WO2003051306A3 - N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections - Google Patents
N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections Download PDFInfo
- Publication number
- WO2003051306A3 WO2003051306A3 PCT/US2002/040090 US0240090W WO03051306A3 WO 2003051306 A3 WO2003051306 A3 WO 2003051306A3 US 0240090 W US0240090 W US 0240090W WO 03051306 A3 WO03051306 A3 WO 03051306A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acylcytosine
- viral infections
- treatment
- dioxolane nucleosides
- dioxolane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002364730A AU2002364730A1 (en) | 2001-12-14 | 2002-12-16 | N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34155501P | 2001-12-14 | 2001-12-14 | |
US60/341,555 | 2001-12-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003051306A2 WO2003051306A2 (en) | 2003-06-26 |
WO2003051306A3 true WO2003051306A3 (en) | 2003-12-18 |
Family
ID=23338072
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/040081 WO2003063771A2 (en) | 2001-12-14 | 2002-12-13 | N4-acylcytosine nucleosides for treatment of viral iinfections |
PCT/US2002/040090 WO2003051306A2 (en) | 2001-12-14 | 2002-12-16 | N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/040081 WO2003063771A2 (en) | 2001-12-14 | 2002-12-13 | N4-acylcytosine nucleosides for treatment of viral iinfections |
Country Status (10)
Country | Link |
---|---|
US (6) | US7105527B2 (en) |
EP (1) | EP1569652A4 (en) |
JP (1) | JP2005519916A (en) |
KR (1) | KR100978904B1 (en) |
CN (1) | CN100560073C (en) |
AU (2) | AU2002365234B2 (en) |
BR (1) | BR0214944A (en) |
CA (1) | CA2470255C (en) |
MX (1) | MXPA04005779A (en) |
WO (2) | WO2003063771A2 (en) |
Families Citing this family (41)
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US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
BR0110023A (en) | 2000-04-13 | 2003-12-30 | Pharmasset Ltd | Substituted 3'-or-2 'nucleoside derivatives for treatment of hepatitis virus infections |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
KR20080021797A (en) * | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | Methods and compositions for treating flaviviruses and pestiviruses |
US7105527B2 (en) * | 2001-12-14 | 2006-09-12 | Otto Michael J | N4-acylcytosine nucleosides for treatment of viral infections |
US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
CA2489552A1 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
CN101172993A (en) * | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
BR0313164A (en) | 2002-08-01 | 2007-07-17 | Pharmasset Inc | compounds with the non-bicyclic system [4.2.1] for the treatment of flaviviridae infections |
MXPA05005192A (en) * | 2002-11-15 | 2005-09-08 | Idenix Cayman Ltd | 2aCOE-BRANCHED NUCLEOSIDES AND FLAVIVIRIDAE. |
WO2004052899A2 (en) * | 2002-12-12 | 2004-06-24 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
CA2425031A1 (en) * | 2003-04-01 | 2004-10-01 | Smithkline Beecham Corporation | Pharmaceutical compositions |
SI3521297T1 (en) | 2003-05-30 | 2022-04-29 | Gilead Pharmasset Llc | Modified fluorinated nucleoside analogues |
US7741334B2 (en) * | 2004-04-01 | 2010-06-22 | Achillion Pharmaceuticals, Inc. | Low dose therapy for treating viral infections |
CN101023094B (en) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives |
ES2725457T3 (en) | 2004-09-14 | 2019-09-24 | Gilead Pharmasset Llc | Preparation of ribofuranosyl pyrimidines and 2'fluoro-2'-alkyl-substituted or other optionally substituted purines and their derivatives |
CA2584670A1 (en) * | 2004-10-19 | 2006-04-27 | Achillion Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
US7968703B2 (en) | 2005-03-07 | 2011-06-28 | Shire Canada Inc. | Process and methods for the preparation of optically active cis-2-hydroxymethyl-4- (cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof |
WO2007075876A2 (en) * | 2005-12-23 | 2007-07-05 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
GB0623493D0 (en) | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
TW201031675A (en) | 2008-12-23 | 2010-09-01 | Pharmasset Inc | Synthesis of purine nucleosides |
CA2748057C (en) | 2008-12-23 | 2018-07-03 | Pharmasset, Inc. | Nucleoside phosphoramidates |
NZ593649A (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Nucleoside analogs |
TWI583692B (en) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | Nucleoside phosphoramidates |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
KR101715981B1 (en) | 2010-03-31 | 2017-03-13 | 길리애드 파마셋 엘엘씨 | Nucleoside phosphoramidates |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
EP3042910B1 (en) | 2010-11-30 | 2019-01-09 | Gilead Pharmasset LLC | 2'-spiro-nucleosides for use in the therapy of hepatitis c |
DE202012013382U1 (en) | 2011-09-16 | 2016-08-23 | Gilead Pharmasset Llc | Compositions for the treatment of HCV |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CN103242400B (en) * | 2012-02-08 | 2016-06-08 | 河南师范大学 | There is 5-substituted pyrimidines nucleoside-thiazolidhybrid hybrid and its preparation method of HIV (human immunodeficiency virus)-resistant activity |
PT2950786T (en) | 2013-01-31 | 2020-03-03 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
SI3650014T1 (en) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
CA3182565A1 (en) | 2015-03-06 | 2016-09-15 | Atea Pharmaceuticals, Inc. | .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
PL3512863T3 (en) | 2016-09-07 | 2022-04-04 | Atea Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
KR102335193B1 (en) | 2017-02-01 | 2021-12-03 | 아테아 파마슈티컬즈, 인크. | Nucleotide hemi-sulfate salts for treating hepatitis C virus |
KR20200140865A (en) | 2018-04-10 | 2020-12-16 | 아테아 파마슈티컬즈, 인크. | Treatment of HCV-infected patients with cirrhosis |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US5922867A (en) * | 1995-12-14 | 1999-07-13 | Biochem Pharma Inc. | Method and compositions for the synthesis of dioxolane nucleosides with β configuration |
US20030013660A1 (en) * | 2000-10-13 | 2003-01-16 | Shire Biochem Inc. | Dioxolane analogs for improved inter-cellular delivery |
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US3309359A (en) * | 1965-10-22 | 1967-03-14 | Hoffmann La Roche | N-mono-acyl-5-fluorocytosine derivatives and process |
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US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
GB8719367D0 (en) | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
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US6350753B1 (en) * | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
NL8901258A (en) | 1989-05-19 | 1990-12-17 | Stichting Rega V Z W | New 5-halo-2'-3'-di:deoxy-cytidine derivs. - useful as anti-retro-viral agents, esp. for treating HIV infections |
DD293498A5 (en) | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | METHOD FOR PRODUCING A MEDIUM FOR THE TREATMENT OR PROPHYLAXIS OF HEPATITE INFECTIONS IN HUMANS AND ANIMALS |
JPH05310777A (en) | 1992-05-14 | 1993-11-22 | Yoshitomi Pharmaceut Ind Ltd | 2'-deoxy-2'-methylidynecytidine compound |
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TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
WO1998017281A1 (en) * | 1996-10-24 | 1998-04-30 | Vion Pharmaceuticals, Inc. | MONOPHOSPHATE PRODRUGS OF β-L-FD4C AND β-L-FddC AS POTENT ANTIVIRAL AGENTS |
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DE69933860T2 (en) * | 1998-02-25 | 2007-05-31 | Emory University | 2'-FLUORONUKLEOSIDE |
KR20040028657A (en) * | 2000-10-18 | 2004-04-03 | 파마셋, 리미티드 | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
US7105527B2 (en) * | 2001-12-14 | 2006-09-12 | Otto Michael J | N4-acylcytosine nucleosides for treatment of viral infections |
-
2002
- 2002-12-13 US US10/318,511 patent/US7105527B2/en not_active Expired - Fee Related
- 2002-12-13 MX MXPA04005779A patent/MXPA04005779A/en active IP Right Grant
- 2002-12-13 AU AU2002365234A patent/AU2002365234B2/en not_active Ceased
- 2002-12-13 BR BR0214944-3A patent/BR0214944A/en not_active Application Discontinuation
- 2002-12-13 KR KR1020047009263A patent/KR100978904B1/en not_active IP Right Cessation
- 2002-12-13 CN CNB028278402A patent/CN100560073C/en not_active Expired - Fee Related
- 2002-12-13 EP EP02804833A patent/EP1569652A4/en not_active Withdrawn
- 2002-12-13 WO PCT/US2002/040081 patent/WO2003063771A2/en active Application Filing
- 2002-12-13 JP JP2003563467A patent/JP2005519916A/en active Pending
- 2002-12-13 CA CA2470255A patent/CA2470255C/en not_active Expired - Fee Related
- 2002-12-16 WO PCT/US2002/040090 patent/WO2003051306A2/en not_active Application Discontinuation
- 2002-12-16 AU AU2002364730A patent/AU2002364730A1/en not_active Abandoned
- 2002-12-16 US US10/320,350 patent/US6908924B2/en not_active Ceased
-
2006
- 2006-07-31 US US11/461,338 patent/US20070078080A1/en not_active Abandoned
-
2007
- 2007-06-21 US US11/821,076 patent/USRE42015E1/en not_active Expired - Fee Related
-
2008
- 2008-01-04 US US11/969,427 patent/US8114997B2/en not_active Expired - Fee Related
-
2012
- 2012-02-13 US US13/371,654 patent/US20120202766A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922867A (en) * | 1995-12-14 | 1999-07-13 | Biochem Pharma Inc. | Method and compositions for the synthesis of dioxolane nucleosides with β configuration |
US20030013660A1 (en) * | 2000-10-13 | 2003-01-16 | Shire Biochem Inc. | Dioxolane analogs for improved inter-cellular delivery |
Also Published As
Publication number | Publication date |
---|---|
US7105527B2 (en) | 2006-09-12 |
KR20040094398A (en) | 2004-11-09 |
USRE42015E1 (en) | 2010-12-28 |
MXPA04005779A (en) | 2005-05-16 |
EP1569652A4 (en) | 2008-07-02 |
KR100978904B1 (en) | 2010-08-31 |
WO2003051306A2 (en) | 2003-06-26 |
AU2002364730A1 (en) | 2003-06-30 |
BR0214944A (en) | 2005-06-07 |
US20090176730A1 (en) | 2009-07-09 |
US20030176319A1 (en) | 2003-09-18 |
US8114997B2 (en) | 2012-02-14 |
CN1617726A (en) | 2005-05-18 |
WO2003063771A3 (en) | 2005-07-07 |
WO2003063771A2 (en) | 2003-08-07 |
CN100560073C (en) | 2009-11-18 |
US20040214844A1 (en) | 2004-10-28 |
AU2002365234B2 (en) | 2009-01-29 |
EP1569652A2 (en) | 2005-09-07 |
JP2005519916A (en) | 2005-07-07 |
AU2002364730A8 (en) | 2003-06-30 |
CA2470255C (en) | 2012-01-17 |
US20120202766A1 (en) | 2012-08-09 |
US6908924B2 (en) | 2005-06-21 |
US20070078080A1 (en) | 2007-04-05 |
CA2470255A1 (en) | 2003-08-07 |
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