WO2003070194A3 - Amino acid and peptide-modified forms of glucocorticoids - Google Patents

Amino acid and peptide-modified forms of glucocorticoids Download PDF

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Publication number
WO2003070194A3
WO2003070194A3 PCT/US2003/005204 US0305204W WO03070194A3 WO 2003070194 A3 WO2003070194 A3 WO 2003070194A3 US 0305204 W US0305204 W US 0305204W WO 03070194 A3 WO03070194 A3 WO 03070194A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
glucocorticoids
peptide
modified forms
pharmaceutical compositions
Prior art date
Application number
PCT/US2003/005204
Other languages
French (fr)
Other versions
WO2003070194A2 (en
Inventor
Mark G Currie
Paul Grover
Steve Jones
Chris H Senanayake
Xiaoyi Nie
Original Assignee
Sepracor Inc
Mark G Currie
Paul Grover
Steve Jones
Chris H Senanayake
Xiaoyi Nie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc, Mark G Currie, Paul Grover, Steve Jones, Chris H Senanayake, Xiaoyi Nie filed Critical Sepracor Inc
Priority to AU2003217623A priority Critical patent/AU2003217623A1/en
Publication of WO2003070194A2 publication Critical patent/WO2003070194A2/en
Publication of WO2003070194A3 publication Critical patent/WO2003070194A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Amino acid corticosteroid esters which may function as pro-drugs, and formulations of the amino acid corticosteroid esters with a second active ingredient such as formoterol are disclosed. Composition of the invention include amino acid corticosteroid esters of Formula (I) that are used to make solution-stable pharmaceutical compositions or stable co-dispersions of pharmaceutical compositions in an aerosol formulation, or in a manual pump spray formulation containing one or more active ingredients. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
PCT/US2003/005204 2002-02-20 2003-02-20 Amino acid and peptide-modified forms of glucocorticoids WO2003070194A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003217623A AU2003217623A1 (en) 2002-02-20 2003-02-20 Amino acid and peptide-modified forms of glucocorticoids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35811502P 2002-02-20 2002-02-20
US60/358,115 2002-02-20

Publications (2)

Publication Number Publication Date
WO2003070194A2 WO2003070194A2 (en) 2003-08-28
WO2003070194A3 true WO2003070194A3 (en) 2003-12-04

Family

ID=27757703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005204 WO2003070194A2 (en) 2002-02-20 2003-02-20 Amino acid and peptide-modified forms of glucocorticoids

Country Status (2)

Country Link
AU (1) AU2003217623A1 (en)
WO (1) WO2003070194A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US8304382B2 (en) 2006-07-21 2012-11-06 Cristalia Productos Quimicos Farmaceuticos Ltda. Anti-inflammatory and anti-allergic cyclic peptides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571791A (en) * 1993-07-02 1996-11-05 Board Of Regents, The University Of Texas System Modified polypeptide fragments of the glucocorticoid receptor
US6136294A (en) * 1998-09-22 2000-10-24 Aeropharm Technology Inc. Amino acid stabilized medical aerosol formulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571791A (en) * 1993-07-02 1996-11-05 Board Of Regents, The University Of Texas System Modified polypeptide fragments of the glucocorticoid receptor
US6136294A (en) * 1998-09-22 2000-10-24 Aeropharm Technology Inc. Amino acid stabilized medical aerosol formulation
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation

Also Published As

Publication number Publication date
AU2003217623A1 (en) 2003-09-09
AU2003217623A8 (en) 2003-09-09
WO2003070194A2 (en) 2003-08-28

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