WO2003095978A3 - Methods for time-alignment of liquid chromatography-mass spectrometry data - Google Patents

Methods for time-alignment of liquid chromatography-mass spectrometry data Download PDF

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Publication number
WO2003095978A3
WO2003095978A3 PCT/US2003/014729 US0314729W WO03095978A3 WO 2003095978 A3 WO2003095978 A3 WO 2003095978A3 US 0314729 W US0314729 W US 0314729W WO 03095978 A3 WO03095978 A3 WO 03095978A3
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WIPO (PCT)
Prior art keywords
alignment
time
methods
mass spectrometry
liquid chromatography
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Application number
PCT/US2003/014729
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French (fr)
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WO2003095978A2 (en
Inventor
Scott Norton
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Surromed Inc
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Publication date
Application filed by Surromed Inc filed Critical Surromed Inc
Priority to AU2003239409A priority Critical patent/AU2003239409A1/en
Priority to CA002484625A priority patent/CA2484625A1/en
Publication of WO2003095978A2 publication Critical patent/WO2003095978A2/en
Publication of WO2003095978A3 publication Critical patent/WO2003095978A3/en

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8665—Signal analysis for calibrating the measuring apparatus
    • G01N30/8668—Signal analysis for calibrating the measuring apparatus using retention times
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8644—Data segmentation, e.g. time windows
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/12—Classification; Matching

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method for comparing mass spectrometer data comprising the steps of obtaining raw data (22), time aligning data set pairs (26), and comparing the resultant spectra (28).
PCT/US2003/014729 2002-05-09 2003-05-09 Methods for time-alignment of liquid chromatography-mass spectrometry data WO2003095978A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003239409A AU2003239409A1 (en) 2002-05-09 2003-05-09 Methods for time-alignment of liquid chromatography-mass spectrometry data
CA002484625A CA2484625A1 (en) 2002-05-09 2003-05-09 Methods for time-alignment of liquid chromatography-mass spectrometry data

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37900302P 2002-05-09 2002-05-09
US60/379,003 2002-05-09

Publications (2)

Publication Number Publication Date
WO2003095978A2 WO2003095978A2 (en) 2003-11-20
WO2003095978A3 true WO2003095978A3 (en) 2004-02-05

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Family Applications (1)

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PCT/US2003/014729 WO2003095978A2 (en) 2002-05-09 2003-05-09 Methods for time-alignment of liquid chromatography-mass spectrometry data

Country Status (4)

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US (2) US6989100B2 (en)
AU (1) AU2003239409A1 (en)
CA (1) CA2484625A1 (en)
WO (1) WO2003095978A2 (en)

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