WO2003024518A3 - Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives - Google Patents

Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives Download PDF

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Publication number
WO2003024518A3
WO2003024518A3 PCT/US2002/029228 US0229228W WO03024518A3 WO 2003024518 A3 WO2003024518 A3 WO 2003024518A3 US 0229228 W US0229228 W US 0229228W WO 03024518 A3 WO03024518 A3 WO 03024518A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
composition
stratum corneum
microstructures
Prior art date
Application number
PCT/US2002/029228
Other languages
English (en)
Other versions
WO2003024518A2 (fr
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391 external-priority patent/US7108681B2/en
Priority claimed from US10/216,148 external-priority patent/US20040087992A1/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority to JP2003528611A priority Critical patent/JP2005503210A/ja
Priority to CA002456626A priority patent/CA2456626C/fr
Priority to EP02798965A priority patent/EP1425064A2/fr
Priority to AU2002333636A priority patent/AU2002333636A1/en
Publication of WO2003024518A2 publication Critical patent/WO2003024518A2/fr
Publication of WO2003024518A3 publication Critical patent/WO2003024518A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Abstract

L'invention concerne une méthode et un appareil améliorés sous la forme d'un système permettant de distribuer une composition, de préférence une composition médicale ou pharmaceutique ou une substance active, par l'intermédiaire de la couche cornée de la peau, sans saignement ou endommagement du tissu et sans douleur ou autre traumatisme. La taille et la forme des micro-éléments sont ajustées en fonction de la profondeur de pénétration souhaitée dans la peau. Les micro-éléments peuvent être creux, d'où la formation de passages traversants permettant l'écoulement de la composition dans la peau à partir d'une chambre et par l'intermédiaire des micro-éléments. Ces micro-éléments peuvent éventuellement être solides, la composition étant alors appliquée directement sur la peau juste avant ou juste après l'application des micro-éléments sur la surface de la peau, d'où la formation d'ouvertures dans la couche cornée. Dans un autre mode de réalisation, on utilise des microstructures cylindriques appliquées par rotation sur la peau, ces microstructures pénétrant dans la couche cornée et permettant la distribution d'un fluide au moyen de plusieurs structures différentes.
PCT/US2002/029228 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives WO2003024518A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003528611A JP2005503210A (ja) 2001-09-14 2002-09-13 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
CA002456626A CA2456626C (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
EP02798965A EP1425064A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
AU2002333636A AU2002333636A1 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/952,391 US7108681B2 (en) 2000-10-16 2001-09-14 Microstructures for delivering a composition cutaneously to skin
US09/952,391 2001-09-14
US10/216,148 2002-08-09
US10/216,148 US20040087992A1 (en) 2002-08-09 2002-08-09 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Publications (2)

Publication Number Publication Date
WO2003024518A2 WO2003024518A2 (fr) 2003-03-27
WO2003024518A3 true WO2003024518A3 (fr) 2003-09-25

Family

ID=26910709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029228 WO2003024518A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives

Country Status (5)

Country Link
EP (1) EP1425064A2 (fr)
JP (1) JP2005503210A (fr)
AU (1) AU2002333636A1 (fr)
CA (1) CA2456626C (fr)
WO (1) WO2003024518A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
WO2005007020A2 (fr) 2003-07-03 2005-01-27 Corium International, Inc. Pansement, dispositif d'administration d'ingredient et dispositif de fixation intraveineux et procede associe
JP4457229B2 (ja) 2003-11-10 2010-04-28 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチ マイクロニードルおよびマイクロニードルの製造
JP2005246595A (ja) * 2004-03-05 2005-09-15 Ritsumeikan マイクロニードルアレイ及びその製造方法
WO2005110525A2 (fr) * 2004-04-12 2005-11-24 Allergan, Inc. Systeme d'injection multi-sites
JP4659822B2 (ja) * 2004-04-30 2011-03-30 チョ，ギュング，スゥ 電動式角質除去器
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JP5066566B2 (ja) 2006-07-03 2012-11-07 ホナム ペトロケミカル コープ マイクロニードルローラアセンブリ
JP4821993B2 (ja) * 2006-07-21 2011-11-24 芳一 飛永 マイクロインプリメント及びその製造方法
KR200451185Y1 (ko) 2007-02-15 2010-12-01 (주)클리니칼레졸루션아시아 모듈식 마이크로니들 롤러
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
CN101888826A (zh) * 2007-12-07 2010-11-17 Dts罗勒斯株式会社 盘针辊轮
WO2009130926A1 (fr) * 2008-04-22 2009-10-29 南部化成株式会社 Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique
WO2009144624A1 (fr) * 2008-05-28 2009-12-03 Koninklijke Philips Electronics N.V. Dispositif d'apport de médicament commandé
CN103083795A (zh) * 2008-09-03 2013-05-08 迪特斯实验室株式会社 皮肤刺激器
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
EP2859910B1 (fr) * 2012-06-12 2020-03-25 Hisamitsu Pharmaceutical Co., Inc. Feuille de micro-aiguilles
SG11201504495XA (en) * 2012-12-06 2015-07-30 Srgi Holdings Llc Pixel array medical devices and methods
MX2015008157A (es) 2012-12-21 2016-02-22 Corium Int Inc Microarreglo para la entrega de agente terapeutico y metodos de uso.
EP4094799A1 (fr) 2013-03-12 2022-11-30 Corium, Inc. Applicateurs de microprojection
JP2016514133A (ja) 2013-03-15 2016-05-19 コリウム インターナショナル， インコーポレイテッド ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
RU2711567C2 (ru) 2013-03-15 2020-01-17 Кориум, ИНК. Микрочип для доставки лекарственного средства и способы его использования
CA2903583C (fr) 2013-03-15 2021-12-28 Corium International, Inc. Micro-reseau pour administrer un agent therapeutique, procedes d'utilisation et procedes de fabrication
KR101751653B1 (ko) 2013-06-18 2017-06-27 히사미쓰 세이야꾸 가부시키가이샤 어플리케이터
ES2753423T3 (es) 2013-06-19 2020-04-08 Hisamitsu Pharmaceutical Co Aplicador
US9694142B2 (en) 2013-09-03 2017-07-04 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
KR20160052590A (ko) 2013-09-06 2016-05-12 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들·시트
US20170049695A1 (en) 2014-02-27 2017-02-23 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10589077B2 (en) 2014-12-05 2020-03-17 Hisamitsu Pharmaceutical Co., Inc. Microneedle device system
US10004887B2 (en) * 2015-02-18 2018-06-26 Alma Therapeutics Ltd. Transdermal delivery assembly
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
CN108367142A (zh) 2015-12-15 2018-08-03 久光制药株式会社 微针片材
US11007358B2 (en) 2016-09-01 2021-05-18 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
CN109925590B (zh) * 2019-03-28 2021-10-08 吴晓苏 一种耦合剂快速刷涂及擦拭装置

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319591A1 (de) * 1973-04-18 1974-11-14 Kirchner & Wilhelm Nadelapparat fuer medizinische zwecke und vorrichtung zur sterilisation seines nadelkoerpers
US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
WO1996017648A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
WO1998000193A1 (fr) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
US5948488A (en) * 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
WO2000035530A1 (fr) * 1998-12-18 2000-06-22 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4637758Y1 (fr) * 1967-12-13 1971-12-27
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
JP2646766B2 (ja) * 1989-11-08 1997-08-27 日本電気株式会社 皮膚角層の除去器具
JP3189337B2 (ja) * 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
JP3097600B2 (ja) * 1997-05-30 2000-10-10 日本電気株式会社 角質層穿刺装置
US5938684A (en) * 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
ATE221400T1 (de) * 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6532386B2 (en) * 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319591A1 (de) * 1973-04-18 1974-11-14 Kirchner & Wilhelm Nadelapparat fuer medizinische zwecke und vorrichtung zur sterilisation seines nadelkoerpers
US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
WO1996017648A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
US5948488A (en) * 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
WO1998000193A1 (fr) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
WO2000035530A1 (fr) * 1998-12-18 2000-06-22 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

Also Published As

Publication number Publication date
AU2002333636A1 (en) 2003-04-01
JP2005503210A (ja) 2005-02-03
CA2456626C (fr) 2009-01-20
EP1425064A2 (fr) 2004-06-09
WO2003024518A2 (fr) 2003-03-27
CA2456626A1 (fr) 2003-03-27

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