B2 (en) 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US8852240B2 (en) 2004-10-25 2014-10-07 Kieran Murphy, Llc Methods and compositions for fostering and preserving bone growth
US8545866B2 (en) 2004-10-29 2013-10-01 Smith & Nephew, Inc. Bioabsorbable polymers
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
CN103349793B (en) 2005-09-09 2016-02-10 阿格诺沃斯健康关爱公司 Composite bone graft substitute cement and the goods obtained by it
KR101105890B1 (en) * 2005-12-14 2012-01-16 에스씨아이엘 테크놀로지 게엠베하 A moldable biomaterial for bone regeneration
EP2046361A4 (en) 2006-07-26 2011-06-29 Univ California Osteogenic enhancer composition
EP1891984A1 (en) * 2006-08-24 2008-02-27 Graftys Macroporous and highly resorbable apatitic calcium-phosphate cement
AU2007352435B2 (en) * 2007-04-27 2012-01-19 Unigene Laboratories, Inc. Methods and compositions for fostering and preserving bone growth
US8709149B2 (en) 2008-11-12 2014-04-29 Ossdsign Ab Hydraulic cements, methods and products
FR2948573B1 (en) * 2009-07-31 2011-11-18 Adocia NEW FORM OF ADMINISTRATION OF OSTEOGENIC PROTEIN COMPLEXES
EP2435468B1 (en) 2009-05-26 2018-11-14 The Regents of The University of California Fibromodulin peptide
TWI579007B (en) 2010-07-02 2017-04-21 艾格諾福斯保健公司 Use of bone regenerative material
CN103080301B (en) 2010-08-19 2016-10-19 加州大学董事会 Comprise blood vessel week stem cell and the compositions of NELL-1 albumen
ES2465571T3 (en) * 2010-10-19 2014-06-06 National Cheng Kung University Bone cement formula and bioresorbable hardened bone cement composite materials prepared therewith
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
EP2931325B1 (en) * 2012-12-14 2020-02-19 OssDsign AB Cement-forming compositions, monetite cements, implants and methods for correcting bone defects
CN103394120B (en) * 2013-07-31 2015-01-28 华南理工大学 Calcium phosphate-based composite microsphere support and preparation method thereof
US20180264167A1 (en) * 2015-09-23 2018-09-20 Ossdsign Ab Cement-forming compositions, apatite cements, implants and methods for correcting bone defects
CN107303397B (en) * 2016-04-20 2019-10-01 中国科学院化学研究所 A kind of biologically active Injectable compound bone cement and its preparation method and application
CA3026661A1 (en) 2016-06-10 2017-12-14 Dsm Ip Assets B.V. Settable bone void filler
CN106806403B (en) * 2017-02-17 2020-11-27 福建康是美生物科技有限公司 Traditional Chinese medicine compound composition for increasing bone mineral density and preparation method thereof
WO2019048697A1 (en) 2017-09-11 2019-03-14 Bone Support Ab Macro- and microporous composite cryogel biomaterial for use in bone regeneration
CN108114323A (en) * 2018-01-24 2018-06-05 广西医科大学 A kind of calcium phosphate bone cement compound of porous injectable
TWI739485B (en) * 2019-08-19 2021-09-11 喜樂醫療器材股份有限公司 Hemostatic method
CN111790004A (en) * 2020-06-17 2020-10-20 天津市康婷生物工程集团有限公司 Preparation method of universal drug-loaded calcium-phosphorus cement porous scaffold
CN114191619A (en) * 2021-12-17 2022-03-18 苏州大学附属第一医院 Preparation method of injectable porous microspheres with micro/nano composite topological structure

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WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6281257B1 (en) * 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6395307B1 (en) * 1997-04-30 2002-05-28 Reckitt Benckiser (Uk) Limited Pourable alginate compositions

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Patent Citations (6)

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WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices
US6281256B1 (en) * 1997-03-31 2001-08-28 The Regents Of The University Of Michigan Open pore biodegradable matrices
US6395307B1 (en) * 1997-04-30 2002-05-28 Reckitt Benckiser (Uk) Limited Pourable alginate compositions
US6281257B1 (en) * 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Non-Patent Citations (2)

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Title
KUO C.K. ET AL.: "Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties", BIOMATERIALS, vol. 22, March 2001 (2001-03-01), pages 511 - 521, XP004313856 *
See also references of EP1446445A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9446170B2 (en) 2013-12-13 2016-09-20 Agnovos Healthcare, Llc Multiphasic bone graft substitute material

Also Published As

Publication number Publication date
AU2002327007B2 (en) 2005-10-20
WO2003024316A2 (en) 2003-03-27
JP2005508217A (en) 2005-03-31
EP1446445A2 (en) 2004-08-18
EP1446445A4 (en) 2007-04-04
CA2460843A1 (en) 2003-03-27

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