WO2003074990A3 - Artificial receptors, building blocks, and methods - Google Patents

Artificial receptors, building blocks, and methods Download PDF

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Publication number
WO2003074990A3
WO2003074990A3 PCT/US2003/005328 US0305328W WO03074990A3 WO 2003074990 A3 WO2003074990 A3 WO 2003074990A3 US 0305328 W US0305328 W US 0305328W WO 03074990 A3 WO03074990 A3 WO 03074990A3
Authority
WO
WIPO (PCT)
Prior art keywords
building blocks
artificial receptors
receptors
methods
arrays
Prior art date
Application number
PCT/US2003/005328
Other languages
French (fr)
Other versions
WO2003074990A9 (en
WO2003074990A2 (en
Inventor
Robert E Carlson
Original Assignee
Receptors Llc
Robert E Carlson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ535080A priority Critical patent/NZ535080A/en
Priority to MXPA04008467A priority patent/MXPA04008467A/en
Priority to EP03709250A priority patent/EP1483578B1/en
Priority to IL16368603A priority patent/IL163686A0/en
Priority to JP2003573401A priority patent/JP4988147B2/en
Priority to CA002477749A priority patent/CA2477749A1/en
Priority to AU2003213204A priority patent/AU2003213204B2/en
Priority to AT03709250T priority patent/ATE538379T1/en
Application filed by Receptors Llc, Robert E Carlson filed Critical Receptors Llc
Publication of WO2003074990A2 publication Critical patent/WO2003074990A2/en
Publication of WO2003074990A9 publication Critical patent/WO2003074990A9/en
Priority to US10/812,850 priority patent/US20050037428A1/en
Priority to US10/813,568 priority patent/US20050037381A1/en
Publication of WO2003074990A3 publication Critical patent/WO2003074990A3/en
Priority to IL163686A priority patent/IL163686A/en
Priority to ZA200406710A priority patent/ZA200406710B/en
Priority to US10/934,977 priority patent/US7960311B2/en
Priority to US10/934,865 priority patent/US20050106630A1/en
Priority to US11/004,593 priority patent/US20050170385A1/en
Priority to US11/217,384 priority patent/US20060057625A1/en
Priority to US11/709,696 priority patent/US20070238091A1/en
Priority to US11/978,936 priority patent/US20080058225A1/en
Priority to AU2009200852A priority patent/AU2009200852A1/en
Priority to IL199259A priority patent/IL199259A0/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, typically immobilized in a spot on a support. The present invention also includes the building blocks, combinations of building blocks, arrays of building blocks, and receptors constructed of these building blocks together with a support. The present invention also includes methods of making and using these arrays and receptors.
PCT/US2003/005328 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods WO2003074990A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
AU2003213204A AU2003213204B2 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
EP03709250A EP1483578B1 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
IL16368603A IL163686A0 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
JP2003573401A JP4988147B2 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
CA002477749A CA2477749A1 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
NZ535080A NZ535080A (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods
AT03709250T ATE538379T1 (en) 2002-03-01 2003-02-19 ARTIFICIAL RECEPTORS, COMPONENTS AND PROCESSES
MXPA04008467A MXPA04008467A (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods.
US10/812,850 US20050037428A1 (en) 2002-09-16 2004-03-29 Artificial receptors including reversibly immobilized building blocks, the building blocks, and methods
US10/813,568 US20050037381A1 (en) 2002-09-16 2004-03-29 Artificial receptors, building blocks, and methods
IL163686A IL163686A (en) 2002-03-01 2004-08-23 Methods of making arrays of artificial receptors
ZA200406710A ZA200406710B (en) 2002-03-01 2004-08-24 Artificial receptors, building blocks, and methods
US10/934,865 US20050106630A1 (en) 2002-09-16 2004-09-03 Building blocks for artificial receptors
US10/934,977 US7960311B2 (en) 2002-09-16 2004-09-03 Methods employing combinatorial artificial receptors
US11/004,593 US20050170385A1 (en) 2002-09-16 2004-12-02 Artificial receptors including gradients
US11/217,384 US20060057625A1 (en) 2002-09-16 2005-09-01 Scaffold-based artificial receptors and methods
US11/709,696 US20070238091A1 (en) 2002-09-16 2007-02-22 Artificial receptors, building blocks, and methods
US11/978,936 US20080058225A1 (en) 2002-09-16 2007-10-30 Artificial receptors, building blocks, and methods
AU2009200852A AU2009200852A1 (en) 2002-03-01 2009-03-04 Artificial receptors, building blocks, and methods
IL199259A IL199259A0 (en) 2002-03-01 2009-06-09 Artificial receptors, building blocks, and methods

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US36098002P 2002-03-01 2002-03-01
US60/360,980 2002-03-01
US36260002P 2002-03-08 2002-03-08
US60/362,600 2002-03-08
US37565502P 2002-04-26 2002-04-26
US60/375,655 2002-04-26
US40060502P 2002-08-02 2002-08-02
US60/400,605 2002-08-02
US10/244,727 2002-09-16
US10/244,727 US7504364B2 (en) 2002-03-01 2002-09-16 Methods of making arrays and artificial receptors

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/812,850 Continuation-In-Part US20050037428A1 (en) 2002-09-16 2004-03-29 Artificial receptors including reversibly immobilized building blocks, the building blocks, and methods
US10/813,568 Continuation-In-Part US20050037381A1 (en) 2002-09-16 2004-03-29 Artificial receptors, building blocks, and methods
US10/934,865 Continuation-In-Part US20050106630A1 (en) 2002-09-16 2004-09-03 Building blocks for artificial receptors

Publications (3)

Publication Number Publication Date
WO2003074990A2 WO2003074990A2 (en) 2003-09-12
WO2003074990A9 WO2003074990A9 (en) 2004-01-22
WO2003074990A3 true WO2003074990A3 (en) 2004-07-29

Family

ID=29255676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005328 WO2003074990A2 (en) 2002-03-01 2003-02-19 Artificial receptors, building blocks, and methods

Country Status (11)

Country Link
US (5) US7504364B2 (en)
EP (1) EP1483578B1 (en)
JP (1) JP4988147B2 (en)
CN (1) CN100533145C (en)
AT (1) ATE538379T1 (en)
AU (2) AU2003213204B2 (en)
CA (1) CA2477749A1 (en)
IL (3) IL163686A0 (en)
MX (1) MXPA04008467A (en)
NZ (1) NZ535080A (en)
WO (1) WO2003074990A2 (en)

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