WO2004002547A3 - Drug-eluting stents for treating vulnerable coronary plaques - Google Patents

Drug-eluting stents for treating vulnerable coronary plaques Download PDF

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Publication number
WO2004002547A3
WO2004002547A3 PCT/US2003/020010 US0320010W WO2004002547A3 WO 2004002547 A3 WO2004002547 A3 WO 2004002547A3 US 0320010 W US0320010 W US 0320010W WO 2004002547 A3 WO2004002547 A3 WO 2004002547A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
stent
eluting
layer
release
Prior art date
Application number
PCT/US2003/020010
Other languages
French (fr)
Other versions
WO2004002547A2 (en
Inventor
David R Fischell
John J Spaltro
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Priority to AU2003253696A priority Critical patent/AU2003253696A1/en
Priority to EP03762027A priority patent/EP1534357A2/en
Priority to CA002490898A priority patent/CA2490898A1/en
Priority to MXPA05000203A priority patent/MXPA05000203A/en
Priority to JP2004517804A priority patent/JP2005537044A/en
Publication of WO2004002547A2 publication Critical patent/WO2004002547A2/en
Publication of WO2004002547A3 publication Critical patent/WO2004002547A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers

Abstract

A drug-eluting intravascular stent comprising an anti-restenosis agent covered by a biodegradable coating, and a method for treating vulnerable plaque in coronary vessels using said stent is disclosed. The biodegradable layer covers at least a portion of the drug-eluting layer of the stent, and is adapted to slowly erode over a preset period of time, preventing the release of therapeutic amounts of the anti-restenosis agent from the drug-eluting layer during the preset period. By delaying the release of the anti-restenosis agent, a thin layer of neointima will grow during the preset period. This tissue growth is sufficient to encapsulate the stent and cover the vulnerable plaque, but not significant enough to cause harmful restenosis or occlusion of the vessel. Once the biodegradable coating is eroded, the anti-restenosis agent begins release from the drug-eluting layer, and the progression of neointimal hyperplasia ceases.
PCT/US2003/020010 2002-06-28 2003-06-24 Drug-eluting stents for treating vulnerable coronary plaques WO2004002547A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003253696A AU2003253696A1 (en) 2002-06-28 2003-06-24 Drug-eluting stents for treating vulnerable coronary plaques
EP03762027A EP1534357A2 (en) 2002-06-28 2003-06-24 Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents
CA002490898A CA2490898A1 (en) 2002-06-28 2003-06-24 Drug-eluting stents for treating vulnerable coronary plaques
MXPA05000203A MXPA05000203A (en) 2002-06-28 2003-06-24 Drug-eluting stents for treating vulnerable coronary plaques.
JP2004517804A JP2005537044A (en) 2002-06-28 2003-06-24 Method and apparatus for treating coronary vulnerable plaque using a drug eluting stent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/185,021 US20040002755A1 (en) 2002-06-28 2002-06-28 Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents
US10/185,021 2002-06-28

Publications (2)

Publication Number Publication Date
WO2004002547A2 WO2004002547A2 (en) 2004-01-08
WO2004002547A3 true WO2004002547A3 (en) 2004-04-01

Family

ID=29779499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020010 WO2004002547A2 (en) 2002-06-28 2003-06-24 Drug-eluting stents for treating vulnerable coronary plaques

Country Status (9)

Country Link
US (2) US20040002755A1 (en)
EP (1) EP1534357A2 (en)
JP (1) JP2005537044A (en)
CN (1) CN1678359A (en)
AU (1) AU2003253696A1 (en)
CA (1) CA2490898A1 (en)
MX (1) MXPA05000203A (en)
TW (1) TW200404527A (en)
WO (1) WO2004002547A2 (en)

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Also Published As

Publication number Publication date
MXPA05000203A (en) 2005-09-30
US20050113907A1 (en) 2005-05-26
WO2004002547A2 (en) 2004-01-08
CA2490898A1 (en) 2004-01-08
JP2005537044A (en) 2005-12-08
US20040002755A1 (en) 2004-01-01
CN1678359A (en) 2005-10-05
EP1534357A2 (en) 2005-06-01
TW200404527A (en) 2004-04-01
AU2003253696A1 (en) 2004-01-19

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