WO2004004648A3 - Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use - Google Patents
Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use Download PDFInfo
- Publication number
- WO2004004648A3 WO2004004648A3 PCT/US2003/021026 US0321026W WO2004004648A3 WO 2004004648 A3 WO2004004648 A3 WO 2004004648A3 US 0321026 W US0321026 W US 0321026W WO 2004004648 A3 WO2004004648 A3 WO 2004004648A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nitric oxide
- treating
- nitrosated
- therapeutic agent
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002491127A CA2491127A1 (en) | 2002-07-03 | 2003-07-03 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
AU2003247792A AU2003247792B2 (en) | 2002-07-03 | 2003-07-03 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
EP03763193A EP1539729A4 (en) | 2002-07-03 | 2003-07-03 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
JP2004562619A JP2005539089A (en) | 2002-07-03 | 2003-07-03 | Nitrosated non-steroidal anti-inflammatory compounds, compositions and methods of use |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39311102P | 2002-07-03 | 2002-07-03 | |
US60/393,111 | 2002-07-03 | ||
US39797902P | 2002-07-24 | 2002-07-24 | |
US60/397,979 | 2002-07-24 | ||
US41835302P | 2002-10-16 | 2002-10-16 | |
US60/418,353 | 2002-10-16 | ||
US44979803P | 2003-02-26 | 2003-02-26 | |
US60/449,798 | 2003-02-26 | ||
US45618203P | 2003-03-21 | 2003-03-21 | |
US60/456,182 | 2003-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004004648A2 WO2004004648A2 (en) | 2004-01-15 |
WO2004004648A3 true WO2004004648A3 (en) | 2004-10-28 |
Family
ID=30119449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/021026 WO2004004648A2 (en) | 2002-07-03 | 2003-07-03 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
Country Status (6)
Country | Link |
---|---|
US (6) | US7163958B2 (en) |
EP (1) | EP1539729A4 (en) |
JP (3) | JP2005539089A (en) |
AU (2) | AU2003247792B2 (en) |
CA (1) | CA2491127A1 (en) |
WO (1) | WO2004004648A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355666B1 (en) | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
CA2491127A1 (en) * | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
ITMI20021861A1 (en) * | 2002-08-29 | 2004-02-29 | Nicox Sa | NITROXIALKYL ESTER SYNTHESIS PROCESS OF CARBOXYLIC ACIDS, INTERMEDIATES THAT CAN BE USED IN THAT PROCEDURE AND THEIR PREPARATION. |
WO2004032864A2 (en) * | 2002-10-07 | 2004-04-22 | Radiorx, Inc. | X-nitro compounds, pharmaceutical compositions thereof and uses therof |
MXPA06000529A (en) * | 2003-07-18 | 2006-08-11 | Santarus Inc | Pharmaceutical composition for inhibiting acid secretion. |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
WO2005060603A2 (en) * | 2003-12-10 | 2005-07-07 | Nitromed, Inc. | Nitric oxide releasing pyruvate compounds, compositions and methods of use |
US7879817B2 (en) * | 2004-01-07 | 2011-02-01 | Seikagaku Corporation | Hyaluronic acid derivative and drug containing the same |
WO2005070006A2 (en) * | 2004-01-22 | 2005-08-04 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
US20090215838A1 (en) * | 2005-03-09 | 2009-08-27 | Nitromed, Inc. | Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use |
WO2007019448A2 (en) * | 2005-08-08 | 2007-02-15 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
EP2056805B1 (en) * | 2006-08-16 | 2011-05-25 | Action Medicines, S.L. | Use of 2, 5-dihydroxybenzene derivatives for the treatment of tissue reactive diseases |
JP2010532780A (en) * | 2007-07-09 | 2010-10-14 | ニコックス エス エイ | Use of nitric oxide releasing compounds in the treatment of chronic pain |
WO2009012425A2 (en) * | 2007-07-19 | 2009-01-22 | Logigal Therapeutics, Inc. | Compositions including leukotriene antagonists and nsaids and methods of using the same |
EP2048129A1 (en) * | 2007-10-12 | 2009-04-15 | Lonza Ag | Method for the preparation of organic nitrates |
EP2177216A1 (en) * | 2008-10-13 | 2010-04-21 | Lacer, S.A. | Use of dianhydrohexite mononitrate derivatives as healing agents |
CN108191846B (en) | 2008-12-04 | 2021-08-20 | 于崇曦 | High penetration composition and application thereof |
US8062653B2 (en) | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
WO2010096320A2 (en) * | 2009-02-18 | 2010-08-26 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
BRPI0901298A2 (en) * | 2009-04-06 | 2011-01-04 | Ems Sa | phthalimide derivatives of nonsteroidal antiinflammatory compounds and / or modulators of tnf- (alpha), process for obtaining them, pharmaceutical compositions containing them and their uses in the treatment of inflammatory diseases |
US20100286257A1 (en) * | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Methods Of Use Of Nitroalkane Compositions In Dermatologic Applications To Prevent or Treat Skin Aging |
US20100286272A1 (en) * | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications |
US20100286271A1 (en) * | 2009-05-08 | 2010-11-11 | Perricone Nicholas V | Nitro-alkyl Compound Compositions |
WO2011012400A2 (en) | 2009-07-28 | 2011-02-03 | Nicox S.A. | Nitric oxide releasing naproxen |
ES2362894B1 (en) * | 2009-11-16 | 2012-05-21 | Ferrer Internacional S.A. | PREPARATION PROCEDURE FOR �? CIDO 4-NITRO-OXI-METIL-BENZOICO. |
GB2477590A (en) * | 2010-02-05 | 2011-08-10 | Biocopea Ltd | A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier |
US8471041B2 (en) * | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
AR081268A1 (en) * | 2010-06-02 | 2012-07-18 | Cardiolynx Ag | PIOGLITAZONA NITRATE DERIVATIVES |
US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
AU2012319071B2 (en) | 2011-10-07 | 2017-08-03 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
JP6405312B2 (en) * | 2012-10-23 | 2018-10-17 | ニコックス サイエンス アイルランド | Quinone-based nitric oxide donor compounds for ophthalmology |
US9757529B2 (en) * | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
WO2014111957A1 (en) | 2013-01-21 | 2014-07-24 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
WO2017123593A1 (en) | 2016-01-11 | 2017-07-20 | Epicentrx, Inc. | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
WO2017137489A1 (en) * | 2016-02-12 | 2017-08-17 | Dsm Ip Assets B.V. | Anti-methanogenic compositions and uses thereof |
CN107459538B (en) * | 2016-06-03 | 2020-10-16 | 首都医科大学 | Diindole-2-propane-2-indole-3-acetyl lysyl glucosamine, synthesis, activity and application thereof |
KR102491748B1 (en) | 2016-09-29 | 2023-01-25 | 케이.엘.알.엠., 엘엘씨 | Compositions and methods for the treatment of orthopedic disorders |
JP7332469B2 (en) | 2016-10-14 | 2023-08-23 | エピセントアールエックス,インコーポレイテッド | Sulfoxyalkyl organic nitrogens and related compounds and pharmaceutical compositions for use in medicine |
JP7377791B2 (en) | 2017-07-07 | 2023-11-10 | エピセントアールエックス,インコーポレイテッド | Compositions for parenteral administration of therapeutic agents |
US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
WO2020163519A1 (en) * | 2019-02-06 | 2020-08-13 | K.L.R.M., Llc | Compositions and methods for the treatment of constipation and other ailments of the gastrointestinal system |
CN110372876A (en) * | 2019-07-29 | 2019-10-25 | 南京工业大学 | A kind of method that solvent evaporation induction prepares metal-organic framework materials |
WO2023142996A1 (en) * | 2022-01-28 | 2023-08-03 | 上海岸阔医药科技有限公司 | Method for preventing or treating disease or disorder associated with antineoplastic agent |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5780495A (en) * | 1993-10-06 | 1998-07-14 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
US5844696A (en) * | 1995-04-19 | 1998-12-01 | Prodes, S.A. | Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process |
US5861426A (en) * | 1994-05-10 | 1999-01-19 | Nicox S.A. | Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities |
US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
US6677374B2 (en) * | 1996-06-04 | 2004-01-13 | Queen's University At Kingston | Nitrate esters and methods of making same |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1238679B (en) | 1990-01-29 | 1993-09-01 | Resa Farma | OPTICALLY ACTIVE DERIVATIVE OF D-2- (6-METHOXY-2-NAFTIL) ACID - PROPIONIC AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
GB9200114D0 (en) | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
GB2284350B (en) | 1992-07-30 | 1996-08-28 | Cal Int Ltd | Pharmaceutical compositions comprising esters of organic nitrates and a salicylate |
IT1256345B (en) * | 1992-08-20 | 1995-12-01 | NITRIC ESTERS OF PHENYLACETIC 2- (2,6-DI-HALO-PHENYLAMIN) DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION | |
IT1256450B (en) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | NITRIC ESTERS WITH PHARMACOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION |
US5643943A (en) | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5607966A (en) | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
US5483426A (en) | 1994-12-27 | 1996-01-09 | General Motors Corporation | Aimable vehicle headlamp assembly |
US5703073A (en) | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US6051588A (en) | 1995-04-19 | 2000-04-18 | Nitromed Inc | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US6043232A (en) | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
DE19515970A1 (en) | 1995-05-02 | 1996-11-07 | Bayer Ag | Acetylsalicylsäurenitrate |
IT1276071B1 (en) | 1995-10-31 | 1997-10-24 | Nicox Ltd | ANTI-INFLAMMATORY ACTIVITY COMPOSITES |
US5653548A (en) * | 1996-02-07 | 1997-08-05 | Illinois Tool Works Inc. | Method and apparatus for a ball and socket joint |
IT1282686B1 (en) | 1996-02-26 | 1998-03-31 | Nicox Sa | COMPOUNDS ABLE TO REDUCE DRUG TOXICITY |
US7115661B1 (en) * | 1999-12-29 | 2006-10-03 | Queen's University At Kingston | Methods and compositions for mitigating pain |
US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
IT1288123B1 (en) | 1996-09-04 | 1998-09-10 | Nicox Sa | USE OF NITRO-DERIVATIVES FOR URINARY INCONTINENCE |
DE19651243A1 (en) | 1996-12-10 | 1998-06-18 | Basf Ag | Amphiphilic graft polymers based on graft bases containing N-vinylcarboxamide units, process for their preparation and their use |
DE19753776A1 (en) | 1997-12-04 | 1999-06-10 | Bosch Gmbh Robert | Measuring device for contactless detection of an angle of rotation |
US6113301A (en) | 1998-02-13 | 2000-09-05 | Burton; John E. | Disengageable pivot joint |
IT1298338B1 (en) | 1998-03-05 | 1999-12-20 | Nicox Sa | PHARMACEUTICAL COMPOSITIONS FOR THE ULCER |
IT1299198B1 (en) | 1998-03-05 | 2000-02-29 | Nicox Sa | NITRATED SALTS OF ANTI-ULCER DRUGS |
SE9802333D0 (en) | 1998-06-29 | 1998-06-29 | Astra Pharma Prod | Novel combination |
IT1303672B1 (en) | 1998-07-28 | 2001-02-23 | Nicox Sa | NITRATED SALTS OF DRUGS ACTIVE IN BONE DISORDERS |
EP1126838A4 (en) | 1998-10-30 | 2005-02-16 | Nitromed Inc | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
IT1307928B1 (en) | 1999-01-26 | 2001-11-29 | Nicox Sa | METHOD OF SYNTHESIS OF NITROXYMETHYLPHENYL ESTERS OF ASPIRINE DERIVATIVES. |
IT1308633B1 (en) * | 1999-03-02 | 2002-01-09 | Nicox Sa | NITROSSIDERIVATI. |
IT1311923B1 (en) | 1999-04-13 | 2002-03-20 | Nicox Sa | PHARMACEUTICAL COMPOUNDS. |
IT1311922B1 (en) | 1999-04-13 | 2002-03-20 | Nicox Sa | PHARMACEUTICAL COMPOUNDS. |
IT1311921B1 (en) | 1999-04-13 | 2002-03-20 | Nicox Sa | PHARMACEUTICAL COMPOUNDS. |
IT1311924B1 (en) | 1999-04-13 | 2002-03-20 | Nicox Sa | PHARMACEUTICAL COMPOUNDS. |
US6244735B1 (en) * | 1999-05-11 | 2001-06-12 | John E. Burton | Headlamp adjuster with anti-rotation ball stud head |
TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
IT1312115B1 (en) | 1999-06-24 | 2002-04-04 | Nicox Sa | AMORPHOUS COMPOUNDS AND RELATED PHARMACEUTICAL COMPOSITIONS |
ITMI991517A1 (en) | 1999-07-09 | 2001-01-09 | Nicox Sa | PROCEDURE FOR OBTAINING EXTERNAL NITROXYMETHYL FENYL OF SALICYLIC ACID DERIVATIVES |
IT1313596B1 (en) | 1999-08-04 | 2002-09-09 | Nicox Sa | PROCESS FOR THE PREPARATION OF NITROXIALKYL ESTERS OF NAPROXENE |
IT1314184B1 (en) | 1999-08-12 | 2002-12-06 | Nicox Sa | PHARMACEUTICAL COMPOSITIONS FOR THE THERAPY OF STRESS-OXIDATIVE CONDITIONS |
TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
SE0000773D0 (en) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
US6433317B1 (en) | 2000-04-07 | 2002-08-13 | Watlow Polymer Technologies | Molded assembly with heating element captured therein |
CA2406947A1 (en) | 2000-04-19 | 2001-10-25 | Johns Hopkins University | Methods for prevention and treatment of gastrointestinal disorders |
AU2001275036A1 (en) | 2000-06-02 | 2001-12-17 | Medinox, Inc. | Protected forms of a combination of pharmacologically active agents and uses therefor |
US6429223B1 (en) | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
US6355666B1 (en) | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
SE0002476D0 (en) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
IT1318673B1 (en) | 2000-08-08 | 2003-08-27 | Nicox Sa | DRUGS FOR SEXUAL DYSFUNCTIONS. |
IT1318674B1 (en) | 2000-08-08 | 2003-08-27 | Nicox Sa | DO IT FOR INCONTINENCE. |
JP2002118295A (en) | 2000-10-11 | 2002-04-19 | Sumitomo Special Metals Co Ltd | Thermoelectric conversion material, manufacturing method thereof and thermoelectric conversion element |
IT1319202B1 (en) * | 2000-10-12 | 2003-09-26 | Nicox Sa | DRUGS FOR INFLAMMATORY-BASED DISEASES. |
IT1320176B1 (en) | 2000-12-22 | 2003-11-26 | Nicox Sa | SOLID DISPERSIONS OF NITRATED ACTIVE INGREDIENTS. |
EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
CN1133626C (en) * | 2001-01-08 | 2004-01-07 | 南京长澳医药科技有限公司 | Diclofenac coupled derivative and its synthesizing process and inflammation relieving action |
SE0100901D0 (en) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | New composition |
ITMI20010985A1 (en) | 2001-05-15 | 2002-11-15 | Nicox Sa | DRUGS FOR ALZHEIMER DISEASE |
ITMI20011240A1 (en) | 2001-06-13 | 2002-12-13 | Nicox Sa | DRUGS FOR VASCULOPATHIES |
ITMI20011307A1 (en) | 2001-06-21 | 2002-12-21 | Nicox Sa | DRUGS FOR EPILEPSY |
ITMI20011308A1 (en) | 2001-06-21 | 2002-12-21 | Nicox Sa | DRUGS FOR CHRONIC PAIN |
ITMI20011744A1 (en) * | 2001-08-09 | 2003-02-09 | Nicox Sa | DRUGS FOR VASCULOPATHIES |
SE0102993D0 (en) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
ITMI20020773A1 (en) | 2002-04-11 | 2003-10-13 | Nicox Sa | DRUGS FOR THE TREATMENT OF ARTHRITIS |
US20040077691A1 (en) | 2002-06-21 | 2004-04-22 | Medinox, Inc. | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs |
ITMI20021392A1 (en) | 2002-06-25 | 2003-12-29 | Nicox Sa | PHARMACEUTICAL FORMS FOR THE ORAL ADMINISTRATION OF LIQUID DRUGS AT AMBIENT TEMPERATURE EQUIPPED WITH BETTER BIOAVAILABILITY |
ITMI20021399A1 (en) | 2002-06-25 | 2003-12-29 | Nicox Sa | CYCLOOXYGENASE INHIBITORS 2 |
CA2491127A1 (en) * | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
ITMI20021861A1 (en) | 2002-08-29 | 2004-02-29 | Nicox Sa | NITROXIALKYL ESTER SYNTHESIS PROCESS OF CARBOXYLIC ACIDS, INTERMEDIATES THAT CAN BE USED IN THAT PROCEDURE AND THEIR PREPARATION. |
RU2322434C2 (en) | 2002-09-20 | 2008-04-20 | Никокс С.А. | Method for preparing no-donor compounds, such as no-donor diclofenac |
-
2003
- 2003-07-03 CA CA002491127A patent/CA2491127A1/en not_active Abandoned
- 2003-07-03 US US10/612,014 patent/US7163958B2/en not_active Expired - Lifetime
- 2003-07-03 AU AU2003247792A patent/AU2003247792B2/en not_active Ceased
- 2003-07-03 EP EP03763193A patent/EP1539729A4/en not_active Withdrawn
- 2003-07-03 JP JP2004562619A patent/JP2005539089A/en not_active Withdrawn
- 2003-07-03 WO PCT/US2003/021026 patent/WO2004004648A2/en active Application Filing
-
2005
- 2005-05-23 US US11/134,358 patent/US7754772B2/en active Active
-
2009
- 2009-12-11 US US12/636,329 patent/US8304409B2/en not_active Expired - Lifetime
- 2009-12-11 US US12/636,306 patent/US7883714B2/en not_active Expired - Lifetime
- 2009-12-11 US US12/636,316 patent/US8088762B2/en not_active Expired - Fee Related
- 2009-12-17 AU AU2009250989A patent/AU2009250989A1/en not_active Abandoned
-
2010
- 2010-07-08 JP JP2010155442A patent/JP2010265292A/en active Pending
- 2010-07-08 JP JP2010155441A patent/JP2010280665A/en active Pending
- 2010-12-28 US US12/980,077 patent/US8222277B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5780495A (en) * | 1993-10-06 | 1998-07-14 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
US5861426A (en) * | 1994-05-10 | 1999-01-19 | Nicox S.A. | Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities |
US5844696A (en) * | 1995-04-19 | 1998-12-01 | Prodes, S.A. | Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process |
US6677374B2 (en) * | 1996-06-04 | 2004-01-13 | Queen's University At Kingston | Nitrate esters and methods of making same |
US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
Also Published As
Publication number | Publication date |
---|---|
US7754772B2 (en) | 2010-07-13 |
EP1539729A2 (en) | 2005-06-15 |
US20050222243A1 (en) | 2005-10-06 |
US8222277B2 (en) | 2012-07-17 |
US8304409B2 (en) | 2012-11-06 |
CA2491127A1 (en) | 2004-01-15 |
AU2003247792B2 (en) | 2009-09-24 |
AU2003247792A1 (en) | 2004-01-23 |
JP2010265292A (en) | 2010-11-25 |
WO2004004648A2 (en) | 2004-01-15 |
US20040024057A1 (en) | 2004-02-05 |
US7883714B2 (en) | 2011-02-08 |
US20100137291A1 (en) | 2010-06-03 |
US20100093671A1 (en) | 2010-04-15 |
US7163958B2 (en) | 2007-01-16 |
US20110098253A1 (en) | 2011-04-28 |
US8088762B2 (en) | 2012-01-03 |
US20100093708A1 (en) | 2010-04-15 |
AU2009250989A1 (en) | 2010-01-14 |
JP2005539089A (en) | 2005-12-22 |
JP2010280665A (en) | 2010-12-16 |
EP1539729A4 (en) | 2008-02-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004004648A3 (en) | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use | |
HK1257517A1 (en) | 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease | |
WO2004002409A3 (en) | Cyclooxygenase-2 selective inhibitors, compositions and methods of use | |
NO20044054L (en) | Administration of agents for the treatment of inflammation | |
WO2004012659A3 (en) | Nitrosated proton pump inhibitors, compositions and methods of use | |
WO2002098352A3 (en) | PHARMACEUTICAL COMPOSITIONS FOR THE COORDINATED DELIVERY OF NSAIDs | |
WO2002046129A3 (en) | Inhibitors of histone deacetylase | |
BR0307050A (en) | Compound, pharmaceutical composition, methods for treating prostaglandin d2 mediated diseases, for treating nasal congestion, for treating allergic asthma, and for treating allergic rhinitis, pharmaceutically acceptable salt, and use of a compound or salt | |
NO20035496D0 (en) | Substituted Sulfonamide Compounds, Methods for Their Use as a Drug for the Treatment of CNS Disorders, Overweight and Type II Diabetes | |
CY2009002I1 (en) | USE OF AMINO ACID ANTISPLASMICS FOR THE THERAPEUTIC TREATMENT OF PAIN | |
WO2006127591A3 (en) | Organic nitric oxide enhancing salts of nonsteroidal antiinflammatory compounds, compositions and methods of use | |
NO20052698D0 (en) | 4 (phenylpiperazinylmethyl) benzamide derivatives and their use in the treatment of pain and gaseous tract disorders. | |
NO20041833L (en) | Heterocyclic compounds for use in the treatment of urinary tract disorders | |
WO2001038311A3 (en) | Pyrimidine derivatives as selective inhibitors of cox-2 | |
BR0316458A (en) | Compound, pharmaceutical composition, method of treating or preventing disease, method for enhancing cognition in a healthy patient, and use of a compound | |
NZ533269A (en) | Inhibitors of cytosolic phospholipase A2 | |
EE200300363A (en) | Use of N- (Pyridinyl) -1H-Indole-1-Amine Compounds in the manufacture of a medicament for the treatment of diseases and conditions associated with myelin loss | |
NO20025394L (en) | Formulations containing a glucocorticoid drug for the treatment of bronchopulmonary diseases | |
WO2004002420A3 (en) | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use | |
WO2004010945A3 (en) | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use | |
AU2003278664A1 (en) | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | |
DK1309322T3 (en) | Use of 3-benzoylphenylacetic acid derivatives for the treatment of retinal disorders | |
NO20032006L (en) | Use of melagatran for the manufacture of a medicament for the treatment of ischemic disorders | |
SE0102639D0 (en) | Novel compounds | |
HUP0300876A3 (en) | Use of diclofenac for the manufacture of medicament for the topical treatment of burns |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003247792 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2491127 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004562619 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003763193 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003763193 Country of ref document: EP |