WO2003040308A3 - Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo - Google Patents
Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo Download PDFInfo
- Publication number
- WO2003040308A3 WO2003040308A3 PCT/US2002/024235 US0224235W WO03040308A3 WO 2003040308 A3 WO2003040308 A3 WO 2003040308A3 US 0224235 W US0224235 W US 0224235W WO 03040308 A3 WO03040308 A3 WO 03040308A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- odn
- sscl
- encapsulating
- cationic liposomes
- sterically stabilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/484,991 US7666674B2 (en) | 2001-07-27 | 2002-07-29 | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
US12/647,320 US20100104507A1 (en) | 2001-07-27 | 2009-12-24 | Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30828301P | 2001-07-27 | 2001-07-27 | |
US60/308,283 | 2001-07-27 | ||
US20640702A | 2002-07-25 | 2002-07-25 | |
US10/206,407 | 2002-07-25 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US20640702A Continuation-In-Part | 2001-07-27 | 2002-07-25 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/647,320 Continuation US20100104507A1 (en) | 2001-07-27 | 2009-12-24 | Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003040308A2 WO2003040308A2 (en) | 2003-05-15 |
WO2003040308A3 true WO2003040308A3 (en) | 2003-11-20 |
Family
ID=26901314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/024235 WO2003040308A2 (en) | 2001-07-27 | 2002-07-29 | Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2003040308A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9404126B2 (en) | 2006-06-12 | 2016-08-02 | Kuros Biosciences Ag | Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
EP2196217A1 (en) | 2001-09-14 | 2010-06-16 | Cytos Biotechnology AG | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
JP4976653B2 (en) * | 2002-11-01 | 2012-07-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシス | Method for preventing infections caused by bioterrorism pathogens using immunostimulatory CpG oligonucleotides |
AU2003300919A1 (en) | 2002-12-11 | 2004-06-30 | Coley Pharmaceutical Gmbh | 5' cpg nucleic acids and methods of use |
US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
CA2544240A1 (en) * | 2003-07-22 | 2005-02-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
CA2536139A1 (en) * | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
AU2006325225B2 (en) | 2005-12-14 | 2013-07-04 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
US9394369B2 (en) * | 2011-01-03 | 2016-07-19 | The Regents Of The University Of California | Luminescent porous silicon nanoparticles for targeted delivery and immunization |
WO2012142669A1 (en) | 2011-04-20 | 2012-10-26 | The University Of Sydney | A method for the treatment of a solid tumour |
KR101465365B1 (en) * | 2013-10-15 | 2014-11-25 | 성균관대학교산학협력단 | Lipid-supported polymeric functional particles and method thereof |
WO2017048860A1 (en) * | 2015-09-14 | 2017-03-23 | Vgsk Technologies, Inc. | A sterically stabilized carrier for subcutaneous, sublingual and oral therapeutics, compositions and methods for treating a mammal |
EP3824891A4 (en) * | 2018-07-19 | 2022-07-13 | The Research Foundation for Microbial Diseases of Osaka University | Lipid particle containing a-type cpg oligodeoxynucleotide |
CN110772635B (en) * | 2019-11-11 | 2023-01-31 | 扬州大学 | Bionic nano vaccine coated by influenza virus corpuscle and preparation method thereof |
CN113975408A (en) * | 2021-08-26 | 2022-01-28 | 上海市肿瘤研究所 | Nano vaccine based on non-methylated CpG, preparation method and application |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6218371B1 (en) * | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
-
2002
- 2002-07-29 WO PCT/US2002/024235 patent/WO2003040308A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6218371B1 (en) * | 1998-04-03 | 2001-04-17 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
Non-Patent Citations (2)
Title |
---|
BEI ET AL.: "The use of a cationic liposome formulation (DOTAP) mixed with a recombinant tumor-associated antigen to induce immune responses and protective immunity in mice", JOURNAL OF IMMUNOTHERAPY, vol. 21, no. 3, 1998, pages 159 - 169, XP002963675 * |
FRIEDMARK ET AL.: "Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes", THE JOURNAL OF IMMUNOLOGY, vol. 160, 1998, pages 4580 - 4586, XP002067073 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9404126B2 (en) | 2006-06-12 | 2016-08-02 | Kuros Biosciences Ag | Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages |
Also Published As
Publication number | Publication date |
---|---|
WO2003040308A2 (en) | 2003-05-15 |
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