WO2003105768A3 - Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus - Google Patents

Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus Download PDF

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Publication number
WO2003105768A3
WO2003105768A3 PCT/US2003/018763 US0318763W WO03105768A3 WO 2003105768 A3 WO2003105768 A3 WO 2003105768A3 US 0318763 W US0318763 W US 0318763W WO 03105768 A3 WO03105768 A3 WO 03105768A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypoglycemic episodes
subject
insulin
treatment
methods
Prior art date
Application number
PCT/US2003/018763
Other languages
French (fr)
Other versions
WO2003105768A2 (en
Inventor
James Gordon Still
Gordana Kosutic
Original Assignee
Nobex Corp
James Gordon Still
Gordana Kosutic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp, James Gordon Still, Gordana Kosutic filed Critical Nobex Corp
Priority to AU2003236521A priority Critical patent/AU2003236521A1/en
Publication of WO2003105768A2 publication Critical patent/WO2003105768A2/en
Publication of WO2003105768A3 publication Critical patent/WO2003105768A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.
PCT/US2003/018763 2002-06-13 2003-06-13 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus WO2003105768A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003236521A AU2003236521A1 (en) 2002-06-13 2003-06-13 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38898802P 2002-06-13 2002-06-13
US60/388,988 2002-06-13

Publications (2)

Publication Number Publication Date
WO2003105768A2 WO2003105768A2 (en) 2003-12-24
WO2003105768A3 true WO2003105768A3 (en) 2004-03-11

Family

ID=29736572

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018763 WO2003105768A2 (en) 2002-06-13 2003-06-13 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus

Country Status (3)

Country Link
US (1) US7601688B2 (en)
AU (1) AU2003236521A1 (en)
WO (1) WO2003105768A2 (en)

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US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
CA2526957C (en) * 2003-07-25 2011-07-12 Conjuchem Inc. Long lasting insulin derivatives and methods thereof
US20050266031A1 (en) * 2004-05-25 2005-12-01 Jay Dickerson Pharmaceutical suspension composition
ES2435522T3 (en) 2005-02-02 2013-12-20 Novo Nordisk A/S Insulin derivatives
US20070031373A1 (en) * 2005-08-04 2007-02-08 Carlos Lopez Reversal of Adult Onset Disorders with Granulocyte-Colony Stimulating Factors
BRPI0713426A2 (en) 2006-06-14 2012-10-09 Macrogenics Inc methods of treating, slowing the progression, or ameliorating one or more symptoms of a disorder, and preventing or delaying the onset of a disorder
EP2049149B1 (en) * 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
CA2663074A1 (en) * 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
WO2008101172A2 (en) * 2007-02-16 2008-08-21 Ohio University System and method for managing diabetes
EP2152245B1 (en) * 2007-04-30 2015-12-02 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2008145730A1 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
US9260502B2 (en) * 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
PL2910570T3 (en) 2008-03-18 2017-06-30 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
AU2013247047A1 (en) 2012-04-11 2014-10-23 Novo Nordisk A/S Insulin formulations
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
CN110087674B (en) 2016-12-16 2023-01-03 诺和诺德股份有限公司 Pharmaceutical composition containing insulin

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Also Published As

Publication number Publication date
AU2003236521A1 (en) 2003-12-31
WO2003105768A2 (en) 2003-12-24
US7601688B2 (en) 2009-10-13
US20040038867A1 (en) 2004-02-26
AU2003236521A8 (en) 2003-12-31

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