WO2004000420A1 - Laser beam homogenisers in medical applications - Google Patents

Laser beam homogenisers in medical applications Download PDF

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Publication number
WO2004000420A1
WO2004000420A1 PCT/AU2003/000791 AU0300791W WO2004000420A1 WO 2004000420 A1 WO2004000420 A1 WO 2004000420A1 AU 0300791 W AU0300791 W AU 0300791W WO 2004000420 A1 WO2004000420 A1 WO 2004000420A1
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WO
WIPO (PCT)
Prior art keywords
laser
laser beam
homogeniser
treatment
apparent source
Prior art date
Application number
PCT/AU2003/000791
Other languages
French (fr)
Inventor
Richard Walmsley
Original Assignee
Riancorp Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riancorp Pty Ltd filed Critical Riancorp Pty Ltd
Priority to AU2003238546A priority Critical patent/AU2003238546A1/en
Priority to US10/519,181 priority patent/US7758570B2/en
Publication of WO2004000420A1 publication Critical patent/WO2004000420A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B2018/2255—Optical elements at the distal end of probe tips
    • A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light

Definitions

  • This invention relates to laser systems and in particular to lasers used in the medical field.
  • Laser emitting devices that do not fall within the Class I definition require the device and the user, and in medical applications the patient, to use or be subject to one or more of the following: use of safety spectacles, interlock systems, warning lights, etc.
  • Laser emitting devices have a wide range of wavelength, energy and pulse characteristics and the classification system is a guide as to the way in which each device having one or more of those characteristics can be used and by whom the device can be used.
  • a Class I laser-emitting device can be used without restriction but in accordance with the manufacturer's instructions for the purpose for which it was designed. This means that special training and additional safety equipment is not required. Thus operating costs are less when compared to the attendant operating costs of other classes of laser- emitting devices.
  • a major consideration when designing laser-err ⁇ tting devices is the amount of power that the source laser in the device is required to emit so as to provide adequate laser emission power from the laser device.
  • One of the determinants of this characteristic is the required power density to be delivered at the application site over a desired area.
  • the apparent aperture of the laser source Apart from the power, pulse parameters and wavelength of the laser, another of the critical features in specifying the class of the laser is the apparent aperture of the laser source.
  • the apparent aperture will determine the image size that the laser source can form for example on the retina of an inadvertent observer.
  • the emitting aperture (the area of the spot beam) of the laser radiation is typically 7 x 1 microns for a 904 nanometer Gallium Arsenide (Ga-As) laser diode.
  • Ga-As Gallium Arsenide
  • These devices typically have pulsed outputs with 1 and 5 Watt peak powers with the pulse repetition and duration being variable to suit the application.
  • the device type described above is an example of such devices.
  • the present invention provides a device for a medical diagnostic or therapeutic purpose, said device including: laser generating means for generating a laser beam, said laser generating means having an apparent source size; homogenising means for modifying said laser beam; wherein said modifying adjusts the apparent source size of said laser beam.
  • the homogenising means further modifies a spot size of said laser beam.
  • the apparent source size of said laser beam is greater than that required as a minimum condition for classification of said device as a Class I laser.
  • the homogenizing means includes an optical homogeniser.
  • the optical homogeniser includes a microlens array.
  • the optical homogeniser includes a holographic diffuser.
  • the device further includes positioning means for positioning said device at a predetermined distance and orientation from a surface according to a requirement of said medical purpose.
  • Fig 1 depicts use of a preferred embodiment of the invention for the treatment of lymphodeama
  • Fig 2 depicts a generic arrangement of a preferred laser-emitting device according to the invention.
  • low power level laser radiation is known to have beneficial medical effects in some disease and restorative therapies.
  • lymphoedema other examples include use of low level laser therapy to induce a photochemical reaction (non-heating) which is used in the treatment of conditions like tendonitis and other soft tissue injuries, wound healing and pain relief.
  • photochemical reaction non-heating
  • the frequency, power level (continuously on or modulated on/ off duty cycle of the radiation at the same or changing levels) and characteristics of the laser are determined by the nature of the treatment outcome desired by a clinician.
  • the area of effective laser irradiation on the relevant tissue or organ of the patient is a matter of design and specification by the clinician.
  • Laser source emitting 600-1000 nanometers wavelength at lmW to 1W power can be used.
  • Such devices are usually class IIIB but by using the invention described herein will become Class 1.
  • the laser source is a Gallium Arsenide Laser diode having an emitting aperture of 7 x 1 microns of 904 nanometer wavelength having 5- Watts peak power.
  • the laser output is modulated or controlled to have a low 2,500 Hz and high 5,000 Hz repetition rate of 200-nanosecond duration. Such a device falls near the Class I and adjacent Class IIIB boundary.
  • the operator holds the treatment device 20 incorporating the laser emitting device 10 so that the apparent aperture is moved in a predetermined path over the patient's treatment area.
  • the treatment area is usually the tissue in near vicinity of the potentially or actually diseased lymph nodes, under the patients arm (as shown) or the groin area are examples of treatment sites.
  • the treatment device 20 may include a plastic or metal frame 18 that has an abutment surface that is positioned on the treatment area to be irradiated whilst the other end is fixed relative to treatment device 20.
  • the invention includes the use of an optical homogeniser such as for example a CORNINGTM high performance microlens array.
  • an optical homogeniser such as for example a CORNINGTM high performance microlens array.
  • a specification of its characteristics includes that it is made from either fused silica, silicon or polymer-on-silica. It has a center to center spacing tolerance of less than 1 micrometer and a total run-out over maximum substrate diameter of 150 mm and minimum substrate thickness of 400 micrometers.
  • Characteristics of the microlens are as follows. It can be spherical or aspherical and is designed with a polymer surface irregularity less than one quarter of a wavelength at 633 nanometers. For the silicon oxide (Si ⁇ 2) variety at least 97% of the lens surface has a surface irregularity of less than one half of a wavelength at 633 nanometers.
  • the focal length for a microlens can be designed to vary between 1.5 mm and 6.0 mm at wavelengths greater than or equal to 200 micrometers.
  • the focal length tolerance in air for a polymer microlens is plus or minus 10 micrometers within the array and plus or minus 25 micrometers when measured array to array.
  • the focal length tolerance in air is plus or minus 50 micrometers within the array and plus or minus 50 micrometers when measured array to array.
  • Clear aperture dimension is less than or equal to 1.3 mm and surface roughness is less than 100 Angstroms A°(Ra).
  • the operating temperature is permitted to be between 0 and 70°C.
  • the surface relief dif fuser version of the microlens array is used in preferred arrangements that are designed to spread light in a predeterrnined gain distribution. Both symmetric and asymmetric surface relief diffusers can be used dependent on the application. This is not the only type of homogeniser that can be used, there are other fabrication techniques such as holographic diffusers. The important aspect is that the homogeniser acts like a near perfect diffuser thus causing the apparent aperture to be the homogeniser not the aperture of the emitting device.
  • the apparent aperture of the source laser device is made uniformly larger to the order of 6 mm 2 .
  • the preferred distance between the laser source aperture and the optical homogeniser is 5 mm. This accounts for the divergence of the source laser beam and as a result the apparent aperture and power distribution is such that the full device falls well within Class I limits.
  • Fig. 2 displays the laser source 10 and a homogeniser element 12 located a distance Dl from the laser source.
  • the slightly divergent laser beam 14 from the source is exaggerated for the purpose of illustration only.
  • the resultant laser beam power distribution is pictorially shown at 16 a distance D2 from the homogeniser element.
  • a larger area can be treated at the same time, thus reducing treatment time and complexity of movement. This further benefits the patient, as the period of potential discomfort is minirnized.

Abstract

A device is disclosed usable for low level laser therapy to induce a photochemical reaction (non-heating) which is used in the treatment of conditions like tendonitis and other soft tissue injuries, wound healing and pain relief. The arrangement proposed will allow the device to be a Class I laser device thus providing long term minimization of the running costs of the device. The device includes a laser generating means (10) for generating a laser beam (14), the laser generating means (10) having an apparent source size and homogenising means (12) for modifying the laser beam (14) for modifying the apparent source size of the laser beam (14).

Description

LASER BEAM HOMOGENISERS IN MEDICAL APPLICATIONS
FIELD OF THE INVENTION
This invention relates to laser systems and in particular to lasers used in the medical field.
BACKGROUND OF THE INVENTION
Safety when using or being exposed to lasers is a very important consideration. International Standards exist with regards to the classification of laser devices and the way in which different classes of laser can be used. Those laser devices that conform to the laser safety Class I definition (ie IEC825-1, AS2211) are considered the safest.
Laser emitting devices that do not fall within the Class I definition require the device and the user, and in medical applications the patient, to use or be subject to one or more of the following: use of safety spectacles, interlock systems, warning lights, etc.
Laser emitting devices have a wide range of wavelength, energy and pulse characteristics and the classification system is a guide as to the way in which each device having one or more of those characteristics can be used and by whom the device can be used.
A Class I laser-emitting device can be used without restriction but in accordance with the manufacturer's instructions for the purpose for which it was designed. This means that special training and additional safety equipment is not required. Thus operating costs are less when compared to the attendant operating costs of other classes of laser- emitting devices.
A major consideration when designing laser-errύtting devices is the amount of power that the source laser in the device is required to emit so as to provide adequate laser emission power from the laser device. One of the determinants of this characteristic is the required power density to be delivered at the application site over a desired area.
As the area required to be treated increases for a required power density so does the power of the source laser needed to support that requirement.
Apart from the power, pulse parameters and wavelength of the laser, another of the critical features in specifying the class of the laser is the apparent aperture of the laser source. The apparent aperture will determine the image size that the laser source can form for example on the retina of an inadvertent observer.
The requirement described above is sometimes referred to as the apparent source and it is this characteristic that is used to determine the class of the laser-emitting device.
Current laser device configurations are restricted somewhat by the physics of the devices used to generate the source laser. For diode laser sources, the emitting aperture (the area of the spot beam) of the laser radiation is typically 7 x 1 microns for a 904 nanometer Gallium Arsenide (Ga-As) laser diode. These devices typically have pulsed outputs with 1 and 5 Watt peak powers with the pulse repetition and duration being variable to suit the application. There are many other laser diode configurations, the device type described above is an example of such devices.
In some applications it is desired to not only provide the laser radiation over a larger area but also to control the power density thus requiring an adequately high power laser source.
It is an aim of the invention described herein to provide a laser emitting device that meets not only a desired power density and spot area requirement, but that meets Class I requirements thus providing long term minimization of the running costs of the device. SUMMARY OF THE INVENTION
Accordingly the present invention provides a device for a medical diagnostic or therapeutic purpose, said device including: laser generating means for generating a laser beam, said laser generating means having an apparent source size; homogenising means for modifying said laser beam; wherein said modifying adjusts the apparent source size of said laser beam.
Preferably the homogenising means further modifies a spot size of said laser beam.
Preferably the apparent source size of said laser beam is greater than that required as a minimum condition for classification of said device as a Class I laser.
Preferably the homogenizing means includes an optical homogeniser.
Preferably the optical homogeniser includes a microlens array.
Optionally the optical homogeniser includes a holographic diffuser.
Preferably the device further includes positioning means for positioning said device at a predetermined distance and orientation from a surface according to a requirement of said medical purpose.
BRIEF DESCRIPTION OF THE FIGURES
Specific embodiments of the invention will now be described in some further detail with reference to and as illustrated in the accompanying figures. These embodiments are illustrative, and not meant to be restrictive of the scope of the invention. Suggestions and descriptions of other embodiments may be included within the scope of the invention but they may not be illustrated in the accompanying figures or alternatively features of the invention may be shown in the figures but not described in the specification.
Fig 1 depicts use of a preferred embodiment of the invention for the treatment of lymphodeama; and
Fig 2 depicts a generic arrangement of a preferred laser-emitting device according to the invention.
DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT
Although a particular medical application is described herein and a particular laser emitting device configuration is also described, it should be understood that these details are illustrative only and not meant to be limiting in any way upon the application or configuration of the principle of the invention.
In the medical field, low power level laser radiation is known to have beneficial medical effects in some disease and restorative therapies.
One example is the treatment of lymphoedema other examples include use of low level laser therapy to induce a photochemical reaction (non-heating) which is used in the treatment of conditions like tendonitis and other soft tissue injuries, wound healing and pain relief.
Clearly, the frequency, power level (continuously on or modulated on/ off duty cycle of the radiation at the same or changing levels) and characteristics of the laser are determined by the nature of the treatment outcome desired by a clinician.
The area of effective laser irradiation on the relevant tissue or organ of the patient is a matter of design and specification by the clinician. Laser source emitting 600-1000 nanometers wavelength at lmW to 1W power can be used. Such devices are usually class IIIB but by using the invention described herein will become Class 1.
In a preferred arrangement the laser source is a Gallium Arsenide Laser diode having an emitting aperture of 7 x 1 microns of 904 nanometer wavelength having 5- Watts peak power. In a lymphoedema application such as depicted in Fig 2, the laser output is modulated or controlled to have a low 2,500 Hz and high 5,000 Hz repetition rate of 200-nanosecond duration. Such a device falls near the Class I and adjacent Class IIIB boundary.
As shown in Fig 1, in this type of medical procedure the operator holds the treatment device 20 incorporating the laser emitting device 10 so that the apparent aperture is moved in a predetermined path over the patient's treatment area. The treatment area is usually the tissue in near vicinity of the potentially or actually diseased lymph nodes, under the patients arm (as shown) or the groin area are examples of treatment sites. The treatment device 20 may include a plastic or metal frame 18 that has an abutment surface that is positioned on the treatment area to be irradiated whilst the other end is fixed relative to treatment device 20.
There is exists a slight divergence of the laser beam which is factored into the design, the amount of divergence being directly proportional to the distance between the output aperture of the laser diode and the patient's treatment site.
The invention includes the use of an optical homogeniser such as for example a CORNING™ high performance microlens array. A specification of its characteristics includes that it is made from either fused silica, silicon or polymer-on-silica. It has a center to center spacing tolerance of less than 1 micrometer and a total run-out over maximum substrate diameter of 150 mm and minimum substrate thickness of 400 micrometers.
Characteristics of the microlens are as follows. It can be spherical or aspherical and is designed with a polymer surface irregularity less than one quarter of a wavelength at 633 nanometers. For the silicon oxide (Siθ2) variety at least 97% of the lens surface has a surface irregularity of less than one half of a wavelength at 633 nanometers.
The focal length for a microlens can be designed to vary between 1.5 mm and 6.0 mm at wavelengths greater than or equal to 200 micrometers. The focal length tolerance in air for a polymer microlens is plus or minus 10 micrometers within the array and plus or minus 25 micrometers when measured array to array. For a Si02 array the focal length tolerance in air is plus or minus 50 micrometers within the array and plus or minus 50 micrometers when measured array to array.
Clear aperture dimension is less than or equal to 1.3 mm and surface roughness is less than 100 Angstroms A°(Ra). The operating temperature is permitted to be between 0 and 70°C.
The surface relief dif fuser version of the microlens array is used in preferred arrangements that are designed to spread light in a predeterrnined gain distribution. Both symmetric and asymmetric surface relief diffusers can be used dependent on the application. This is not the only type of homogeniser that can be used, there are other fabrication techniques such as holographic diffusers. The important aspect is that the homogeniser acts like a near perfect diffuser thus causing the apparent aperture to be the homogeniser not the aperture of the emitting device.
In the subject application the apparent aperture of the source laser device is made uniformly larger to the order of 6 mm2. The preferred distance between the laser source aperture and the optical homogeniser is 5 mm. This accounts for the divergence of the source laser beam and as a result the apparent aperture and power distribution is such that the full device falls well within Class I limits.
Fig. 2 displays the laser source 10 and a homogeniser element 12 located a distance Dl from the laser source. The slightly divergent laser beam 14 from the source is exaggerated for the purpose of illustration only. The resultant laser beam power distribution is pictorially shown at 16 a distance D2 from the homogeniser element.
Having the arrangement described allows for the power output of the source laser to be increased allowing the ideal required power distribution to be homogeneously distributed over a much greater area than would otherwise be the case. This in turn allows the total laser-radiating device to remain within the Class I laser classification. This ultimately reduces cost to the patient.
A larger area can be treated at the same time, thus reducing treatment time and complexity of movement. This further benefits the patient, as the period of potential discomfort is minirnized.
It will be appreciated by those skilled in the art that the invention is not restricted in its use to the particular application described. Neither is the present invention restricted in its preferred embodiment with regard to the particular elements and/ or features described or depicted herein. It will be appreciated that various modifications can be made without departing from the principles of the invention. Therefore, the invention should be understood to include all such modifications within its scope.

Claims

1. A device for a medical diagnostic or therapeutic purpose, said device including: laser generating means for generating a laser beam, said laser generating means having an apparent source size; homogenising means for modifying said laser beam; wherein said modifying adjusts the apparent source size of said laser beam.
2. A device as claimed in claim 1, wherein said homogenising means further modifies a spot size of said laser beam.
3. A device as claimed in claim 1 or 2, wherein said apparent source size of said laser beam is greater than that required as a minimum condition for classification of said device as a Class I laser.
4. A device as claimed in any one of claims 1 to 3, wherein said laser generating means includes a laser emitting diode.
5. A device as claimed in any one of claims 1 to 4, wherein said homogenizing means includes an optical homogeniser.
6. A device as claimed in claim 5, wherein said optical homogeniser includes a microlens array.
7. A device as claimed in claim 5, wherein said optical homogeniser includes a holographic diffuser.
8. A device as claimed in any one of the preceding claims wherein said medical diagnostic or therapeutic purpose is the treatment of conditions ameliorated by photochemical low level laser therapy.
9. A device as claimed in any one of the preceding claims wherein said medical diagnostic or therapeutic process is the treatment of lymphoedema.
10. A device as claimed in any one of the preceding claims further including a positioning means for positioning said device at a predetermined distance and orientation from a surface according to a requirement of said medical purpose.
11. A device as claimed in claim 10, wherein said positioning means includes a frame, said frame adjustably attached to said device and when in use for a medical diagnostic or therapeutic purpose providing an abutment surface relative to said treatment area:
12.. A device substantially as herein described with reference to any one of the Embodiments of the invention illustrated in the accompanying drawings.
PCT/AU2003/000791 2002-06-25 2003-06-25 Laser beam homogenisers in medical applications WO2004000420A1 (en)

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AU2003238546A AU2003238546A1 (en) 2002-06-25 2003-06-25 Laser beam homogenisers in medical applications
US10/519,181 US7758570B2 (en) 2002-06-25 2003-06-25 Laser beam homogenisers in medical applications

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AUPS3138 2002-06-25

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WO2006108093A2 (en) * 2005-04-06 2006-10-12 Board Of Trustees Of Michigan State University A system for low-level laser radiation

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AU2003238546A1 (en) 2004-01-06
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US20060100676A1 (en) 2006-05-11

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