WO2003057151A2 - A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof - Google Patents
A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof Download PDFInfo
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- WO2003057151A2 WO2003057151A2 PCT/US2002/041430 US0241430W WO03057151A2 WO 2003057151 A2 WO2003057151 A2 WO 2003057151A2 US 0241430 W US0241430 W US 0241430W WO 03057151 A2 WO03057151 A2 WO 03057151A2
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- dosage form
- pharmaceutical dosage
- oral pharmaceutical
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- 239000000843 powder Substances 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002359857A AU2002359857B8 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
EP02794423A EP1465601A4 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
IL16245802A IL162458A0 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
CA002471715A CA2471715A1 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34412001P | 2001-12-28 | 2001-12-28 | |
US60/344,120 | 2001-12-28 | ||
US36635102P | 2002-03-21 | 2002-03-21 | |
US60/366,351 | 2002-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003057151A2 true WO2003057151A2 (en) | 2003-07-17 |
WO2003057151A3 WO2003057151A3 (en) | 2004-01-08 |
Family
ID=26993762
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/041430 WO2003057151A2 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
PCT/US2002/041429 WO2003057150A2 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/041429 WO2003057150A2 (en) | 2001-12-28 | 2002-12-27 | A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof |
Country Status (6)
Country | Link |
---|---|
US (5) | US7138137B2 (en) |
EP (2) | EP1465601A4 (en) |
AU (2) | AU2002360775B9 (en) |
CA (2) | CA2471715A1 (en) |
IL (2) | IL162458A0 (en) |
WO (2) | WO2003057151A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005034954A2 (en) * | 2003-10-08 | 2005-04-21 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation |
WO2010041051A1 (en) * | 2008-10-07 | 2010-04-15 | Astrazeneca Uk Limited | Pharmaceutical formulation 514 |
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WO2010037398A1 (en) * | 2008-10-03 | 2010-04-08 | H. Lundbeck A/S | Oral formulation |
US20040208932A1 (en) * | 2003-04-17 | 2004-10-21 | Ramachandran Thembalath | Stabilized paroxetine hydrochloride formulation |
CN1905860A (en) * | 2003-11-21 | 2007-01-31 | 先灵公司 | Phosphodiesterase V inhibitor formulations |
CN100558252C (en) * | 2004-03-08 | 2009-11-11 | 维他麦食品(福建)有限公司 | The manufacture method of compression oatmeal and compression oatmeal thereof |
WO2005107716A1 (en) * | 2004-03-25 | 2005-11-17 | Cadila Healthcare Limited | Controlled release paroxetine-containing tablets based on a core and a coating |
US20050244492A1 (en) * | 2004-04-30 | 2005-11-03 | Mehra Dev K | Rapidly disintegrating tablets comprising titanium dioxide |
ATE407933T1 (en) * | 2005-05-26 | 2008-09-15 | Apotecnia S A | METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE |
WO2007012968A2 (en) * | 2005-07-29 | 2007-02-01 | Aurobindo Pharma Ltd | Stable dosage form of an antidepressant |
WO2007035816A2 (en) * | 2005-09-20 | 2007-03-29 | Dr. Reddy's Laboratories Ltd. | Paroxetine compositions |
US8703191B2 (en) * | 2006-07-25 | 2014-04-22 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
MX2010012037A (en) * | 2008-05-07 | 2010-11-30 | Lundbeck & Co As H | Method for treating cognitive deficits. |
US20090285889A1 (en) * | 2008-05-14 | 2009-11-19 | Capricom Pharma Inc. | Modified release formulations of dihydropyridine compounds and methods of making same |
CN102355892B (en) * | 2009-01-30 | 2014-10-22 | 桑诺维恩药品公司 | Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating |
US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
MA52088A (en) * | 2018-03-22 | 2021-01-27 | Komipharm Int Australia Pty Ltd | PHARMACEUTICAL COMPOSITION CONSISTING OF META-ARSENITE AND METHOD OF MANUFACTURING |
CN110037995B (en) * | 2019-04-17 | 2021-07-06 | 石家庄龙泽制药股份有限公司 | Stable paroxetine hydrochloride tablet and preparation method thereof |
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US6150376A (en) * | 1998-08-05 | 2000-11-21 | Georgetown University | Bi- and tri-cyclic aza compounds and their uses |
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-
2002
- 2002-12-27 AU AU2002360775A patent/AU2002360775B9/en not_active Ceased
- 2002-12-27 US US10/330,616 patent/US7138137B2/en not_active Expired - Fee Related
- 2002-12-27 AU AU2002359857A patent/AU2002359857B8/en not_active Ceased
- 2002-12-27 EP EP02794423A patent/EP1465601A4/en not_active Withdrawn
- 2002-12-27 CA CA002471715A patent/CA2471715A1/en not_active Abandoned
- 2002-12-27 WO PCT/US2002/041430 patent/WO2003057151A2/en not_active Application Discontinuation
- 2002-12-27 IL IL16245802A patent/IL162458A0/en unknown
- 2002-12-27 WO PCT/US2002/041429 patent/WO2003057150A2/en not_active Application Discontinuation
- 2002-12-27 CA CA002470496A patent/CA2470496A1/en not_active Abandoned
- 2002-12-27 EP EP02796057A patent/EP1575478A2/en not_active Withdrawn
- 2002-12-27 IL IL16266602A patent/IL162666A0/en unknown
- 2002-12-27 US US10/330,969 patent/US7396542B2/en not_active Expired - Fee Related
-
2004
- 2004-07-14 US US10/891,561 patent/US7357945B2/en not_active Expired - Fee Related
-
2005
- 2005-04-14 US US11/108,009 patent/US20050191350A1/en not_active Abandoned
-
2008
- 2008-03-18 US US12/077,458 patent/US20080187584A1/en not_active Abandoned
Patent Citations (2)
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US5776969A (en) * | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
US6150376A (en) * | 1998-08-05 | 2000-11-21 | Georgetown University | Bi- and tri-cyclic aza compounds and their uses |
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Title |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005034954A2 (en) * | 2003-10-08 | 2005-04-21 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation |
WO2005034954A3 (en) * | 2003-10-08 | 2005-06-02 | Ranbaxy Lab Ltd | Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation |
WO2010041051A1 (en) * | 2008-10-07 | 2010-04-15 | Astrazeneca Uk Limited | Pharmaceutical formulation 514 |
US8475842B2 (en) | 2008-10-07 | 2013-07-02 | Astrazeneca Ab | Immediate release pharmaceutical formulation of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one |
EA020783B1 (en) * | 2008-10-07 | 2015-01-30 | Астразенека Юк Лимитед | Pharmaceutical formulation comprising 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2h-phthalazin-1-one and copovidone |
US11633396B2 (en) | 2008-10-07 | 2023-04-25 | Kudos Pharmaceuticals Limited | Immediate release pharmaceutical formulation of 4-[3-(4- cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H- phthalazin-1-one |
Also Published As
Publication number | Publication date |
---|---|
WO2003057150A2 (en) | 2003-07-17 |
CA2470496A1 (en) | 2003-07-17 |
AU2002360775B9 (en) | 2008-07-24 |
US7138137B2 (en) | 2006-11-21 |
WO2003057151A3 (en) | 2004-01-08 |
AU2002359857A1 (en) | 2003-07-24 |
EP1465601A4 (en) | 2006-02-15 |
AU2002360775B2 (en) | 2008-06-19 |
AU2002359857B2 (en) | 2008-12-11 |
IL162666A0 (en) | 2005-11-20 |
US20030144324A1 (en) | 2003-07-31 |
IL162458A0 (en) | 2005-11-20 |
US20080187584A1 (en) | 2008-08-07 |
WO2003057150A3 (en) | 2006-06-08 |
US20050191350A1 (en) | 2005-09-01 |
US7396542B2 (en) | 2008-07-08 |
US20030158230A1 (en) | 2003-08-21 |
EP1575478A2 (en) | 2005-09-21 |
EP1465601A2 (en) | 2004-10-13 |
CA2471715A1 (en) | 2003-07-17 |
US20050059701A1 (en) | 2005-03-17 |
US7357945B2 (en) | 2008-04-15 |
AU2002360775A1 (en) | 2003-07-24 |
AU2002359857B8 (en) | 2009-01-08 |
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