WO2003105658A3 - Methods and systems for management of alzheimer's disease - Google Patents

Methods and systems for management of alzheimer's disease Download PDF

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Publication number
WO2003105658A3
WO2003105658A3 PCT/IL2003/000508 IL0300508W WO03105658A3 WO 2003105658 A3 WO2003105658 A3 WO 2003105658A3 IL 0300508 W IL0300508 W IL 0300508W WO 03105658 A3 WO03105658 A3 WO 03105658A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
disease
alzheimer
management
systems
Prior art date
Application number
PCT/IL2003/000508
Other languages
French (fr)
Other versions
WO2003105658A2 (en
Inventor
Alon Shalev
Original Assignee
Brainsgate Ltd
Alon Shalev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/294,310 external-priority patent/US7146209B2/en
Application filed by Brainsgate Ltd, Alon Shalev filed Critical Brainsgate Ltd
Priority to AU2003241131A priority Critical patent/AU2003241131A1/en
Priority to EP03730451A priority patent/EP1521614A2/en
Priority to CA002489341A priority patent/CA2489341A1/en
Publication of WO2003105658A2 publication Critical patent/WO2003105658A2/en
Publication of WO2003105658A3 publication Critical patent/WO2003105658A3/en
Priority to US10/952,536 priority patent/US20050159790A1/en
Priority to IL16576404A priority patent/IL165764A0/en
Priority to US10/518,322 priority patent/US7640062B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin

Abstract

Methods of diagnosing and treating Alzheimer's disease (AD) are provided. The methods include stimulating the sphenopalatine ganglion (SPG) (6) of a subject with an olfactory or electrical stimulator (4) so that the concentration of a substance in the subject's brain changes.
PCT/IL2003/000508 2000-05-08 2003-06-13 Methods and systems for management of alzheimer's disease WO2003105658A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003241131A AU2003241131A1 (en) 2002-06-14 2003-06-13 Methods and systems for management of alzheimer's disease
EP03730451A EP1521614A2 (en) 2002-06-14 2003-06-13 Methods and systems for management of alzheimer's disease
CA002489341A CA2489341A1 (en) 2002-06-14 2003-06-13 Methods and systems for management of alzheimer's disease
US10/952,536 US20050159790A1 (en) 2000-05-08 2004-09-27 Stimulation for treating and diagnosing conditions
IL16576404A IL165764A0 (en) 2002-06-14 2004-12-14 Methods and systems for managment of Alzheimers disease
US10/518,322 US7640062B2 (en) 2000-05-08 2005-07-08 Methods and systems for management of alzheimer's disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38893102P 2002-06-14 2002-06-14
US60/388,931 2002-06-14
US10/294,310 2002-11-14
US10/294,310 US7146209B2 (en) 2000-05-08 2002-11-14 Stimulation for treating eye pathologies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/952,536 Continuation-In-Part US20050159790A1 (en) 2000-05-08 2004-09-27 Stimulation for treating and diagnosing conditions

Publications (2)

Publication Number Publication Date
WO2003105658A2 WO2003105658A2 (en) 2003-12-24
WO2003105658A3 true WO2003105658A3 (en) 2004-03-18

Family

ID=29739267

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000508 WO2003105658A2 (en) 2000-05-08 2003-06-13 Methods and systems for management of alzheimer's disease

Country Status (4)

Country Link
EP (1) EP1521614A2 (en)
AU (1) AU2003241131A1 (en)
CA (1) CA2489341A1 (en)
WO (1) WO2003105658A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
JP7265591B2 (en) 2017-05-30 2023-04-26 森永乳業株式会社 Composition for improving brain function

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7117033B2 (en) * 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
WO2001085094A2 (en) 2000-05-08 2001-11-15 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US7684859B2 (en) 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US7616990B2 (en) * 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
CN102898519B (en) 2005-11-30 2015-10-28 Abbvie公司 Monoclonal antibody of anti-amyloid beta protein and uses thereof
US7965180B2 (en) 2006-09-28 2011-06-21 Semiconductor Energy Laboratory Co., Ltd. Wireless sensor device
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
WO2011024159A2 (en) 2009-08-24 2011-03-03 Refael Hof Phase-change and shape-change materials
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
CN107206082B (en) 2014-11-25 2022-01-11 纽菲斯有限公司 Phase-change nanoparticles
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792100A (en) * 1995-05-19 1998-08-11 Shantha; T. R. Treatment method for transsphenoidal stimulation of the pituitary gland and of nerve structures
US6325475B1 (en) * 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
US6338715B1 (en) * 1999-03-31 2002-01-15 Microfab Technologies, Inc. Digital olfactometer and method for testing olfactory thresholds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287793B1 (en) 1988-08-19 2001-09-11 Elan Pharmaceuticals, Inc. Diagnostic methods for alzheimer's disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792100A (en) * 1995-05-19 1998-08-11 Shantha; T. R. Treatment method for transsphenoidal stimulation of the pituitary gland and of nerve structures
US6325475B1 (en) * 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
US6338715B1 (en) * 1999-03-31 2002-01-15 Microfab Technologies, Inc. Digital olfactometer and method for testing olfactory thresholds

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
JP7265591B2 (en) 2017-05-30 2023-04-26 森永乳業株式会社 Composition for improving brain function

Also Published As

Publication number Publication date
CA2489341A1 (en) 2003-12-24
WO2003105658A2 (en) 2003-12-24
AU2003241131A1 (en) 2003-12-31
AU2003241131A8 (en) 2003-12-31
EP1521614A2 (en) 2005-04-13

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