WO2003059386A3 - Prion protein carrier-conjugates - Google Patents

Prion protein carrier-conjugates Download PDF

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Publication number
WO2003059386A3
WO2003059386A3 PCT/EP2003/000460 EP0300460W WO03059386A3 WO 2003059386 A3 WO2003059386 A3 WO 2003059386A3 EP 0300460 W EP0300460 W EP 0300460W WO 03059386 A3 WO03059386 A3 WO 03059386A3
Authority
WO
WIPO (PCT)
Prior art keywords
prion
provides
prion protein
conjugates
ordered
Prior art date
Application number
PCT/EP2003/000460
Other languages
French (fr)
Other versions
WO2003059386A2 (en
Inventor
Martin Bachmann
Patrick Maurer
Erica Pellicioli
Wolfgang A Renner
Original Assignee
Cytos Biotechnology Ag
Martin Bachmann
Patrick Maurer
Erica Pellicioli
Wolfgang A Renner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/050,902 external-priority patent/US7264810B2/en
Application filed by Cytos Biotechnology Ag, Martin Bachmann, Patrick Maurer, Erica Pellicioli, Wolfgang A Renner filed Critical Cytos Biotechnology Ag
Priority to AU2003205623A priority Critical patent/AU2003205623A1/en
Publication of WO2003059386A2 publication Critical patent/WO2003059386A2/en
Publication of WO2003059386A3 publication Critical patent/WO2003059386A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a prion peptide or prion protein-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one prion protein (PrP) or a dimer thereof, or a PrP peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of prion diseases and as a pharmaccine to prevent or cure prion diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
PCT/EP2003/000460 2002-01-18 2003-01-17 Prion protein carrier-conjugates WO2003059386A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003205623A AU2003205623A1 (en) 2002-01-18 2003-01-17 Prion protein carrier-conjugates

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10/050,902 2002-01-18
US10/050,902 US7264810B2 (en) 2001-01-19 2002-01-18 Molecular antigen array
PCT/IB2002/000166 WO2002056905A2 (en) 2001-01-19 2002-01-21 Molecular antigen array
IBPCT/IB02/00166 2002-01-21
US39372502P 2002-07-08 2002-07-08
US60/393,725 2002-07-08
US39659002P 2002-07-18 2002-07-18
US60/396,590 2002-07-18

Publications (2)

Publication Number Publication Date
WO2003059386A2 WO2003059386A2 (en) 2003-07-24
WO2003059386A3 true WO2003059386A3 (en) 2004-03-11

Family

ID=27452011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000460 WO2003059386A2 (en) 2002-01-18 2003-01-17 Prion protein carrier-conjugates

Country Status (2)

Country Link
AU (1) AU2003205623A1 (en)
WO (1) WO2003059386A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9404126B2 (en) 2006-06-12 2016-08-02 Kuros Biosciences Ag Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2492826C (en) 2001-09-14 2016-12-13 Cytos Biotechnology Ag Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
PT1853285E (en) 2005-02-01 2011-06-06 Univ Ramot Method for treating inflammation associated with amyloid deposits and brain inflammation involving activated microglia
AU2006325225B2 (en) 2005-12-14 2013-07-04 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
EP2895497B1 (en) * 2012-09-17 2017-11-22 F. Hoffmann-La Roche AG Method for the production of polypeptides in the periplasm of prokaryotic cells
CA3010975A1 (en) 2015-01-15 2016-07-21 University Of Copenhagen Virus-like particle with efficient epitope display
US11129882B2 (en) 2015-10-30 2021-09-28 University Of Copenhagen Virus like particle with efficient epitope display

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (en) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use
WO2000078344A1 (en) * 1999-06-23 2000-12-28 Caprion Pharmaceuticals, Inc. Prion protein peptides and uses thereof
WO2001053457A2 (en) * 2000-01-21 2001-07-26 University Of Connecticut Health Center Vaccines against neurodegenerative disorders
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
EP1158003A1 (en) * 2000-05-23 2001-11-28 Blood Transfusion Centre of Slovenia Antibodies capable to selectively detect prion PrP Sc isoforms

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032227A2 (en) * 1998-11-30 2000-06-08 Cytos Biotechnology Ag Ordered molecular presentation of antigens, method of preparation and use
WO2000078344A1 (en) * 1999-06-23 2000-12-28 Caprion Pharmaceuticals, Inc. Prion protein peptides and uses thereof
WO2001053457A2 (en) * 2000-01-21 2001-07-26 University Of Connecticut Health Center Vaccines against neurodegenerative disorders
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
EP1158003A1 (en) * 2000-05-23 2001-11-28 Blood Transfusion Centre of Slovenia Antibodies capable to selectively detect prion PrP Sc isoforms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VASILJEVA I ET AL: "Mosaic Qbeta coats as a new presentation model", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 431, no. 1, 10 July 1998 (1998-07-10), pages 7 - 11, XP004258931, ISSN: 0014-5793 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9404126B2 (en) 2006-06-12 2016-08-02 Kuros Biosciences Ag Processes for packaging aggregated oligonucleotides into virus-like particles of RNA bacteriophages

Also Published As

Publication number Publication date
AU2003205623A8 (en) 2003-07-30
AU2003205623A1 (en) 2003-07-30
WO2003059386A2 (en) 2003-07-24

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