WO2003049700A3 - Growth hormone releasing hormone suplementation for treating chronically ill subjects - Google Patents

Growth hormone releasing hormone suplementation for treating chronically ill subjects Download PDF

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Publication number
WO2003049700A3
WO2003049700A3 PCT/US2002/039509 US0239509W WO03049700A3 WO 2003049700 A3 WO2003049700 A3 WO 2003049700A3 US 0239509 W US0239509 W US 0239509W WO 03049700 A3 WO03049700 A3 WO 03049700A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
retarding
ghrh
nucleic acid
growth
Prior art date
Application number
PCT/US2002/039509
Other languages
French (fr)
Other versions
WO2003049700B1 (en
WO2003049700A2 (en
Inventor
Ruxandra Draghia-Akli
Robert H Carpenter
Douglas R Kern
Robert J Schwartz
Glen King
Kevin Hahn
Malcolm K Brenner
Original Assignee
Advisys Inc
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advisys Inc, Baylor College Medicine filed Critical Advisys Inc
Priority to BR0214869-2A priority Critical patent/BR0214869A/en
Priority to EP02804771.0A priority patent/EP1465654B1/en
Priority to CA2469310A priority patent/CA2469310C/en
Priority to MXPA04005713A priority patent/MXPA04005713A/en
Priority to AU2002357143A priority patent/AU2002357143B2/en
Publication of WO2003049700A2 publication Critical patent/WO2003049700A2/en
Publication of WO2003049700A3 publication Critical patent/WO2003049700A3/en
Publication of WO2003049700B1 publication Critical patent/WO2003049700B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding cachexia, wasting, anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the animal tissue specific constitutive expression is achieved. Furthermore, external regulation of the GHRH or functional biological equivalent thereof gene can be accomplished by utilizing inducible promoters that are regulated by molecular switch molecules, which are given to the animal. The preferred method to deliver the constitutive or inducible nucleic acid encoding sequences of GHRH or the functional biological equivalents thereof is directly into the cells of the animal by the process of in vivo electroporation. In addition, a treatment for retarding the growth of the tumor, and retarding cachexia or the wasting effects that are commonly associated with tumors is achieved by the delivery of recombinant GHRH or biological equivalent into the animal.
PCT/US2002/039509 2001-12-11 2002-12-10 Growth hormone releasing hormone suplementation for treating chronically ill subjects WO2003049700A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BR0214869-2A BR0214869A (en) 2001-12-11 2002-12-10 Plasmid-mediated supplementation for treatment of chronically ill individuals
EP02804771.0A EP1465654B1 (en) 2001-12-11 2002-12-10 Plasmid mediated supplementation for treating chronically ill subjects
CA2469310A CA2469310C (en) 2001-12-11 2002-12-10 Plasmid mediated supplementation for treating chronically ill subjects
MXPA04005713A MXPA04005713A (en) 2001-12-11 2002-12-10 Growth hormone releasing hormone suplementation for treating chronically ill subjects.
AU2002357143A AU2002357143B2 (en) 2001-12-11 2002-12-10 Growth hormone releasing hormone supplementation for treating chronically ill subjects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33961001P 2001-12-11 2001-12-11
US60/339,610 2001-12-11

Publications (3)

Publication Number Publication Date
WO2003049700A2 WO2003049700A2 (en) 2003-06-19
WO2003049700A3 true WO2003049700A3 (en) 2003-09-18
WO2003049700B1 WO2003049700B1 (en) 2003-10-30

Family

ID=23329825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039509 WO2003049700A2 (en) 2001-12-11 2002-12-10 Growth hormone releasing hormone suplementation for treating chronically ill subjects

Country Status (11)

Country Link
US (2) US7241744B2 (en)
EP (1) EP1465654B1 (en)
CN (1) CN1615151A (en)
AR (1) AR037778A1 (en)
AU (1) AU2002357143B2 (en)
BR (1) BR0214869A (en)
CA (1) CA2469310C (en)
MX (1) MXPA04005713A (en)
MY (1) MY142457A (en)
TW (1) TW200301778A (en)
WO (1) WO2003049700A2 (en)

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AU2002324909A1 (en) * 2001-09-07 2003-03-24 Baylor College Of Medicine Linear dna fragments for gene expression
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EP1465654B1 (en) * 2001-12-11 2015-02-25 Inovio Pharmaceuticals, Inc. Plasmid mediated supplementation for treating chronically ill subjects
US7250405B2 (en) * 2002-02-07 2007-07-31 Baylor College Of Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
EP1513559A4 (en) * 2002-05-28 2006-01-18 Advisys Inc Increased delivery of a nucleic acid constrtuct in vivo by the poly-l-glutamate (plg) system
AU2003295366B2 (en) * 2002-11-04 2011-11-24 Advisys, Inc. Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
CA2575926C (en) * 2003-08-04 2014-02-25 Advisys, Inc. Canine specific growth hormone releasing hormone
AU2005269724B2 (en) * 2004-07-23 2011-03-10 Advisys, Inc. Growth hormone releasing hormone enhances the immune response induced by vaccination
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US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
US8980249B2 (en) 2010-06-03 2015-03-17 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
WO2012145577A1 (en) 2011-04-20 2012-10-26 Merial Limited Adjuvanted rabies vaccine with improved viscosity profile
US8993316B2 (en) 2011-11-16 2015-03-31 Brian P. Hanley Methods and compositions for gene therapy and GHRH therapy
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
WO2013138776A1 (en) 2012-03-16 2013-09-19 Merial Limited Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders

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Also Published As

Publication number Publication date
BR0214869A (en) 2005-03-08
TW200301778A (en) 2003-07-16
US20090170748A1 (en) 2009-07-02
US20040057941A1 (en) 2004-03-25
WO2003049700B1 (en) 2003-10-30
CN1615151A (en) 2005-05-11
CA2469310C (en) 2013-01-29
AU2002357143B2 (en) 2009-07-30
EP1465654A2 (en) 2004-10-13
CA2469310A1 (en) 2003-06-19
EP1465654A4 (en) 2007-08-29
WO2003049700A2 (en) 2003-06-19
MXPA04005713A (en) 2005-06-06
US7241744B2 (en) 2007-07-10
EP1465654B1 (en) 2015-02-25
US8178504B2 (en) 2012-05-15
MY142457A (en) 2010-11-30
AR037778A1 (en) 2004-12-01
AU2002357143A1 (en) 2003-06-23

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