WO2003028703A3 - Immediate release tablet - Google Patents

Immediate release tablet Download PDF

Info

Publication number
WO2003028703A3
WO2003028703A3 PCT/US2002/030613 US0230613W WO03028703A3 WO 2003028703 A3 WO2003028703 A3 WO 2003028703A3 US 0230613 W US0230613 W US 0230613W WO 03028703 A3 WO03028703 A3 WO 03028703A3
Authority
WO
WIPO (PCT)
Prior art keywords
immediate release
tablet
release tablet
wax
hydrophobic
Prior art date
Application number
PCT/US2002/030613
Other languages
French (fr)
Other versions
WO2003028703A2 (en
Inventor
Joseph Luber
Frank J Bunick
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Priority to AU2002327068A priority Critical patent/AU2002327068A1/en
Priority to EP02761834A priority patent/EP1429809A2/en
Priority to CA2461893A priority patent/CA2461893C/en
Priority to MXPA04002890A priority patent/MXPA04002890A/en
Publication of WO2003028703A2 publication Critical patent/WO2003028703A2/en
Publication of WO2003028703A3 publication Critical patent/WO2003028703A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Abstract

An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90 °C. The tablet may advantageously be produced by direct compression. Although the wax is hydrophobic, the tablet has excellent disintegration.
PCT/US2002/030613 2001-09-28 2002-09-26 Immediate release tablet WO2003028703A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002327068A AU2002327068A1 (en) 2001-09-28 2002-09-26 Immediate release tablet
EP02761834A EP1429809A2 (en) 2001-09-28 2002-09-26 Immediate release tablet
CA2461893A CA2461893C (en) 2001-09-28 2002-09-26 Immediate release tablet comprising a powered wax
MXPA04002890A MXPA04002890A (en) 2001-09-28 2002-09-26 Immediate release tablet.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/966,493 2001-09-28
US09/966,493 US7323192B2 (en) 2001-09-28 2001-09-28 Immediate release tablet

Publications (2)

Publication Number Publication Date
WO2003028703A2 WO2003028703A2 (en) 2003-04-10
WO2003028703A3 true WO2003028703A3 (en) 2003-07-10

Family

ID=25511492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/030613 WO2003028703A2 (en) 2001-09-28 2002-09-26 Immediate release tablet

Country Status (6)

Country Link
US (2) US7323192B2 (en)
EP (1) EP1429809A2 (en)
AU (1) AU2002327068A1 (en)
CA (1) CA2461893C (en)
MX (1) MXPA04002890A (en)
WO (1) WO2003028703A2 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0206062A (en) * 2001-09-28 2004-01-13 Mcneil Ppc Inc Dosage forms having an inner core and outer shell
US7323192B2 (en) * 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
US20040146559A1 (en) * 2002-09-28 2004-07-29 Sowden Harry S. Dosage forms having an inner core and outer shell with different shapes
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US7807197B2 (en) * 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US9561182B2 (en) * 2003-08-22 2017-02-07 Cure Pharmaceutical Corporation Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals
US20040191302A1 (en) 2003-03-28 2004-09-30 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US20040131662A1 (en) 2003-11-12 2004-07-08 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US8999372B2 (en) * 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
DE60313745T2 (en) * 2003-05-19 2008-01-24 Euro-Celtique S.A. Use of soaps like magnesium stearate to speed up the release of active ingredients
US20050074514A1 (en) * 2003-10-02 2005-04-07 Anderson Oliver B. Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms
GB0403628D0 (en) * 2004-02-18 2004-03-24 Arrow Group Ltd Compression-coated tablets and the manufacture thereof
US20050220865A1 (en) * 2004-04-02 2005-10-06 Koleng John J Compressed composition comprising magnesium salt
US8174037B2 (en) * 2004-09-22 2012-05-08 Cree, Inc. High efficiency group III nitride LED with lenticular surface
US20060088593A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070190133A1 (en) * 2004-10-27 2007-08-16 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US8383159B2 (en) * 2004-10-27 2013-02-26 Mcneil-Ppc, Inc. Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088586A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088587A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060087051A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US8673352B2 (en) * 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
US20070048373A1 (en) * 2005-08-30 2007-03-01 Cima Labs Inc. Dried milled granulate and methods
US20070048247A1 (en) * 2005-08-31 2007-03-01 Kimberly-Clark Worldwide, Inc. Deodorizing tablets
JP5389656B2 (en) 2006-10-20 2014-01-15 マクニール−ピーピーシー・インコーポレーテツド Acetaminophen / ibuprofen combinations and methods for their use
CN101528205A (en) * 2006-10-25 2009-09-09 麦克内尔-Ppc股份有限公司 Ibuprofen composition
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
CN101801354A (en) * 2007-09-17 2010-08-11 麦克内尔-Ppc股份有限公司 Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum
RU2482839C2 (en) * 2007-10-31 2013-05-27 МакНЕЙЛС-ППС, ИНК. Drug form desintegrating in oral cavity
ES2384305T3 (en) * 2008-02-19 2012-07-03 Mcneil-Ppc, Inc. Immersion coating compositions containing a starch with high amylose content
PL2379056T3 (en) * 2008-11-28 2016-10-31 Solid pharmaceutical composition comprising at least one stabilizing agent
US9610224B2 (en) * 2009-09-24 2017-04-04 Johnson & Johnson Consumer Inc. Manufacture of tablet in a die utilizing powder blend containing water-containing material
US20110070286A1 (en) * 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
US8858210B2 (en) 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
FR2963889B1 (en) * 2010-08-20 2013-04-12 Debregeas Et Associes Pharma NALBUPHINE-BASED FORMULATIONS AND USES THEREOF
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
KR20160107254A (en) 2014-01-10 2016-09-13 존슨 앤드 존슨 컨수머 인코포레이티드 Process for making tablet using radiofrequency and lossy coated particles
WO2018064559A1 (en) 2016-09-30 2018-04-05 Biotie Therapies, Inc. Compositions and methods for treating alzheimer's disease and parkinson's disease
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB866681A (en) * 1958-05-22 1961-04-26 May & Baker Ltd N-substituted piperidines
US4076819A (en) * 1975-05-30 1978-02-28 Parcor Thieno-pyridine derivatives and therapeutic composition containing same
US4097606A (en) * 1975-10-08 1978-06-27 Bristol-Myers Company APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4686212A (en) * 1985-08-13 1987-08-11 Pharmacontrol Corp. Stable sodium aspirin tablet compositions
US4894236A (en) * 1988-01-12 1990-01-16 Choong-Gook Jang Direct compression tablet binders for acetaminophen
EP0387885A2 (en) * 1989-03-16 1990-09-19 Bristol-Myers Squibb Company Direct compression cholestyramine tablet and solvent-free coating therefor
EP0610854A1 (en) * 1993-02-10 1994-08-17 Takeda Chemical Industries, Ltd. Tablets with improved abrasion resistance and method to produce them
EP0740938A2 (en) * 1995-05-05 1996-11-06 IPR-Institute for Pharmaceutical Research Riehen AG Proline and 4-hydroxyproline as therapeutic agents
EP0864324A1 (en) * 1997-03-12 1998-09-16 Basf Aktiengesellschaft Method to produce solid combined pharmaceutical forms
WO1999000122A1 (en) * 1997-06-25 1999-01-07 Ipr-Institute For Pharmaceutical Research Ag Method for reducing body weight
WO1999032092A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
WO2000025755A1 (en) * 1998-10-30 2000-05-11 Fuisz Technologies Ltd. Dosage forms containing taste masked active agents

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US599865A (en) 1898-03-01 Emanuel l
US582438A (en) 1897-05-11 John scheidler
US2307371A (en) 1941-08-13 1943-01-05 Ray O Vac Co Molding process
US2996431A (en) 1953-12-16 1961-08-15 Barry Richard Henry Friable tablet and process for manufacturing same
GB972128A (en) 1960-01-21 1964-10-07 Wellcome Found Pellets for supplying biologically active substances to ruminants and the manufacture of such pellets
US3108046A (en) * 1960-11-25 1963-10-22 Smith Kline French Lab Method of preparing high dosage sustained release tablet and product of this method
NL272604A (en) 1960-12-28
US3627583A (en) 1969-04-29 1971-12-14 Sucrest Corp Direct compression vehicles
US3832252A (en) 1970-09-29 1974-08-27 T Higuchi Method of making a drug-delivery device
US3726622A (en) 1971-08-20 1973-04-10 Wolverine Pentronix Compacting apparatus
DE2157465C3 (en) 1971-11-19 1975-04-24 Werner & Pfleiderer, 7000 Stuttgart Filling device for a hydraulic block press
US4139589A (en) 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
US4230693A (en) 1975-04-21 1980-10-28 Armour-Dial, Inc. Antacid tablets and processes for their preparation
GB2030042A (en) 1978-09-21 1980-04-02 Beecham Group Ltd Antacid fondant
NL7906689A (en) 1979-09-06 1981-03-10 Dawsonville Corp Nv TATTOO.
US4273793A (en) 1979-10-26 1981-06-16 General Foods Corporation Apparatus and process for the preparation of gasified confectionaries by pressurized injection molding
US4271206A (en) 1979-10-26 1981-06-02 General Foods Corporation Gasified candy having a predetermined shape
US4473526A (en) 1980-01-23 1984-09-25 Eugen Buhler Method of manufacturing dry-pressed molded articles
US4292017A (en) 1980-07-09 1981-09-29 Doepel Wallace A Apparatus for compressing tablets
US4362757A (en) 1980-10-22 1982-12-07 Amstar Corporation Crystallized, readily water dispersible sugar product containing heat sensitive, acidic or high invert sugar substances
US5002970A (en) 1981-07-31 1991-03-26 Eby Iii George A Flavor masked ionizable zinc compositions for oral absorption
US4372942A (en) 1981-08-13 1983-02-08 Beecham Inc. Candy base and liquid center hard candy made therefrom
DE3144678A1 (en) 1981-11-10 1983-05-19 Eugen Dipl.-Ing. 8871 Burtenbach Bühler METHOD AND DEVICE FOR THE PRODUCTION OF MOLDINGS FROM A GIANT CAPABILITY
US4882167A (en) 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4533345A (en) 1983-06-14 1985-08-06 Fertility & Genetics Associates Uterine catheter
US4749575A (en) 1983-10-03 1988-06-07 Bio-Dar Ltd. Microencapsulated medicament in sweet matrix
US4781714A (en) 1983-11-02 1988-11-01 Alza Corporation Dispenser for delivering thermo-responsive composition
DE3404108A1 (en) 1984-02-07 1985-08-14 Kilian & Co GmbH, 5000 Köln TABLET PRESS
US4518335A (en) 1984-03-14 1985-05-21 Allied Corporation Dilatant mold and dilatant molding apparatus
JPS60217106A (en) 1984-04-12 1985-10-30 高橋　信之 Inorganic-powder freezing molding method
US4528335A (en) 1984-05-18 1985-07-09 Phillips Petroleum Company Polymer blends
US4894234A (en) * 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for antiarrhythmics
US4665116A (en) * 1985-08-28 1987-05-12 Turtle Wax, Inc. Clear cleaner/polish composition
US5188840A (en) 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US5229164A (en) 1985-12-19 1993-07-20 Capsoid Pharma Gmbh Process for producing individually dosed administration forms
US4757090A (en) 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4762719A (en) 1986-08-07 1988-08-09 Mark Forester Powder filled cough product
CA1290526C (en) 1986-11-07 1991-10-15 Marianne Wieser Mold and die operation
US4820524A (en) 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4813818A (en) 1987-08-25 1989-03-21 Michael Sanzone Apparatus and method for feeding powdered materials
US4851226A (en) 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
US5030447A (en) * 1988-03-31 1991-07-09 E. R. Squibb & Sons, Inc. Pharmaceutical compositions having good stability
US4929446A (en) 1988-04-19 1990-05-29 American Cyanamid Company Unit dosage form
EP0419410A3 (en) 1989-09-19 1991-08-14 Ciba-Geigy Ag Alkanophenones
US5146730A (en) 1989-09-20 1992-09-15 Banner Gelatin Products Corp. Film-enrobed unitary-core medicament and the like
DK469989D0 (en) 1989-09-22 1989-09-22 Bukh Meditec PHARMACEUTICAL PREPARATION
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
US5223266A (en) 1990-01-24 1993-06-29 Alza Corporation Long-term delivery device with early startup
US4980169A (en) 1990-05-03 1990-12-25 Warner-Lambert Company Flavor enhancing and increasing efficacy of cough drops
US5213738A (en) 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
US5089270A (en) 1990-05-15 1992-02-18 L. Perrigo Company Capsule-shaped tablet
US5075114A (en) 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
US5464631A (en) 1990-06-27 1995-11-07 Warner-Lambert Company Encapsulated dosage forms
US5228916A (en) 1990-11-05 1993-07-20 Mcneil-Ppc, Inc. Apparatus for creating a gelatin coating
US5503673A (en) 1990-11-05 1996-04-02 Mcneil-Ppc, Inc Apparatus for dip coating product
US5538125A (en) 1990-11-05 1996-07-23 Mcneil-Ppc, Inc. Indexing and feeding systems for apparatus for gelatin coating tablets
US5436026A (en) 1990-11-05 1995-07-25 Mcneil-Ppc, Inc. Discharge and transfer system for apparatus for gelatin coating tablets
US5098715A (en) * 1990-12-20 1992-03-24 Burroughs Wellcome Co. Flavored film-coated tablet
NZ241613A (en) 1991-02-27 1993-06-25 Janssen Pharmaceutica Nv Highlighting intagliations in tablets
CA2068402C (en) 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets
US5200191A (en) 1991-09-11 1993-04-06 Banner Gelatin Products Corp. Softgel manufacturing process
US5200195A (en) 1991-12-06 1993-04-06 Alza Corporation Process for improving dosage form delivery kinetics
US5317849A (en) 1992-08-07 1994-06-07 Sauter Manufacturing Corporation Encapsulation equipment and method
EP0670716B1 (en) * 1992-11-30 2003-03-26 Kv Pharmaceutical Company Tastemasked pharmaceutical materials
US5391378A (en) 1993-02-22 1995-02-21 Elizabeth-Hata International, Inc. Two-part medicinal tablet and method of manufacture
JP2524955B2 (en) 1993-04-22 1996-08-14 トーワ株式会社 Method and apparatus for resin sealing molding of electronic parts
EP0621032B1 (en) 1993-04-23 2000-08-09 Novartis AG Controlled release drug delivery device
US5415868A (en) 1993-06-09 1995-05-16 L. Perrigo Company Caplets with gelatin cover and process for making same
IT1264696B1 (en) * 1993-07-09 1996-10-04 Applied Pharma Res PHARMACEUTICAL FORMS INTENDED FOR ORAL ADMINISTRATION ABLE TO RELEASE ACTIVE SUBSTANCES AT A CONTROLLED AND DIFFERENTIATED SPEED
US5622719A (en) 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
DE4341442C2 (en) 1993-12-04 1998-11-05 Lohmann Therapie Syst Lts Device for the controlled release of active substances and their use
US5452748A (en) * 1994-01-07 1995-09-26 Simmons; John M. Synchronized dual thread connector
IT1274034B (en) 1994-07-26 1997-07-14 Applied Pharma Res PHARMACEUTICAL COMPOSITIONS BASED ON RUBBER TO BE CHEWED AND PROCEDURE FOR THEIR PREPARATION
US5614578A (en) 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
ES2194100T3 (en) 1995-05-09 2003-11-16 Phoqus Ltd ELECTROSTATIC COATING.
US5578336A (en) 1995-06-07 1996-11-26 Monte; Woodrow C. Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making
US5614207A (en) 1995-06-30 1997-03-25 Mcneil-Ppc, Inc. Dry mouth lozenge
AUPN605795A0 (en) * 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
DE19539361A1 (en) 1995-10-23 1997-04-24 Basf Ag Process for the preparation of multilayer, solid pharmaceutical forms for oral or rectal administration
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5807579A (en) 1995-11-16 1998-09-15 F.H. Faulding & Co. Limited Pseudoephedrine combination pharmaceutical compositions
US5643984A (en) * 1996-01-03 1997-07-01 Flint Ink Corporation New Wax composition for the printing ink industry and ink compositions and overprint varnishes containing same
US5824338A (en) 1996-08-19 1998-10-20 L. Perrigo Company Caplet and gelatin covering therefor
US5837301A (en) 1997-04-28 1998-11-17 Husky Injection Molding Systems Ltd. Injection molding machine having a high speed turret
US6149939A (en) 1997-05-09 2000-11-21 Strumor; Mathew A. Healthful dissolvable oral tablets, and mini-bars
US5942034A (en) 1997-07-24 1999-08-24 Bayer Corporation Apparatus for the gelatin coating of medicaments
US5891476A (en) * 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6365185B1 (en) 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6372254B1 (en) * 1998-04-02 2002-04-16 Impax Pharmaceuticals Inc. Press coated, pulsatile drug delivery system suitable for oral administration
US6103257A (en) 1998-07-17 2000-08-15 Num-Pop, Inc. System for delivering pharmaceuticals to the buccal mucosa
DE19834180A1 (en) 1998-07-29 2000-02-03 Benckiser Nv Composition for use in a dishwasher
US6200590B1 (en) 1998-08-10 2001-03-13 Naphcare, Inc. Controlled, phased-release suppository and its method of production
US6270790B1 (en) * 1998-08-18 2001-08-07 Mxneil-Ppc, Inc. Soft, convex shaped chewable tablets having reduced friability
DE19840256A1 (en) 1998-09-03 2000-03-09 Basf Ag Widely applicable, continuous method for preparing coated solid dosage forms, comprises extruding mixture of drug and thermoplastic binder then applying coating composition in liquid or vapor form
US5997905A (en) 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
US6174547B1 (en) 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
DE59901613D1 (en) * 1999-02-10 2002-07-11 Suwelack Skin & Health Care Ag Freeze-dried product containing Euglena beta-1,3-glucan, its manufacture and use
US6248760B1 (en) 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
GB9921933D0 (en) * 1999-09-17 1999-11-17 Univ Gent Solid shaped articles comprising biologically active substances and a method for their production
JP2001122769A (en) * 1999-10-22 2001-05-08 Lion Corp Solid preparation and method for improving disintegration/dissolution of solid preparation
DE19963569B4 (en) 1999-12-29 2006-11-16 Reckitt Benckiser N.V. Composition for use in a dishwasher
US20020028240A1 (en) 2000-04-17 2002-03-07 Toyohiro Sawada Timed-release compression-coated solid composition for oral administration
US7323192B2 (en) * 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
MXPA04007428A (en) * 2002-02-01 2004-10-11 Pfizer Prod Inc Immediate release dosage forms containing solid drug dispersions.

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB866681A (en) * 1958-05-22 1961-04-26 May & Baker Ltd N-substituted piperidines
US4076819A (en) * 1975-05-30 1978-02-28 Parcor Thieno-pyridine derivatives and therapeutic composition containing same
US4097606A (en) * 1975-10-08 1978-06-27 Bristol-Myers Company APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4686212A (en) * 1985-08-13 1987-08-11 Pharmacontrol Corp. Stable sodium aspirin tablet compositions
US4894236A (en) * 1988-01-12 1990-01-16 Choong-Gook Jang Direct compression tablet binders for acetaminophen
EP0387885A2 (en) * 1989-03-16 1990-09-19 Bristol-Myers Squibb Company Direct compression cholestyramine tablet and solvent-free coating therefor
EP0610854A1 (en) * 1993-02-10 1994-08-17 Takeda Chemical Industries, Ltd. Tablets with improved abrasion resistance and method to produce them
EP0740938A2 (en) * 1995-05-05 1996-11-06 IPR-Institute for Pharmaceutical Research Riehen AG Proline and 4-hydroxyproline as therapeutic agents
EP0864324A1 (en) * 1997-03-12 1998-09-16 Basf Aktiengesellschaft Method to produce solid combined pharmaceutical forms
WO1999000122A1 (en) * 1997-06-25 1999-01-07 Ipr-Institute For Pharmaceutical Research Ag Method for reducing body weight
WO1999032092A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
WO2000025755A1 (en) * 1998-10-30 2000-05-11 Fuisz Technologies Ltd. Dosage forms containing taste masked active agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DE BRABANDER C ET AL: "Matrix mini-tablets based on starch/microcrystalline wax mixtures.", INTERNATIONAL JOURNAL OF PHARMACEUTICS. NETHERLANDS 20 APR 2000, vol. 199, no. 2, 20 April 2000 (2000-04-20), pages 195 - 203, XP002233674, ISSN: 0378-5173 *
See also references of EP1429809A2 *

Also Published As

Publication number Publication date
MXPA04002890A (en) 2005-06-20
US7323192B2 (en) 2008-01-29
AU2002327068A1 (en) 2003-04-14
US20080095845A1 (en) 2008-04-24
CA2461893A1 (en) 2003-04-10
US20030068373A1 (en) 2003-04-10
CA2461893C (en) 2010-07-06
WO2003028703A2 (en) 2003-04-10
EP1429809A2 (en) 2004-06-23

Similar Documents

Publication Publication Date Title
WO2003028703A3 (en) Immediate release tablet
WO2000041681A3 (en) MEDICINAL FORMULATIONS CONTAINING AN OPIOID AND AN α-ANTAGONIST
CA2427815A1 (en) Controlled release hydrocodone formulations
WO2004012700A3 (en) Dosage form comprising high dose high soluble active ingredient as modified release and low dose active ingredient as immediate release
CA2469369A1 (en) Compositions containing both sedative and non-sedative antihistamines
WO2006035417A3 (en) Dihydropyrimidine microcapsule - formulations
JP2002511411A5 (en)
EP1690530A3 (en) Sustained release pharmaceutical composition free of food effect and a method for alleviating food effect in drug release
CA2420874A1 (en) Active ingredient combinations with insecticidal and acaricidal properties
CA2238553A1 (en) Cholesterol-lowering composition
CA2382014A1 (en) Liquid pesticide composition
CA2342634A1 (en) Pharmaceutical composition comprising entacapone or nitecapone as well as a cross-linked cellulose derivative
MXPA03008420A (en) Solid orally-dispersible pharmaceutical formulation.
GB0204772D0 (en) Pharmaceutical dosage forms
AU2002238855A1 (en) N-phenylarylsulfonamide compound, drug containing the compound as active ingredient, intermediate for the compound, and processes for producing the same
WO2001007049A3 (en) Ophthalmic composition comprising ketotifen
PT1195160E (en) Sustained release trimetazidine pharmaceutical compositions and a method of their preparation
AU2002309038A1 (en) Compositions for transmucosal administration containing coenzyme Q as the active ingredient
WO2003059329A3 (en) Polytartrate composition
WO2001078682A3 (en) Sustained release drug compositions
WO2003024933A1 (en) 2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same
EP1250937A3 (en) Controlled dissolution of active ingredients
HUP0301072A2 (en) Tablet obtained by direct compression comprising 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid as active ingredient
AU3323902A (en) Microparticles with an improved release profile and method for the production thereof
WO2004064517A3 (en) Termiticide compositions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002761834

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: PA/a/2004/002890

Country of ref document: MX

Ref document number: 2461893

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 2002761834

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: JP