WO2003083069A8 - Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb - Google Patents
Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bbInfo
- Publication number
- WO2003083069A8 WO2003083069A8 PCT/US2003/009415 US0309415W WO03083069A8 WO 2003083069 A8 WO2003083069 A8 WO 2003083069A8 US 0309415 W US0309415 W US 0309415W WO 03083069 A8 WO03083069 A8 WO 03083069A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tumor
- genes
- cells
- activation
- lymphocytes via
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 230000004913 activation Effects 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 101150013553 CD40 gene Proteins 0.000 abstract 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 239000011324 bead Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001124—CD20
-
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
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Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003243138A AU2003243138A1 (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb |
IL16421603A IL164216A0 (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb |
CA002480263A CA2480263A1 (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb |
KR10-2004-7015322A KR20050000376A (en) | 2002-03-26 | 2003-03-26 | Activation of Tumor-Reactive Lymphocytes via Antibodies or Genes Recognizing CD3 or 4-1BB |
MXPA04009340A MXPA04009340A (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb. |
JP2003580505A JP2005528892A (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes that recognize CD3 or 4-1BB |
EP03745635A EP1537219A2 (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb |
CN03812095.XA CN1894413A (en) | 2003-03-26 | 2003-03-26 | Activation of tumor reactive lynphatic cell of identifying CD3 or 4-1BB antibody or gene mediation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/107,991 | 2002-03-26 | ||
US10/107,991 US20040058445A1 (en) | 2001-04-26 | 2002-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
US10/207,655 | 2002-07-25 | ||
US10/207,655 US7754208B2 (en) | 2001-01-17 | 2002-07-25 | Binding domain-immunoglobulin fusion proteins |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2003083069A2 WO2003083069A2 (en) | 2003-10-09 |
WO2003083069A3 WO2003083069A3 (en) | 2005-04-14 |
WO2003083069A8 true WO2003083069A8 (en) | 2005-07-07 |
Family
ID=34658226
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/009415 WO2003083069A2 (en) | 2002-03-26 | 2003-03-26 | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing cd3 or 4-1bb |
PCT/US2003/024918 WO2005037989A2 (en) | 2001-01-17 | 2003-07-26 | Binding domain-immunoglobulin fusion proteins |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/024918 WO2005037989A2 (en) | 2001-01-17 | 2003-07-26 | Binding domain-immunoglobulin fusion proteins |
Country Status (3)
Country | Link |
---|---|
US (6) | US7754208B2 (en) |
JP (1) | JP2005528892A (en) |
WO (2) | WO2003083069A2 (en) |
Families Citing this family (507)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
WO2003035835A2 (en) * | 2001-10-25 | 2003-05-01 | Genentech, Inc. | Glycoprotein compositions |
US7737260B2 (en) | 2003-11-13 | 2010-06-15 | Hanmi Pharm. Co., Ltd | Protein complex using an immunoglobulin fragment and method for the preparation thereof |
US7662925B2 (en) * | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
US20070148171A1 (en) * | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US20080254027A1 (en) * | 2002-03-01 | 2008-10-16 | Bernett Matthew J | Optimized CD5 antibodies and methods of using the same |
US20080260731A1 (en) * | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
US20030219436A1 (en) * | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
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-
2002
- 2002-07-25 US US10/207,655 patent/US7754208B2/en not_active Expired - Fee Related
-
2003
- 2003-03-26 WO PCT/US2003/009415 patent/WO2003083069A2/en not_active Application Discontinuation
- 2003-03-26 JP JP2003580505A patent/JP2005528892A/en active Pending
- 2003-07-26 WO PCT/US2003/024918 patent/WO2005037989A2/en active Application Filing
-
2009
- 2009-08-13 US US12/541,062 patent/US8147835B2/en not_active Expired - Fee Related
-
2010
- 2010-03-15 US US12/724,333 patent/US20100203052A1/en not_active Abandoned
-
2011
- 2011-03-02 US US13/039,097 patent/US20110223164A1/en not_active Abandoned
-
2012
- 2012-02-14 US US13/396,147 patent/US8853366B2/en not_active Expired - Fee Related
-
2013
- 2013-03-15 US US13/835,833 patent/US20140010809A1/en not_active Abandoned
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US20030118592A1 (en) | 2003-06-26 |
US20120213773A1 (en) | 2012-08-23 |
WO2005037989A3 (en) | 2007-05-03 |
US20140010809A1 (en) | 2014-01-09 |
WO2003083069A3 (en) | 2005-04-14 |
US7754208B2 (en) | 2010-07-13 |
WO2005037989A2 (en) | 2005-04-28 |
US20100034820A1 (en) | 2010-02-11 |
US20100203052A1 (en) | 2010-08-12 |
WO2003083069A2 (en) | 2003-10-09 |
US20110223164A1 (en) | 2011-09-15 |
US8147835B2 (en) | 2012-04-03 |
US8853366B2 (en) | 2014-10-07 |
JP2005528892A (en) | 2005-09-29 |
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