WO2003024518A2 - Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives - Google Patents

Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives Download PDF

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Publication number
WO2003024518A2
WO2003024518A2 PCT/US2002/029228 US0229228W WO03024518A2 WO 2003024518 A2 WO2003024518 A2 WO 2003024518A2 US 0229228 W US0229228 W US 0229228W WO 03024518 A2 WO03024518 A2 WO 03024518A2
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
substrate
microelement
microstructure
Prior art date
Application number
PCT/US2002/029228
Other languages
English (en)
Other versions
WO2003024518A3 (fr
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391 external-priority patent/US7108681B2/en
Priority claimed from US10/216,148 external-priority patent/US20040087992A1/en
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to EP02798965A priority Critical patent/EP1425064A2/fr
Priority to CA002456626A priority patent/CA2456626C/fr
Priority to JP2003528611A priority patent/JP2005503210A/ja
Priority to AU2002333636A priority patent/AU2002333636A1/en
Publication of WO2003024518A2 publication Critical patent/WO2003024518A2/fr
Publication of WO2003024518A3 publication Critical patent/WO2003024518A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Abstract

L'invention concerne une méthode et un appareil améliorés sous la forme d'un système permettant de distribuer une composition, de préférence une composition médicale ou pharmaceutique ou une substance active, par l'intermédiaire de la couche cornée de la peau, sans saignement ou endommagement du tissu et sans douleur ou autre traumatisme. La taille et la forme des micro-éléments sont ajustées en fonction de la profondeur de pénétration souhaitée dans la peau. Les micro-éléments peuvent être creux, d'où la formation de passages traversants permettant l'écoulement de la composition dans la peau à partir d'une chambre et par l'intermédiaire des micro-éléments. Ces micro-éléments peuvent éventuellement être solides, la composition étant alors appliquée directement sur la peau juste avant ou juste après l'application des micro-éléments sur la surface de la peau, d'où la formation d'ouvertures dans la couche cornée. Dans un autre mode de réalisation, on utilise des microstructures cylindriques appliquées par rotation sur la peau, ces microstructures pénétrant dans la couche cornée et permettant la distribution d'un fluide au moyen de plusieurs structures différentes.
PCT/US2002/029228 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives WO2003024518A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02798965A EP1425064A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
CA002456626A CA2456626C (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
JP2003528611A JP2005503210A (ja) 2001-09-14 2002-09-13 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
AU2002333636A AU2002333636A1 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/952,391 US7108681B2 (en) 2000-10-16 2001-09-14 Microstructures for delivering a composition cutaneously to skin
US09/952,391 2001-09-14
US10/216,148 2002-08-09
US10/216,148 US20040087992A1 (en) 2002-08-09 2002-08-09 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Publications (2)

Publication Number Publication Date
WO2003024518A2 true WO2003024518A2 (fr) 2003-03-27
WO2003024518A3 WO2003024518A3 (fr) 2003-09-25

Family

ID=26910709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029228 WO2003024518A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives

Country Status (5)

Country Link
EP (1) EP1425064A2 (fr)
JP (1) JP2005503210A (fr)
AU (1) AU2002333636A1 (fr)
CA (1) CA2456626C (fr)
WO (1) WO2003024518A2 (fr)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
EP1572264A2 (fr) * 2002-11-18 2005-09-14 Nano Pass Technologies Ltd. Systeme a rouleau comprenant des microstructures
JP2005246595A (ja) * 2004-03-05 2005-09-15 Ritsumeikan マイクロニードルアレイ及びその製造方法
WO2005109996A2 (fr) * 2004-04-30 2005-11-24 Gyung Su Cho Dispositif de dermabrasion electrique
WO2005110525A2 (fr) * 2004-04-12 2005-11-24 Allergan, Inc. Systeme d'injection multi-sites
WO2008125798A1 (fr) * 2007-04-16 2008-10-23 Dewan Fazlul Hoque Chowdhury Dispositif d'administration transdermique à micro-aiguille
US7497980B2 (en) 2003-11-10 2009-03-03 Agency For Science, Technology And Research Microneedles and microneedle fabrication
WO2009144624A1 (fr) * 2008-05-28 2009-12-03 Koninklijke Philips Electronics N.V. Dispositif d'apport de médicament commandé
US7763203B2 (en) 2001-03-14 2010-07-27 Corium International, Inc. Method of manufacturing microneedle structures using photolithography
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
EP2514374A1 (fr) * 2005-08-05 2012-10-24 Biovalve Technologies, Inc. Dispositifs d'administration d'agents à travers des barrières biologiques
WO2012153266A2 (fr) 2011-05-09 2012-11-15 University College Cork Procédé
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9694142B2 (en) 2013-09-03 2017-07-04 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
US9839560B2 (en) 2003-07-03 2017-12-12 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
CN109925590A (zh) * 2019-03-28 2019-06-25 河南省省立医院有限公司 一种耦合剂快速刷涂及擦拭装置
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10589077B2 (en) 2014-12-05 2020-03-17 Hisamitsu Pharmaceutical Co., Inc. Microneedle device system
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10987502B2 (en) 2015-12-15 2021-04-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US11007358B2 (en) 2016-09-01 2021-05-18 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9987475B2 (en) 2006-07-03 2018-06-05 Lotte Chemical Corporation Micro needle roller assembly
JP4821993B2 (ja) * 2006-07-21 2011-11-24 芳一 飛永 マイクロインプリメント及びその製造方法
KR200451185Y1 (ko) 2007-02-15 2010-12-01 (주)클리니칼레졸루션아시아 모듈식 마이크로니들 롤러
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
CN101888826A (zh) * 2007-12-07 2010-11-17 Dts罗勒斯株式会社 盘针辊轮
WO2009130926A1 (fr) * 2008-04-22 2009-10-29 南部化成株式会社 Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique
CN102143778B (zh) * 2008-09-03 2013-04-24 迪特斯实验室株式会社 皮肤刺激器
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
TWI583412B (zh) 2012-06-12 2017-05-21 Hisamitsu Pharmaceutical Co Micro Needle Cloth
MX2015007227A (es) * 2012-12-06 2016-02-18 Srgi Holdings Llc Dispositivos médicos de arreglo de pixeles y métodos.
EP3011992B1 (fr) 2013-06-18 2019-10-16 Hisamitsu Pharmaceutical Co., Inc. Applicateur
US10039911B2 (en) 2013-06-19 2018-08-07 Hisamitsu Pharmaceutical Co., Inc. Applicator
EP3042690B1 (fr) 2013-09-06 2021-04-14 Hisamitsu Pharmaceutical Co., Inc. Feuille à micro-aiguilles
CN106061544B (zh) 2014-02-27 2019-11-26 久光制药株式会社 微型针薄片
US10004887B2 (en) * 2015-02-18 2018-06-26 Alma Therapeutics Ltd. Transdermal delivery assembly

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319591A1 (de) * 1973-04-18 1974-11-14 Kirchner & Wilhelm Nadelapparat fuer medizinische zwecke und vorrichtung zur sterilisation seines nadelkoerpers
US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
WO1996017648A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
WO1998000193A1 (fr) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
US5948488A (en) * 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
WO2000035530A1 (fr) * 1998-12-18 2000-06-22 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4637758Y1 (fr) * 1967-12-13 1971-12-27
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
JP2646766B2 (ja) * 1989-11-08 1997-08-27 日本電気株式会社 皮膚角層の除去器具
JP3189337B2 (ja) * 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
JP3097600B2 (ja) * 1997-05-30 2000-10-10 日本電気株式会社 角質層穿刺装置
US5938684A (en) * 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
ATE221400T1 (de) * 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
EP1109594B1 (fr) * 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Dispositif d'electrotransport comprenant des lames

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319591A1 (de) * 1973-04-18 1974-11-14 Kirchner & Wilhelm Nadelapparat fuer medizinische zwecke und vorrichtung zur sterilisation seines nadelkoerpers
US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
WO1996017648A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
US5948488A (en) * 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
WO1998000193A1 (fr) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
WO2000035530A1 (fr) * 1998-12-18 2000-06-22 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7763203B2 (en) 2001-03-14 2010-07-27 Corium International, Inc. Method of manufacturing microneedle structures using photolithography
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
EP1572264A2 (fr) * 2002-11-18 2005-09-14 Nano Pass Technologies Ltd. Systeme a rouleau comprenant des microstructures
EP1572264A4 (fr) * 2002-11-18 2007-08-08 Nano Pass Technologies Ltd Systeme a rouleau comprenant des microstructures
US9839560B2 (en) 2003-07-03 2017-12-12 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
US7497980B2 (en) 2003-11-10 2009-03-03 Agency For Science, Technology And Research Microneedles and microneedle fabrication
JP2005246595A (ja) * 2004-03-05 2005-09-15 Ritsumeikan マイクロニードルアレイ及びその製造方法
US8882717B2 (en) 2004-04-12 2014-11-11 Allergan, Inc. Multi-site injection system
US10293149B2 (en) 2004-04-12 2019-05-21 Allergan, Inc. Multi-site injection system
JP2007532245A (ja) * 2004-04-12 2007-11-15 アラーガン、インコーポレイテッド マルチサイト注射システム
WO2005110525A3 (fr) * 2004-04-12 2006-03-09 Allergan Inc Systeme d'injection multi-sites
WO2005110525A2 (fr) * 2004-04-12 2005-11-24 Allergan, Inc. Systeme d'injection multi-sites
AU2005243727B2 (en) * 2004-04-12 2011-04-28 Allergan, Inc. Multi-site injection system
WO2005109996A3 (fr) * 2004-04-30 2006-04-13 Gyung Su Cho Dispositif de dermabrasion electrique
US8137363B2 (en) 2004-04-30 2012-03-20 Gyung Su Cho Electrical dermabrasion device
WO2005109996A2 (fr) * 2004-04-30 2005-11-24 Gyung Su Cho Dispositif de dermabrasion electrique
EP2514374A1 (fr) * 2005-08-05 2012-10-24 Biovalve Technologies, Inc. Dispositifs d'administration d'agents à travers des barrières biologiques
US9011392B2 (en) 2005-08-05 2015-04-21 Valeritas, Inc. Methods and devices for delivering agents across biological barriers
US9561042B2 (en) 2005-08-05 2017-02-07 Valeritas, Inc. Methods and devices for delivering agents across biological barriers
WO2008125798A1 (fr) * 2007-04-16 2008-10-23 Dewan Fazlul Hoque Chowdhury Dispositif d'administration transdermique à micro-aiguille
AU2008237775B2 (en) * 2007-04-16 2013-11-21 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
US9649483B2 (en) 2007-04-16 2017-05-16 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
WO2009144624A1 (fr) * 2008-05-28 2009-12-03 Koninklijke Philips Electronics N.V. Dispositif d'apport de médicament commandé
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2012153266A2 (fr) 2011-05-09 2012-11-15 University College Cork Procédé
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US11110259B2 (en) 2013-03-12 2021-09-07 Corium, Inc. Microprojection applicators and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US11027075B2 (en) 2013-09-03 2021-06-08 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
US9694142B2 (en) 2013-09-03 2017-07-04 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10589077B2 (en) 2014-12-05 2020-03-17 Hisamitsu Pharmaceutical Co., Inc. Microneedle device system
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10987502B2 (en) 2015-12-15 2021-04-27 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US11007358B2 (en) 2016-09-01 2021-05-18 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
CN109925590B (zh) * 2019-03-28 2021-10-08 吴晓苏 一种耦合剂快速刷涂及擦拭装置
CN109925590A (zh) * 2019-03-28 2019-06-25 河南省省立医院有限公司 一种耦合剂快速刷涂及擦拭装置

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CA2456626A1 (fr) 2003-03-27
AU2002333636A1 (en) 2003-04-01
JP2005503210A (ja) 2005-02-03
CA2456626C (fr) 2009-01-20
WO2003024518A3 (fr) 2003-09-25
EP1425064A2 (fr) 2004-06-09

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