WO2003033526A3 - Synthesis of cyclosporin analogs - Google Patents
Synthesis of cyclosporin analogs Download PDFInfo
- Publication number
- WO2003033526A3 WO2003033526A3 PCT/CA2002/001559 CA0201559W WO03033526A3 WO 2003033526 A3 WO2003033526 A3 WO 2003033526A3 CA 0201559 W CA0201559 W CA 0201559W WO 03033526 A3 WO03033526 A3 WO 03033526A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- isomers
- isatx247
- cyclosporine
- derivatives
- mixtures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Abstract
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2461740A CA2461740C (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
IL16076302A IL160763A0 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analog |
NZ53194402A NZ531944A (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
SI200230376T SI1436321T1 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
JP2003536264A JP4261355B2 (en) | 2001-10-19 | 2002-10-17 | A method for the synthesis of cyclosporine analogues. |
AU2002331509A AU2002331509B2 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
KR1020047005699A KR100982466B1 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
DK06013976T DK1714977T3 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
EP20020767027 EP1436321B9 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
CNB028207998A CN100334106C (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
BRPI0213658A BRPI0213658A8 (en) | 2001-10-19 | 2002-10-17 | METHOD FOR PREPARING A PREDETERMINED OR NON-DETERMINED ISOMERIC MIXTURE OF CYCLOSPORIN A ANALOGS MODIFIED IN THE 1-AMINO ACID RESIDUE, METHOD FOR PRODUCING A MIXTURE ENRICHED WITH E-ISOMER OR Z-ISOMER OF CYCLOSPORIN A ANALOGS MODIFIED IN THE 1-AMINO ACID RESIDUE, MIXTURE OF (E) AND (Z)-ISOMERS, COMPOSITION, METHOD FOR THE STEREOSE SELECTIVE SYNTHESIS OF THE Z-ISOMER OF ISATX247, METHOD FOR THE PREPARATION OF CYCLOSPORIN A ALDEHYDE |
DE2002613115 DE60213115T2 (en) | 2001-10-19 | 2002-10-17 | SYNTHESIS OF CYCLOSPORINANALOGA |
MXPA04003625A MXPA04003625A (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs. |
IL160763A IL160763A (en) | 2001-10-19 | 2004-03-05 | METHODS OF PREPARING A MIXTURE OF (E) AND (Z)-ISOMERS OF ISA Tx247 |
ZA2004/02269A ZA200402269B (en) | 2001-10-19 | 2004-03-23 | Synthesis of cyclosporin analogs |
TNP2004000068A TNSN04068A1 (en) | 2001-10-19 | 2004-04-16 | Synthesis of cyclosporin analogs |
HRP20040355AA HRP20040355B1 (en) | 2001-10-19 | 2004-04-19 | Synthesis of cyclosporin analogs |
NO20042031A NO332459B1 (en) | 2001-10-19 | 2004-05-14 | Process for preparing a mixture of (E) and (Z) isomers of ISATX247. |
HK04105427A HK1062568A1 (en) | 2001-10-19 | 2004-07-22 | Synthesis of cyclosporin analogs |
CY20061101044T CY1105111T1 (en) | 2001-10-19 | 2006-07-27 | COMPOSITION OF CYCLOSPORIN ANALOGUES |
HRP20070058AA HRP20070058B1 (en) | 2001-10-19 | 2007-02-14 | Synthesis of cyclosporin analogs |
IL186140A IL186140A (en) | 2001-10-19 | 2007-09-20 | Method of producing an e-isomer enriched mixture of isa tx 247 and a z-isomer enriched mixture of isa tx 247 |
AU2007221839A AU2007221839B2 (en) | 2001-10-19 | 2007-10-05 | Synthesis of cyclosporin analogs |
AU2010206069A AU2010206069A1 (en) | 2001-10-19 | 2010-07-30 | Synthesis of cyclosporin analogs |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34620101P | 2001-10-19 | 2001-10-19 | |
US60/346,201 | 2001-10-19 | ||
US37059602P | 2002-04-05 | 2002-04-05 | |
US60/370,596 | 2002-04-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003033526A2 WO2003033526A2 (en) | 2003-04-24 |
WO2003033526A3 true WO2003033526A3 (en) | 2004-02-12 |
Family
ID=26994746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2002/001559 WO2003033526A2 (en) | 2001-10-19 | 2002-10-17 | Synthesis of cyclosporin analogs |
Country Status (28)
Country | Link |
---|---|
US (13) | US7141648B2 (en) |
EP (2) | EP1714977B1 (en) |
JP (3) | JP4261355B2 (en) |
KR (2) | KR101006206B1 (en) |
CN (1) | CN100334106C (en) |
AT (2) | ATE425178T1 (en) |
AU (2) | AU2002331509B2 (en) |
BR (1) | BRPI0213658A8 (en) |
CA (1) | CA2461740C (en) |
CO (1) | CO5580836A2 (en) |
CY (1) | CY1105111T1 (en) |
DE (2) | DE60231570D1 (en) |
DK (2) | DK1436321T3 (en) |
ES (2) | ES2326040T3 (en) |
HK (1) | HK1062568A1 (en) |
HR (2) | HRP20040355B1 (en) |
IL (3) | IL160763A0 (en) |
MA (1) | MA27293A1 (en) |
MX (1) | MXPA04003625A (en) |
NO (1) | NO332459B1 (en) |
NZ (1) | NZ531944A (en) |
PL (2) | PL210795B1 (en) |
PT (2) | PT1436321E (en) |
RU (1) | RU2321593C9 (en) |
SI (1) | SI1436321T1 (en) |
TN (1) | TNSN04068A1 (en) |
WO (1) | WO2003033526A2 (en) |
ZA (1) | ZA200402269B (en) |
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US9017725B2 (en) | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
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ES2326040T3 (en) * | 2001-10-19 | 2009-09-29 | Isotechnika Inc. | SYNTHESIS OF CYCLOSPORINE ANALOGS. |
ATE401339T1 (en) * | 2001-10-19 | 2008-08-15 | Isotechnika Inc | MIXTURES OF CYCLOSPORINE ANALOGUES AND THEIR USE AS IMMUNE MODULATORS |
WO2004082629A2 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
TW200505946A (en) * | 2003-04-08 | 2005-02-16 | Hoffmann La Roche | Process for preparation of cyclosporin a analog |
US20040266669A1 (en) * | 2003-06-20 | 2004-12-30 | Wu Frank X. H. | Cyclosporin derivatives for the treatment of immune disorders |
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WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
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