WO2004003160A3 - Use of adhesion molecules as bond stress-enhanced nanoscale binding switches - Google Patents

Use of adhesion molecules as bond stress-enhanced nanoscale binding switches Download PDF

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Publication number
WO2004003160A3
WO2004003160A3 PCT/US2003/020434 US0320434W WO2004003160A3 WO 2004003160 A3 WO2004003160 A3 WO 2004003160A3 US 0320434 W US0320434 W US 0320434W WO 2004003160 A3 WO2004003160 A3 WO 2004003160A3
Authority
WO
WIPO (PCT)
Prior art keywords
adhesion molecules
force
binding
changing
adhesion
Prior art date
Application number
PCT/US2003/020434
Other languages
French (fr)
Other versions
WO2004003160A2 (en
Inventor
Viola Vogel
Wendy Thomas
Manu Forero
Evgeni Sokurenko
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority to AU2003256329A priority Critical patent/AU2003256329A1/en
Publication of WO2004003160A2 publication Critical patent/WO2004003160A2/en
Publication of WO2004003160A3 publication Critical patent/WO2004003160A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

Methods, compositions and devices are provided based on changing the binding strength of an adhesion molecule to a ligand by changing the force exerted on the bound complex between adhesion molecule and ligand, for example by changing the shear stress acting on the complex. The adhesion molecules and their ligands of this invention bind more tightly when a force-activated bond stress, such as shear force, applied to the adhesion molecules is increased, and bond less tightly when the stress is decreased. The adhesion molecules can be isolated from their sources in nature or can remain attached to their natural sources. They can be engineered, e.g., by altering their amino acid sequences or by binding to antibodies or other particles, to alter their binding properties. They can be attached to a wide range of substrates including particles and device surfaces to form adhesive systems which are capable of sticking to other particles and/or device surfaces to which ligands for the adhesion molecules have been attached. The adhesion molecules and ligands described herein can be used to control binding and release of components of an adhesive system by increasing or decreasing the force-­activated bond stresses applied to the adhesion molecules.
PCT/US2003/020434 2002-06-27 2003-06-27 Use of adhesion molecules as bond stress-enhanced nanoscale binding switches WO2004003160A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003256329A AU2003256329A1 (en) 2002-06-27 2003-06-27 Use of adhesion molecules as bond stress-enhanced nanoscale binding switches

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39246702P 2002-06-27 2002-06-27
US60/392,467 2002-06-27

Publications (2)

Publication Number Publication Date
WO2004003160A2 WO2004003160A2 (en) 2004-01-08
WO2004003160A3 true WO2004003160A3 (en) 2004-07-15

Family

ID=30000876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020434 WO2004003160A2 (en) 2002-06-27 2003-06-27 Use of adhesion molecules as bond stress-enhanced nanoscale binding switches

Country Status (3)

Country Link
US (2) US20040067544A1 (en)
AU (1) AU2003256329A1 (en)
WO (1) WO2004003160A2 (en)

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US20100249920A1 (en) * 2007-01-08 2010-09-30 Millipede Llc Reconfiguring heart features
US20100121433A1 (en) * 2007-01-08 2010-05-13 Millipede Llc, A Corporation Of Michigan Reconfiguring heart features
FR2921260B1 (en) * 2007-09-25 2012-08-24 Lesaffre & Cie USE OF A NEW NATURAL AGENT IN COSMETIC COMPOSITIONS
US7520951B1 (en) 2008-04-17 2009-04-21 International Business Machines (Ibm) Corporation Method of transferring nanoparticles to a surface
US20120053680A1 (en) 2010-08-24 2012-03-01 Bolling Steven F Reconfiguring Heart Features
US8664463B2 (en) 2010-10-06 2014-03-04 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Reversible adhesives
US10849755B2 (en) 2012-09-14 2020-12-01 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US10543088B2 (en) 2012-09-14 2020-01-28 Boston Scientific Scimed, Inc. Mitral valve inversion prostheses
US8967263B2 (en) 2012-09-18 2015-03-03 Halliburton Energy Services, Inc. Methods of treating a subterranean formation with stress-activated resins
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
US9778249B2 (en) * 2014-09-26 2017-10-03 University Of Houston System Sequence and chiral selectivity of DNA-drug interactions revealed by force spectroscopy
EP3200917B1 (en) * 2014-09-29 2020-02-19 Biosurfit, S.A. Cell counting
EP3256077B1 (en) 2015-02-13 2024-03-27 Boston Scientific Scimed, Inc. Valve replacement using rotational anchors
US10335275B2 (en) 2015-09-29 2019-07-02 Millipede, Inc. Methods for delivery of heart valve devices using intravascular ultrasound imaging
EP3377000B1 (en) 2015-11-17 2023-02-01 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US10507252B2 (en) 2016-03-17 2019-12-17 Paul C. Lee Nanoparticle probes and methods of making and use thereof
US10507253B2 (en) 2016-03-17 2019-12-17 Paul C. Lee Nanoparticle probes and methods of making and use thereof
US10548731B2 (en) 2017-02-10 2020-02-04 Boston Scientific Scimed, Inc. Implantable device and delivery system for reshaping a heart valve annulus
US11069220B2 (en) 2017-07-10 2021-07-20 Biovigil Hygiene Technologies, Llc Hand cleanliness monitoring

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US20090325259A1 (en) 2009-12-31
US20040067544A1 (en) 2004-04-08
WO2004003160A2 (en) 2004-01-08
AU2003256329A8 (en) 2004-01-19
AU2003256329A1 (en) 2004-01-19

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