WO2003042396A3 - Electronic detection of biological molecules using thin layers - Google Patents

Electronic detection of biological molecules using thin layers Download PDF

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Publication number
WO2003042396A3
WO2003042396A3 PCT/US2002/018319 US0218319W WO03042396A3 WO 2003042396 A3 WO2003042396 A3 WO 2003042396A3 US 0218319 W US0218319 W US 0218319W WO 03042396 A3 WO03042396 A3 WO 03042396A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
thin layers
biological molecules
electronic detection
analyte
Prior art date
Application number
PCT/US2002/018319
Other languages
French (fr)
Other versions
WO2003042396A2 (en
Inventor
Sobha M Pisharody
Sandeep Kunwar
George T Mathai
Original Assignee
Genorx Inc
Sobha M Pisharody
Sandeep Kunwar
George T Mathai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/970,087 external-priority patent/US6824974B2/en
Application filed by Genorx Inc, Sobha M Pisharody, Sandeep Kunwar, George T Mathai filed Critical Genorx Inc
Priority to AU2002363627A priority Critical patent/AU2002363627A1/en
Priority to EP02799869A priority patent/EP1417352A4/en
Priority to JP2003544210A priority patent/JP2005509846A/en
Priority to CA002450109A priority patent/CA2450109A1/en
Priority to US10/480,409 priority patent/US20040248282A1/en
Priority to US10/335,482 priority patent/US20040023253A1/en
Publication of WO2003042396A2 publication Critical patent/WO2003042396A2/en
Publication of WO2003042396A3 publication Critical patent/WO2003042396A3/en

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F41—WEAPONS
    • F41H—ARMOUR; ARMOURED TURRETS; ARMOURED OR ARMED VEHICLES; MEANS OF ATTACK OR DEFENCE, e.g. CAMOUFLAGE, IN GENERAL
    • F41H11/00—Defence installations; Defence devices
    • F41H11/12—Means for clearing land minefields; Systems specially adapted for detection of landmines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material

Abstract

This invention provides novel sensors that facilitate the detection of essentially any analyte (20). In general, the biosensors of this invention utilize a binding agent (14) (e.g. biomolecule) to specifically bind to one or more target analytes (20). In preferred embodiments, the biomolecules (14) spans a gap (16) between two electrodes (10, 12). Binding of the target analyte (20) changes conductivity of the sensor thereby facilitating ready detection of the binding event and thus detection and/or quantitation of the bound analyte (20).
PCT/US2002/018319 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers WO2003042396A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002363627A AU2002363627A1 (en) 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers
EP02799869A EP1417352A4 (en) 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers
JP2003544210A JP2005509846A (en) 2001-06-11 2002-06-10 Electronic detection of biomolecules using thin layers
CA002450109A CA2450109A1 (en) 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers
US10/480,409 US20040248282A1 (en) 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers
US10/335,482 US20040023253A1 (en) 2001-06-11 2002-12-26 Device structure for closely spaced electrodes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US29758301P 2001-06-11 2001-06-11
US60/297,583 2001-06-11
US09/970,087 2001-10-02
US09/970,087 US6824974B2 (en) 2001-06-11 2001-10-02 Electronic detection of biological molecules using thin layers
US37893802P 2002-05-10 2002-05-10
US60/378,938 2002-05-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/335,482 Continuation-In-Part US20040023253A1 (en) 2001-06-11 2002-12-26 Device structure for closely spaced electrodes

Publications (2)

Publication Number Publication Date
WO2003042396A2 WO2003042396A2 (en) 2003-05-22
WO2003042396A3 true WO2003042396A3 (en) 2004-03-11

Family

ID=27404499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/018319 WO2003042396A2 (en) 2001-06-11 2002-06-10 Electronic detection of biological molecules using thin layers

Country Status (6)

Country Link
US (1) US20040248282A1 (en)
EP (1) EP1417352A4 (en)
JP (1) JP2005509846A (en)
AU (1) AU2002363627A1 (en)
CA (1) CA2450109A1 (en)
WO (1) WO2003042396A2 (en)

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