WO2003025119A3 - Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies - Google Patents

Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies Download PDF

Info

Publication number
WO2003025119A3
WO2003025119A3 PCT/US2002/024154 US0224154W WO03025119A3 WO 2003025119 A3 WO2003025119 A3 WO 2003025119A3 US 0224154 W US0224154 W US 0224154W WO 03025119 A3 WO03025119 A3 WO 03025119A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
enhance
receptor
immunostimulatory oligonucleotides
mediated
Prior art date
Application number
PCT/US2002/024154
Other languages
French (fr)
Other versions
WO2003025119A2 (en
Inventor
De Winkel Jan G J Van
George Weiner
Original Assignee
Medarex Inc
Univ Iowa Res Found
De Winkel Jan G J Van
George Weiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex Inc, Univ Iowa Res Found, De Winkel Jan G J Van, George Weiner filed Critical Medarex Inc
Priority to EP02759219A priority Critical patent/EP1501359A4/en
Priority to JP2003529893A priority patent/JP2005518343A/en
Priority to CA002456193A priority patent/CA2456193A1/en
Publication of WO2003025119A2 publication Critical patent/WO2003025119A2/en
Publication of WO2003025119A3 publication Critical patent/WO2003025119A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Abstract

Compositions comprising immunostimulatory oligonucleotides (CpGODN) and FcR-directed immunotherapeutics are disclosed. Also disclosed are methods of using the compositions to enhance FcR-mediated antigen presentation, ADCC, and other FcR-mediated immune responses.
PCT/US2002/024154 2001-08-03 2002-07-30 Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies WO2003025119A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02759219A EP1501359A4 (en) 2001-08-03 2002-07-30 Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies
JP2003529893A JP2005518343A (en) 2001-08-03 2002-07-30 Novel PGC-1 isoforms and their use to improve use-mediated immunotherapy
CA002456193A CA2456193A1 (en) 2001-08-03 2002-07-30 Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31043701P 2001-08-03 2001-08-03
US60/310,437 2001-08-03

Publications (2)

Publication Number Publication Date
WO2003025119A2 WO2003025119A2 (en) 2003-03-27
WO2003025119A3 true WO2003025119A3 (en) 2004-12-02

Family

ID=23202486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024154 WO2003025119A2 (en) 2001-08-03 2002-07-30 Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies

Country Status (5)

Country Link
US (1) US20030072762A1 (en)
EP (1) EP1501359A4 (en)
JP (1) JP2005518343A (en)
CA (1) CA2456193A1 (en)
WO (1) WO2003025119A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
AU3108001A (en) * 2000-01-20 2001-12-24 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for inducing a th2 immune response
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
US7354909B2 (en) * 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
AU2002366710A1 (en) * 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8263091B2 (en) * 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
MXPA05004588A (en) 2002-10-29 2005-12-14 Coley Pharmaceutical Group Ltd Use of cpg oligonucleotides in the treatment of hepatitis c virus infection.
AU2003300919A1 (en) 2002-12-11 2004-06-30 Coley Pharmaceutical Gmbh 5' cpg nucleic acids and methods of use
AU2004241093B2 (en) * 2003-05-16 2009-08-27 Idera Pharmaceuticals, Inc. Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents
US20060121023A1 (en) * 2004-12-07 2006-06-08 George Weiner Method to decrease nonspecific staining by Cy5
CN1810970B (en) * 2005-01-27 2011-05-18 长春华普生物技术有限公司 CpG-containing single-stranded deoxynucleotide, its vaccine composition and their application
JP5659332B2 (en) 2008-06-27 2015-01-28 ゾエティス・エルエルシー Novel adjuvant composition
PT2560658T (en) 2010-04-21 2017-05-26 Ventirx Pharmaceuticals Inc Enhancing antibody-dependent cellular cytotoxicity
JP5985481B2 (en) * 2010-09-01 2016-09-06 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Rapid production of anti-idiotype antibodies
KR102257743B1 (en) 2013-09-19 2021-05-28 조에티스 서비시즈 엘엘씨 Oil-based adjuvants
PL3244920T3 (en) 2015-01-16 2023-09-25 Zoetis Services Llc Foot-and-mouth disease vaccine
JP6602958B2 (en) * 2015-05-20 2019-11-06 イミュンワーク インク． Molecular constructs having targeting and effector components and uses thereof
WO2022192268A1 (en) * 2021-03-10 2022-09-15 University Of Iowa Research Foundation Methods of enhancing antibody therapies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863538A (en) * 1992-03-05 1999-01-26 Board Of Regents, The University Of Texas System Compositions for targeting the vasculature of solid tumors
US6218371B1 (en) * 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248332B1 (en) * 1990-10-05 2001-06-19 Medarex, Inc. Targeted immunostimulation with bispecific reagents
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2267100T5 (en) * 1994-07-15 2011-04-08 The University Of Iowa Research Foundation IMMUNOMODULATING OLIGONUCLEOTIDES.
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
AU4642600A (en) * 1999-04-15 2000-11-02 Regents Of The University Of California, The Methods and compositions for use in potentiating antigen presentation by antigenpresenting cells
US20020156033A1 (en) * 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
AU7013401A (en) * 2000-06-22 2002-01-02 Univ Iowa Res Found Methods for enhancing antibody-induced cell lysis and treating cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863538A (en) * 1992-03-05 1999-01-26 Board Of Regents, The University Of Texas System Compositions for targeting the vasculature of solid tumors
US6218371B1 (en) * 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEIJNEN ET AL: "A human Fc gamma RI/CD64 transgenic model for in vivo analysis of (bispecific) antibody therapeutics", JOURNAL OF HEMATOTHERAPY, vol. 4, no. 5, October 1995 (1995-10-01), pages 351 - 356, XP002982153 *

Also Published As

Publication number Publication date
WO2003025119A2 (en) 2003-03-27
EP1501359A4 (en) 2007-04-18
CA2456193A1 (en) 2003-03-27
US20030072762A1 (en) 2003-04-17
JP2005518343A (en) 2005-06-23
EP1501359A2 (en) 2005-02-02

Similar Documents

Publication Publication Date Title
WO2003025119A3 (en) Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies
WO2003000187A3 (en) Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
WO2004099249A3 (en) Optimized fc variants and methods for their generation
EP2292271A3 (en) Remodelling and glycoconjugation of an antibody
WO2003011115A3 (en) Peptide-based multimeric targeted contrast agents
EP2345671B8 (en) Optimized fc variants and methods for their generation
WO2003008583A3 (en) Novel compositions and methods for cancer
WO2004064595A3 (en) Multivalent constructs for therapeutic and diagnostic applications
WO2003029262A3 (en) The human mob-5 (il-24) receptors and uses thereof
WO2001035991A3 (en) Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
WO2005037190A3 (en) Multiplex vaccines
WO2005032582A3 (en) Immunogenic compositions for streptococcus pyogenes
WO2004099231A3 (en) Glycopegylation methods and proteins/peptides produced by the methods
WO2002024792A3 (en) Adhesive compositions including self-assembling molecules, adhesives, articles, and methods
DE60141773D1 (en) GREAT SIMILAR RECEPTOR 5-LIGANDS AND USE PROCESS
WO2007133290A3 (en) Anti-ox40l antibodies and methods using same
WO2000056360A3 (en) Vaccine against antigens from bacteriae
WO2004075829A3 (en) Adjuvanted influenza vaccine
WO2004091572A3 (en) Cochleate compositions directed against expression of proteins
WO2001047959A3 (en) Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
WO2004093808A3 (en) Novel tumor-associated antigens
WO2003104425A3 (en) Novel stable anti-cd22 antibodies
WO2003000186A3 (en) Novel phenylamino-pyrimidines and uses thereof
WO2005037470A3 (en) Encapsulated nanoparticles, products containing the same, and methods for using the same
WO2004005476A3 (en) Nucleic acid compositions for stimulating immune responses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PL PT RO SD SE SG SI SK SL TJ TM TN TR TT UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2456193

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002324569

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003529893

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002759219

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002759219

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2002759219

Country of ref document: EP