WO2003083491A3 - Method and apparatus for controlling fluid movement in a microfluidic system - Google Patents

Method and apparatus for controlling fluid movement in a microfluidic system Download PDF

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Publication number
WO2003083491A3
WO2003083491A3 PCT/US2003/009162 US0309162W WO03083491A3 WO 2003083491 A3 WO2003083491 A3 WO 2003083491A3 US 0309162 W US0309162 W US 0309162W WO 03083491 A3 WO03083491 A3 WO 03083491A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
microfluidic system
controlling fluid
fluid movement
moving
Prior art date
Application number
PCT/US2003/009162
Other languages
French (fr)
Other versions
WO2003083491A2 (en
Inventor
Henry Petithory
Original Assignee
Centrifluidics Inc
Henry Petithory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrifluidics Inc, Henry Petithory filed Critical Centrifluidics Inc
Priority to AU2003222072A priority Critical patent/AU2003222072A1/en
Publication of WO2003083491A2 publication Critical patent/WO2003083491A2/en
Publication of WO2003083491A3 publication Critical patent/WO2003083491A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Abstract

The invention provides a method for moving a fluid sample within an open channel flow device by centrifugal force and specially adapted apparatus for practicing the method of the invention. The inventive method is a mechanically simple method for moving a fluid in a platform by changing the orientation of a platform relative to the direction of applied forces when the centrifuge rotor is at rest in order to move a fluid sequentially through a plurality of chambers, wherein movement of the fluid is controlled by the location, size or shape of the passages connecting chambers relative to the direction of forces acting on the fluid.
PCT/US2003/009162 2002-03-25 2003-03-24 Method and apparatus for controlling fluid movement in a microfluidic system WO2003083491A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003222072A AU2003222072A1 (en) 2002-03-25 2003-03-24 Method and apparatus for controlling fluid movement in a microfluidic system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36811302P 2002-03-25 2002-03-25
US60/368,113 2002-03-25

Publications (2)

Publication Number Publication Date
WO2003083491A2 WO2003083491A2 (en) 2003-10-09
WO2003083491A3 true WO2003083491A3 (en) 2003-11-06

Family

ID=28675446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/009162 WO2003083491A2 (en) 2002-03-25 2003-03-24 Method and apparatus for controlling fluid movement in a microfluidic system

Country Status (2)

Country Link
AU (1) AU2003222072A1 (en)
WO (1) WO2003083491A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006110523A (en) * 2004-10-18 2006-04-27 Hitachi Software Eng Co Ltd Chemical reaction device
JP4673149B2 (en) * 2005-06-29 2011-04-20 ローム株式会社 Method of using microchip, microchannel, and microchip
JP2008268194A (en) * 2007-03-27 2008-11-06 Toray Ind Inc Analysis method
JP5504690B2 (en) * 2008-05-15 2014-05-28 東レ株式会社 Analysis chip
NO332016B1 (en) * 2009-12-29 2012-05-21 Stiftelsen Sintef Sample processing cartridge and method for processing and / or analyzing a sample under centrifugal force
KR101680185B1 (en) * 2010-01-15 2016-11-28 삼성전자주식회사 Apparatus For Analyzing Sample
JP5359965B2 (en) * 2010-03-31 2013-12-04 ブラザー工業株式会社 Inspection device
JP5549361B2 (en) * 2010-05-07 2014-07-16 住友ベークライト株式会社 Microchannel device
JP5889639B2 (en) * 2011-07-29 2016-03-22 ローム株式会社 Disc type analysis chip
JP5924967B2 (en) * 2012-02-08 2016-05-25 アークレイ株式会社 Spotting device and spotting method
JP6221296B2 (en) * 2013-03-28 2017-11-01 ブラザー工業株式会社 Inspection chip and inspection system
JP5975055B2 (en) * 2014-03-31 2016-08-23 ブラザー工業株式会社 Inspection chip
WO2015181725A1 (en) * 2014-05-26 2015-12-03 National Research Council Of Canada Swivel mount for centrifugal microfluidic chip
JP6260486B2 (en) * 2014-07-30 2018-01-17 ブラザー工業株式会社 Inspection device and inspection program
US10493448B2 (en) 2015-03-13 2019-12-03 Bio-Rad Laboratories, Inc. Assay cartridge
JP2016191577A (en) * 2015-03-31 2016-11-10 ブラザー工業株式会社 Inspection device
CN107159329A (en) * 2017-05-22 2017-09-15 天津微纳芯科技有限公司 A kind of chip and its method for packing for sample detection
NO346147B1 (en) * 2017-11-09 2022-03-21 Spinchip Diagnostics As Method and apparatus for controlling a focus point of stationary beam focusing on a sample in a rotating cartridge placed in a rotating disc
NO343863B1 (en) 2017-11-09 2019-06-24 Spinchip Diagnostics As Centrifuge apparatus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812294A (en) * 1986-02-28 1989-03-14 Automated Diagnostic Systems, Inc. Specimen processing system
US4883763A (en) * 1984-05-03 1989-11-28 Abbott Laboratories Sample processor card for centrifuge
US5089417A (en) * 1987-07-01 1992-02-18 Miles Inc. Fluid separation and processing device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883763A (en) * 1984-05-03 1989-11-28 Abbott Laboratories Sample processor card for centrifuge
US4812294A (en) * 1986-02-28 1989-03-14 Automated Diagnostic Systems, Inc. Specimen processing system
US5089417A (en) * 1987-07-01 1992-02-18 Miles Inc. Fluid separation and processing device

Also Published As

Publication number Publication date
AU2003222072A1 (en) 2003-10-13
WO2003083491A2 (en) 2003-10-09

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