WO2003050266A3 - Tissue engineered cellular sheets, methods of making and use thereof - Google Patents

Tissue engineered cellular sheets, methods of making and use thereof Download PDF

Info

Publication number
WO2003050266A3
WO2003050266A3 PCT/US2002/039789 US0239789W WO03050266A3 WO 2003050266 A3 WO2003050266 A3 WO 2003050266A3 US 0239789 W US0239789 W US 0239789W WO 03050266 A3 WO03050266 A3 WO 03050266A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
stent
vessel
organs
sheets
Prior art date
Application number
PCT/US2002/039789
Other languages
French (fr)
Other versions
WO2003050266A2 (en
Inventor
Todd N Mcallister
Heureux Nicolas L
Original Assignee
Cytograft Tissue Engineering I
Todd N Mcallister
Heureux Nicolas L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytograft Tissue Engineering I, Todd N Mcallister, Heureux Nicolas L filed Critical Cytograft Tissue Engineering I
Priority to EP02799936A priority Critical patent/EP1451299A4/en
Priority to AU2002364558A priority patent/AU2002364558A1/en
Publication of WO2003050266A2 publication Critical patent/WO2003050266A2/en
Publication of WO2003050266A3 publication Critical patent/WO2003050266A3/en
Priority to US11/640,470 priority patent/US20070178588A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture

Abstract

The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign obdy responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic. The use of tissue manipulation devices further allows for the assembly of complex tissue engineered organs. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolnged maturation and subsequent increased mechanical strength. The tissue manipulation devcies also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes.
PCT/US2002/039789 2001-12-11 2002-12-11 Tissue engineered cellular sheets, methods of making and use thereof WO2003050266A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02799936A EP1451299A4 (en) 2001-12-11 2002-12-11 Tissue engineered cellular sheets, methods of making and use thereof
AU2002364558A AU2002364558A1 (en) 2001-12-11 2002-12-11 Tissue engineered cellular sheets, methods of making and use thereof
US11/640,470 US20070178588A1 (en) 2001-12-11 2006-12-14 Tissue control rods for sheet-based tissue engineering

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34096401P 2001-12-11 2001-12-11
US60/340,964 2001-12-11
US35528302P 2002-02-07 2002-02-07
US60/355,283 2002-02-07

Publications (2)

Publication Number Publication Date
WO2003050266A2 WO2003050266A2 (en) 2003-06-19
WO2003050266A3 true WO2003050266A3 (en) 2003-12-04

Family

ID=26992313

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039789 WO2003050266A2 (en) 2001-12-11 2002-12-11 Tissue engineered cellular sheets, methods of making and use thereof

Country Status (4)

Country Link
US (4) US7166464B2 (en)
EP (1) EP1451299A4 (en)
AU (1) AU2002364558A1 (en)
WO (1) WO2003050266A2 (en)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7959664B2 (en) * 1996-12-26 2011-06-14 Medinol, Ltd. Flat process of drug coating for stents
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6962814B2 (en) * 2000-08-16 2005-11-08 Duke University Decellularized tissue engineered constructs and tissues
CA2468323A1 (en) * 2001-11-28 2003-06-05 Universite Laval Method for improving functionality of tissue constructs
US7166464B2 (en) * 2001-12-11 2007-01-23 Cytograft Tissue Engineering, Inc. Method of culturing cells to produce a tissue sheet
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
CA2479512C (en) * 2002-03-15 2012-10-16 Laura E. Niklason Tissue engineering
BR0205047C1 (en) * 2002-11-21 2003-11-04 Ronaldo Da Rocha Loures Bueno Biosynthetic cellulose membrane coated stent graft
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US7044965B1 (en) * 2002-12-13 2006-05-16 Spielberg Theodore E Therapeutic cellular stent
EP1641913B1 (en) 2003-06-27 2016-01-06 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
CA2544726C (en) 2003-11-07 2018-06-26 University Of Connecticut Artificial tissue systems and uses thereof
WO2005089507A2 (en) * 2004-03-19 2005-09-29 Moldovan Nicanor I System for providing implant compatibility with recipient
US8039258B2 (en) * 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
US7402172B2 (en) * 2004-10-13 2008-07-22 Boston Scientific Scimed, Inc. Intraluminal therapeutic patch
JP4279233B2 (en) * 2004-10-25 2009-06-17 国立大学法人広島大学 Sheet for inducing mesenchymal tissue regeneration and method for producing the same
US7439057B2 (en) * 2004-11-16 2008-10-21 La Jolla Bioengineering Institute Convective flow tissue assembly
DE102005018778B4 (en) * 2004-11-22 2010-05-06 Perea Saavedra, Héctor, Dipl.-Ing. A method of producing a unitary or multidimensional unit structure and structure produced by the method
WO2006083394A2 (en) * 2004-12-21 2006-08-10 Ethicon, Inc. Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
WO2006101548A2 (en) * 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
PL1831356T3 (en) 2004-12-23 2017-07-31 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US20080274545A1 (en) * 2005-03-02 2008-11-06 Government Of The Us, As Represented By The Secret Bioreactor Chamber Apparatus, and Method and System for Fabricating and Mechanically Stimulating Natural and Engineered Tissues
WO2006110110A1 (en) * 2005-04-11 2006-10-19 National University Of Singapore Tissue construct and method thereof
US9788821B2 (en) * 2005-04-29 2017-10-17 Cook Biotech Incorporated Physically modified extracellular matrix materials and uses thereof
GB0524087D0 (en) 2005-11-25 2006-01-04 Symetis Ag Biodegradable scaffold
US8828077B2 (en) 2006-03-15 2014-09-09 Medinol Ltd. Flat process of preparing drug eluting stents
US8003388B2 (en) 2006-03-24 2011-08-23 Nortis, Inc. Method for creating perfusable microvessel systems
US8445280B2 (en) * 2006-03-24 2013-05-21 Nortis, Inc. Method for creating perfusable microvessel systems
US7622298B2 (en) * 2006-03-24 2009-11-24 Norits, Inc. Method for creating perfusable microvessel systems
JP4821466B2 (en) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 Droplet discharge head
US8142805B1 (en) 2006-11-06 2012-03-27 Clemson University Research Foundation Implantable devices including fixed tissues
US20100189712A1 (en) * 2006-11-17 2010-07-29 Cytograft Tissue Engineering, Inc. Preparation And Use Of Cell-Synthesized Threads
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
ES2639183T3 (en) 2007-09-19 2017-10-25 The Charles Stark Draper Laboratory, Inc. Microfluidic structures with circular cross section
US20110293666A1 (en) * 2007-11-28 2011-12-01 Xianyan Wang Bioengineered Tissue Constructs and Methods for Production and Use
CN101925675A (en) * 2007-11-28 2010-12-22 器官发生有限公司 Bioengineered tissue constructs and methods for production and use
WO2009098698A2 (en) 2008-02-07 2009-08-13 Shahar Cohen Compartmental extract compositions for tissue engineering
US8017396B2 (en) * 2008-02-22 2011-09-13 Vijay Kumar Cellulose based heart valve prosthesis
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
US20100040663A1 (en) * 2008-06-16 2010-02-18 Cytograft Tissue Engineering, Inc. Arterial Implants
WO2010115187A1 (en) * 2009-04-03 2010-10-07 Duke University Methods of making cell sheets, tissue sheets and tissue engineered blood vessels
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
WO2011057206A1 (en) 2009-11-07 2011-05-12 University Of Iowa Research Foundation Cellulose capsules and methods for making them
EP2515960B1 (en) 2009-12-23 2014-03-19 Jockenhövel, Stefan Implant, method for producing such an implant, and use
CA2787050A1 (en) * 2010-01-14 2011-07-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
US20110287079A1 (en) * 2010-05-19 2011-11-24 Xylos Corporation Supporting material for cell sheet
EP2412798A1 (en) 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetic membrane for cell expansion
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
SG10201601962WA (en) 2010-12-14 2016-04-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9968446B2 (en) 2011-03-23 2018-05-15 The Regents Of The University Of California Tubular scaffold for fabrication of heart valves
US10016461B2 (en) 2012-12-03 2018-07-10 The Regents Of The University Of California Apparatus and process for growing a heart valve in three-dimensions
CN104302245A (en) * 2012-03-23 2015-01-21 细胞移植组织工程有限公司 Tissue-engineered heart valve for transcatheter repair
US9994812B2 (en) 2012-04-04 2018-06-12 University Of Washington Through Its Center For Commercialization Systems and method for engineering muscle tissue
US20130337565A1 (en) * 2012-06-19 2013-12-19 Medtrain Technologies, Llc Method and Apparatus for Patterning Cells
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
WO2014182542A1 (en) 2013-05-06 2014-11-13 Abbott Cardiovascular Systems Inc. A hollow stent filled with a therapeutic agent formulation
CN103349795B (en) * 2013-06-28 2014-11-12 华侨大学 Construction method of tissue engineered tissue based on artificial cell
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
CA2938156C (en) 2014-02-05 2022-05-10 Modern Meadow, Inc. Dried food products formed from cultured muscle cells
US9801910B2 (en) 2014-03-17 2017-10-31 Ethicon, Inc. Decellularized pleural matrix
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US10076644B2 (en) 2014-05-16 2018-09-18 Terumo Kabushiki Kaisha Method and apparatus for treating urethral stricture
US20160045300A1 (en) * 2014-05-16 2016-02-18 Terumo Kabushiki Kaisha Method and apparatus for treating urethral stricture
US10293082B2 (en) 2014-07-23 2019-05-21 Clemson University Research Foundation Decellularization method and system and decellularized tissue formed thereby
US11034928B2 (en) 2014-07-23 2021-06-15 Clemson University Research Foundation Modular bioreactor, compliance chamber for a bioreactor, and cell seeding apparatus
US10022225B2 (en) 2014-07-23 2018-07-17 Clemson University Research Foundation Self-adjusting tissue holder
CN106715676A (en) 2014-09-26 2017-05-24 泰尔茂比司特公司 Scheduled feed
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3127561A1 (en) 2015-08-05 2017-02-08 Jenpolymer Materials UG & Co. KG Medical implant based on nanocellulose
ES2842501T5 (en) 2015-09-21 2023-04-13 Modern Meadow Inc Fiber Reinforced Fabric Composite Materials
KR20170096093A (en) 2016-02-15 2017-08-23 브렌던 패트릭 퍼셀 Composite biofabricated material
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US10305064B2 (en) * 2017-04-28 2019-05-28 Wuhan China Star Optoelectronics Technology Co., Ltd. Flexible organic light emitting diode display and manufacturing method thereof
WO2018231702A1 (en) * 2017-06-13 2018-12-20 The Regents Of The University Of California Methods of improving cell-based therapy
US20200165575A1 (en) * 2017-07-14 2020-05-28 The Board Of Regents Of The University Of Oklahoma Surface-modified polymer scaffolds and uses thereof
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
US20210054341A1 (en) * 2017-12-27 2021-02-25 Gen Suzuki Cardiosphere-derived cell sheet and methods of making and using the same
EP3704202A4 (en) 2019-01-17 2020-12-16 Modern Meadow, Inc. Layered collagen materials and methods of making the same
US11788045B2 (en) 2019-12-06 2023-10-17 Diversified Biotech, Inc. Polylactide cell culture containers and use in cell culture
US11279909B2 (en) 2019-12-06 2022-03-22 Diversified Biotech, Inc. Polylactide cell culture containers and use in cell culture

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443950A (en) * 1986-04-18 1995-08-22 Advanced Tissue Sciences, Inc. Three-dimensional cell and tissue culture system
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents
US6127448A (en) * 1997-10-11 2000-10-03 Alomone Labs Ltd. Biocompatible polymeric coating material
US6140127A (en) * 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4441215A (en) * 1980-11-17 1984-04-10 Kaster Robert L Vascular graft
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
GB9007966D0 (en) * 1990-04-09 1990-06-06 Dynal As Antigen/anti-antigen cleavage
US5256141A (en) * 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5618718A (en) * 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US5628786A (en) * 1995-05-12 1997-05-13 Impra, Inc. Radially expandable vascular graft with resistance to longitudinal compression and method of making same
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5865723A (en) 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
JPH1089425A (en) * 1996-09-19 1998-04-07 Hiroyasu Shiokawa Multistage transmission
US5902228A (en) * 1996-10-11 1999-05-11 Cornell Research Foundation, Inc. Method and apparatus for support and tubularization of surgical grafts
US6077217A (en) * 1997-06-25 2000-06-20 Ramus Medical Technologies, Inc. System and method for assembling graft structures
US6468300B1 (en) * 1997-09-23 2002-10-22 Diseno Y Desarrollo Medico, S.A. De C.V. Stent covered heterologous tissue
CA2333058C (en) * 1998-05-21 2004-11-16 Children's Medical Center Corporation Corporal tissue penile reconstruction
US6455310B1 (en) * 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
EP1187909B1 (en) * 1999-04-30 2005-02-02 Massachusetts General Hospital Fabrication of threedimensional vascularized tissue using microfabricated two-dimensional molds
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6471723B1 (en) * 2000-01-10 2002-10-29 St. Jude Medical, Inc. Biocompatible prosthetic tissue
WO2002016557A2 (en) * 2000-08-21 2002-02-28 Rice University Tissue engineering scaffolds promoting matrix protein production
US6579307B2 (en) * 2001-07-19 2003-06-17 The Cleveland Clinic Foundation Endovascular prosthesis having a layer of biological tissue
US7166464B2 (en) * 2001-12-11 2007-01-23 Cytograft Tissue Engineering, Inc. Method of culturing cells to produce a tissue sheet
WO2003082153A2 (en) * 2002-03-25 2003-10-09 Cook Incorporated Branched vessel prothesis
AU2003272226A1 (en) 2002-08-20 2004-03-11 Cook Incorporated Stent graft with improved proximal end
AU2003295797B2 (en) 2002-11-22 2009-01-29 Cook Biotech, Inc. Stent tissue graft prosthesis
EP3141215B1 (en) * 2003-01-14 2021-03-24 The Cleveland Clinic Foundation Branched vessel endoluminal device
US20100189712A1 (en) * 2006-11-17 2010-07-29 Cytograft Tissue Engineering, Inc. Preparation And Use Of Cell-Synthesized Threads
US20100040663A1 (en) * 2008-06-16 2010-02-18 Cytograft Tissue Engineering, Inc. Arterial Implants

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443950A (en) * 1986-04-18 1995-08-22 Advanced Tissue Sciences, Inc. Three-dimensional cell and tissue culture system
US6127448A (en) * 1997-10-11 2000-10-03 Alomone Labs Ltd. Biocompatible polymeric coating material
US6140127A (en) * 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6010573A (en) * 1998-07-01 2000-01-04 Virginia Commonwealth University Apparatus and method for endothelial cell seeding/transfection of intravascular stents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCOTT N.A. ET AL.: "Seeding of intracoronary stents with immortalized human microvascular endothelial cells", AM. HEART J., vol. 129, no. 5, 1995, pages 860 - 866, XP002963849 *

Also Published As

Publication number Publication date
EP1451299A2 (en) 2004-09-01
US7166464B2 (en) 2007-01-23
US20030138945A1 (en) 2003-07-24
EP1451299A4 (en) 2008-03-05
US7504258B2 (en) 2009-03-17
AU2002364558A1 (en) 2003-06-23
WO2003050266A2 (en) 2003-06-19
AU2002364558A8 (en) 2003-06-23
US20030138950A1 (en) 2003-07-24
US8076137B2 (en) 2011-12-13
US20070178588A1 (en) 2007-08-02
US20090233356A1 (en) 2009-09-17

Similar Documents

Publication Publication Date Title
WO2003050266A3 (en) Tissue engineered cellular sheets, methods of making and use thereof
AU2001245734A1 (en) Coating that promotes endothelial cell adherence
EP1863545B1 (en) Prosthetic implants including ECM composite material
JP4716479B2 (en) Epidermal cultured cell sheet, stratified cultured skin sheet, and production method thereof
US20210369923A1 (en) Recombinant human collagen-based multifunctional stent coating and preparation method thereof
CA2472031A1 (en) Medical device with coating that promotes endothelial cell adherence and differentiation
JP2008532565A5 (en)
CN101361988B (en) Preparation method of blood vessel support or cardiac valve surface coating with good biocompatibility
DE50004406D1 (en) In vitro method for the production of a homologous heart valve or vascular prosthesis
WO2005009498A2 (en) Decellularized bone marrow extracellular matrix
EP1769775A3 (en) Methods and apparatus for manufacturing an intravascular stent
WO2005042703A3 (en) Placental stem cells and uses thereof
Yang et al. Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO 2 nanotubes for improved vascular biocompatibility
EP1228773A4 (en) Transplant material and process for producing the same
WO2005120549A3 (en) Local delivery of growth factors for stem cell transplantation
AU2742502A (en) Tissue-engineered vascular structures
JP2017074050A (en) Method for maintaining function of liver tissue cell over long period of time
CN110129748A (en) The preparation method of cardiac vascular medical equipment surfaces Ti-Cu-N coating with the anti-proliferation of smooth muscle of antibiosis anticoagulative blood
CN101269242A (en) Transgenic cell overlapped vascular inner rack and manufacture method thereof
CN213388862U (en) Coating for stainless steel surface deposition
Ko et al. A thin carboxymethyl cellulose culture substrate for the cellulase-induced harvesting of an endothelial cell sheet
AU3897200A (en) Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor
WO2018083683A1 (en) Vascular grafts, method of manufacturing thereof and articles comprising the same
WO2000067672A3 (en) Tissue engineering for making tubular implants
Liu et al. A degradable inorganic coating on vascular stent to used to accelerate endothelialization in vivo

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002799936

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002799936

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP