WO2003070749A3 - Self-assembly of peptide-amphiphile nanofibers under physiological conditions - Google Patents

Self-assembly of peptide-amphiphile nanofibers under physiological conditions Download PDF

Info

Publication number
WO2003070749A3
WO2003070749A3 PCT/US2003/004779 US0304779W WO03070749A3 WO 2003070749 A3 WO2003070749 A3 WO 2003070749A3 US 0304779 W US0304779 W US 0304779W WO 03070749 A3 WO03070749 A3 WO 03070749A3
Authority
WO
WIPO (PCT)
Prior art keywords
self
assembly
physiological conditions
peptide
under physiological
Prior art date
Application number
PCT/US2003/004779
Other languages
French (fr)
Other versions
WO2003070749A2 (en
Inventor
Samuel I Stupp
Jeffrey D Hartgerink
Elia Beniash
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern filed Critical Univ Northwestern
Priority to AU2003215280A priority Critical patent/AU2003215280A1/en
Publication of WO2003070749A2 publication Critical patent/WO2003070749A2/en
Priority to PCT/US2003/035902 priority patent/WO2005003292A2/en
Priority to US10/534,097 priority patent/US7554021B2/en
Priority to AU2003304280A priority patent/AU2003304280A1/en
Publication of WO2003070749A3 publication Critical patent/WO2003070749A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/705—Protein or peptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12014—All metal or with adjacent metals having metal particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24355—Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]
    • Y10T428/24372—Particulate matter
    • Y10T428/24413—Metal or metal compound

Abstract

Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
PCT/US2003/004779 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions WO2003070749A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003215280A AU2003215280A1 (en) 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions
PCT/US2003/035902 WO2005003292A2 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles
US10/534,097 US7554021B2 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003304280A AU2003304280A1 (en) 2002-11-12 2003-11-12 Composition and method for self-assembly and mineralization of peptide amphiphiles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35722802P 2002-02-15 2002-02-15
US60/357,228 2002-02-15

Publications (2)

Publication Number Publication Date
WO2003070749A2 WO2003070749A2 (en) 2003-08-28
WO2003070749A3 true WO2003070749A3 (en) 2004-04-01

Family

ID=27757587

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004779 WO2003070749A2 (en) 2002-02-15 2003-02-18 Self-assembly of peptide-amphiphile nanofibers under physiological conditions

Country Status (3)

Country Link
US (3) US7371719B2 (en)
AU (1) AU2003215280A1 (en)
WO (1) WO2003070749A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518876B2 (en) 2007-08-03 2013-08-27 PharmalN Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7781396B2 (en) * 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) * 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004046167A2 (en) * 2002-11-14 2004-06-03 Northwestern University Synthesis and self-assembly of abc triblock bola peptide
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
WO2004060791A1 (en) * 2003-01-07 2004-07-22 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
WO2004072104A2 (en) * 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
WO2005014615A2 (en) * 2003-06-25 2005-02-17 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
JP4741510B2 (en) * 2003-12-05 2011-08-03 ノースウエスタン ユニバーシティ Branched peptide amphiphiles, related epitope compounds and their self-assembled structures
KR20070004560A (en) * 2003-12-05 2007-01-09 노오쓰웨스턴 유니버시티 Self-assembling peptide amphiphiles and related methods for growth factor delivery
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
EP1781310B1 (en) 2004-08-02 2015-10-14 Ramot at Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
US7786086B2 (en) 2004-09-08 2010-08-31 Ramot At Tel-Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
WO2006079036A2 (en) 2005-01-21 2006-07-27 Northwestern University Methods and compositions for encapsulation of cells
US7851445B2 (en) 2005-03-04 2010-12-14 Northwestern University Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
EP1973928A2 (en) 2005-10-11 2008-10-01 Ramot at Tel-Aviv University Ltd. Self-assembled fmoc-ff hydrogels
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8080262B2 (en) * 2006-10-24 2011-12-20 Northwestern University Encapsulated peptide amphiphile nanostructures
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US9066885B2 (en) * 2007-03-16 2015-06-30 University Of Maryland, College Park Advanced functional biocompatible polymeric matrix containing nano-compartments
US8932560B2 (en) * 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
ITMI20070690A1 (en) * 2007-04-03 2008-10-04 Getters Spa METHOD FOR THE ABSORPTION OF GASEOUS CONTAMINANTS BY NANOSTRUCTURED ABSORBERS IN THE FORM OF FIBER
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8034396B2 (en) * 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
US9399068B2 (en) 2008-06-10 2016-07-26 The Board Of Trustees Of The Leland Stanford Junior University Hetero-assembling, tunable, and injectable hydrogels for cell encapsulation
US9011914B2 (en) 2008-06-10 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Hetero-assembled hydrogels
CA2753173C (en) 2009-02-21 2017-05-30 Sofradim Production Medical devices with an activated coating
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
AU2010215192B2 (en) * 2009-02-21 2015-04-30 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
WO2010095052A2 (en) 2009-02-21 2010-08-26 Sofradim Production Compounds and medical devices activated with solvophobic linkers
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
CA2753179A1 (en) 2009-02-21 2010-08-26 Sofradim Production Crosslinked fibers and method of making same by extrusion
AU2010215931A1 (en) 2009-02-21 2011-10-13 Covidien Lp Medical devices having activated surfaces
US8663689B2 (en) * 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
US8877170B2 (en) * 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
WO2010095047A2 (en) 2009-02-21 2010-08-26 Sofradim Production Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices
US8968733B2 (en) * 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
EP2398584A2 (en) 2009-02-21 2011-12-28 Sofradim Production Apparatus and method of reaching polymers by exposure to uv radiation to produce injectable medical devices
AU2010215936B2 (en) 2009-02-21 2015-03-05 Covidien Lp Medical devices having activated surfaces
EP2398943B1 (en) 2009-02-21 2013-04-17 Sofradim Production Crosslinked fibers and method of making same using uv radiation
WO2010111652A2 (en) 2009-03-27 2010-09-30 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
US9334304B2 (en) * 2009-04-02 2016-05-10 The Johns Hopkins University Self-assembling peptides bearing organic electronic functionality and applications employing the same
WO2010120830A1 (en) 2009-04-13 2010-10-21 Northwestern University Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US8062555B2 (en) * 2009-04-16 2011-11-22 Rhodia Operations Co-assembly method and co-assembled structures made thereby
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
WO2011017382A2 (en) 2009-08-03 2011-02-10 The Regents Of The University Of California Nanofibers and morphology shifting micelles
US8668899B2 (en) 2009-11-13 2014-03-11 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
WO2011112856A2 (en) * 2010-03-10 2011-09-15 Kansas State University Research Foundation Novel protein peptide hydrogels
AU2011231245B2 (en) 2010-03-25 2015-03-26 Covidien Lp Medical devices incorporating functional adhesives
WO2011117745A2 (en) 2010-03-25 2011-09-29 Sofradim Production Surgical fasteners and methods for sealing wounds
WO2011132018A1 (en) 2010-04-19 2011-10-27 Universita' Degli Studi Di Milano Bicocca Novel self-assembling peptides and their use in the formation of hydrogels
AU2011276443A1 (en) 2010-06-29 2013-01-31 Covidien Lp Microwave-powered reactor and method for in situ forming implants
CA2804251A1 (en) 2010-07-01 2012-01-05 Sofradim Production Medical device with predefined activated cellular integration
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
EP2598178B1 (en) 2010-07-27 2018-07-11 Sofradim Production Polymeric fibers having tissue reactive members
WO2012021877A2 (en) 2010-08-13 2012-02-16 University Of Maryland, College Park Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
WO2012075457A2 (en) 2010-12-02 2012-06-07 University Of Maryland, College Park Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
KR20130018195A (en) * 2011-08-10 2013-02-20 김태국 Method for physiological modulations by high density molecular display
KR20130018194A (en) 2011-08-10 2013-02-20 김태국 High density molecular display methods for quantitatively tracking and labelling target molecular interactions using energy transfer and signal alterations
US8871903B2 (en) * 2012-10-22 2014-10-28 The Johns Hopkins University Palladium catalyzed reactions executed on solid-phase peptide synthesis supports for the production of self-assembling peptides embedded with complex organic electronic subunits
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
US9616088B2 (en) 2013-03-13 2017-04-11 Gel-E, Inc. Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9200082B2 (en) * 2013-03-14 2015-12-01 The University Of Chicago Methods and compositions involving fibrillizing polypeptides for nanofibers
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (en) 2015-01-20 2016-07-21 Emc Microcollections Gmbh New modular functionalizable peptide hydrogels
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
WO2017066545A1 (en) * 2015-10-14 2017-04-20 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
US9795718B1 (en) 2016-08-05 2017-10-24 International Business Machines Corporation Biocompatible devices with dissolvable substrates and methods of forming the same
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10752656B2 (en) 2016-10-21 2020-08-25 Northwestern University Anti-microbial supramolecular structures
WO2019089584A2 (en) * 2017-10-30 2019-05-09 The Curators Of The University Of Missouri Triblock peptide amphiphiles, micelles and methods of use
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
CN113476613A (en) * 2021-06-21 2021-10-08 江苏大学 Method for improving structural stability of amphiphilic compound assembly

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007752A1 (en) * 1996-08-23 1998-02-26 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) * 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (en) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol Length control of short fiber-type helical molecule associated form
DE4026978A1 (en) 1990-08-25 1992-02-27 Bayer Ag Coated substrates for electro=optical applications, etc.
DK0585368T3 (en) 1991-04-25 1998-03-16 Univ Brown Res Found Implantable biocompatible immuno-insulating vehicle for delivery of selected therapeutic products
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (en) 1994-07-19 1996-01-20 Medicarb Ab wound healing agent
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (en) 1995-10-17 1998-01-02 Coletica AMPHIPHILIC COMPLEXES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THE SAME
SE9504347D0 (en) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
DE69731632D1 (en) * 1996-06-12 2004-12-23 Treofan Germany Gmbh & Co Kg TRANSPARENT BARRIER COVERS WITH REDUCED THIN FILM INTERFERENCE
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US5733866A (en) * 1996-08-22 1998-03-31 International Flavors & Fragrances Inc. Methyl substituted hexahydroindanols and alkyl ethers thereof, organoleptic uses thereof, processes for preparing same and process intermediates therefor
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6132729A (en) 1997-01-22 2000-10-17 Board Of Regents, The University Of Texas System Combined tissue factor and chemotherapeutic methods and compositions for coagulation and tumor treatment
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
CN100529063C (en) 1997-12-02 2009-08-19 泽恩比奥公司 Differentiation of adipose stromal cells into osteobalsts and uses thereof
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (en) * 1998-03-30 2003-04-15 Viranative Ab Nutritional medium containing methionine and its use
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
EP1107791B8 (en) 1998-09-04 2007-11-07 Scios Inc. Hydrogel compositions for the controlled release administration of growth factors
US6207218B1 (en) * 1998-09-15 2001-03-27 Isotis B.V. Method for coating medical implants
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
MXPA01007777A (en) 1999-02-01 2003-10-06 Eidgenoess Tech Hochschule Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups.
WO2000045831A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
IL145151A0 (en) 1999-03-02 2002-06-30 Univ Massachusetts Embr0yonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
WO2000064481A1 (en) 1999-04-22 2000-11-02 Eidgenössische Technische Hochschule (ETH) Controlled release of growth factors from heparin containing matrices
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
EP1196426A4 (en) 1999-06-30 2003-09-03 Advanced Cell Tech Inc Cytoplasmic transfer to de-differentiate recipient cells
US6444723B1 (en) * 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
CA2395957A1 (en) 1999-12-28 2001-07-05 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
CA2392438A1 (en) 2000-01-31 2001-08-02 Craig A. Rosen Nucleic acids, proteins, and antibodies
US20030044890A1 (en) * 2000-01-31 2003-03-06 Rosen Craig A. Nucleic acids, proteins, and antibodies
ES2206407T3 (en) 2000-02-04 2004-05-16 Chienna B.V. PROTEIN COATING.
US6896054B2 (en) * 2000-02-15 2005-05-24 Mcclung, Iii Guy L. Microorganism enhancement with earth loop heat exchange systems
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
EP1287039A1 (en) 2000-04-28 2003-03-05 University College Dublin Amphiphilic macrocyclic derivatives and their analogues
JP2004501429A (en) 2000-05-11 2004-01-15 ユニバーシティ・オブ・サザン・カリフォルニア Machine translation techniques
DE60142840D1 (en) 2000-09-08 2010-09-30 Univ Texas BY PHAGENDISPLAY IDENTIFIED TARGET PEPTIDES OF HUMANS AND MOUSE
EP1355965B1 (en) 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method of synthesizing block copolymers for multifunctional self-assembled systems
ES2282163T3 (en) 2000-11-06 2007-10-16 Thrasos, Inc. SCRUTINY METHODS OF MINEETICS OF MORPHOGENETICS OSEA.
GB2388699A (en) 2001-01-23 2003-11-19 Educational Testing Service Methods for automated essay analysis
DE60230593D1 (en) 2001-02-06 2009-02-12 Massachusetts Inst Technology PEPTIDE FURNACE DECONTULATION OF TISSUE CELLS AND USES THEREOF
US7449180B2 (en) 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
US7179784B2 (en) 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
US20050260179A1 (en) 2001-11-06 2005-11-24 The General Hospital Corporation D/B/A Massachusetts General Hospital Stem and progenitor cell capture for tissue regeneration
US7491690B2 (en) 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US7371719B2 (en) 2002-02-15 2008-05-13 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
AU2003226428A1 (en) 2002-04-18 2003-11-03 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (en) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences VEGETABLE FULL-LENGTH cDNA AND UTILIZATION THEREOF
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
AU2003285853A1 (en) 2002-07-23 2004-04-30 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
US7534761B1 (en) * 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
WO2004106359A2 (en) 2002-09-23 2004-12-09 Northwestern University Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
AU2003304280A1 (en) 2002-11-12 2005-01-21 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2004046167A2 (en) 2002-11-14 2004-06-03 Northwestern University Synthesis and self-assembly of abc triblock bola peptide
WO2004072104A2 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7259140B2 (en) 2003-03-28 2007-08-21 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
JP4741510B2 (en) 2003-12-05 2011-08-03 ノースウエスタン ユニバーシティ Branched peptide amphiphiles, related epitope compounds and their self-assembled structures
KR20070004560A (en) 2003-12-05 2007-01-09 노오쓰웨스턴 유니버시티 Self-assembling peptide amphiphiles and related methods for growth factor delivery
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
CN1956726B (en) * 2004-03-23 2011-04-13 生命线营养健康公司 Composition and method for releasing mammal inflammation and oxidation stress
WO2006079036A2 (en) 2005-01-21 2006-07-27 Northwestern University Methods and compositions for encapsulation of cells
JP2008528509A (en) * 2005-01-21 2008-07-31 アルザ コーポレイション Therapeutic peptide formulation for coating microneedles with improved stability comprising at least one counter ion
US7851445B2 (en) * 2005-03-04 2010-12-14 Northwestern University Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use
CN1915438A (en) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 New type bracket material for tissue engineering of polypeptide nerve, preparation method and application
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US6201065B1 (en) * 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
WO1998007752A1 (en) * 1996-08-23 1998-02-26 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9498501B2 (en) 2003-06-27 2016-11-22 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9579351B2 (en) 2003-06-27 2017-02-28 DePuy Synthes Products, Inc. Postpartum cells derived from placental tissue, and methods of making and using the same
US8518876B2 (en) 2007-08-03 2013-08-27 PharmalN Corporation Composition for long-acting peptide analogs
US9090664B2 (en) 2007-08-03 2015-07-28 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same

Also Published As

Publication number Publication date
US20080177033A1 (en) 2008-07-24
US7371719B2 (en) 2008-05-13
US8063014B2 (en) 2011-11-22
AU2003215280A8 (en) 2003-09-09
US20110008890A1 (en) 2011-01-13
US20040001893A1 (en) 2004-01-01
US7745708B2 (en) 2010-06-29
WO2003070749A2 (en) 2003-08-28
AU2003215280A1 (en) 2003-09-09

Similar Documents

Publication Publication Date Title
WO2003070749A3 (en) Self-assembly of peptide-amphiphile nanofibers under physiological conditions
WO2002070438A3 (en) Compositions for delivering bisphosphonates
WO2002008186A3 (en) Cyclopentanoindoles, compositions containing such compounds and methods of treatment
WO2004021989A3 (en) Imidazolopyridines and methods of making and using the same
WO2002000194A3 (en) Polymeric micelle compositions
WO2001078683A3 (en) Sustained release formulations comprising growth hormone
WO2006069363A3 (en) Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
WO2003020700A3 (en) SUBSTITUTED INDENO[1,2-c]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF
WO2000004862A3 (en) Bioenhanced formulations comprising eprosartan in oral solid dosage form
WO2003057145A3 (en) SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[imn]PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES
WO2005009387A3 (en) Azepine derivatives as pharmaceutical agents
HK1068928A1 (en) Single ingredient, multi-structural filaments and process of making the same
MXPA02008402A (en) Derivatives of quinoline as alpha-2 antagonists.
WO2003045330A3 (en) Materials and methods for making improved micelle compositions
EP1426370A4 (en) Propanolamine derivative having 1,4 benzodioxane ring
WO2005016883A3 (en) Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
WO2005033048A3 (en) Wnt pathway antagonists
AU2001285304A1 (en) Fiber-forming polyamide composition
IS6980A (en) 3,7-diazabicyclo [3.3.1] preparations as antithrombotic compounds
WO2002040451A3 (en) Lactam compound
WO2002024695A3 (en) Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
WO2001078682A3 (en) Sustained release drug compositions
WO2004111047A3 (en) Cycloalkanepyrrolopyridines as dp receptor antagonists
WO2002094178A3 (en) Treatment of renal fibrosis
CA2372664A1 (en) Substituted benzimidazole, the production thereof and the use thereof as means against parasitic protozoa

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP