WO2003048334A3 - Immunocytokines with modulated selectivity - Google Patents
Immunocytokines with modulated selectivity Download PDFInfo
- Publication number
- WO2003048334A3 WO2003048334A3 PCT/US2002/038780 US0238780W WO03048334A3 WO 2003048334 A3 WO2003048334 A3 WO 2003048334A3 US 0238780 W US0238780 W US 0238780W WO 03048334 A3 WO03048334 A3 WO 03048334A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fusion proteins
- immunocytokines
- cytokine
- bind
- therapeutic index
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES02792325T ES2381025T3 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
BR0214650-9A BR0214650A (en) | 2001-12-04 | 2002-12-04 | Modulated selectivity immunocytokines |
AT02792325T ATE542137T1 (en) | 2001-12-04 | 2002-12-04 | IMMUNOCYTOKINE WITH MODULATED SELECTIVITY |
EP02792325A EP1454138B1 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
AU2002357784A AU2002357784B2 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
JP2003549513A JP4795640B2 (en) | 2001-12-04 | 2002-12-04 | Immune cytokines with regulated selectivity |
DK02792325.9T DK1454138T3 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
HU0402541A HU229098B1 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
CA2469151A CA2469151C (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
MXPA04005266A MXPA04005266A (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity. |
ZA2004/05247A ZA200405247B (en) | 2001-12-04 | 2004-07-01 | Immunocytokines with modulated selectivity |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33711301P | 2001-12-04 | 2001-12-04 | |
US60/337,113 | 2001-12-04 | ||
US37196602P | 2002-04-12 | 2002-04-12 | |
US60/371,966 | 2002-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003048334A2 WO2003048334A2 (en) | 2003-06-12 |
WO2003048334A3 true WO2003048334A3 (en) | 2003-09-04 |
Family
ID=26990541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/038780 WO2003048334A2 (en) | 2001-12-04 | 2002-12-04 | Immunocytokines with modulated selectivity |
Country Status (18)
Country | Link |
---|---|
US (3) | US7186804B2 (en) |
EP (2) | EP1454138B1 (en) |
JP (1) | JP4795640B2 (en) |
KR (1) | KR100988180B1 (en) |
CN (1) | CN100390282C (en) |
AT (1) | ATE542137T1 (en) |
AU (1) | AU2002357784B2 (en) |
BR (1) | BR0214650A (en) |
CA (1) | CA2469151C (en) |
DK (1) | DK1454138T3 (en) |
ES (1) | ES2381025T3 (en) |
HU (1) | HU229098B1 (en) |
MX (1) | MXPA04005266A (en) |
PL (1) | PL206975B1 (en) |
PT (1) | PT1454138E (en) |
RU (1) | RU2312677C9 (en) |
WO (1) | WO2003048334A2 (en) |
ZA (1) | ZA200405247B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8907066B2 (en) | 2009-04-22 | 2014-12-09 | Merck Patent Gmbh | Antibody fusion proteins with a modified FcRn binding site |
US11851467B2 (en) | 2016-12-22 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
US11958893B2 (en) | 2021-07-21 | 2024-04-16 | Cue Biopharma, Inc. | Methods for modulating an immune response |
Families Citing this family (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE267215T1 (en) | 1997-12-08 | 2004-06-15 | Lexigen Pharm Corp | HETERODIMARY FUSION PROTEINS FOR USE FOR TARGETED IMMUNTHERAPY AND GENERAL IMMUNE EXCITATION |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
PL343462A1 (en) * | 1998-04-15 | 2001-08-13 | Lexigen Pharm Corp | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
WO2001010912A1 (en) * | 1999-08-09 | 2001-02-15 | Lexigen Pharmaceuticals Corp. | Multiple cytokine-antibody complexes |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CA2399832C (en) | 2000-02-11 | 2011-09-20 | Stephen D. Gillies | Enhancing the circulating half-life of antibody-based fusion proteins |
ES2288967T3 (en) * | 2000-06-29 | 2008-02-01 | Merck Patent Gmbh | REINFORCEMENT OF IMMUNE ANSWERS MEDIATED BY THE ANTIBODY-CYTOKIN FUSION PROTEIN THROUGH THE TREATMENT COMBINED BY AGENTS THAT IMPROVE THE INCORPORATION OF IMMUNOCITOQUINE. |
CA2440221C (en) | 2001-03-07 | 2013-02-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Expression technology for proteins containing a hybrid isotype antibody moiety |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
BR0209177A (en) | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Recombinant tumor specific antibody and use |
ES2381025T3 (en) | 2001-12-04 | 2012-05-22 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
ES2346205T3 (en) | 2002-12-17 | 2010-10-13 | Merck Patent Gmbh | HUMANIZED ANTIBODY (H14.18) OF ANTIBODY 14.18 OF MOUSE THAT LINKS TO GD2 AND ITS FUSION WITH IL-2. |
US7541439B2 (en) * | 2003-06-26 | 2009-06-02 | Merck Patent Gmbh | Thrombopoietin proteins with improved properties |
DK1648931T3 (en) | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunctional cytokines |
DE602004031341D1 (en) | 2003-07-21 | 2011-03-24 | Transgene Sa | MULTIFUNCTIONAL CYTOKINE |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
WO2005063820A2 (en) | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Il-7 fusion proteins |
KR20060124656A (en) * | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | Fc-erythropoietin fusion protein with improved pharmacokinetics |
WO2005066348A2 (en) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
CA2553883C (en) | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
DE602005020837D1 (en) * | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | IL-7 VARIANTS WITH REDUCED IMMUNOGENITY |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
PT2270050E (en) | 2005-12-30 | 2013-09-12 | Merck Patent Gmbh | Anti-cd19 antibodies with reduced immunogenicity |
CA2635618C (en) * | 2005-12-30 | 2015-10-06 | Merck Patent Gesellschaft Mit Beschraekter Haftung | Interleukin-12p40 variants with improved stability |
EP2038417A2 (en) * | 2006-07-06 | 2009-03-25 | Merck Patent GmbH | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
WO2008124086A2 (en) | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
DE102008023820A1 (en) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | An agent for the treatment and / or prophylaxis of an autoimmune disease and for the production of regulatory T cells |
CN101343323B (en) * | 2008-08-29 | 2011-02-16 | 浙江大学 | Anti-interleukins-8 antibody |
EP2337579A1 (en) * | 2008-10-21 | 2011-06-29 | Merck Patent GmbH | Cancer treatments with radiation and immunocytokines |
WO2010077831A1 (en) * | 2008-12-16 | 2010-07-08 | Tod Lauerman | Targeted cytokine for treatment of diseases |
CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
CU23734A1 (en) | 2009-11-27 | 2011-11-15 | Centro Inmunologia Molecular | IMMUNOMODULATOR POLIPEPTIDES DERIVED FROM IL-2 WITH ANTIGONIST ACTIVITY OF THIS CITOCINE USED IN CANCER THERAPY AND CHRONIC INFECTIOUS DISEASES |
CU23923B1 (en) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | POLYPEPTIDES DERIVED FROM IL-2 WITH AGONIST ACTIVITY |
EP3971206A1 (en) * | 2011-02-10 | 2022-03-23 | Roche Glycart AG | Mutant interleukin-2 polypeptides |
BR112013019083A2 (en) | 2011-02-10 | 2017-04-04 | Roche Glycart Ag | combination of (a) an immunoconjugate, pharmaceutical composition, use of (a) an immunoconjugate, method of treating a disease in an individual, method of stimulating cellular function in an individual, and kit for treating a disease. |
WO2012129330A1 (en) | 2011-03-23 | 2012-09-27 | Option Pharmaceutical, Llc | Targeted cytokine for treatment of musculoskeletal diseases |
EA201892619A1 (en) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS |
EP2537933A1 (en) * | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
US11492383B2 (en) | 2011-06-24 | 2022-11-08 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
EP2734232B1 (en) * | 2011-07-19 | 2017-11-01 | Philogen S.p.A. | Sequential anti-ctla4 and targeted il-2 therapy |
US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
CA2872195A1 (en) | 2012-08-07 | 2014-02-13 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
AU2013359907B2 (en) | 2012-12-11 | 2018-01-18 | Albert Einstein College Of Medicine, Inc. | Methods for high throughput receptor:ligand identification |
US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
CA3093606A1 (en) | 2013-03-15 | 2014-09-18 | Xencor, Inc. | Heterodimeric proteins for induction of t cells |
CN105324124A (en) | 2013-04-19 | 2016-02-10 | 赛腾制药 | Cytokine derived treatment with reduced vascular leak syndrome |
DK3299466T3 (en) * | 2013-07-18 | 2019-11-18 | Vib Vzw | FUSOKINES INVOLVING CYTOKINES WITH POWERFULLY REDUCED RECEPTOR BINDING EFFINITIES |
US10781242B2 (en) | 2013-09-24 | 2020-09-22 | Medicenna Therapeutics Inc. | Interleukin-2 fusion proteins and uses thereof |
CA2931114A1 (en) * | 2014-02-06 | 2015-08-13 | F. Hoffmann-La Roche Ag | Interleukin-2 fusion proteins and uses thereof |
EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
EP3134102B1 (en) * | 2014-04-24 | 2019-07-03 | The Board of Trustees of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
US10308697B2 (en) | 2014-04-30 | 2019-06-04 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
US10758614B2 (en) | 2014-06-09 | 2020-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health | Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase |
WO2015191602A2 (en) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies targeting tumor-associated stroma or tumor cells |
WO2015191610A2 (en) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways |
WO2015191590A2 (en) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies targeting tumor-associated stroma or tumor cells and microtubules |
US11034757B2 (en) | 2014-06-09 | 2021-06-15 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature |
WO2015191615A2 (en) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and alkylating agents |
WO2015191617A2 (en) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells |
PT3172227T (en) * | 2014-07-21 | 2019-12-06 | Delinia Inc | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
SG11201700629TA (en) * | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
EP3233192B1 (en) | 2014-12-15 | 2021-04-14 | Washington University | Compositions and methods for targeted cytokine delivery |
TWI691512B (en) | 2015-02-20 | 2020-04-21 | 日商橘生藥品工業股份有限公司 | Fc fusion high affinity IgE receptor alpha chain |
MY188430A (en) | 2015-04-10 | 2021-12-08 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
CN106699888B (en) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | PD-1 antibody and preparation method and application thereof |
JP7299021B2 (en) * | 2015-09-11 | 2023-06-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Biorelevant Orthogonal Cytokine/Receptor Pairs |
US10149887B2 (en) * | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
JP7325186B2 (en) | 2015-12-09 | 2023-08-14 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Type II anti-CD20 antibody for reducing the formation of anti-drug antibodies |
EP3178848A1 (en) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
CA3011374A1 (en) | 2016-02-05 | 2017-08-10 | Washington University | Compositions and methods for targeted cytokine delivery |
WO2017139570A1 (en) | 2016-02-12 | 2017-08-17 | Massachusetts Intitute Of Technology | Synergistic tumor treatment with il-2, an integrin-binding-fc fusion protein, and a cancer vaccinne |
BR112018073606A2 (en) | 2016-05-18 | 2019-02-26 | Cue Biopharma, Inc. | T-cell modulating multimeric polypeptides and methods of using them |
IL262606B2 (en) | 2016-05-18 | 2023-04-01 | Albert Einstein College Medicine Inc | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
CN109952370B (en) | 2016-10-19 | 2023-09-08 | 豪夫迈·罗氏有限公司 | Methods for producing immunoconjugates |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
SG11201903882VA (en) | 2016-11-08 | 2019-05-30 | Delinia Inc | Il-2 variants for the treatment of autoimmune diseases |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
WO2018170288A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
SG11201908391XA (en) * | 2017-03-15 | 2019-10-30 | Cue Biopharma Inc | Methods for modulating an immune response |
CN110392692B (en) | 2017-04-03 | 2023-07-21 | 豪夫迈·罗氏有限公司 | Immunoconjugates of anti-PD-1 antibodies with mutant IL-2 or with IL-15 |
WO2018184965A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
CN110505883A (en) | 2017-04-13 | 2019-11-26 | 豪夫迈·罗氏有限公司 | Proleulzin immunoconjugates used in method for treating cancer, CD40 agonist, and optionally PD-1 axis binding antagonists |
CN110662762A (en) * | 2017-05-24 | 2020-01-07 | 诺华股份有限公司 | Antibody cytokine transplantation proteins and methods for treating cancer |
AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
WO2018215938A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
JOP20190271A1 (en) * | 2017-05-24 | 2019-11-21 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use for immune related disorders |
EP3641814A4 (en) | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | Uses and methods for il-2 superagonists, agonists, and fusions thereof |
CN111094330A (en) | 2017-07-03 | 2020-05-01 | 转矩医疗股份有限公司 | Polynucleotides encoding immunostimulatory fusion molecules and uses thereof |
US20200181220A1 (en) * | 2017-08-03 | 2020-06-11 | Synthorx, Inc. | Cytokine conjugates for the treatment of proliferative and infectious diseases |
IL297361B1 (en) * | 2017-09-07 | 2024-03-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of use thereof |
AU2018337686B2 (en) * | 2017-09-21 | 2023-04-20 | Merck Patent Gmbh | Fusion protein comprising an FGF-18 moiety |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US20200317787A1 (en) * | 2017-12-26 | 2020-10-08 | Nanjingjinsirui Science & Technology Biology Corp. | Fusion protein dimer using antibody fc region as backbone and use thereof |
AU2018394189B2 (en) | 2017-12-27 | 2023-12-21 | Kyowa Kirin Co., Ltd. | IL-2 variant |
CN111886241A (en) * | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | Multimeric T cell modulating polypeptides and methods of use thereof |
WO2019168791A2 (en) * | 2018-02-28 | 2019-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Single-chain il-2/antibody fusions that selectively activate regulatory t cells |
CN108503714A (en) * | 2018-04-10 | 2018-09-07 | 浙江科途医学科技有限公司 | A kind of human interleukin 2 and anti-human signal transduction factor scfv fusion protein and its application |
AU2019271148B2 (en) * | 2018-05-14 | 2023-07-06 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
US20210130430A1 (en) * | 2018-05-14 | 2021-05-06 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
WO2019246404A1 (en) * | 2018-06-22 | 2019-12-26 | Cugene Inc. | Interleukin-2 variants and methods of uses thereof |
CN112654633A (en) | 2018-06-22 | 2021-04-13 | 科优基因公司 | Cytokine-based bioactivatable agents and methods of use thereof |
WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
JP7289158B2 (en) | 2018-08-06 | 2023-06-09 | メディカイン、インコーポレイテッド | IL-2 receptor binding compounds |
AU2019343850A1 (en) * | 2018-09-17 | 2020-06-25 | Gi Innovation, Inc. | Fusion protein comprising IL-2 protein and CD80 protein, and use thereof |
MX2021003580A (en) * | 2018-09-28 | 2021-10-13 | Pf Medicament | New immunocytokines for the treatment of cancer. |
US20220056094A1 (en) * | 2018-12-21 | 2022-02-24 | Jiangsu Hengrui Medicine Co., Ltd. | Human interleukin-2 variant or derivative thereof |
JP2022515223A (en) | 2018-12-21 | 2022-02-17 | オーエスイー・イミュノセラピューティクス | Bifunctional molecule for human PD-1 |
WO2020154032A1 (en) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
CN111944036A (en) * | 2019-05-14 | 2020-11-17 | 上海盖浦生物科技有限公司 | Mutant protein for proliferating immune cells |
CN111944008A (en) * | 2019-05-14 | 2020-11-17 | 上海盖浦生物科技有限公司 | Method for mutating protein and obtained mutant protein |
BR112021023345A2 (en) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Targeted immunotolerance in madcam |
AU2020279534A1 (en) | 2019-05-20 | 2021-11-11 | Cytune Pharma | IL-2/IL-15Rβy agonist dosing regimens for treating cancer or infectious diseases |
CN114728040A (en) * | 2019-06-14 | 2022-07-08 | 科优基因公司 | Novel interleukin-2 variants and bifunctional fusion molecules thereof |
EP3994169A1 (en) | 2019-07-02 | 2022-05-11 | F. Hoffmann-La Roche AG | Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody |
JP7427287B2 (en) * | 2019-11-05 | 2024-02-05 | メディカイン、インコーポレイテッド | Dual IL-2R and IL-7R binding compounds |
AU2020380296A1 (en) | 2019-11-05 | 2022-06-16 | Medikine Inc. | IL-2RβγC binding compounds |
IL293680B2 (en) | 2019-12-13 | 2024-04-01 | Synthekine Inc | Il-2 orthologs and methods of use |
WO2021127487A2 (en) * | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Novel il2 agonists and methods of use thereof |
JP2023514010A (en) | 2020-01-10 | 2023-04-05 | ブライト ピーク セラピューティクス エージー | Modified IL-2 polypeptides and uses thereof |
EP4090674A4 (en) * | 2020-01-14 | 2024-01-24 | Synthekine Inc | Biased il2 muteins methods and compositions |
MX2022009302A (en) | 2020-02-03 | 2022-11-16 | Medikine Inc | Il-7rî± binding compounds. |
BR112022015002A2 (en) | 2020-02-03 | 2022-12-06 | Medikine Inc | IL-7R-ALPHA/GAMMA/C LIGAND, COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF A DISEASE IN A PATIENT, AND NUCLEIC ACID |
JP2023527690A (en) | 2020-05-11 | 2023-06-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Combination therapy with modified PBMC and immunoconjugate |
MX2022013208A (en) | 2020-05-12 | 2022-11-14 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of use thereof. |
JP2023529981A (en) | 2020-06-19 | 2023-07-12 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Immunostimulatory Fc domain binding molecules |
US20230398185A1 (en) | 2020-10-26 | 2023-12-14 | Cytune Pharma | Il-2/il-15r-beta-gamma agonist for treating non-melanoma skin cancer |
IL302321A (en) | 2020-10-26 | 2023-06-01 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
AU2021393752A1 (en) | 2020-12-04 | 2023-05-18 | F. Hoffmann-La Roche Ag | Ph-dependent mutant interleukin-2 polypeptides |
WO2022148853A1 (en) | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
EP4314032A1 (en) | 2021-03-30 | 2024-02-07 | F. Hoffmann-La Roche AG | Protease-activated polypeptides |
CA3213917A1 (en) | 2021-04-09 | 2022-10-13 | Nicolas Poirier | New scaffold for bifunctional molecules with improved properties |
EP4342983A1 (en) | 2021-05-18 | 2024-03-27 | Cells & Genes Biotech (Shanghai) Co., Ltd | Method for modifying cell |
TW202317623A (en) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | Il2-based therapeutics and methods of use thereof |
WO2022266467A2 (en) | 2021-06-17 | 2022-12-22 | Dana-Farber Cancer Institute, Inc. | Recombinant histone polypeptide and uses thereof |
WO2023017191A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
WO2023230594A1 (en) | 2022-05-27 | 2023-11-30 | Regeneron Pharmaceuticals, Inc. | Interleukin-2 proproteins and uses thereof |
US20230391844A1 (en) | 2022-06-04 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Interleukin-2 proproteins and uses thereof |
WO2024068705A1 (en) | 2022-09-29 | 2024-04-04 | F. Hoffmann-La Roche Ag | Protease-activated polypeptides |
CN116041539B (en) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | IL-2 mutant immunoconjugates |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
Family Cites Families (172)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2922685A (en) * | 1957-11-12 | 1960-01-26 | Brunswick Balke Collender Co | Adjustable top desk |
US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4469797A (en) * | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
KR850004274A (en) * | 1983-12-13 | 1985-07-11 | 원본미기재 | Method for preparing erythropoietin |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US5082658A (en) * | 1984-01-16 | 1992-01-21 | Genentech, Inc. | Gamma interferon-interleukin-2 synergism |
EP0158198A1 (en) | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US5679543A (en) | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5359035A (en) | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
DE3712985A1 (en) | 1987-04-16 | 1988-11-03 | Hoechst Ag | BIFUNCTIONAL PROTEINS |
EP0237019A3 (en) | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Interferon conjugate and production thereof using recombinant gene |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
DK173067B1 (en) | 1986-06-27 | 1999-12-13 | Univ Washington | Human erythropoietin gene, method of expression thereof in transfected cell lines, the transfected cell lines |
US4894227A (en) | 1986-08-01 | 1990-01-16 | Cetus Corporation | Composition of immunotoxins with interleukin-2 |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5508031A (en) * | 1986-11-21 | 1996-04-16 | Cetus Oncology Corporation | Method for treating biological damage using a free-radial scavenger and interleukin-2 |
US5019368A (en) * | 1989-02-23 | 1991-05-28 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
EP0307434B2 (en) * | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
DE3856559T2 (en) | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunctional proteins with predetermined objectives |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5091513A (en) * | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
ATE122238T1 (en) | 1987-06-10 | 1995-05-15 | Dana Farber Cancer Inst Inc | BIFUNCTIONAL ANTIBODY CONSTRUCTIONS AND METHOD FOR SELECTIVE KILLING OF CELLS. |
US5064646A (en) | 1988-08-02 | 1991-11-12 | The University Of Maryland | Novel infectious bursal disease virus |
ES2054753T3 (en) | 1987-09-02 | 1994-08-16 | Ciba Geigy Ag | CONJUGATES OF CYTOKINES WITH IMMUNOGLOBULINS. |
EP0308936B1 (en) | 1987-09-23 | 1994-07-06 | Bristol-Myers Squibb Company | Antibody heteroconjugates for the killing of HIV-infected cells |
NZ226414A (en) | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
AU2635088A (en) | 1987-12-04 | 1989-06-08 | Du Pont Merck Pharmaceutical Company, The | Immobilized interleukin 2 and interleukin 2 containing a carboxyl-terminal extension |
WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
CA1341588C (en) | 1988-01-26 | 2009-01-06 | Michel Revel | Human ifn-beta2/i1-6, its purification and use |
US5120525A (en) * | 1988-03-29 | 1992-06-09 | Immunomedics, Inc. | Radiolabeled antibody cytotoxic therapy of cancer |
US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
IT1217724B (en) | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | SPECIFIC MONOCLONAL ANTIBODY FOR A SEQUENCE OF FIBRONETIN EXPRESSED IN TRANSFORMED HYBRID CELLS ACCORDING TO SUCH ANTIBODY AND USE OF THE MONOCLONAL ANTIBODY FOR THE DIAGNOSIS OF TUMORS |
IE62463B1 (en) | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
US5457038A (en) | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US5242824A (en) | 1988-12-22 | 1993-09-07 | Oncogen | Monoclonal antibody to human carcinomas |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
ZA902949B (en) | 1989-05-05 | 1992-02-26 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6291158B1 (en) * | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
ATE123065T1 (en) * | 1989-07-07 | 1995-06-15 | Takeda Chemical Industries Ltd | PROTEINS AND THEIR PRODUCTION. |
US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
ATE163675T1 (en) | 1989-12-22 | 1998-03-15 | Hoffmann La Roche | CYTOTOXIC LYMPHOCYTE MATURATION FACTOR |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
US5238823A (en) * | 1990-08-22 | 1993-08-24 | Veterinary Infectious Disease Organization | Interleukin-2-leukotoxin gene fusions and uses thereof |
US5650150A (en) * | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
US5709859A (en) * | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
US6072039A (en) | 1991-04-19 | 2000-06-06 | Rohm And Haas Company | Hybrid polypeptide comparing a biotinylated avidin binding polypeptide fused to a polypeptide of interest |
DE69233482T2 (en) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
ATE173763T1 (en) | 1991-08-30 | 1998-12-15 | Hutchinson Fred Cancer Res | HYBRID CYTOKINE |
US20020037558A1 (en) * | 1991-10-23 | 2002-03-28 | Kin-Ming Lo | E.coli produced immunoglobulin constructs |
JP2597060B2 (en) * | 1991-12-13 | 1997-04-02 | 富士通株式会社 | Array disk device |
US6627615B1 (en) | 1991-12-17 | 2003-09-30 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
ATE260971T1 (en) | 1992-04-01 | 2004-03-15 | Univ Rockefeller | METHOD FOR THE IN VITRO CULTIVATION OF DENDRITIC PRECURSOR CELLS AND THEIR USE FOR IMMUNOGENIC PRODUCTION |
DK0615451T3 (en) * | 1992-05-26 | 2006-04-24 | Immunex Corp | Hitherto unknown cytokine that binds to CD30 |
CA2134773A1 (en) | 1992-06-04 | 1993-12-09 | Robert J. Debs | Methods and compositions for in vivo gene therapy |
US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
CA2142007C (en) | 1992-08-11 | 2007-10-30 | Robert Glen Urban | Immunomodulatory peptides |
DE4228839A1 (en) | 1992-08-29 | 1994-03-03 | Behringwerke Ag | Methods for the detection and determination of mediators |
DE69232604T2 (en) | 1992-11-04 | 2002-11-07 | City Of Hope Duarte | ANTIBODY CONSTRUCTS |
EP1757694A3 (en) * | 1992-11-05 | 2008-02-27 | Sloan Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5543297A (en) * | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
JPH08509614A (en) * | 1993-04-29 | 1996-10-15 | アボツト・ラボラトリーズ | Erythropoietin analog compositions and methods |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
CN1057534C (en) | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | Erythropoietin analogs |
US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
AU692865B2 (en) * | 1994-04-26 | 1998-06-18 | Children's Medical Center Corporation | Angiostatin and method of use for inhibition of angiogenesis |
US5837682A (en) | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
CU22615A1 (en) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | PROCEDURE FOR OBTAINING LESS IMMUNOGENIC MONOCLONAL ANTIBODIES. MONOCLONAL ANTIBODIES OBTAINED |
US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US5888773A (en) * | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
PT706799E (en) | 1994-09-16 | 2002-05-31 | Merck Patent Gmbh | IMUNOCONJUGADOS II |
US6485726B1 (en) | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US6086875A (en) * | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
US5691309A (en) | 1995-01-31 | 1997-11-25 | Eli Lilly And Company | Anti-obesity proteins |
US5552524A (en) * | 1995-01-31 | 1996-09-03 | Eli Lilly And Company | Anti-obesity proteins |
US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
ES2225874T3 (en) * | 1995-03-10 | 2005-03-16 | Genentech, Inc. | RECEIVER ACTIVATION THROUGH GAS. |
US5719266A (en) * | 1995-03-17 | 1998-02-17 | Eli Lilly And Company | Anti-obesity proteins |
US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
WO1997002004A2 (en) * | 1995-06-30 | 1997-01-23 | Eli Lilly And Company | Methods for treating diabetes |
US6406689B1 (en) * | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
US5854205A (en) | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
US6080409A (en) * | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
US6750334B1 (en) * | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
US6008361A (en) * | 1996-04-09 | 1999-12-28 | Pfizer Inc. | Substituted pyridines |
CN1136197C (en) * | 1996-05-30 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | Novel pyridajinone derivatives |
US5922685A (en) | 1996-06-05 | 1999-07-13 | Powderject Vaccines, Inc. | IL-12 gene therapy of tumors |
ATE218143T1 (en) * | 1996-09-03 | 2002-06-15 | Gsf Forschungszentrum Umwelt | USE OF BI- AND TRISPECIFIC ANTIBODIES TO INDUCE TUMOR IMMUNITY |
US5994104A (en) * | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
US6100387A (en) * | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
US6277375B1 (en) * | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
EP0973550B1 (en) * | 1997-04-11 | 2002-10-09 | G.D. SEARLE & CO. | Antagonistic anti-avb3 integrin antibodies |
ATE267215T1 (en) * | 1997-12-08 | 2004-06-15 | Lexigen Pharm Corp | HETERODIMARY FUSION PROTEINS FOR USE FOR TARGETED IMMUNTHERAPY AND GENERAL IMMUNE EXCITATION |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
PL343462A1 (en) | 1998-04-15 | 2001-08-13 | Lexigen Pharm Corp | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
EP1071469A2 (en) * | 1998-04-17 | 2001-01-31 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor |
WO1999054484A1 (en) * | 1998-04-20 | 1999-10-28 | The Regents Of The University Of California | Modified immunoglobulin molecules and methods for use thereof |
WO1999058662A1 (en) | 1998-05-14 | 1999-11-18 | Merck Patent Gmbh | Fused protein |
DZ2788A1 (en) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Selective IL-2 agonists and antagonists. |
US6955807B1 (en) * | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
GB9814383D0 (en) | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
US20020142374A1 (en) | 1998-08-17 | 2002-10-03 | Michael Gallo | Generation of modified molecules with increased serum half-lives |
CA2339331C (en) * | 1998-08-25 | 2011-03-01 | Lexigen Pharmaceuticals Corporation | Expression and export of angiogenesis inhibitors as immunofusins |
US6646113B1 (en) | 1998-09-17 | 2003-11-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants |
US6335176B1 (en) * | 1998-10-16 | 2002-01-01 | Pharmacopeia, Inc. | Incorporation of phosphorylation sites |
KR20020007287A (en) * | 1999-01-07 | 2002-01-26 | 추후보정 | EXPRESSION AND EXPORT OF ANTI-OBESITY PROTEINS AS Fc FUSION PROTEINS |
US7115261B1 (en) * | 1999-02-12 | 2006-10-03 | The Scripps Research Institute | Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies |
KR100922809B1 (en) | 1999-05-06 | 2009-10-21 | 웨이크 포리스트 유니버시티 | Compositions And Methods For Identifying Antigens Which Elicit An Immune Response |
US6348192B1 (en) * | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
EP1187852B1 (en) * | 1999-05-19 | 2007-08-08 | EMD Lexigen Research Center Corp. | EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS |
CZ299516B6 (en) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof |
JO2291B1 (en) * | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythopintin derivatives |
CN1114617C (en) * | 1999-07-19 | 2003-07-16 | 王革 | Process for preparing recombined human interleukin-11 by use of hydroxylamine to cut fusion protein |
US7067110B1 (en) * | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
WO2001010912A1 (en) | 1999-08-09 | 2001-02-15 | Lexigen Pharmaceuticals Corp. | Multiple cytokine-antibody complexes |
WO2001036489A2 (en) * | 1999-11-12 | 2001-05-25 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CA2399832C (en) | 2000-02-11 | 2011-09-20 | Stephen D. Gillies | Enhancing the circulating half-life of antibody-based fusion proteins |
PT1257297E (en) * | 2000-02-24 | 2006-12-29 | Philogen Spa | Compositions and methods for treatemnt of angiogenesis in pathological lesions |
US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
MXPA02011016A (en) * | 2000-05-12 | 2004-03-16 | Neose Technologies Inc | In vitro. |
ES2288967T3 (en) * | 2000-06-29 | 2008-02-01 | Merck Patent Gmbh | REINFORCEMENT OF IMMUNE ANSWERS MEDIATED BY THE ANTIBODY-CYTOKIN FUSION PROTEIN THROUGH THE TREATMENT COMBINED BY AGENTS THAT IMPROVE THE INCORPORATION OF IMMUNOCITOQUINE. |
JP2004525621A (en) * | 2001-01-18 | 2004-08-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Bifunctional fusion protein having glucocerebrosidase activity |
JP2004532620A (en) * | 2001-02-19 | 2004-10-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Artificial proteins with reduced immunogenicity |
WO2002069232A2 (en) | 2001-02-19 | 2002-09-06 | Merck Patent Gmbh | Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity |
CA2440221C (en) | 2001-03-07 | 2013-02-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Expression technology for proteins containing a hybrid isotype antibody moiety |
WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
BR0209177A (en) | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Recombinant tumor specific antibody and use |
EP1476180A4 (en) * | 2001-08-13 | 2005-04-20 | Univ Southern California | Interleukin-2 mutants with reduced toxicity |
ES2381025T3 (en) * | 2001-12-04 | 2012-05-22 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
ES2346205T3 (en) * | 2002-12-17 | 2010-10-13 | Merck Patent Gmbh | HUMANIZED ANTIBODY (H14.18) OF ANTIBODY 14.18 OF MOUSE THAT LINKS TO GD2 AND ITS FUSION WITH IL-2. |
US20050025573A1 (en) | 2003-07-31 | 2005-02-03 | Waldman John Jeffrey | Liquid control structure |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
WO2005063820A2 (en) * | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Il-7 fusion proteins |
KR20060124656A (en) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CA2553883C (en) | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
DE602005020837D1 (en) * | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | IL-7 VARIANTS WITH REDUCED IMMUNOGENITY |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
KR20080090484A (en) | 2005-12-30 | 2008-10-08 | 메르크 파텐트 게엠베하 | Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130 |
PT2270050E (en) * | 2005-12-30 | 2013-09-12 | Merck Patent Gmbh | Anti-cd19 antibodies with reduced immunogenicity |
CA2635618C (en) * | 2005-12-30 | 2015-10-06 | Merck Patent Gesellschaft Mit Beschraekter Haftung | Interleukin-12p40 variants with improved stability |
AU2007229698B9 (en) | 2006-03-24 | 2012-11-08 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
EP2038417A2 (en) * | 2006-07-06 | 2009-03-25 | Merck Patent GmbH | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
US9908376B2 (en) | 2015-08-24 | 2018-03-06 | Alireza Sedighpour | Tire grip enhancing assembly |
US11258202B2 (en) | 2019-10-24 | 2022-02-22 | Jonathon R. Weeks | Secure outlet device and method |
-
2002
- 2002-12-04 ES ES02792325T patent/ES2381025T3/en not_active Expired - Lifetime
- 2002-12-04 CN CNB028242793A patent/CN100390282C/en not_active Expired - Fee Related
- 2002-12-04 EP EP02792325A patent/EP1454138B1/en not_active Expired - Lifetime
- 2002-12-04 RU RU2004119961/15A patent/RU2312677C9/en active
- 2002-12-04 CA CA2469151A patent/CA2469151C/en not_active Expired - Lifetime
- 2002-12-04 DK DK02792325.9T patent/DK1454138T3/en active
- 2002-12-04 BR BR0214650-9A patent/BR0214650A/en not_active Application Discontinuation
- 2002-12-04 KR KR1020047008572A patent/KR100988180B1/en active IP Right Grant
- 2002-12-04 EP EP10010445A patent/EP2354791A1/en not_active Withdrawn
- 2002-12-04 MX MXPA04005266A patent/MXPA04005266A/en active IP Right Grant
- 2002-12-04 AU AU2002357784A patent/AU2002357784B2/en not_active Ceased
- 2002-12-04 PL PL369741A patent/PL206975B1/en unknown
- 2002-12-04 JP JP2003549513A patent/JP4795640B2/en not_active Expired - Fee Related
- 2002-12-04 PT PT02792325T patent/PT1454138E/en unknown
- 2002-12-04 US US10/310,719 patent/US7186804B2/en active Active
- 2002-12-04 HU HU0402541A patent/HU229098B1/en not_active IP Right Cessation
- 2002-12-04 WO PCT/US2002/038780 patent/WO2003048334A2/en active Application Filing
- 2002-12-04 AT AT02792325T patent/ATE542137T1/en active
-
2004
- 2004-07-01 ZA ZA2004/05247A patent/ZA200405247B/en unknown
-
2006
- 2006-10-16 US US11/581,663 patent/US7462350B2/en not_active Expired - Lifetime
-
2008
- 2008-12-01 US US12/325,599 patent/US7888071B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8907066B2 (en) | 2009-04-22 | 2014-12-09 | Merck Patent Gmbh | Antibody fusion proteins with a modified FcRn binding site |
US11851467B2 (en) | 2016-12-22 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
US11958893B2 (en) | 2021-07-21 | 2024-04-16 | Cue Biopharma, Inc. | Methods for modulating an immune response |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003048334A3 (en) | Immunocytokines with modulated selectivity | |
EP2248892A3 (en) | Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function | |
AU3501197A (en) | Human stem cell antigens, dna coding therefor and their use | |
CA2440094A1 (en) | Structural reinforcement member and method of use therefor | |
AU7833698A (en) | Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use | |
WO2001049728A3 (en) | HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS | |
WO2000005367A3 (en) | Human proteins having hydrophobic domains and dnas encoding these proteins | |
EP1571216A3 (en) | Phosphodiesterase 8A | |
WO2002059315A3 (en) | Human nucleic acids and polypeptides and methods of use thereof | |
EP0754229A1 (en) | Alfamin: a human serum albumin-like protein | |
WO2000029448A3 (en) | Human proteins having hydrophobic domains and dnas encoding these proteins | |
WO2000069884A3 (en) | Compositions isolated from skin cells and methods for their use | |
WO2004083245A3 (en) | Agent comprise an albumin-like first polypeptide bound to a second polypeptide | |
AU1952497A (en) | Novel antibody-cytokine fusion protein, and methods of making and using the same | |
WO2001085961A3 (en) | Human caspase-12 | |
AU2002334781A1 (en) | Novel human proteins, polynucleotides encoding them and methods of using the same | |
AU6774198A (en) | Human rab protein, srab | |
WO2000077179A3 (en) | Human poly(adp-ribose) polymerase 2 materials and methods | |
WO2001004297A3 (en) | Human proteins having hydrophobic domains and dnas encoding these proteins | |
EP0887416A3 (en) | Human AFC1 | |
WO2002046408A3 (en) | Human proteins, polynucleotides encoding them and methods of using the same | |
WO2002072611A8 (en) | Novel human egf-family proteins and polynucleotides encoding the same | |
WO2000053628A3 (en) | Genes encoding human potassium channel proteins | |
AU5300999A (en) | Novel protein, gene encoding the same and utilization thereof | |
WO2001042297A3 (en) | Clasp-3 transmembrane protein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002792325 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2004/005266 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003549513 Country of ref document: JP Ref document number: 2469151 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20028242793 Country of ref document: CN Ref document number: 1020047008572 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004/05247 Country of ref document: ZA Ref document number: 200405247 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002357784 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004119961 Country of ref document: RU |
|
WWP | Wipo information: published in national office |
Ref document number: 2002792325 Country of ref document: EP |