WO2003103813A3 - Materials and reactor systems having humidity and gas control - Google Patents

Materials and reactor systems having humidity and gas control Download PDF

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Publication number
WO2003103813A3
WO2003103813A3 PCT/US2003/017816 US0317816W WO03103813A3 WO 2003103813 A3 WO2003103813 A3 WO 2003103813A3 US 0317816 W US0317816 W US 0317816W WO 03103813 A3 WO03103813 A3 WO 03103813A3
Authority
WO
WIPO (PCT)
Prior art keywords
reactor
permeability
chip
cases
humidity
Prior art date
Application number
PCT/US2003/017816
Other languages
French (fr)
Other versions
WO2003103813A2 (en
Inventor
Seth T Rodgers
Peter A Russo
Howard Schreyer
Andrey J Zarur
Original Assignee
Bioprocessors Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprocessors Corp filed Critical Bioprocessors Corp
Priority to AU2003237427A priority Critical patent/AU2003237427A1/en
Priority to JP2004510929A priority patent/JP2005528212A/en
Priority to EP03736881A priority patent/EP1509315A2/en
Publication of WO2003103813A2 publication Critical patent/WO2003103813A2/en
Publication of WO2003103813A3 publication Critical patent/WO2003103813A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00907—Separation using membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00957—Compositions or concentrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/00981—Gas sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The present invention is directed to materials and reactor systems humidity and/or gas control. The material (20) may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip (10) or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site (12). The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers (22, 24). Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.
PCT/US2003/017816 2002-06-05 2003-06-05 Materials and reactor systems having humidity and gas control WO2003103813A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003237427A AU2003237427A1 (en) 2002-06-05 2003-06-05 Materials and reactor systems having humidity and gas control
JP2004510929A JP2005528212A (en) 2002-06-05 2003-06-05 Humidity and gas-fluid materials and reactor systems
EP03736881A EP1509315A2 (en) 2002-06-05 2003-06-05 Materials and reactor systems having humidity and gas control

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38632302P 2002-06-05 2002-06-05
US60/386,323 2002-06-05

Publications (2)

Publication Number Publication Date
WO2003103813A2 WO2003103813A2 (en) 2003-12-18
WO2003103813A3 true WO2003103813A3 (en) 2004-03-04

Family

ID=29736152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017816 WO2003103813A2 (en) 2002-06-05 2003-06-05 Materials and reactor systems having humidity and gas control

Country Status (4)

Country Link
EP (1) EP1509315A2 (en)
JP (1) JP2005528212A (en)
AU (1) AU2003237427A1 (en)
WO (1) WO2003103813A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6840069B2 (en) 2000-06-05 2005-01-11 Procter & Gamble Company Systems for controlling a drying cycle in a drying apparatus
US6828292B2 (en) 2000-06-05 2004-12-07 Procter & Gamble Company Domestic fabric article refreshment in integrated cleaning and treatment processes
US6670317B2 (en) 2000-06-05 2003-12-30 Procter & Gamble Company Fabric care compositions and systems for delivering clean, fresh scent in a lipophilic fluid treatment process
WO2005120698A2 (en) * 2004-06-07 2005-12-22 Bioprocessors Corp. Control of reactor environmental conditions
WO2006044368A1 (en) * 2004-10-12 2006-04-27 Bioprocessors Corp. Microreactors incorporating interpenetrating and/or semi-interpenetrating polymers
JP2007104975A (en) * 2005-10-14 2007-04-26 Toyo Seikan Kaisha Ltd Culture container and culture method
DE102006030068A1 (en) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Apparatus and method for the supply and removal of fluids in shaken microreactors arrays
JP2008194029A (en) * 2007-01-19 2008-08-28 Tosoh Corp Cell fusion apparatus and cell fusion method using the same
JP2013215152A (en) * 2012-04-11 2013-10-24 Vessel Inc Three-dimensional cell culture plate and method for producing the same
DE102018210370A1 (en) * 2018-06-26 2020-01-02 Irubis Gmbh Disposable bioreactor and its use

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173225A (en) * 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
US5254143A (en) * 1990-07-09 1993-10-19 Dainippon Ink And Chemical, Inc. Diaphragm for gas-liquid contact, gas-liquid contact apparatus and process for producing liquid containing gas dissolved therein
US5593632A (en) * 1991-05-27 1997-01-14 Seiji Kagawa Method of making a porous film
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
WO2000003805A1 (en) * 1998-07-15 2000-01-27 Combichem, Inc. Microtitre chemical reaction system
WO2000056870A1 (en) * 1999-03-23 2000-09-28 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
WO2001038559A2 (en) * 1999-11-23 2001-05-31 3M Innovative Properties Company Device for propagation and storage of microorganisms
US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
WO2001068257A1 (en) * 2000-03-10 2001-09-20 Bioprocessors Corporation Microreactor
US20010024821A1 (en) * 1999-12-09 2001-09-27 Potter Steve M. Sealed culture chamber
WO2002011880A2 (en) * 2000-08-09 2002-02-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microreactor device for solid-phase supported synthesis and microreactor system comprising individual microreactor devices
WO2002057200A2 (en) * 2000-08-15 2002-07-25 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173225A (en) * 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
US5254143A (en) * 1990-07-09 1993-10-19 Dainippon Ink And Chemical, Inc. Diaphragm for gas-liquid contact, gas-liquid contact apparatus and process for producing liquid containing gas dissolved therein
US5593632A (en) * 1991-05-27 1997-01-14 Seiji Kagawa Method of making a porous film
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2000003805A1 (en) * 1998-07-15 2000-01-27 Combichem, Inc. Microtitre chemical reaction system
WO2000056870A1 (en) * 1999-03-23 2000-09-28 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
WO2001038559A2 (en) * 1999-11-23 2001-05-31 3M Innovative Properties Company Device for propagation and storage of microorganisms
US20010024821A1 (en) * 1999-12-09 2001-09-27 Potter Steve M. Sealed culture chamber
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
WO2001068257A1 (en) * 2000-03-10 2001-09-20 Bioprocessors Corporation Microreactor
WO2002011880A2 (en) * 2000-08-09 2002-02-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microreactor device for solid-phase supported synthesis and microreactor system comprising individual microreactor devices
WO2002057200A2 (en) * 2000-08-15 2002-07-25 Bioforce Nanosciences, Inc. Nanoscale molecular arrayer

Also Published As

Publication number Publication date
WO2003103813A2 (en) 2003-12-18
JP2005528212A (en) 2005-09-22
EP1509315A2 (en) 2005-03-02
AU2003237427A1 (en) 2003-12-22
AU2003237427A8 (en) 2003-12-22

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