WO2003093495A3 - Diffraction-based diagnostic devices - Google Patents

Diffraction-based diagnostic devices Download PDF

Info

Publication number
WO2003093495A3
WO2003093495A3 PCT/US2003/011756 US0311756W WO03093495A3 WO 2003093495 A3 WO2003093495 A3 WO 2003093495A3 US 0311756 W US0311756 W US 0311756W WO 03093495 A3 WO03093495 A3 WO 03093495A3
Authority
WO
WIPO (PCT)
Prior art keywords
diffraction
diagnostic devices
based diagnostic
substrate
areas
Prior art date
Application number
PCT/US2003/011756
Other languages
French (fr)
Other versions
WO2003093495A2 (en
Inventor
David Cohen
Rosann Kaylor
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Priority to AU2003228555A priority Critical patent/AU2003228555A1/en
Publication of WO2003093495A2 publication Critical patent/WO2003093495A2/en
Publication of WO2003093495A3 publication Critical patent/WO2003093495A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/002Electrode membranes
    • C12Q1/003Functionalisation

Abstract

A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process.
PCT/US2003/011756 2002-05-03 2003-04-15 Diffraction-based diagnostic devices WO2003093495A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003228555A AU2003228555A1 (en) 2002-05-03 2003-04-15 Diffraction-based diagnostic devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/139,018 US7485453B2 (en) 2002-05-03 2002-05-03 Diffraction-based diagnostic devices
US10/139,018 2002-05-03

Publications (2)

Publication Number Publication Date
WO2003093495A2 WO2003093495A2 (en) 2003-11-13
WO2003093495A3 true WO2003093495A3 (en) 2004-01-22

Family

ID=29269485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/011756 WO2003093495A2 (en) 2002-05-03 2003-04-15 Diffraction-based diagnostic devices

Country Status (4)

Country Link
US (2) US7485453B2 (en)
AU (1) AU2003228555A1 (en)
TW (1) TWI273230B (en)
WO (1) WO2003093495A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US10094762B2 (en) * 2013-05-30 2018-10-09 UNIVERSITé LAVAL Patterned capillary device and process for fabricating thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003496A1 (en) * 1992-07-30 1994-02-17 Commonwealth Scientific And Industrial Research Organisation Biomaterials and biosensors containing immobilized modified antibodies
US5478527A (en) * 1990-05-17 1995-12-26 Adeza Biomedical Corporation Highly reflective biogratings
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641354A (en) 1967-03-08 1972-02-08 Jack De Ment Optical modulation by fluidic optics utilizing chromatic aberration
US4587213A (en) 1971-09-29 1986-05-06 Malecki George J Methods and means of determining microorganism population
US4011009A (en) 1975-05-27 1977-03-08 Xerox Corporation Reflection diffraction grating having a controllable blaze angle
EP0007108B1 (en) 1978-07-18 1983-04-13 Nippon Telegraph and Telephone Public Corporation A method of manufacturing a diffraction grating structure
US4312228A (en) * 1979-07-30 1982-01-26 Henry Wohltjen Methods of detection with surface acoustic wave and apparati therefor
US4274706A (en) 1979-08-30 1981-06-23 Hughes Aircraft Company Wavelength multiplexer/demultiplexer for optical circuits
SE434438B (en) * 1980-02-21 1984-07-23 Gambro Engstrom Ab DEVICE FOR DETECTING THE EXISTENCE OF A GAS COMPONENT IN A GAS MIXTURE
US4442204A (en) 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US4363874A (en) 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
US4477158A (en) 1981-10-15 1984-10-16 Pollock Stephen C Lens system for variable refraction
US4416505A (en) * 1981-10-26 1983-11-22 International Business Machines Corporation Method for making holographic optical elements with high diffraction efficiencies
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4690715A (en) * 1982-06-18 1987-09-01 American Telephone And Telegraph Company, At&T Bell Laboratories Modification of the properties of metals
US4534356A (en) * 1982-07-30 1985-08-13 Diamond Shamrock Chemicals Company Solid state transcutaneous blood gas sensors
US4632559A (en) 1982-11-29 1986-12-30 Miles Laboratories, Inc. Optical readhead
DE3376685D1 (en) * 1982-12-21 1988-06-23 Ares Serono Nv Assay technique
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4528260A (en) 1983-04-27 1985-07-09 Rca Corporation Method of fabricating lenticular arrays
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
DE3464252D1 (en) 1983-06-03 1987-07-23 Hoffmann La Roche Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
CH662421A5 (en) 1983-07-13 1987-09-30 Suisse Horlogerie Rech Lab PIEZOELECTRIC CONTAMINATION DETECTOR.
US4552458A (en) 1983-10-11 1985-11-12 Eastman Kodak Company Compact reflectometer
US4698262A (en) 1984-04-27 1987-10-06 Becton, Dickinson And Company Fluorescently labeled microbeads
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
USRE33581E (en) 1984-06-25 1991-04-30 Immunoassay using optical interference detection
US4661235A (en) * 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4596697A (en) * 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
DE3481644D1 (en) 1984-12-10 1990-04-19 Prutec Ltd METHOD FOR THE OPTICAL DETECTION OF PARAMETERS OF SUBSTANCES IN A LIQUID ANALYT.
US6060237A (en) * 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
AU5815886A (en) 1985-05-29 1986-12-24 Kurt Tiefenthaler Optical sensor for selectively determining the presence of substances and the variation of the refraction index in the measured substances
US5238815A (en) 1985-08-30 1993-08-24 Toyo Soda Manufacturing Co., Ltd. Enzymatic immunoassay involving detecting fluorescence while oscillating magnetic beads
US4917503A (en) 1985-12-02 1990-04-17 Lifelines Technology, Inc. Photoactivatable leuco base time-temperature indicator
US5482830A (en) * 1986-02-25 1996-01-09 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5468606A (en) * 1989-09-18 1995-11-21 Biostar, Inc. Devices for detection of an analyte based upon light interference
US4776944A (en) * 1986-03-20 1988-10-11 Jiri Janata Chemical selective sensors utilizing admittance modulated membranes
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
US5182135A (en) * 1986-08-12 1993-01-26 Bayer Aktiengesellschaft Process for improving the adherency of metallic coatings deposited without current on plastic surfaces
GB2197065A (en) * 1986-11-03 1988-05-11 Stc Plc Optical sensor device
US4837715A (en) * 1987-01-27 1989-06-06 Kimberly-Clark Corporation Method and apparatus for detecting the placement of components on absorbent articles
US4876208A (en) * 1987-01-30 1989-10-24 Yellowstone Diagnostics Corporation Diffraction immunoassay apparatus and method
US4851816A (en) * 1987-02-24 1989-07-25 Helene Macias Crib death (SIDS) warning device
US5079600A (en) * 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
GB8705649D0 (en) * 1987-03-10 1987-04-15 Pa Consulting Services Assay sensor
US4812221A (en) * 1987-07-15 1989-03-14 Sri International Fast response time microsensors for gaseous and vaporous species
US4842633A (en) 1987-08-25 1989-06-27 Matsushita Electric Industrial Co., Ltd. Method of manufacturing molds for molding optical glass elements and diffraction gratings
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
US5057560A (en) * 1987-10-05 1991-10-15 Ciba-Geigy Corporation Thermotropic copolymer hydrogels from N,N-dimethylacrylamide and methoxy-ethyl (meth) acrylate
JP2763635B2 (en) 1988-02-08 1998-06-11 ユニバーシティ カレッジ カーディフ コンサルタンツ リミティド Detection of diamines in biological fluids
US5268306A (en) 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
US5391463A (en) * 1988-04-14 1995-02-21 The United States Of America As Represented By The Secretary Of The Navy Surface modification to create regions resistant to adsorption of biomolecules
DE68907519T2 (en) * 1988-05-10 1993-10-21 Amersham Int Plc Biosensors.
EP0341928A1 (en) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
GB8811919D0 (en) * 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
GB8813307D0 (en) * 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
US5089387A (en) * 1988-07-07 1992-02-18 Adeza Biomedical Corporation Dna probe diffraction assay and reagents
AT390517B (en) * 1988-08-04 1990-05-25 Avl Verbrennungskraft Messtech OPTICAL SENSOR AND METHOD FOR THE PRODUCTION THEREOF
EP0363504A1 (en) * 1988-10-10 1990-04-18 Dräger Nederland B.V. Method of providing a substrate with a layer comprising a polyvinylbased hydrogel and a biochemically active material
SE8804074D0 (en) * 1988-11-10 1988-11-10 Pharmacia Ab SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM
SE8902043L (en) * 1988-11-10 1990-05-11 Pharmacia Ab PROCEDURE CHARACTERIZES MACROMOLECULES
SE462454B (en) * 1988-11-10 1990-06-25 Pharmacia Ab METHOD FOR USE IN BIOSENSORS
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US4895017A (en) * 1989-01-23 1990-01-23 The Boeing Company Apparatus and method for early detection and identification of dilute chemical vapors
US5096671A (en) * 1989-03-15 1992-03-17 Cordis Corporation Fiber optic chemical sensors incorporating electrostatic coupling
US4999489A (en) 1989-03-17 1991-03-12 The Boeing Company Optical sensor using concave diffraction grating
US6416952B1 (en) * 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
GB9008261D0 (en) * 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
JPH0366384A (en) * 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk System for controlling release of physiologically active material
US5235238A (en) * 1989-08-10 1993-08-10 Dainabot Company, Limited Electrode-separated piezoelectric crystal oscillator and method for measurement using the electrode-separated piezoelectric crystal oscillator
US5225935A (en) 1989-10-30 1993-07-06 Sharp Kabushiki Kaisha Optical device having a microlens and a process for making microlenses
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
GB8927503D0 (en) 1989-12-04 1990-02-07 Kronem Systems Inc Enzyme-amplified lanthanide chelate luminescence
FR2656925B1 (en) * 1990-01-08 1992-05-15 Eg G MOISTURE SENSOR AND MEASUREMENT INSTALLATION COMPRISING A PLURALITY OF SUCH SENSORS.
US5922615A (en) * 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
EP0455067B1 (en) * 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Micro-optical sensor
DE69128786T2 (en) 1990-06-06 1998-08-20 Kol Ohr Corp Tunable light source and fiber optic systems with tunable light source
DE4024544A1 (en) 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh ANALYZING ELEMENT AND METHOD FOR THE PRODUCTION THEREOF
GB9019123D0 (en) 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5076094A (en) 1990-10-03 1991-12-31 The United States Of America As Represented By The United States Department Of Energy Dual output acoustic wave sensor for molecular identification
US5510481A (en) * 1990-11-26 1996-04-23 The Regents, University Of California Self-assembled molecular films incorporating a ligand
US5155791A (en) * 1990-12-07 1992-10-13 E. I. Du Pont De Nemours And Company Hybrid optical waveguides for phase-matched nonlinear wavelength conversion
GB9102646D0 (en) * 1991-02-07 1991-03-27 Fisons Plc Analytical device
DE69221758T2 (en) * 1991-03-22 1998-01-02 Seiko Instr Inc Electrochemical measuring device
US5196350A (en) * 1991-05-29 1993-03-23 Omnigene, Inc. Ligand assay using interference modulation
US5418136A (en) * 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
DE4202850A1 (en) 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh ANALYSIS ELEMENT FOR IMMUNOASSAYS
US5137609A (en) 1992-01-31 1992-08-11 Biometric Imaging Inc. Differential separation assay
DE59307719D1 (en) * 1992-03-23 1998-01-08 Siemens Ag Biosensor
US5304293A (en) * 1992-05-11 1994-04-19 Teknekron Sensor Development Corporation Microsensors for gaseous and vaporous species
US5321492A (en) 1992-08-07 1994-06-14 Miles Inc. Dual function readhead for a reflectance instrument
DK0588153T3 (en) 1992-09-14 1997-06-16 Siemens Ag The gas
US5402075A (en) * 1992-09-29 1995-03-28 Prospects Corporation Capacitive moisture sensor
US5351548A (en) * 1992-12-02 1994-10-04 Walbro Corporation Capacitive pressure sensor
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5430815A (en) * 1993-02-05 1995-07-04 Raychem Corporation Optical fiber water sensor
US5280548A (en) * 1993-03-11 1994-01-18 Boc Health Care, Inc. Emission based fiber optic sensors for pH and carbon dioxide analysis
DE4310142A1 (en) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologically active conjugates and a process for their preparation
US5552272A (en) * 1993-06-10 1996-09-03 Biostar, Inc. Detection of an analyte by fluorescence using a thin film optical device
US5658443A (en) * 1993-07-23 1997-08-19 Matsushita Electric Industrial Co., Ltd. Biosensor and method for producing the same
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5464741A (en) 1993-10-08 1995-11-07 Henwell, Inc. Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
US5352582A (en) * 1993-10-28 1994-10-04 Hewlett-Packard Company Holographic based bio-assay
US5455475A (en) * 1993-11-01 1995-10-03 Marquette University Piezoelectric resonant sensor using the acoustoelectric effect
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
JP3027770B2 (en) * 1994-03-05 2000-04-04 ロシュ ダイアグノスティックス ゲーエムベーハー Interference removers for use in immunoassays
AU692252B2 (en) * 1994-04-15 1998-06-04 Cobe Cardiovascular, Inc. Biocompatible coated article
US5514501A (en) * 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5489988A (en) * 1995-01-03 1996-02-06 Motorola Environmental sensor and method therefor
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
DE19507218C1 (en) * 1995-03-02 1996-08-22 Daimler Benz Ag Process for dividing and separating self-adhesive plastic composites
US6395558B1 (en) * 1996-08-29 2002-05-28 Zeptosens Ag Optical chemical/biochemical sensor
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
GB9624224D0 (en) * 1996-11-21 1997-01-08 Horsell Graphic Ind Ltd Planographic printing
US5922550A (en) * 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
JPH10244751A (en) * 1997-03-03 1998-09-14 Fuji Photo Film Co Ltd Ablation recording material
US6180288B1 (en) * 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
US6203758B1 (en) * 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
WO2000043552A2 (en) * 1999-01-25 2000-07-27 Ut-Battelle, Llc Multifunctional and multispectral biosensor devices and methods of use
US6790531B2 (en) * 1999-02-23 2004-09-14 Airbus France Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer
US6399295B1 (en) * 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US6423465B1 (en) * 2000-01-28 2002-07-23 International Business Machines Corporation Process for preparing a patterned continuous polymeric brush on a substrate surface
CA2403427C (en) * 2000-03-22 2013-04-30 M. Cynthia Goh Method and apparatus for assay for multiple analytes
DE10027776A1 (en) * 2000-06-07 2002-02-14 Roche Diagnostics Gmbh Novel core-shell particles
US20040058385A1 (en) * 2000-11-17 2004-03-25 Abel Andreas Peter Kit and method for determining multiple analytes, with provisions for refrencing the density of immobilised recognition elements

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478527A (en) * 1990-05-17 1995-12-26 Adeza Biomedical Corporation Highly reflective biogratings
WO1994003496A1 (en) * 1992-07-30 1994-02-17 Commonwealth Scientific And Industrial Research Organisation Biomaterials and biosensors containing immobilized modified antibodies
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors

Also Published As

Publication number Publication date
US8158408B2 (en) 2012-04-17
AU2003228555A1 (en) 2003-11-17
US20030207257A1 (en) 2003-11-06
TWI273230B (en) 2007-02-11
TW200402531A (en) 2004-02-16
US7485453B2 (en) 2009-02-03
US20090142826A1 (en) 2009-06-04
WO2003093495A2 (en) 2003-11-13

Similar Documents

Publication Publication Date Title
WO2003093822A3 (en) Device for closure of a vascular defect
CA2235183A1 (en) Device and apparatus for the simultaneous detection of multiple analytes
WO2004099383A3 (en) Chromatographic assay system
EP1285629A4 (en) Lancet-integrated sensor, measurer for lancet-integrated sensor, and cartridge
AU4701200A (en) A method of detecting an analyte using semiconductor nanocrystals
AU2002799A (en) Methods and apparatus for improved luminescence assays using microparticles
ATE331949T1 (en) BIOSENSOR
CA2318161A1 (en) Microfabricated aperture-based sensor
EP2267439B8 (en) Biosensor for quantifying a substrate
WO2007057664A3 (en) A method of patterning a thin film
WO2004067162A3 (en) Apparatus for microfluidic processing and reading of biochip arrays
WO1999053319A3 (en) High-density, miniaturized arrays and methods of manufacturing same
EP1426757A4 (en) Method, tool and device for measuring concentration
EP1464952A4 (en) Apparatus for stimulating an animal cell and recording its physiological signal and production and use methods thereof
WO2003034042A3 (en) Method of monitoring extent of cure of a coating
EP1094318A3 (en) DNA chip and method for producing the same
WO2003052130A3 (en) A method for determining the biological activity of defibrotide
WO2007052225A3 (en) Pillar based biosensor and method of making the same
WO2005004210A3 (en) Imprint lithography process and sensor
SE0400783D0 (en) Pattern method for biosensor applications
WO2003093495A3 (en) Diffraction-based diagnostic devices
WO2004007745A3 (en) Method for chemiluminescent detection
EP1251352A3 (en) Reaction apparatus and its use in a method of analyzing biologically active substances
ATE512564T1 (en) MOUNTING MEMBER, ELECTROLUMINescent DEVICE THEREFOR, AND SUBSTRATE FOR THE DEVICE
AU1492388A (en) Assay apparatus and use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP