WO2003054161A3 - USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS - Google Patents

USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS Download PDF

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Publication number
WO2003054161A3
WO2003054161A3 PCT/US2002/040955 US0240955W WO03054161A3 WO 2003054161 A3 WO2003054161 A3 WO 2003054161A3 US 0240955 W US0240955 W US 0240955W WO 03054161 A3 WO03054161 A3 WO 03054161A3
Authority
WO
WIPO (PCT)
Prior art keywords
inducing
tissue
cell
induce angiogenesis
cpg oligodeoxynucleotides
Prior art date
Application number
PCT/US2002/040955
Other languages
French (fr)
Other versions
WO2003054161A2 (en
Inventor
Dennis M Klinman
Mei Zheng
Barry T Rouse
Original Assignee
Us Gov Health & Human Serv
Univ Tennessee Res Corp
Dennis M Klinman
Mei Zheng
Barry T Rouse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Univ Tennessee Res Corp, Dennis M Klinman, Mei Zheng, Barry T Rouse filed Critical Us Gov Health & Human Serv
Priority to AU2002366710A priority Critical patent/AU2002366710A1/en
Priority to US10/499,597 priority patent/US7615227B2/en
Publication of WO2003054161A2 publication Critical patent/WO2003054161A2/en
Publication of WO2003054161A3 publication Critical patent/WO2003054161A3/en
Priority to US11/839,217 priority patent/US7935351B2/en
Priority to US12/205,756 priority patent/US8466116B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

This disclosure provides a method of inducing production of vascular endothelial growth factor by a cell. The method includes contacting the cell with a CpG oligonucleotide, thereby inducing the production of vascular endothelial growth factor by the cell. The disclosure further provides a method inducing neovascularization in a tissue. This method includes comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, thereby inducing neovascularization in the area of the tissue.
PCT/US2002/040955 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS WO2003054161A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002366710A AU2002366710A1 (en) 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US10/499,597 US7615227B2 (en) 2001-12-20 2002-12-19 Use of CpG oligodeoxynucleotides to induce angiogenesis
US11/839,217 US7935351B2 (en) 2001-12-20 2007-08-15 Use of CPG oligodeoxynucleotides to induce angiogenesis
US12/205,756 US8466116B2 (en) 2001-12-20 2008-09-05 Use of CpG oligodeoxynucleotides to induce epithelial cell growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34345701P 2001-12-20 2001-12-20
US60/343,457 2001-12-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10499597 A-371-Of-International 2002-12-19
US11/839,217 Continuation US7935351B2 (en) 2001-12-20 2007-08-15 Use of CPG oligodeoxynucleotides to induce angiogenesis
US12/205,756 Continuation-In-Part US8466116B2 (en) 2001-12-20 2008-09-05 Use of CpG oligodeoxynucleotides to induce epithelial cell growth

Publications (2)

Publication Number Publication Date
WO2003054161A2 WO2003054161A2 (en) 2003-07-03
WO2003054161A3 true WO2003054161A3 (en) 2003-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040955 WO2003054161A2 (en) 2001-12-20 2002-12-19 USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS

Country Status (3)

Country Link
US (2) US7615227B2 (en)
AU (1) AU2002366710A1 (en)
WO (1) WO2003054161A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
AU4343700A (en) 1999-04-12 2000-11-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Oligodeoxynucleotide and its use to induce an immune response
EP1322655B1 (en) * 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
AU2002366710A1 (en) * 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
AR040996A1 (en) * 2002-08-19 2005-04-27 Coley Pharm Group Inc IMMUNE STIMULATING NUCLEIC ACIDS
SI2241325T1 (en) * 2002-10-29 2012-05-31 Coley Pharm Group Inc Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
US7615539B2 (en) * 2003-09-25 2009-11-10 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
MY159370A (en) * 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
KR100721928B1 (en) 2004-11-05 2007-05-28 주식회사 바이오씨에스 Pharmaceutical composition for treating or preventing dermatitis comprising CpG oligodeoxynucleotide
CN101171033A (en) 2005-03-04 2008-04-30 戴纳瓦克斯技术公司 Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients
EP2185160B1 (en) * 2007-08-31 2019-02-13 Neurimmune Holding AG Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
US9169450B2 (en) * 2008-02-12 2015-10-27 Chevron U.S.A. Inc. Method of upgrading heavy hydrocarbon streams to jet and diesel products
US10383887B2 (en) 2008-02-20 2019-08-20 New York University Preventing and treating amyloid-beta deposition by stimulation of innate immunity
US8552165B2 (en) * 2008-12-09 2013-10-08 Heather Davis Immunostimulatory oligonucleotides
SI2759306T1 (en) 2008-12-09 2016-05-31 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
US8685416B2 (en) 2010-03-02 2014-04-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for the treatment of cancer
WO2013162828A1 (en) * 2012-04-27 2013-10-31 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Use of cpg oligonucleotides co-formulated with an antibiotic to accelarate wound healing
JP2016507520A (en) 2013-01-23 2016-03-10 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Stabilized hepatitis B core polypeptide
JP6397937B2 (en) * 2014-06-03 2018-09-26 ヘレラ アルトゥーロ ソリス Animal model of corneal neovascularization and corneal dilatation disease, production method, and method of use thereof
USD944829S1 (en) 2020-05-14 2022-03-01 Lutron Technology Company Llc Display screen or portion thereof with graphical user interface

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2215233A (en) 1937-11-13 1940-09-17 Simon L Ruskin Iron compound of nucleotides and their organic hydrolytic decomposition products and method of making same
US3906092A (en) 1971-11-26 1975-09-16 Merck & Co Inc Stimulation of antibody response
US3911117A (en) 1971-12-20 1975-10-07 Fredrik Ender Raw fish and iron chelated with glutamic or ribonucleic acid in a mink diet
US3914450A (en) 1973-04-09 1975-10-21 Anheuser Busch Concentrated extract of yeast and processes of making same
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
WO1983001451A1 (en) 1981-10-23 1983-04-28 Molecular Biosystems Inc Oligonucleotide therapeutic agent and methods of making same
US5023243A (en) * 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
ES507187A0 (en) 1981-11-16 1983-01-01 Union Ind Y Agro Ganader S A U PROCEDURE FOR OBTAINING AN ADDITIONAL HUMANIZED MILK OF NUCLEOTIDES FOR CHILD FEEDING.
JPS60126220A (en) * 1983-12-09 1985-07-05 Otsuka Pharmaceut Factory Inc Nucleic acid component composition
US4741914A (en) * 1984-11-13 1988-05-03 Ajinomoto Co., Inc. Flavor enhancing seasoning containing deodorized garlic extract and process
US4956296A (en) 1987-06-19 1990-09-11 Genex Corporation Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
JPS62275667A (en) * 1986-05-22 1987-11-30 Ajinomoto Co Inc Production of seasoning with good body or food with enhanced good body
US4950652A (en) 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
EP0291980B1 (en) 1987-05-20 1992-01-02 Chugai Seiyaku Kabushiki Kaisha Salt substitute and foodstuffs containing same
ES2007350A6 (en) 1987-05-29 1989-06-16 Ganadera Union Ind Agro Food products enriched with nucleosides and/or nucleotides and preparation thereof.
CA1339596C (en) 1987-08-07 1997-12-23 New England Medical Center Hospitals, Inc. Viral expression inhibitors
US5268365A (en) 1988-03-11 1993-12-07 Rudolph Frederick B Nucleotides, nucleosides, and nucleobases in immune function restoration enhancement or maintenance
CA1336174C (en) * 1988-07-22 1995-07-04 Ronald Peter Potman Method for the preparation of a yeast extract said yeast extract, its use as a food flavour and a food composition comprising the yeast extract
US5231085A (en) * 1988-10-31 1993-07-27 Sandoz Ltd. Compositions and methods for the enhancement of host defense mechanisms
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
US5248670A (en) 1990-02-26 1993-09-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotides for inhibiting herpesviruses
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
US5234811A (en) * 1991-09-27 1993-08-10 The Scripps Research Institute Assay for a new gaucher disease mutation
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
ATE260971T1 (en) 1992-04-01 2004-03-15 Univ Rockefeller METHOD FOR THE IN VITRO CULTIVATION OF DENDRITIC PRECURSOR CELLS AND THEIR USE FOR IMMUNOGENIC PRODUCTION
EP0572735B1 (en) 1992-06-04 1998-11-25 VYSIS, Inc. Nucleic acid probes for the detection of Mycoplasma fermentans
US5585479A (en) 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
JPH08504570A (en) 1992-10-05 1996-05-21 ハイブライドン インコーポレイテッド Therapeutic anti-HIV oligonucleotides and drugs
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
WO1995001097A1 (en) * 1993-06-30 1995-01-12 Board Of Regents, The University Of Texas System Nucleotide preparation and uses thereof in wound healing
US5849719A (en) 1993-08-26 1998-12-15 The Regents Of The University Of California Method for treating allergic lung disease
US20030109469A1 (en) * 1993-08-26 2003-06-12 Carson Dennis A. Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
US5488039A (en) * 1994-01-10 1996-01-30 Abbott Laboratories Method for the production of an enteral formula containing ribo-nucleotides
US5492899A (en) * 1994-01-10 1996-02-20 Abbott Laboratories Infant nutritional formula with ribo-nucleotides
US5602109A (en) * 1994-01-10 1997-02-11 Abbott Laboratories Method to enhance the immune system of a human
US5700590A (en) 1994-01-10 1997-12-23 Abbott Laboratories Nutritional formula with ribo-nucleotides
EP0672354B1 (en) 1994-03-18 2000-07-12 Ajinomoto Co., Inc. Proteinaceous material for enhancing food taste quality
WO1995026204A1 (en) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
EP1167379A3 (en) * 1994-07-15 2004-09-08 University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030050263A1 (en) * 1994-07-15 2003-03-13 The University Of Iowa Research Foundation Methods and products for treating HIV infection
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US5591721A (en) * 1994-10-25 1997-01-07 Hybridon, Inc. Method of down-regulating gene expression
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US6428788B1 (en) 1995-03-15 2002-08-06 Penn State University Compositions and methods for specifically targeting tumors
JP3580900B2 (en) 1995-04-20 2004-10-27 ホクレン農業協同組合連合会 Food and feed containing, as an active ingredient, a composition mainly comprising a sugar containing an α-glucosidase inhibitor
US5612060A (en) * 1995-05-25 1997-03-18 Alexander; J. Wesley Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
US5976580A (en) 1995-06-07 1999-11-02 Novus International, Inc. Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals
US20030219752A1 (en) 1995-12-07 2003-11-27 Diversa Corporation Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
US6479258B1 (en) 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
GB9525902D0 (en) 1995-12-16 1996-02-21 Zeneca Ltd Fungus
US20030078223A1 (en) * 1996-01-30 2003-04-24 Eyal Raz Compositions and methods for modulating an immune response
ATE437943T1 (en) * 1996-01-30 2009-08-15 Univ California EXPRESSION VECTORS THAT INDUCE AN ANTIGEN-SPECIFIC IMMUNE RESPONSE AND METHODS FOR THEIR USE.
US5895652A (en) * 1996-07-29 1999-04-20 Longevity Institute International Method of metabolic adjuvanation and cellular repair
ES2241042T3 (en) 1996-10-11 2005-10-16 The Regents Of The University Of California IMMUNO STIMULATOR POLINUCLEOTIDE CONJUGATES / IMMUNOMODULATOR MOLECULA.
EP0855184A1 (en) 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
US6214806B1 (en) * 1997-02-28 2001-04-10 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CPC dinucleotide in the treatment of LPS-associated disorders
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DE69734605T2 (en) 1997-04-18 2006-08-03 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Weakened salmonella, used as a vechicle for oral immunization
US20030104044A1 (en) * 1997-05-14 2003-06-05 Semple Sean C. Compositions for stimulating cytokine secretion and inducing an immune response
AU7690898A (en) * 1997-05-20 1998-12-11 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
US20040006034A1 (en) * 1998-06-05 2004-01-08 Eyal Raz Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
EP1003850B1 (en) * 1997-06-06 2009-05-27 The Regents of the University of California Inhibitors of dna immunostimulatory sequence activity
US6589940B1 (en) * 1997-06-06 2003-07-08 Dynavax Technologies Corporation Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
US5922766A (en) * 1997-07-02 1999-07-13 Acosta; Phyllis J. B. Palatable elemental medical food
AU757175B2 (en) * 1997-09-05 2003-02-06 Regents Of The University Of California, The Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation
AU760549B2 (en) * 1998-04-03 2003-05-15 University Of Iowa Research Foundation, The Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
CN1297481A (en) 1998-05-06 2001-05-30 法玛西雅厄普约翰美国公司 Introduction of naked DNA or RNA encoding non-human vertebrate peptide hormones or cytokines into non-human vertebrate
US7227011B2 (en) * 1998-06-04 2007-06-05 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Nucleic acid vaccines for prevention of flavivirus infection
US6562798B1 (en) * 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
US20010034330A1 (en) 1998-08-10 2001-10-25 Charlotte Kensil Innate immunity-stimulating compositions of CpG and saponin and methods thereof
US20020065236A1 (en) * 1998-09-09 2002-05-30 Yew Nelson S. CpG reduced plasmids and viral vectors
DK1832657T3 (en) * 1998-09-09 2012-12-17 Genzyme Corp Methylation of plasmid vectors
US20020142974A1 (en) 1998-09-11 2002-10-03 Leonard D. Kohn Immune activation by double-stranded polynucleotides
WO2000016804A1 (en) * 1998-09-18 2000-03-30 Dynavax Technologies Corporation METHODS OF TREATING IgE-ASSOCIATED DISORDERS AND COMPOSITIONS FOR USE THEREIN
CA2359636A1 (en) * 1999-01-22 2000-07-27 Andrew W. Taylor Activation of regulatory t cells by alpha-melanocyte stimulating hormone
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US6710173B1 (en) * 1999-06-25 2004-03-23 Progenics Pharmaceuticals, Inc. Stabilized viral envelope proteins and uses thereof
ES2250151T3 (en) 1999-06-29 2006-04-16 Glaxosmithkline Biologicals S.A. USE OF CPG AS A VACCINE ASSISTANT AGAINST HIV.
US6514948B1 (en) * 1999-07-02 2003-02-04 The Regents Of The University Of California Method for enhancing an immune response
CN1454091A (en) * 1999-09-25 2003-11-05 衣阿华大学研究基金会 Immunostimulatory nucleic acids
US20020091095A1 (en) * 1999-12-13 2002-07-11 Phillips Nigel C. Modulation of Fas and FasL expression
US20020006403A1 (en) * 1999-12-14 2002-01-17 Xue-Zhong Yu CD28-specific antibody compositions for use in methods of immunosuppression
EP1322655B1 (en) * 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
US20010044416A1 (en) 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
AT409085B (en) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh PHARMACEUTICAL COMPOSITION FOR IMMUNULATING AND PRODUCING VACCINES
US6552006B2 (en) * 2000-01-31 2003-04-22 The Regents Of The University Of California Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
US20030130217A1 (en) * 2000-02-23 2003-07-10 Eyal Raz Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
AU4175101A (en) 2000-02-23 2001-09-03 Univ California Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
JP2003523398A (en) * 2000-02-24 2003-08-05 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Adjuvant therapy by in vivo activation of dendritic cells
US20020156033A1 (en) 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
US20020098199A1 (en) 2000-03-10 2002-07-25 Gary Van Nest Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
US20010046967A1 (en) 2000-03-10 2001-11-29 Gary Van Nest Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
US20020107212A1 (en) * 2000-03-10 2002-08-08 Nest Gary Van Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7129222B2 (en) * 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
US20020028784A1 (en) * 2000-03-10 2002-03-07 Nest Gary Van Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
EP1267618A1 (en) * 2000-03-28 2003-01-02 The Regents Of The University Of California Methods for increasing a cytotoxic t lymphocyte response in vivo
AU2001251407A1 (en) 2000-04-07 2001-10-23 The Regents Of The University Of California Synergistic improvements to polynucleotide vaccines
GB0009470D0 (en) 2000-04-17 2000-06-07 Univ Southampton Materials and methods relating to immune responses to fusion proteins
WO2001085910A2 (en) 2000-05-05 2001-11-15 The Regents Of The University Of California Agents that modulate dna-pk activity and methods of use thereof
US6593511B1 (en) * 2000-05-12 2003-07-15 Bioseek, Inc. Models of chronic and acute inflammatory diseases
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
TR200302015T4 (en) 2000-06-08 2004-01-21 Intercell Biomedizinische Forschungs-Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
SI1296714T1 (en) * 2000-06-22 2010-01-29 S For Entpr University Of Iowa Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.
US20020165178A1 (en) 2000-06-28 2002-11-07 Christian Schetter Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
AU2001280883A1 (en) 2000-07-27 2002-02-13 The Children's Hospital & Research Center At Oakland Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
WO2002009645A2 (en) * 2000-08-01 2002-02-07 The Johns Hopkins University Intercellular transport protein linked to an antigen as a molecular vaccine
US20020198165A1 (en) 2000-08-01 2002-12-26 Bratzler Robert L. Nucleic acids for the prevention and treatment of gastric ulcers
US7811592B2 (en) 2000-08-16 2010-10-12 Auburn University Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia
WO2002016549A2 (en) * 2000-08-25 2002-02-28 Yeda Research And Development Co. Ltd. METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH CpG-CONTAINING POLYNUCLEOTIDE
US20020091097A1 (en) * 2000-09-07 2002-07-11 Bratzler Robert L. Nucleic acids for the prevention and treatment of sexually transmitted diseases
JP2005500806A (en) * 2000-09-15 2005-01-13 コーリー ファーマシューティカル ゲーエムベーハー Process for high-throughput screening of immune agonist / immunoantagonists based on CpG
ES2298269T3 (en) 2000-09-26 2008-05-16 Idera Pharmaceuticals, Inc. MODULATION OF THE IMMUNO-STIMULATING ACTIVITY OF OLIGONUCLEOTIDIC ANALOGS IMMUNO-STIMULANTS THROUGH POSITIONAL CHEMICAL CHANGES.
DE60118228T2 (en) * 2000-09-28 2006-12-14 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville MICROPARTICLES FOR THE ADMINISTRATION OF HETEROLOGIC NUCLEIC ACID
JP2004509914A (en) 2000-09-28 2004-04-02 カイロン　コーポレイション Fine particle composition and method for producing the same
AU2002228932A1 (en) * 2000-10-24 2002-05-06 Schering Corporation Maturation of dendritic cells
KR100331952B1 (en) 2000-11-23 2002-04-09 최수일 The Composition Of Multipurpose High-Functional Alkali Solution, Preparation Thereof, And For The Use Of Nonspecific Immunostimulator
WO2002069369A2 (en) 2000-12-08 2002-09-06 Coley Pharmaceutical Gmbh Cpg-like nucleic acids and methods of use thereof
AU2002248185A1 (en) * 2000-12-14 2002-07-16 Coley Pharmaceutical Group, Inc. Inhibition of angiogenesis by nucleic acids
US20030185848A1 (en) 2000-12-15 2003-10-02 Board Of Regents, The University Of Texas System Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia psittaci
CN1293192C (en) * 2000-12-27 2007-01-03 戴纳瓦克斯技术公司 Immunoregulation polynucleotide and using method thereof
US20030050268A1 (en) * 2001-03-29 2003-03-13 Krieg Arthur M. Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
ATE455793T1 (en) * 2001-04-17 2010-02-15 Novartis Vaccines & Diagnostic MONOCLONAL ANTIBODIES AGAINST MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES
US20030096417A1 (en) * 2001-06-01 2003-05-22 Fischer Laurent Bernard Vaccination against feline immunodeficiency virus
US7547551B2 (en) * 2001-06-21 2009-06-16 University Of Antwerp. Transfection of eukaryontic cells with linear polynucleotides by electroporation
DK2423335T3 (en) 2001-06-21 2014-08-18 Dynavax Tech Corp CHEMICAL IMMUNAL MODULATOR RELATIONS AND PROCEDURES FOR USE THEREOF
US7785610B2 (en) 2001-06-21 2010-08-31 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—III
US7666674B2 (en) * 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
US20030148316A1 (en) 2001-08-01 2003-08-07 Lipford Grayson B. Methods and compositions relating to plasmacytoid dendritic cells
WO2003025119A2 (en) * 2001-08-03 2003-03-27 Medarex, Inc. Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies
AU2002326561B2 (en) * 2001-08-07 2008-04-03 Dynavax Technologies Corporation Immunomodulatory compositions, formulations, and methods for use thereof
US7604955B2 (en) * 2001-08-13 2009-10-20 Swey-Shen Alex Chen Immunoglobulin E vaccines and methods of use thereof
WO2003020884A2 (en) * 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for rapid generation of mature dendritic cells
ES2314099T3 (en) 2001-08-17 2009-03-16 Coley Pharmaceutical Gmbh IMMUNO STIMULANT OLIGONUCLEOTIDES WITH REASONS COMBINED WITH IMPROVED ACTIVITY.
WO2003023000A2 (en) 2001-09-07 2003-03-20 Baylor College Of Medicine Linear dna fragments for gene expression
US20030119774A1 (en) * 2001-09-25 2003-06-26 Marianna Foldvari Compositions and methods for stimulating an immune response
AR045702A1 (en) 2001-10-03 2005-11-09 Chiron Corp COMPOSITIONS OF ASSISTANTS.
KR20050034583A (en) 2001-10-05 2005-04-14 콜리 파마슈티칼 게엠베하 Toll-like receptor 3 signaling agonists and antagonists
EP1478371A4 (en) * 2001-10-12 2007-11-07 Univ Iowa Res Found Methods and products for enhancing immune responses using imidazoquinoline compounds
AU2002362019B2 (en) 2001-11-21 2007-12-20 The Board Of Trustees Of The Leland Stanford Junior University Polynucleotide therapy
TW200303759A (en) * 2001-11-27 2003-09-16 Schering Corp Methods for treating cancer
US8466116B2 (en) * 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
AU2002366710A1 (en) * 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
CA2388049A1 (en) * 2002-05-30 2003-11-30 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof
WO2003103586A2 (en) * 2002-06-05 2003-12-18 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
US20040013688A1 (en) * 2002-07-03 2004-01-22 Cambridge Scientific, Inc. Vaccines to induce mucosal immunity
SG172476A1 (en) * 2002-08-12 2011-07-28 Dynavax Tech Corp Immunomodulatory compositions comprising a cationic condensing agent, an immunostimulatory compound comprising 5'-cg-3', an a non ionic detergent
JP4976653B2 (en) * 2002-11-01 2012-07-18 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシス Method for preventing infections caused by bioterrorism pathogens using immunostimulatory CpG oligonucleotides
AU2006216822A1 (en) * 2005-02-22 2006-08-31 Daniel Rachmilewitz Methods of treating gastrointestinal inflammation
US20070184068A1 (en) * 2005-12-14 2007-08-09 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HONESS R.W. ET AL.: "Deviations from expected frequencies of CpG dinucleotides in herpesvirus DNAs may be diagnostic of differences in the states of their latent genomes", J. GEN. VIROL., vol. 70, no. 4, April 1989 (1989-04-01), pages 837 - 855 *
ISHIBASHI H. ET AL.: "Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor and also cell growth and invasion activities", CANCER RESEARCH, vol. 60, November 2000 (2000-11-01), pages 6531 - 6536, XP002228959 *
ZHENG M. ET AL.: "Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis", J. VIROL., vol. 75, no. 20, October 2001 (2001-10-01), pages 9828 - 9835, XP002965456 *

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