WO2003054143A3 - Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases - Google Patents

Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases Download PDF

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Publication number
WO2003054143A3
WO2003054143A3 PCT/US2002/034679 US0234679W WO03054143A3 WO 2003054143 A3 WO2003054143 A3 WO 2003054143A3 US 0234679 W US0234679 W US 0234679W WO 03054143 A3 WO03054143 A3 WO 03054143A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphisms
genes
disease
chromosome
alzheimer
Prior art date
Application number
PCT/US2002/034679
Other languages
French (fr)
Other versions
WO2003054143A2 (en
Inventor
Kenneth David Becker
Gonul Velicelebi
Kathryn J Elliott
Xin Wang
Rudolph E Tanzi
Lars Bertram
Aleister J Saunders
Kristina M Mullin
Andrew Joseph Sampson
Deborah Lynne Blacker
Original Assignee
Neurogenetics Inc
Gen Hospital Corp
Kenneth David Becker
Gonul Velicelebi
Kathryn J Elliott
Xin Wang
Rudolph E Tanzi
Lars Bertram
Aleister J Saunders
Kristina M Mullin
Andrew Joseph Sampson
Deborah Lynne Blacker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogenetics Inc, Gen Hospital Corp, Kenneth David Becker, Gonul Velicelebi, Kathryn J Elliott, Xin Wang, Rudolph E Tanzi, Lars Bertram, Aleister J Saunders, Kristina M Mullin, Andrew Joseph Sampson, Deborah Lynne Blacker filed Critical Neurogenetics Inc
Priority to AU2002364945A priority Critical patent/AU2002364945A1/en
Priority to US10/600,009 priority patent/US20050009031A1/en
Publication of WO2003054143A2 publication Critical patent/WO2003054143A2/en
Publication of WO2003054143A3 publication Critical patent/WO2003054143A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Probes, primers and kits for detection of polymorphisms in genes involved in neurodegenerative disease are provided. Methods based on detecting such polymorphisms for prognosticating, determining the occurrence, profiling drug response and drug discovery are also provided.
PCT/US2002/034679 2001-10-25 2002-10-25 Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases WO2003054143A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002364945A AU2002364945A1 (en) 2001-10-25 2002-10-25 Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
US10/600,009 US20050009031A1 (en) 2001-10-25 2003-06-18 Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US33952501P 2001-10-25 2001-10-25
US60/339,525 2001-10-25
US33801001P 2001-11-08 2001-11-08
US33692901P 2001-11-08 2001-11-08
US60/338,010 2001-11-08
US60/336,929 2001-11-08
US33836301P 2001-11-09 2001-11-09
US60/338,363 2001-11-09
US33705201P 2001-12-04 2001-12-04
US60/337,052 2001-12-04
US36891902P 2002-03-28 2002-03-28
US60/368,919 2002-03-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/600,009 Continuation-In-Part US20050009031A1 (en) 2001-10-25 2003-06-18 Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases

Publications (2)

Publication Number Publication Date
WO2003054143A2 WO2003054143A2 (en) 2003-07-03
WO2003054143A3 true WO2003054143A3 (en) 2005-03-31

Family

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Family Applications (1)

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PCT/US2002/034679 WO2003054143A2 (en) 2001-10-25 2002-10-25 Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases

Country Status (3)

Country Link
US (1) US20050009031A1 (en)
AU (1) AU2002364945A1 (en)
WO (1) WO2003054143A2 (en)

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AU2002364945A8 (en) 2003-07-09
AU2002364945A1 (en) 2003-07-09
WO2003054143A2 (en) 2003-07-03
US20050009031A1 (en) 2005-01-13

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