WO2003029459A3 - Micro-rna molecules - Google Patents
Micro-rna molecules Download PDFInfo
- Publication number
- WO2003029459A3 WO2003029459A3 PCT/EP2002/010881 EP0210881W WO03029459A3 WO 2003029459 A3 WO2003029459 A3 WO 2003029459A3 EP 0210881 W EP0210881 W EP 0210881W WO 03029459 A3 WO03029459 A3 WO 03029459A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rnas
- micro
- small
- rna molecules
- strnas
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Abstract
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/490,955 US7232806B2 (en) | 2001-09-28 | 2002-09-27 | MicroRNA molecules |
AU2002347035A AU2002347035B2 (en) | 2001-09-28 | 2002-09-27 | Micro-RNA molecules |
IL16110002A IL161100A0 (en) | 2001-09-28 | 2002-09-27 | Identification of novel genes coding for small temporal rnas |
JP2003532675A JP4371812B2 (en) | 2001-09-28 | 2002-09-27 | MicroRNA molecules |
CA2462144A CA2462144C (en) | 2001-09-28 | 2002-09-27 | Micro-rna molecules |
EP11175534.4A EP2447370B1 (en) | 2001-09-28 | 2002-09-27 | MicroRNA molecules |
EP02782801.1A EP1430128B1 (en) | 2001-09-28 | 2002-09-27 | Micro-rna molecules |
EP11175601.1A EP2428571B1 (en) | 2001-09-28 | 2002-09-27 | MicroRNA molecules |
IL161100A IL161100A (en) | 2001-09-28 | 2004-03-25 | Nucleic acid molecules as regulators of developmental timing, recombinant expression vectors comprising the same and compositions comprising them |
US11/747,409 US7723510B1 (en) | 2001-09-28 | 2007-05-11 | MicroRNA molecules |
US12/358,331 US8222394B2 (en) | 2001-09-28 | 2009-01-23 | MicroRNA molecules |
US12/550,596 US7838662B2 (en) | 2001-09-28 | 2009-08-31 | Microrna molecules |
US12/550,579 US7838660B2 (en) | 2001-09-28 | 2009-08-31 | MicroRNA molecules |
US12/550,704 US7838664B2 (en) | 2001-09-28 | 2009-08-31 | MicroRNA molecules |
US12/550,602 US7838663B2 (en) | 2001-09-28 | 2009-08-31 | MicroRNA molecules |
US12/550,586 US7838661B2 (en) | 2001-09-28 | 2009-08-31 | Microrna molecules |
US12/775,952 US8198428B2 (en) | 2001-09-28 | 2010-05-07 | Identification of novel genes coding for small temporal RNAS |
US12/775,947 US8207326B2 (en) | 2001-09-28 | 2010-05-07 | Identification of novel genes coding for small temporal RNAs |
IL219310A IL219310A (en) | 2001-09-28 | 2012-04-19 | Anti-mirna nucleic acid molecules and pharmaceutical compositions comprising them |
US13/472,826 US9000144B2 (en) | 2001-09-28 | 2012-05-16 | Identification of novel genes coding for small temporal RNAs |
US14/609,492 US9550993B2 (en) | 2001-09-28 | 2015-01-30 | Identification of novel genes coding for small temporal RNAs |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01123453 | 2001-09-28 | ||
EP01123453.1 | 2001-09-28 | ||
EP02006712.0 | 2002-03-22 | ||
EP02006712 | 2002-03-22 | ||
EP02016772 | 2002-07-26 | ||
EP02016772.2 | 2002-07-26 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10490955 A-371-Of-International | 2002-09-27 | ||
US10/490,955 A-371-Of-International US7232806B2 (en) | 2001-09-28 | 2002-09-27 | MicroRNA molecules |
US11/747,409 Division US7723510B1 (en) | 2001-09-28 | 2007-05-11 | MicroRNA molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003029459A2 WO2003029459A2 (en) | 2003-04-10 |
WO2003029459A3 true WO2003029459A3 (en) | 2003-11-27 |
Family
ID=27224236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/010881 WO2003029459A2 (en) | 2001-09-28 | 2002-09-27 | Micro-rna molecules |
Country Status (7)
Country | Link |
---|---|
US (12) | US7232806B2 (en) |
EP (15) | EP2224003B1 (en) |
JP (3) | JP4371812B2 (en) |
AU (1) | AU2002347035B2 (en) |
CA (2) | CA2937159C (en) |
IL (3) | IL161100A0 (en) |
WO (1) | WO2003029459A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8946177B2 (en) | 2004-11-12 | 2015-02-03 | Mima Therapeutics, Inc | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9127272B2 (en) | 2006-01-27 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of target nucleic acids |
Families Citing this family (419)
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EP2345742B1 (en) * | 2000-03-30 | 2014-06-11 | The Whitehead Institute for Biomedical Research | RNA sequence-specific mediators of RNA interference |
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US8137910B2 (en) | 2002-05-03 | 2012-03-20 | Duke University | Method of regulating gene expression |
AU2003247777B2 (en) | 2002-07-01 | 2008-09-18 | Wayne State University | Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance |
AU2003261449A1 (en) | 2002-08-07 | 2004-02-25 | Compositions for rna interference and methods of use thereof | |
US20040219565A1 (en) | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
US7892793B2 (en) * | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
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US8163896B1 (en) | 2002-11-14 | 2012-04-24 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
US7655785B1 (en) | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
US7906326B2 (en) * | 2003-05-07 | 2011-03-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides associated with alzheimer's disease and uses thereof |
US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
AU2003298718A1 (en) * | 2002-11-22 | 2004-06-18 | University Of Massachusetts | Modulation of hiv replication by rna interference |
US7790867B2 (en) | 2002-12-05 | 2010-09-07 | Rosetta Genomics Inc. | Vaccinia virus-related nucleic acids and microRNA |
US20040167090A1 (en) * | 2003-02-21 | 2004-08-26 | Monahan Sean D. | Covalent modification of RNA for in vitro and in vivo delivery |
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US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
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US7888497B2 (en) | 2003-08-13 | 2011-02-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US8946177B2 (en) | 2004-11-12 | 2015-02-03 | Mima Therapeutics, Inc | Methods and compositions involving miRNA and miRNA inhibitor molecules |
US9127272B2 (en) | 2006-01-27 | 2015-09-08 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of target nucleic acids |
US9598693B2 (en) | 2006-01-27 | 2017-03-21 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
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