WO2003091311A1 - Monomers containing polyoxyalkylenes and polymer supports therefrom - Google Patents
Monomers containing polyoxyalkylenes and polymer supports therefrom Download PDFInfo
- Publication number
- WO2003091311A1 WO2003091311A1 PCT/GB2003/001774 GB0301774W WO03091311A1 WO 2003091311 A1 WO2003091311 A1 WO 2003091311A1 GB 0301774 W GB0301774 W GB 0301774W WO 03091311 A1 WO03091311 A1 WO 03091311A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protected
- alkyleneoxy
- monomer
- hydroxypolyc
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F12/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F12/02—Monomers containing only one unsaturated aliphatic radical
- C08F12/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F12/14—Monomers containing only one unsaturated aliphatic radical containing one ring substituted by hetero atoms or groups containing heteroatoms
- C08F12/22—Oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
- C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/512,145 US7365132B2 (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
KR10-2004-7017119A KR20050006186A (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
EP03722776.6A EP1504049B1 (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
JP2003587864A JP4497931B2 (en) | 2002-04-26 | 2003-04-25 | Polyoxyalkylene-containing polymer carrier, monomer and method used for the production thereof |
CA2482945A CA2482945C (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
AU2003229938A AU2003229938A1 (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0209539.6A GB0209539D0 (en) | 2002-04-26 | 2002-04-26 | Monomer Polymer and process |
GB0209539.6 | 2002-04-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003091311A1 true WO2003091311A1 (en) | 2003-11-06 |
WO2003091311A8 WO2003091311A8 (en) | 2004-02-26 |
Family
ID=9935542
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/001795 WO2003091267A1 (en) | 2002-04-26 | 2003-04-25 | Process for preparing oligonucleotides |
PCT/GB2003/001774 WO2003091311A1 (en) | 2002-04-26 | 2003-04-25 | Monomers containing polyoxyalkylenes and polymer supports therefrom |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/001795 WO2003091267A1 (en) | 2002-04-26 | 2003-04-25 | Process for preparing oligonucleotides |
Country Status (9)
Country | Link |
---|---|
US (2) | US7476709B2 (en) |
EP (2) | EP1501851B1 (en) |
JP (2) | JP4497931B2 (en) |
KR (2) | KR20050006186A (en) |
CN (2) | CN1649889A (en) |
AU (2) | AU2003229938A1 (en) |
CA (2) | CA2483483C (en) |
GB (1) | GB0209539D0 (en) |
WO (2) | WO2003091267A1 (en) |
Families Citing this family (46)
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GB9425138D0 (en) * | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
CN1302005C (en) * | 2000-12-05 | 2007-02-28 | 艾夫西亚有限公司 | Process for preparation of thiophosphate oligonucleotides |
US8110351B2 (en) | 2002-01-16 | 2012-02-07 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
GB0229443D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
CN101821280B (en) * | 2007-10-15 | 2014-07-23 | 霍尼韦尔国际公司 | Synthesis of oligonucleotides or phosphorothioate oligonucleotide with capping agent of n-methylimidazole free of 1,3,5-trimethylhexahydro-1,3,5-triazine |
US8039612B2 (en) * | 2007-10-15 | 2011-10-18 | Honeywell International, Inc. | Synthesis of oligonucleotides or phosphorothioate oligonucleotide with a capping agent of N-methylimidazole free of 1,3,5-trimethylhexahydro-1,3,5-triazine |
JP5276367B2 (en) * | 2008-06-25 | 2013-08-28 | 日東電工株式会社 | Porous resin beads and method for producing nucleic acid using the same |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP3682905B1 (en) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
RS63244B1 (en) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Modified mrna compositions |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | Modified polynucleotides for the production of oncology-related proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
ES2921623T3 (en) | 2012-11-26 | 2022-08-30 | Modernatx Inc | terminally modified RNA |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
US9409139B2 (en) | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
AU2014329452B2 (en) | 2013-10-03 | 2019-06-20 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
CA2955250A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
AU2016324296A1 (en) | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
US11512347B2 (en) | 2015-09-22 | 2022-11-29 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
CN115920796A (en) | 2015-12-01 | 2023-04-07 | 特韦斯特生物科学公司 | Functionalized surfaces and preparation thereof |
CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
US10907274B2 (en) | 2016-12-16 | 2021-02-02 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
CN110892485B (en) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | Nucleic acid-based data storage |
EP3595674A4 (en) | 2017-03-15 | 2020-12-16 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
EP3681906A4 (en) | 2017-09-11 | 2021-06-09 | Twist Bioscience Corporation | Gpcr binding proteins and synthesis thereof |
GB2583590A (en) | 2017-10-20 | 2020-11-04 | Twist Bioscience Corp | Heated nanowells for polynucleotide synthesis |
KR20200106067A (en) | 2018-01-04 | 2020-09-10 | 트위스트 바이오사이언스 코포레이션 | DNA-based digital information storage |
SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
KR20210143766A (en) | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Variant Nucleic Acid Libraries for the GLP1 Receptor |
WO2020176680A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
EP4329773A1 (en) * | 2021-04-28 | 2024-03-06 | Astrocyte Pharmaceuticals, Inc. | Purine nucleosides, their intermediates, and methods of preparation thereof |
CN113248352A (en) * | 2021-05-18 | 2021-08-13 | 湖南华腾制药有限公司 | Method for solid-phase synthesis of heptaethylene glycol monomethyl ether |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US4908405A (en) * | 1985-01-04 | 1990-03-13 | Ernst Bayer | Graft copolymers of crosslinked polymers and polyoxyethylene, processes for their production, and their usage |
US5466758A (en) * | 1994-04-13 | 1995-11-14 | Yoon-Sik; Lee | Process for preparing polystyrenes having β hydroxy group and polyglycol-grafted polystyrenes thereof |
WO2000002953A1 (en) * | 1998-07-10 | 2000-01-20 | Avecia Limited | Polymer supports containing polyoxyalkylenes |
WO2001026692A1 (en) * | 1999-10-08 | 2001-04-19 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
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BE755158A (en) * | 1969-08-22 | 1971-02-22 | Rhodiaceta | ANTISTATIC THERMOPLASTIC COMPOSITIONS |
DE3777441D1 (en) * | 1986-05-07 | 1992-04-23 | Dai Ichi Kogyo Seiyaku Co Ltd | A POLYMERIZABLE PART CONTAINING SURFACE ACTIVE CONNECTIONS. |
JPH06260383A (en) * | 1993-03-03 | 1994-09-16 | Nikon Corp | Exposure method |
US5614010A (en) | 1994-03-14 | 1997-03-25 | Clearwater, Inc. | Hydrocarbon gels useful in formation fracturing |
US5696248A (en) * | 1994-06-15 | 1997-12-09 | Hoechst Aktiengesellschaft | 3'-modified oligonucleotide derivatives |
WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
DE19781535T1 (en) * | 1996-01-23 | 1999-01-28 | Argonaut Technologies Inc | Highly functionalized polystyrene carriers grafted with polyethylene glycol |
US5869696A (en) * | 1996-04-22 | 1999-02-09 | Beckman Instruments, Inc. | Universal solid supports and methods for their use |
US6096881A (en) * | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
GB9717158D0 (en) * | 1997-08-13 | 1997-10-22 | King S College London | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
US6274725B1 (en) | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
MXPA01009893A (en) * | 1999-04-01 | 2003-07-28 | Esperion Therapeutics Inc | Ether compounds, compositions, and uses thereof. |
JP2001064297A (en) * | 1999-06-25 | 2001-03-13 | Sankyo Co Ltd | New bicyclo nucleoside derivative |
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JP2004508379A (en) * | 2000-09-07 | 2004-03-18 | アベシア・バイオテクノロジー・インコーポレーテッド | Synthons for oligonucleotide synthesis |
AU2002339175A1 (en) | 2001-11-21 | 2003-06-10 | Avecia Biotechnology Inc. | Coupling reagent for h-phosphonate chemistry |
GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
-
2002
- 2002-04-26 GB GBGB0209539.6A patent/GB0209539D0/en not_active Ceased
-
2003
- 2003-04-25 KR KR10-2004-7017119A patent/KR20050006186A/en not_active Application Discontinuation
- 2003-04-25 KR KR10-2004-7017120A patent/KR20050000406A/en not_active Application Discontinuation
- 2003-04-25 US US10/512,138 patent/US7476709B2/en active Active
- 2003-04-25 WO PCT/GB2003/001795 patent/WO2003091267A1/en active Application Filing
- 2003-04-25 AU AU2003229938A patent/AU2003229938A1/en not_active Abandoned
- 2003-04-25 EP EP03722784A patent/EP1501851B1/en not_active Expired - Lifetime
- 2003-04-25 WO PCT/GB2003/001774 patent/WO2003091311A1/en active Application Filing
- 2003-04-25 CN CNA038092026A patent/CN1649889A/en active Pending
- 2003-04-25 CA CA2483483A patent/CA2483483C/en not_active Expired - Lifetime
- 2003-04-25 CN CNB038091933A patent/CN1310999C/en not_active Expired - Fee Related
- 2003-04-25 CA CA2482945A patent/CA2482945C/en not_active Expired - Lifetime
- 2003-04-25 JP JP2003587864A patent/JP4497931B2/en not_active Expired - Lifetime
- 2003-04-25 EP EP03722776.6A patent/EP1504049B1/en not_active Expired - Lifetime
- 2003-04-25 JP JP2003587825A patent/JP4657609B2/en not_active Expired - Lifetime
- 2003-04-25 AU AU2003229946A patent/AU2003229946A1/en not_active Abandoned
- 2003-04-25 US US10/512,145 patent/US7365132B2/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US4908405A (en) * | 1985-01-04 | 1990-03-13 | Ernst Bayer | Graft copolymers of crosslinked polymers and polyoxyethylene, processes for their production, and their usage |
US5466758A (en) * | 1994-04-13 | 1995-11-14 | Yoon-Sik; Lee | Process for preparing polystyrenes having β hydroxy group and polyglycol-grafted polystyrenes thereof |
WO2000002953A1 (en) * | 1998-07-10 | 2000-01-20 | Avecia Limited | Polymer supports containing polyoxyalkylenes |
WO2001026692A1 (en) * | 1999-10-08 | 2001-04-19 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
Non-Patent Citations (1)
Title |
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HIRATANI K ET AL: "PREPARATION AND CATALYTIC BEHAVIOUR OF POLYMERS WITH PENDANT OLIGOETHYLENEOXY-GROUPS (POLYMERS OF NON-CYCLIC CROWN ETHERS)", ISRAEL JOURNAL OF CHEMISTRY, XX, XX, vol. 18, no. 3/4, 1979, pages 208 - 213, XP000604342, ISSN: 0021-2148 * |
Also Published As
Publication number | Publication date |
---|---|
KR20050006186A (en) | 2005-01-15 |
JP4657609B2 (en) | 2011-03-23 |
AU2003229938A1 (en) | 2003-11-10 |
CA2483483C (en) | 2013-04-09 |
WO2003091311A8 (en) | 2004-02-26 |
JP4497931B2 (en) | 2010-07-07 |
JP2005534629A (en) | 2005-11-17 |
JP2005523962A (en) | 2005-08-11 |
EP1501851B1 (en) | 2013-02-13 |
US20050256283A1 (en) | 2005-11-17 |
WO2003091267A1 (en) | 2003-11-06 |
EP1501851A1 (en) | 2005-02-02 |
CA2482945C (en) | 2011-05-24 |
US7365132B2 (en) | 2008-04-29 |
CN1649935A (en) | 2005-08-03 |
US20060036028A1 (en) | 2006-02-16 |
EP1504049B1 (en) | 2013-05-22 |
US7476709B2 (en) | 2009-01-13 |
EP1504049A1 (en) | 2005-02-09 |
AU2003229946A1 (en) | 2003-11-10 |
CN1649889A (en) | 2005-08-03 |
KR20050000406A (en) | 2005-01-03 |
CN1310999C (en) | 2007-04-18 |
CA2482945A1 (en) | 2003-11-06 |
GB0209539D0 (en) | 2002-06-05 |
CA2483483A1 (en) | 2003-11-06 |
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