WO2003082098A3 - Improving performance of an analyte monitoring device - Google Patents

Improving performance of an analyte monitoring device Download PDF

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Publication number
WO2003082098A3
WO2003082098A3 PCT/US2003/008914 US0308914W WO03082098A3 WO 2003082098 A3 WO2003082098 A3 WO 2003082098A3 US 0308914 W US0308914 W US 0308914W WO 03082098 A3 WO03082098 A3 WO 03082098A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microprocessors
analyte
present
analyte monitoring
Prior art date
Application number
PCT/US2003/008914
Other languages
French (fr)
Other versions
WO2003082098A2 (en
Inventor
Miroslaw Bartkowiak
Wesley S Harper
Eray Kulcu
Matthew J Lesho
Janet A Tamada
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Priority to AT03716792T priority Critical patent/ATE482649T1/en
Priority to CA2480550A priority patent/CA2480550C/en
Priority to DE60334365T priority patent/DE60334365D1/en
Priority to EP03716792A priority patent/EP1489961B1/en
Priority to ES03716792T priority patent/ES2357318T3/en
Priority to JP2003579647A priority patent/JP4083689B2/en
Publication of WO2003082098A2 publication Critical patent/WO2003082098A2/en
Publication of WO2003082098A3 publication Critical patent/WO2003082098A3/en
Priority to HK05105451.6A priority patent/HK1074371A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7242—Details of waveform analysis using integration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Abstract

The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
PCT/US2003/008914 2002-03-22 2003-03-21 Improving performance of an analyte monitoring device WO2003082098A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT03716792T ATE482649T1 (en) 2002-03-22 2003-03-21 PERFORMANCE IMPROVEMENT OF AN ANALYTE MONITORING DEVICE
CA2480550A CA2480550C (en) 2002-03-22 2003-03-21 Improving performance of an analyte monitoring device
DE60334365T DE60334365D1 (en) 2002-03-22 2003-03-21 INCREASED PERFORMANCE OF AN ANALYSIS MONITORING DEVICE
EP03716792A EP1489961B1 (en) 2002-03-22 2003-03-21 Improving performance of an analyte monitoring device
ES03716792T ES2357318T3 (en) 2002-03-22 2003-03-21 IMPROVEMENT OF THE PERFORMANCE OF AN ANALYTIC MONITORING DEVICE.
JP2003579647A JP4083689B2 (en) 2002-03-22 2003-03-21 Improved performance of analyte monitoring devices
HK05105451.6A HK1074371A1 (en) 2002-03-22 2005-06-29 Improving performance of an analyte monitoring device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36708702P 2002-03-22 2002-03-22
US60/367,087 2002-03-22
US41398902P 2002-09-25 2002-09-25
US60/413,989 2002-09-25

Publications (2)

Publication Number Publication Date
WO2003082098A2 WO2003082098A2 (en) 2003-10-09
WO2003082098A3 true WO2003082098A3 (en) 2004-04-01

Family

ID=28678180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008914 WO2003082098A2 (en) 2002-03-22 2003-03-21 Improving performance of an analyte monitoring device

Country Status (9)

Country Link
US (4) US20030235817A1 (en)
EP (2) EP1702561B1 (en)
JP (5) JP4083689B2 (en)
AT (2) ATE482649T1 (en)
CA (2) CA2480550C (en)
DE (2) DE60337038D1 (en)
ES (1) ES2357318T3 (en)
HK (2) HK1074371A1 (en)
WO (1) WO2003082098A2 (en)

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