WO2003054142A3 - Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase - Google Patents
Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase Download PDFInfo
- Publication number
- WO2003054142A3 WO2003054142A3 PCT/US2002/034612 US0234612W WO03054142A3 WO 2003054142 A3 WO2003054142 A3 WO 2003054142A3 US 0234612 W US0234612 W US 0234612W WO 03054142 A3 WO03054142 A3 WO 03054142A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sulfurylase
- fusion proteins
- novel
- thermostable
- luciferase fusion
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002465283A CA2465283A1 (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
AU2002365146A AU2002365146B2 (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US10/494,073 US20050124022A1 (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
JP2003554847A JP2005517397A (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion protein and thermostable sulfurylase |
EP02803298A EP1451293A4 (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33594901P | 2001-10-30 | 2001-10-30 | |
US69/335,949 | 2001-10-30 | ||
US10/122,706 | 2002-04-11 | ||
US10/122,706 US6956114B2 (en) | 2001-10-30 | 2002-04-11 | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US10/154,515 | 2002-05-23 | ||
US10/154,515 US6902921B2 (en) | 2001-10-30 | 2002-05-23 | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/122,706 Continuation-In-Part US6956114B2 (en) | 2001-10-30 | 2002-04-11 | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US10/154,515 Continuation-In-Part US6902921B2 (en) | 2001-10-30 | 2002-05-23 | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003054142A2 WO2003054142A2 (en) | 2003-07-03 |
WO2003054142A3 true WO2003054142A3 (en) | 2004-06-10 |
Family
ID=27382840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034612 WO2003054142A2 (en) | 2001-10-30 | 2002-10-30 | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
Country Status (6)
Country | Link |
---|---|
US (2) | US6902921B2 (en) |
EP (2) | EP1451293A4 (en) |
JP (2) | JP2005517397A (en) |
AU (1) | AU2002365146B2 (en) |
CA (1) | CA2465283A1 (en) |
WO (1) | WO2003054142A2 (en) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030096268A1 (en) * | 2001-07-06 | 2003-05-22 | Michael Weiner | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
ES2338654T5 (en) | 2003-01-29 | 2017-12-11 | 454 Life Sciences Corporation | Pearl emulsion nucleic acid amplification |
DE10315640A1 (en) * | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Process for the controlled release of components into a solution |
WO2005054431A2 (en) * | 2003-12-01 | 2005-06-16 | 454 Corporation | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
GB0416944D0 (en) * | 2004-07-29 | 2004-09-01 | Lumora Ltd | Method for determining the amount of template nucleic acid present in a sample |
WO2006080313A1 (en) | 2005-01-25 | 2006-08-03 | Yamasa Corporation | Method of enzymatically synthesizing 3’-phosphoadenosine-5’-phosphosulfate |
JP5220597B2 (en) | 2005-06-23 | 2013-06-26 | キージーン ナムローゼ フェンノートシャップ | Method for identifying one or more polymorphisms and methods of use thereof |
EP1940755A2 (en) | 2005-10-28 | 2008-07-09 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
US8071310B2 (en) * | 2005-11-14 | 2011-12-06 | Keygene Nv | Method for the high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites |
EP3404114B1 (en) | 2005-12-22 | 2021-05-05 | Keygene N.V. | Method for high-throughput aflp-based polymorphism detection |
US8460879B2 (en) | 2006-02-21 | 2013-06-11 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
US11237171B2 (en) | 2006-02-21 | 2022-02-01 | Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
US20090143658A1 (en) * | 2006-02-27 | 2009-06-04 | Edwards Lifesciences Corporation | Analyte sensor |
DK2002017T3 (en) | 2006-04-04 | 2015-09-07 | Keygene Nv | High-capacity detection of molecular markers based on restriction fragments |
US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
EP4170042A1 (en) | 2006-06-14 | 2023-04-26 | Verinata Health, Inc. | Methods for the diagnosis of fetal abnormalities |
DK2038425T3 (en) | 2006-07-12 | 2010-12-06 | Keygene Nv | High capacity physical mapping using AFLP |
GB2442048B (en) * | 2006-07-25 | 2009-09-30 | Proimmune Ltd | Biotinylated MHC complexes and their uses |
CN1995063B (en) * | 2006-12-30 | 2010-09-08 | 中国科学技术大学 | Plant sulfur highly effective exploitation protein and its coding gene and application |
US9581595B2 (en) | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
US20090062132A1 (en) | 2007-08-29 | 2009-03-05 | Borner Scott R | Alternative nucleic acid sequencing methods |
EP2201374B1 (en) | 2007-08-30 | 2015-10-07 | Trustees Of Tufts College | Methods for determining the concentration of an analyte in solution. |
US20090181390A1 (en) * | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
ES2528971T3 (en) | 2008-03-17 | 2015-02-13 | Stichting Genetwister Ip | Discoveries of genes linked to expression |
JP2010029146A (en) * | 2008-07-30 | 2010-02-12 | Hitachi Ltd | Method for analysis of base sequence |
US8222047B2 (en) | 2008-09-23 | 2012-07-17 | Quanterix Corporation | Ultra-sensitive detection of molecules on single molecule arrays |
WO2010064897A1 (en) | 2008-12-05 | 2010-06-10 | Keygene N.V. | Farmesene synthase |
JP2012514977A (en) | 2009-01-13 | 2012-07-05 | キージーン・エン・フェー | New genome sequencing strategy |
CN102858995B (en) | 2009-09-10 | 2016-10-26 | 森特瑞隆技术控股公司 | Targeting sequence measurement |
US10174368B2 (en) | 2009-09-10 | 2019-01-08 | Centrillion Technology Holdings Corporation | Methods and systems for sequencing long nucleic acids |
CA2779750C (en) | 2009-11-06 | 2019-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive diagnosis of graft rejection in organ transplant patients |
WO2011071382A1 (en) | 2009-12-10 | 2011-06-16 | Keygene N.V. | Polymorfphic whole genome profiling |
CN102656279A (en) | 2009-12-17 | 2012-09-05 | 凯津公司 | Restriction enzyme based whole genome sequencing |
CA2783549A1 (en) | 2009-12-18 | 2011-06-23 | Keygene N.V. | Improved bulked mutant analysis |
US9678068B2 (en) | 2010-03-01 | 2017-06-13 | Quanterix Corporation | Ultra-sensitive detection of molecules using dual detection methods |
US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
US8415171B2 (en) | 2010-03-01 | 2013-04-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
EP2542890B1 (en) | 2010-03-01 | 2015-05-06 | Quanterix Corporation | Methods for extending dynamic range in assays for the detection of molecules or particles |
US11225655B2 (en) | 2010-04-16 | 2022-01-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
WO2012008831A1 (en) | 2010-07-13 | 2012-01-19 | Keygene N.V. | Simplified de novo physical map generation from clone libraries |
WO2012018387A2 (en) | 2010-08-02 | 2012-02-09 | Population Diagnotics, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
EP2614159B1 (en) | 2010-09-10 | 2017-11-08 | Bio-Rad Laboratories, Inc. | Size selection of dna for chromatin analysis |
WO2012096579A2 (en) | 2011-01-14 | 2012-07-19 | Keygene N.V. | Paired end random sequence based genotyping |
US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
WO2012106385A2 (en) | 2011-01-31 | 2012-08-09 | Apprise Bio, Inc. | Methods of identifying multiple epitopes in cells |
US20130316358A1 (en) | 2011-01-31 | 2013-11-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing disease using overlap extension pcr |
US20120252682A1 (en) | 2011-04-01 | 2012-10-04 | Maples Corporate Services Limited | Methods and systems for sequencing nucleic acids |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
EP2699588B1 (en) * | 2011-04-22 | 2016-11-30 | Danisco US Inc. | Filamentous fungi having an altered viscosity phenotype |
EP2718309B1 (en) | 2011-06-10 | 2018-04-04 | Keygene N.V. | Transcription factor modulating terpene biosynthesis |
EP2980226A1 (en) | 2011-07-08 | 2016-02-03 | Keygene N.V. | Sequence based genotyping based on oligonucleotide ligation assays |
US10221454B2 (en) | 2011-10-10 | 2019-03-05 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
WO2013067451A2 (en) | 2011-11-04 | 2013-05-10 | Population Diagnostics Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
WO2013070634A1 (en) | 2011-11-07 | 2013-05-16 | Ingenuity Systems, Inc. | Methods and systems for identification of causal genomic variants |
EP3434789A1 (en) | 2012-01-13 | 2019-01-30 | Data2Bio | Genotyping by next-generation sequencing |
EP2812452B1 (en) | 2012-02-09 | 2020-05-27 | Population Bio, Inc. | Methods and compositions for screening and treating developmental disorders |
EP3578669A1 (en) | 2012-08-08 | 2019-12-11 | F. Hoffmann-La Roche AG | Increasing dynamic range for identifying multiple epitopes in cells |
US9976180B2 (en) | 2012-09-14 | 2018-05-22 | Population Bio, Inc. | Methods for detecting a genetic variation in subjects with parkinsonism |
CA2922005A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
WO2014113502A1 (en) | 2013-01-15 | 2014-07-24 | Quanterix Corporation | Detection of dna or rna using single molecule arrays and other techniques |
CN105121661B (en) | 2013-02-01 | 2018-06-08 | 加利福尼亚大学董事会 | The method of phase is determined for genome assembling and haplotype |
US9411930B2 (en) | 2013-02-01 | 2016-08-09 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
EP2964781B1 (en) | 2013-03-08 | 2018-01-10 | Roche Diagnostics GmbH | Egfr mutation blood testing |
CN105189748B (en) | 2013-03-15 | 2021-06-08 | 血统生物科学公司 | Method for sequencing an immune repertoire |
ES2946689T3 (en) | 2013-03-15 | 2023-07-24 | Univ Leland Stanford Junior | Identification and use of circulating nucleic acid tumor markers |
ES2943498T3 (en) | 2013-08-05 | 2023-06-13 | Twist Bioscience Corp | de novo synthesized libraries |
IL285106B (en) | 2013-11-07 | 2022-09-01 | Univ Leland Stanford Junior | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
DK2891722T3 (en) | 2013-11-12 | 2019-01-07 | Population Bio Inc | METHODS AND COMPOSITIONS FOR DIAGNOSTICING, PROGRAMMING AND TREATMENT OF ENDOMETRIOSIS |
EP3540074A1 (en) | 2013-12-11 | 2019-09-18 | The Regents of the University of California | Method of tagging internal regions of nucleic acid molecules |
US10526641B2 (en) | 2014-08-01 | 2020-01-07 | Dovetail Genomics, Llc | Tagging nucleic acids for sequence assembly |
US10724096B2 (en) | 2014-09-05 | 2020-07-28 | Population Bio, Inc. | Methods and compositions for inhibiting and treating neurological conditions |
WO2016105199A1 (en) | 2014-12-24 | 2016-06-30 | Keygene N.V. | Backbone mediated mate pair sequencing |
CA2975855A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
NZ734854A (en) | 2015-02-17 | 2022-11-25 | Dovetail Genomics Llc | Nucleic acid sequence assembly |
WO2016154540A1 (en) | 2015-03-26 | 2016-09-29 | Dovetail Genomics Llc | Physical linkage preservation in dna storage |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
GB2557529A (en) | 2015-09-18 | 2018-06-20 | Twist Bioscience Corp | Oligonucleic acid variant libraries and synthesis thereof |
WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
US10465232B1 (en) | 2015-10-08 | 2019-11-05 | Trace Genomics, Inc. | Methods for quantifying efficiency of nucleic acid extraction and detection |
SG11201803289VA (en) | 2015-10-19 | 2018-05-30 | Dovetail Genomics Llc | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
WO2017095958A1 (en) | 2015-12-01 | 2017-06-08 | Twist Bioscience Corporation | Functionalized surfaces and preparation thereof |
US10975417B2 (en) | 2016-02-23 | 2021-04-13 | Dovetail Genomics, Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
CA3014070C (en) | 2016-03-25 | 2023-03-14 | Karius, Inc. | Synthetic nucleic acid spike-ins |
DK3455356T3 (en) | 2016-05-13 | 2021-11-01 | Dovetail Genomics Llc | RECOVERY OF LONG-TERM BINDING INFORMATION FROM PRESERVED SAMPLES |
CN109996876A (en) | 2016-08-22 | 2019-07-09 | 特韦斯特生物科学公司 | The nucleic acid library of de novo formation |
WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
AU2017378492B2 (en) | 2016-12-16 | 2022-06-16 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
US11550939B2 (en) | 2017-02-22 | 2023-01-10 | Twist Bioscience Corporation | Nucleic acid based data storage using enzymatic bioencryption |
CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
US10697008B2 (en) | 2017-04-12 | 2020-06-30 | Karius, Inc. | Sample preparation methods, systems and compositions |
WO2018195091A1 (en) | 2017-04-18 | 2018-10-25 | Dovetail Genomics, Llc | Nucleic acid characteristics as guides for sequence assembly |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
WO2018231872A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
EP3642358A1 (en) | 2017-06-21 | 2020-04-29 | Bluedot LLC | Systems and methods for identification of nucleic acids in a sample |
SG11202002194UA (en) | 2017-09-11 | 2020-04-29 | Twist Bioscience Corp | Gpcr binding proteins and synthesis thereof |
WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | Methods and systems for sample extraction |
KR20240024357A (en) | 2017-10-20 | 2024-02-23 | 트위스트 바이오사이언스 코포레이션 | Heated nanowells for polynucleotide synthesis |
KR20200106067A (en) | 2018-01-04 | 2020-09-10 | 트위스트 바이오사이언스 코포레이션 | DNA-based digital information storage |
EP3746566A1 (en) | 2018-01-31 | 2020-12-09 | Dovetail Genomics, LLC | Sample prep for dna linkage recovery |
EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
EP4177356A1 (en) | 2018-08-08 | 2023-05-10 | PML Screening, LLC | Methods for assessing risk of developing a viral disease using a genetic test |
CN113785057A (en) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | Variant nucleic acid libraries for antibody optimization |
CA3131689A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265177B1 (en) * | 1997-04-11 | 2001-07-24 | The United States Of America As Represented By The Secretary Of The State Of Defence | Enzyme assay for mutant firefly luciferase |
Family Cites Families (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4863849A (en) | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
DE122007000007I1 (en) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetically transformed animals secreting a desired protein in milk |
US4822746A (en) | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
US5252494A (en) | 1986-06-25 | 1993-10-12 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix |
US5143853A (en) | 1986-06-25 | 1992-09-01 | Trustees Of Tufts College | Absorbance modulated fluorescence detection methods and sensors |
US5254477A (en) | 1986-06-25 | 1993-10-19 | Trustees Of Tufts College | Flourescence intramolecular energy transfer conjugate compositions and detection methods |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
SE8801070D0 (en) | 1988-03-23 | 1988-03-23 | Pharmacia Ab | METHOD FOR IMMOBILIZING A DNA SEQUENCE ON A SOLID SUPPORT |
US4971903A (en) | 1988-03-25 | 1990-11-20 | Edward Hyman | Pyrophosphate-based method and apparatus for sequencing nucleic acids |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US5250264A (en) | 1991-01-25 | 1993-10-05 | Trustees Of Tufts College | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
US5320814A (en) | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US5114984A (en) | 1991-04-26 | 1992-05-19 | Olin Corporation | Process for producing an antimicrobially effective polyurethane |
DE69233331T3 (en) | 1991-11-22 | 2007-08-30 | Affymetrix, Inc., Santa Clara | Combinatorial Polymersynthesis Strategies |
GB9210176D0 (en) | 1992-05-12 | 1992-06-24 | Cemu Bioteknik Ab | Chemical method |
US6114114A (en) | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
US5298741A (en) | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
US5512490A (en) | 1994-08-11 | 1996-04-30 | Trustees Of Tufts College | Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns |
US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
US5648245A (en) | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
US6200737B1 (en) | 1995-08-24 | 2001-03-13 | Trustees Of Tufts College | Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure |
US5843655A (en) | 1995-09-18 | 1998-12-01 | Affymetrix, Inc. | Methods for testing oligonucleotide arrays |
US5962228A (en) | 1995-11-17 | 1999-10-05 | Lynx Therapeutics, Inc. | DNA extension and analysis with rolling primers |
US5780231A (en) | 1995-11-17 | 1998-07-14 | Lynx Therapeutics, Inc. | DNA extension and analysis with rolling primers |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
US5633972A (en) | 1995-11-29 | 1997-05-27 | Trustees Of Tufts College | Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy |
US5814524A (en) | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
US5744341A (en) * | 1996-03-29 | 1998-04-28 | University Of Maryland College Park | Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes |
US6040413A (en) * | 1996-07-10 | 2000-03-21 | Basf Corporation | Composition of polytetramethylene ether glycols and polyoxy alkylene polyether polyols having a low degree of unsaturation |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US6887665B2 (en) | 1996-11-14 | 2005-05-03 | Affymetrix, Inc. | Methods of array synthesis |
GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
US6136543A (en) | 1997-01-31 | 2000-10-24 | Hitachi, Ltd. | Method for determining nucleic acids base sequence and apparatus therefor |
DE69825601T2 (en) | 1997-02-12 | 2005-04-28 | Chan, Eugene Y, Brookline | METHOD FOR THE ANALYSIS OF POLYMERS |
US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
CA2291180A1 (en) | 1997-05-23 | 1998-11-26 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
ATE225858T1 (en) | 1997-07-28 | 2002-10-15 | Medical Biosystems Ltd | SEQUENCE ANALYSIS OF NUCLEIC ACIDS |
US20010006630A1 (en) | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
WO1999032660A1 (en) | 1997-12-19 | 1999-07-01 | Affymetrix | Exploiting genomics in the search for new drugs |
US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
EP1068216B1 (en) | 1998-05-15 | 2003-12-10 | Isis Innovation Limited | Libraries of oligomers labelled with different tags |
GB9811403D0 (en) | 1998-05-27 | 1998-07-22 | Isis Innovation | Polynucleotide multimers and their use in hybridisation assays |
GB9813216D0 (en) | 1998-06-18 | 1998-08-19 | Pyrosequencing Ab | Reaction monitoring systems |
ATE423314T1 (en) | 1998-06-24 | 2009-03-15 | Illumina Inc | DECODING OF MATRIXED SENSORS BY MICROPARTICLES |
CA2339121A1 (en) | 1998-07-30 | 2000-02-10 | Shankar Balasubramanian | Arrayed biomolecules and their use in sequencing |
US6263286B1 (en) | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
JP2002529715A (en) | 1998-11-06 | 2002-09-10 | ソレックサ リミテッド | How to replicate molecular arrays |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
EP1154848B1 (en) | 1999-01-29 | 2014-05-14 | Illumina, Inc. | Apparatus and method for removal of liquid from vessels in chemical synthesis and biological screening |
JP2002536665A (en) | 1999-02-09 | 2002-10-29 | イルミナ インコーポレイテッド | Automatic information processing in randomly arranged arrays. |
ATE462970T1 (en) | 1999-02-09 | 2010-04-15 | Illumina Inc | SCREENING METHOD USING POROUS MICROBEADS AND COMPOSITIONS |
US6255476B1 (en) | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
GB9906477D0 (en) | 1999-03-19 | 1999-05-12 | Pyrosequencing Ab | Liquid dispensing apparatus |
AU3567900A (en) | 1999-03-30 | 2000-10-16 | Solexa Ltd. | Polynucleotide sequencing |
GB9907812D0 (en) | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Sequencing |
GB9907813D0 (en) | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Synthesis |
AU4476900A (en) | 1999-04-20 | 2000-11-02 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US6221653B1 (en) | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
US6544732B1 (en) | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
CA2374596A1 (en) | 1999-05-20 | 2000-11-30 | Illumina, Inc. | Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems |
WO2000075373A2 (en) | 1999-05-20 | 2000-12-14 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
US20020051971A1 (en) | 1999-05-21 | 2002-05-02 | John R. Stuelpnagel | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
CA2382436C (en) | 1999-08-30 | 2011-05-17 | Illumina, Inc. | Methods for improving signal detection from an array |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
GB9923324D0 (en) | 1999-10-01 | 1999-12-08 | Pyrosequencing Ab | Separation apparatus and method |
GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
GB9929381D0 (en) | 1999-12-10 | 2000-02-09 | Pyrosequencing Ab | A method of assessing the amount of nucleic acid in a sample |
EP3157898B1 (en) | 2014-06-20 | 2022-08-10 | P2 Science, Inc. | Film ozonolysis in a tubular or multitubular reactor |
-
2002
- 2002-05-23 US US10/154,515 patent/US6902921B2/en not_active Expired - Fee Related
- 2002-10-30 CA CA002465283A patent/CA2465283A1/en not_active Abandoned
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-
2005
- 2005-06-07 US US11/147,763 patent/US20060078909A1/en not_active Abandoned
-
2009
- 2009-04-03 JP JP2009091606A patent/JP2009148300A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265177B1 (en) * | 1997-04-11 | 2001-07-24 | The United States Of America As Represented By The Secretary Of The State Of Defence | Enzyme assay for mutant firefly luciferase |
Non-Patent Citations (2)
Title |
---|
CAPALDI S. ET AL.: "Signal amplification through nucleotide extension and excision on a dendritic DNA platform", NUCLEIC ACIDS RESEARCH, vol. 28, no. 7, 2000, pages E21I - E21VIII, XP002975740 * |
NYREN P., LUNDIN A.: "Enzymatic method for continuous monitoring of inorganic pyrophosphate synthesis", ANALYTICAL BIOCHEMISTRY, vol. 151, December 1985 (1985-12-01), pages 504 - 509, XP002975741 * |
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EP1451293A2 (en) | 2004-09-01 |
WO2003054142A2 (en) | 2003-07-03 |
JP2005517397A (en) | 2005-06-16 |
CA2465283A1 (en) | 2003-07-03 |
AU2002365146B2 (en) | 2006-10-05 |
EP2338978A1 (en) | 2011-06-29 |
US20060078909A1 (en) | 2006-04-13 |
US6902921B2 (en) | 2005-06-07 |
JP2009148300A (en) | 2009-07-09 |
AU2002365146A1 (en) | 2003-07-09 |
EP1451293A4 (en) | 2006-04-26 |
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