WO2004007682A3 - Methods and compositions for modulating t helper (th) cell development and function - Google Patents
Methods and compositions for modulating t helper (th) cell development and function Download PDFInfo
- Publication number
- WO2004007682A3 WO2004007682A3 PCT/US2003/021975 US0321975W WO2004007682A3 WO 2004007682 A3 WO2004007682 A3 WO 2004007682A3 US 0321975 W US0321975 W US 0321975W WO 2004007682 A3 WO2004007682 A3 WO 2004007682A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- helper
- modulating
- compositions
- methods
- function
- Prior art date
Links
- 230000011712 cell development Effects 0.000 title abstract 2
- 230000003915 cell function Effects 0.000 title abstract 2
- 210000002443 helper t lymphocyte Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 101001010621 Homo sapiens Interleukin-21 Proteins 0.000 abstract 1
- -1 e.g. Proteins 0.000 abstract 1
- 108010074108 interleukin-21 Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03764624A EP1553982A4 (en) | 2002-07-15 | 2003-07-15 | METHODS AND COMPOSITIONS FOR MODULATING T HELPER (T sb H /sb ) CELL DEVELOPMENT AND FUNCTION |
JP2004521793A JP4776228B2 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating the development and function of T helper (TH) cells |
EA200500206A EA011686B1 (en) | 2002-07-15 | 2003-07-15 | Method for modulating t helper (t) cell development |
CA002491320A CA2491320A1 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating t helper (th) cell development and function |
AU2003251900A AU2003251900B2 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating T helper (Th) cell development and function |
MXPA05000655A MXPA05000655A (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating t helper (th. |
BRPI0312738-9A BR0312738A (en) | 2002-07-15 | 2003-07-15 | processes and compositions for modulating helper t cell development and function (th) |
IL16599004A IL165990A0 (en) | 2002-07-15 | 2004-12-26 | Methods and compositions for modulating T helper (TH) cell development and function |
NO20050717A NO20050717L (en) | 2002-07-15 | 2005-02-10 | Method and compositions for modulating T helper (TH) cell development and function |
IL195769A IL195769A0 (en) | 2002-07-15 | 2008-12-07 | Methods and compositions for modulating t helper (th) cell development and function |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39616002P | 2002-07-15 | 2002-07-15 | |
US60/396,160 | 2002-07-15 | ||
US40300102P | 2002-08-12 | 2002-08-12 | |
US60/403,001 | 2002-08-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004007682A2 WO2004007682A2 (en) | 2004-01-22 |
WO2004007682A3 true WO2004007682A3 (en) | 2004-12-29 |
Family
ID=30118569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/021975 WO2004007682A2 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating t helper (th) cell development and function |
Country Status (14)
Country | Link |
---|---|
US (2) | US7314623B2 (en) |
EP (1) | EP1553982A4 (en) |
JP (2) | JP4776228B2 (en) |
KR (1) | KR20050037552A (en) |
CN (1) | CN1688340A (en) |
AU (1) | AU2003251900B2 (en) |
BR (1) | BR0312738A (en) |
CA (1) | CA2491320A1 (en) |
EA (1) | EA011686B1 (en) |
IL (2) | IL165990A0 (en) |
MX (1) | MXPA05000655A (en) |
NO (1) | NO20050717L (en) |
WO (1) | WO2004007682A2 (en) |
ZA (1) | ZA200500480B (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
EP2377549A1 (en) | 2002-06-07 | 2011-10-19 | ZymoGenetics, Inc. | Use of IL-21 for treating viral infections |
BR0312738A (en) | 2002-07-15 | 2007-06-26 | Wyeth Corp | processes and compositions for modulating helper t cell development and function (th) |
JP4914209B2 (en) | 2003-03-14 | 2012-04-11 | ワイス | Antibody against human IL-21 receptor and use of the antibody |
KR20060015482A (en) * | 2003-03-21 | 2006-02-17 | 와이어쓰 | Treating immunological disorder using agonists of interleukin-21/interleukin-21 receptor |
WO2005030196A2 (en) * | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using il-21 |
WO2005035565A1 (en) | 2003-10-10 | 2005-04-21 | Novo Nordisk A/S | Il-21 derivatives |
BRPI0514138A (en) * | 2004-08-05 | 2008-05-27 | Wyeth Corp | method for treating, ameliorating, or preventing a disorder, fusion protein, vector, recombinant host cell, method for producing a fusion protein, pharmaceutical composition, and methods for transplanting / grafting an organ, tissue, cell or cell group into a mammalian individual, and to treat, prevent or ameliorate transplant / graft rejection in a mammalian transplant / graft recipient |
GT200600148A (en) * | 2005-04-14 | 2006-11-22 | METHODS FOR THE TREATMENT AND PREVENTION OF FIBROSIS | |
EP2567973B1 (en) * | 2005-11-28 | 2014-05-14 | Zymogenetics, Inc. | IL-21 antagonists |
US7592427B2 (en) * | 2005-11-28 | 2009-09-22 | Zymogenetics, Inc. | Antibodies to IL-21 receptor |
ES2547689T3 (en) * | 2005-12-02 | 2015-10-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling that involve antibodies that bind to IL-22 and IL-22R |
KR101615215B1 (en) | 2007-12-07 | 2016-04-25 | 지모제넥틱스, 인코포레이티드 | Anti-human il-21 monoclonal antibodies |
EP2238241B1 (en) | 2008-01-18 | 2013-09-11 | The Brigham and Women's Hospital, Inc. | Selective differentiation, identification, and modulation of human th17 cells |
AR071885A1 (en) * | 2008-05-23 | 2010-07-21 | Wyeth Corp | PROTEINS OF UNION TO THE INTERLEUQUINE RECEIVER 21 |
EP2296689A1 (en) * | 2008-05-23 | 2011-03-23 | Wyeth LLC | Methods of treatment utilizing binding proteins of the interleukin-21 receptor |
MX2020004501A (en) | 2010-06-03 | 2021-11-09 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk). |
WO2012099886A1 (en) | 2011-01-18 | 2012-07-26 | Bioniz, Llc | Compositions and mehthods for modulating gamma-c-cytokine activity |
US9920932B2 (en) | 2011-01-26 | 2018-03-20 | United Technologies Corporation | Mixer assembly for a gas turbine engine |
KR20130011056A (en) * | 2011-07-20 | 2013-01-30 | 주식회사에이앤알쎄라퓨틱스 | Receptors targeting inflammation and drug carriers for treatment of inflammatory diseases |
BR112015001690A2 (en) | 2012-07-24 | 2017-11-07 | Pharmacyclics Inc | mutations associated with resistance to bruton tyrosine kinase inhibitors (btk) |
WO2014071231A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
RS58187B1 (en) | 2012-11-08 | 2019-03-29 | Bristol Myers Squibb Co | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn-alpha |
US20140170727A1 (en) * | 2012-12-19 | 2014-06-19 | Nanomr, Inc. | Affinity medium using fixed whole cells |
US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
JP6863974B2 (en) | 2015-10-09 | 2021-04-21 | バイオニズ リミテッド ライアビリティー カンパニー | Regulation of γc cytokine activity |
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US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
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JP4914209B2 (en) | 2003-03-14 | 2012-04-11 | ワイス | Antibody against human IL-21 receptor and use of the antibody |
KR20060015482A (en) | 2003-03-21 | 2006-02-17 | 와이어쓰 | Treating immunological disorder using agonists of interleukin-21/interleukin-21 receptor |
AU2005244942A1 (en) | 2004-05-19 | 2005-12-01 | Wyeth | Modulation of immunoglobulin production and atopic disorders |
BRPI0514138A (en) | 2004-08-05 | 2008-05-27 | Wyeth Corp | method for treating, ameliorating, or preventing a disorder, fusion protein, vector, recombinant host cell, method for producing a fusion protein, pharmaceutical composition, and methods for transplanting / grafting an organ, tissue, cell or cell group into a mammalian individual, and to treat, prevent or ameliorate transplant / graft rejection in a mammalian transplant / graft recipient |
GT200600148A (en) * | 2005-04-14 | 2006-11-22 | METHODS FOR THE TREATMENT AND PREVENTION OF FIBROSIS | |
WO2009100035A2 (en) | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
-
2003
- 2003-07-15 BR BRPI0312738-9A patent/BR0312738A/en not_active IP Right Cessation
- 2003-07-15 EA EA200500206A patent/EA011686B1/en not_active IP Right Cessation
- 2003-07-15 KR KR1020057000735A patent/KR20050037552A/en not_active Application Discontinuation
- 2003-07-15 CA CA002491320A patent/CA2491320A1/en not_active Abandoned
- 2003-07-15 JP JP2004521793A patent/JP4776228B2/en not_active Expired - Fee Related
- 2003-07-15 WO PCT/US2003/021975 patent/WO2004007682A2/en active Application Filing
- 2003-07-15 AU AU2003251900A patent/AU2003251900B2/en not_active Ceased
- 2003-07-15 ZA ZA200500480A patent/ZA200500480B/en unknown
- 2003-07-15 CN CNA038169150A patent/CN1688340A/en active Pending
- 2003-07-15 MX MXPA05000655A patent/MXPA05000655A/en active IP Right Grant
- 2003-07-15 US US10/620,169 patent/US7314623B2/en not_active Expired - Fee Related
- 2003-07-15 EP EP03764624A patent/EP1553982A4/en not_active Withdrawn
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2004
- 2004-12-26 IL IL16599004A patent/IL165990A0/en unknown
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2005
- 2005-02-10 NO NO20050717A patent/NO20050717L/en not_active Application Discontinuation
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2007
- 2007-11-12 US US11/938,618 patent/US7731946B2/en not_active Expired - Fee Related
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2008
- 2008-12-07 IL IL195769A patent/IL195769A0/en unknown
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2009
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057128A (en) * | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
Also Published As
Publication number | Publication date |
---|---|
ZA200500480B (en) | 2006-10-25 |
CN1688340A (en) | 2005-10-26 |
WO2004007682A2 (en) | 2004-01-22 |
MXPA05000655A (en) | 2006-02-22 |
US7731946B2 (en) | 2010-06-08 |
IL195769A0 (en) | 2009-09-01 |
US20040136954A1 (en) | 2004-07-15 |
EP1553982A4 (en) | 2008-03-26 |
IL165990A0 (en) | 2006-01-15 |
BR0312738A (en) | 2007-06-26 |
JP2010090133A (en) | 2010-04-22 |
KR20050037552A (en) | 2005-04-22 |
JP4776228B2 (en) | 2011-09-21 |
AU2003251900A1 (en) | 2004-02-02 |
CA2491320A1 (en) | 2004-01-22 |
AU2003251900B2 (en) | 2008-12-18 |
US7314623B2 (en) | 2008-01-01 |
JP2006507231A (en) | 2006-03-02 |
EA200500206A1 (en) | 2006-06-30 |
EP1553982A2 (en) | 2005-07-20 |
EA011686B1 (en) | 2009-04-28 |
US20090197803A1 (en) | 2009-08-06 |
NO20050717L (en) | 2005-04-11 |
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