WO2004014835A3 - Resolvins: biotemplates for therapeutic interventions - Google Patents

Resolvins: biotemplates for therapeutic interventions Download PDF

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Publication number
WO2004014835A3
WO2004014835A3 PCT/US2003/025336 US0325336W WO2004014835A3 WO 2004014835 A3 WO2004014835 A3 WO 2004014835A3 US 0325336 W US0325336 W US 0325336W WO 2004014835 A3 WO2004014835 A3 WO 2004014835A3
Authority
WO
WIPO (PCT)
Prior art keywords
dha
epa
resolvins
present
compounds
Prior art date
Application number
PCT/US2003/025336
Other languages
French (fr)
Other versions
WO2004014835A9 (en
WO2004014835A2 (en
Inventor
Charles N Serhan
Original Assignee
Brigham & Womens Hospital
Charles N Serhan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Charles N Serhan filed Critical Brigham & Womens Hospital
Priority to AT03785253T priority Critical patent/ATE449057T1/en
Priority to JP2004528101A priority patent/JP4845378B2/en
Priority to EP03785253A priority patent/EP1537067B1/en
Priority to CA2495260A priority patent/CA2495260C/en
Priority to DE60330154T priority patent/DE60330154D1/en
Priority to AU2003258194A priority patent/AU2003258194B2/en
Priority to EP09009237.0A priority patent/EP2216318B1/en
Priority to EP18199438.5A priority patent/EP3584235A3/en
Publication of WO2004014835A2 publication Critical patent/WO2004014835A2/en
Publication of WO2004014835A3 publication Critical patent/WO2004014835A3/en
Publication of WO2004014835A9 publication Critical patent/WO2004014835A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.
PCT/US2003/025336 2002-08-12 2003-08-12 Resolvins: biotemplates for therapeutic interventions WO2004014835A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT03785253T ATE449057T1 (en) 2002-08-12 2003-08-12 RESOLVINE: BIOTEMPLATE FOR PERFORMING THERAPEUTIC APPLICATIONS
JP2004528101A JP4845378B2 (en) 2002-08-12 2003-08-12 Resolvin: Biotemplate for therapeutic treatment
EP03785253A EP1537067B1 (en) 2002-08-12 2003-08-12 Resolvins: biotemplates for therapeutic interventions
CA2495260A CA2495260C (en) 2002-08-12 2003-08-12 Resolvins: biotemplates for novel therapeutic interventions
DE60330154T DE60330154D1 (en) 2002-08-12 2003-08-12 RESOLVINE: BIOTEMPLATE FOR THE IMPLEMENTATION OF THERAPEUTIC APPLICATIONS
AU2003258194A AU2003258194B2 (en) 2002-08-12 2003-08-12 Resolvins: biotemplates for therapeutic interventions
EP09009237.0A EP2216318B1 (en) 2002-08-12 2003-08-12 Resolvins: Biotemplates for therapeutic interventions
EP18199438.5A EP3584235A3 (en) 2002-08-12 2003-08-12 Resolvins: biotemplates for novel therapeutic interventions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40279802P 2002-08-12 2002-08-12
US60/402,798 2002-08-12
US10/639,714 2003-08-12
US10/639,714 US7585856B2 (en) 2002-08-12 2003-08-12 Resolvins: Biotemplates for novel therapeutic interventions

Publications (3)

Publication Number Publication Date
WO2004014835A2 WO2004014835A2 (en) 2004-02-19
WO2004014835A3 true WO2004014835A3 (en) 2004-04-15
WO2004014835A9 WO2004014835A9 (en) 2004-07-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025336 WO2004014835A2 (en) 2002-08-12 2003-08-12 Resolvins: biotemplates for therapeutic interventions

Country Status (12)

Country Link
US (3) US7585856B2 (en)
EP (3) EP2216318B1 (en)
JP (7) JP4845378B2 (en)
AT (1) ATE449057T1 (en)
AU (2) AU2003258194B2 (en)
CA (1) CA2495260C (en)
DE (1) DE60330154D1 (en)
DK (1) DK2216318T3 (en)
ES (1) ES2700133T3 (en)
HU (1) HUE041471T2 (en)
SI (1) SI2216318T1 (en)
WO (1) WO2004014835A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349896B2 (en) 2000-02-16 2013-01-08 The Brigham And Womens's Hospital, Inc. Aspirin-triggered lipid mediators

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268393A2 (en) 2000-03-20 2003-01-02 Trustees Of Boston University Lipoxin analogs and methods for the treatment of periodontal disease
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7902257B2 (en) 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
EP2216318B1 (en) * 2002-08-12 2018-10-10 Brigham And Women's Hospital Resolvins: Biotemplates for therapeutic interventions
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
US20050238589A1 (en) * 2004-04-14 2005-10-27 Van Dyke Thomas E Methods and compositions for preventing or treating periodontal diseases
KR20070090928A (en) * 2004-11-19 2007-09-06 마텍 바이오싸이언스스 코포레이션 Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
US20090318394A1 (en) * 2004-11-19 2009-12-24 Julie Nauroth Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
US20060293288A1 (en) * 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases
US8273792B2 (en) * 2005-10-03 2012-09-25 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers
WO2007061783A1 (en) * 2005-11-18 2007-05-31 Trustees Of Boston University Treatment and prevention of bone loss using resolvins
US20090320148A1 (en) * 2006-01-31 2009-12-24 Martek Biosciences Corporation Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same
AU2007243282A1 (en) * 2006-04-28 2007-11-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of cardiovascular disease
CN101528218A (en) * 2006-07-19 2009-09-09 雷索维克斯药品公司 Compositions and methods for the treatment of mucositis
WO2008063772A2 (en) * 2006-10-13 2008-05-29 The Brigham And Women's Hospital Inc. Resolvin d series and protectin d1 mitigate acute kidney injury
WO2008058274A2 (en) * 2006-11-09 2008-05-15 Children's Medical Center Corporation Use of resolvins and docosatrienes and analogues thereof for the treatment of angiogenesis and ocular neovascularization
WO2008143642A2 (en) * 2006-11-09 2008-11-27 Children's Medical Center Corporation Methods of treating and preventing ocular neovascularization with omega-3 polyunsaturated fatty acids
US20110190389A1 (en) * 2007-02-20 2011-08-04 Linda Arterburn Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
US20110027841A1 (en) * 2007-12-21 2011-02-03 Martek Biosciences Corporation Method for preparation of oxylipins
US20110237495A1 (en) * 2008-05-21 2011-09-29 The Brigham And Women's Hospital, Inc. Corporate Sponsored Research And Licensing Functional metabolomics coupled microfluidic chemotaxis device and identification of novel cell mediators
EP2344441B1 (en) 2008-09-16 2016-02-17 The Brigham And Women's Hospital Inc. 7,14-dihydroxy-docosahexaenoic acid compounds
WO2010095706A1 (en) 2009-02-20 2010-08-26 国立大学法人東京大学 Novel anti-inflammatory compounds
US9416118B2 (en) * 2011-06-10 2016-08-16 The Brigham And Women's Hospital, Inc. Docosahexaenoyl ethanolamides
CA3050298A1 (en) 2012-08-24 2014-02-27 Sun Pharma Global Fze Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions
WO2014039964A2 (en) 2012-09-10 2014-03-13 The Regents Of The University Of California Compounds and methods for modulating vascular injury
CN103588670A (en) * 2013-10-28 2014-02-19 史克勇 Cancer pain medicine
CN103601649A (en) * 2013-10-28 2014-02-26 史克勇 Novel compound
CN103588671A (en) * 2013-10-28 2014-02-19 史克勇 Medicine for treating cancer pain
CN103588673A (en) * 2013-10-29 2014-02-19 史克勇 Cancer pain medicament
FR3029836B1 (en) * 2014-12-11 2016-12-23 Saint Gobain SHEET OF A SHEET OF THICK POLYMERIC MATERIAL AND A THIN GLASS SHEET
CN114377138A (en) * 2015-03-18 2022-04-22 福塞斯儿童牙科医院 Method for stabilizing atherosclerotic plaques using lipoxins, resolvins and analogs thereof
ES2607715B1 (en) * 2015-10-01 2018-01-17 Solutex Na, Lcc PROCESS FOR THE PREPARATION AND STABILIZATION OF EMULSIONS WITH OMEGA-3 THROUGH ISOMETRIC CRYSTAL NETWORKS OF CELLULOSE DERIVATIVES
FI3373976T3 (en) 2015-11-10 2024-03-25 Sun Pharmaceutical Ind Ltd Topical formulations and uses thereof
WO2017205582A1 (en) 2016-05-27 2017-11-30 Forsyth Dental Infirmary For Children Compositions and methods of treating cancer using lipid agonists and receptors thereof
WO2020076578A1 (en) 2018-10-09 2020-04-16 University Of Rochester Treatment of vulvovaginal disorders
EP4091672A4 (en) * 2020-02-18 2024-03-20 Univ Hokkaido Nat Univ Corp Stable bioisostere of resolvin e2
WO2023137554A1 (en) * 2022-01-20 2023-07-27 Benderdour Mohamed Resolvin analogs compounds, methods and uses thereof
WO2023168245A2 (en) 2022-03-03 2023-09-07 Thetis Pharmaceuticals Llc Cyclodextrin complexes of specialized proresolving mediators

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
GB2033745B (en) 1978-05-26 1983-08-17 Wellcome Found Fatty acid and derivatives thereof for use in treatment or prophylaxis of thromboembolic conditions
US4442099A (en) * 1981-11-27 1984-04-10 Research Corporation Leukotriene analogues
US4567290A (en) * 1981-11-27 1986-01-28 Research Corporation Leukotriene analogues
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
US4759880A (en) * 1984-09-27 1988-07-26 Research Corporation Alkanoarachidonic acids
GB8507058D0 (en) * 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
US4710521A (en) * 1986-07-25 1987-12-01 The Celotex Corporation Catalyst mixtures for polyisocyanurate foam
US4810424A (en) * 1987-10-09 1989-03-07 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Method for the recovery of 12-(S)-hydroxyeicosapentaenoic acid from the red alga murrayella periclados
US5136501A (en) * 1989-05-26 1992-08-04 Reuters Limited Anonymous matching system
EP0573423A4 (en) 1990-05-07 1994-06-01 Barry I Bockow Methods and preparations of stable, deodorized oils and pharmaceutical compositions thereof
US5650435A (en) * 1991-04-01 1997-07-22 Madara; James L. Modulation of inflammation related to columnar epithelia
US5087790A (en) * 1991-06-12 1992-02-11 University Of Southern California Method for olefination of carbonyl compounds using titanocene derivatives
CA2112399C (en) * 1991-06-24 2004-06-29 Antonio Ferrante Methods and compositions for treating malaria and other diseases
US5177046A (en) * 1991-09-20 1993-01-05 Air Products And Chemicals, Inc. Amine-boron adducts as reduced odor catalyst compositions for the production of polyurethanes
JPH05186342A (en) 1992-01-10 1993-07-27 Fujirebio Inc Antiinflammatory agent having immunoregulatory action
US5409955A (en) * 1993-05-13 1995-04-25 Bockow; Barry I. Compositions and methods for inhibiting uterine contractility
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US6887901B1 (en) * 1993-06-15 2005-05-03 Brigham & Women's Hospital, Inc. Lipoxin compounds and their use in treating cell proliferative disorders
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
US5411988A (en) * 1993-10-27 1995-05-02 Bockow; Barry I. Compositions and methods for inhibiting inflammation and adhesion formation
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5752238A (en) * 1994-11-03 1998-05-12 Intel Corporation Consumer-driven electronic information pricing mechanism
US5594732A (en) * 1995-03-03 1997-01-14 Intecom, Incorporated Bridging and signalling subsystems and methods for private and hybrid communications systems including multimedia systems
US5845265A (en) * 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5756789A (en) * 1995-06-08 1998-05-26 Texaco, Inc. Synthesis of metal--containing aluminophosphates with layered structure
CA2182851A1 (en) * 1995-08-15 1997-02-16 August Masaru Watanabe Method for treating substance abuse withdrawal
US5709855A (en) * 1995-09-22 1998-01-20 Bockow; Barry I. Compositions of spirulina algae and omega fatty acids for treatment of inflammation and pain
US5870717A (en) * 1995-11-13 1999-02-09 International Business Machines Corporation System for ordering items over computer network using an electronic catalog
ES2311571T3 (en) * 1996-04-12 2009-02-16 G.D. Searle Llc BENCENOSULFONAMIDE DERIVATIVES SUBSTITUTED AS COX-2 INHIBITORS PROFARMS.
US5878400A (en) * 1996-06-17 1999-03-02 Trilogy Development Group, Inc. Method and apparatus for pricing products in multi-level product and organizational groups
US5842040A (en) * 1996-06-18 1998-11-24 Storage Technology Corporation Policy caching method and apparatus for use in a communication device based on contents of one data unit in a subset of related data units
US6602817B1 (en) * 1998-10-23 2003-08-05 University Of Southern California Combination approach to chiral reagents or catalysts having amine or amino alcohol ligands
CA2259203C (en) * 1996-06-28 2008-04-29 Nicos A. Petasis Method for the synthesis of amines and amino acids with organoboron derivatives
US5890138A (en) * 1996-08-26 1999-03-30 Bid.Com International Inc. Computer auction system
US5861399A (en) 1996-07-17 1999-01-19 Heart Care Partners Methods and compositions for the rapid and enduring relief of inadequate myocardial function
US5896379A (en) * 1996-08-26 1999-04-20 Motorola, Inc. Network node for packet switching with selective data processing and method therefor
US5912006A (en) 1996-08-28 1999-06-15 Eboc, Inc. Compositions and methods for alleviating discomforting menstrual pain
US5946467A (en) * 1996-09-20 1999-08-31 Novell, Inc. Application-level, persistent packeting apparatus and method
US20020055539A1 (en) * 1996-10-02 2002-05-09 Bockow Barry I. Compositions and methods for treating cardiovascular conditions
US6201022B1 (en) * 1997-03-27 2001-03-13 Myorx, Inc. Methods for treating neurotransmitter-mediated pain syndromes by topically administering an omega fatty acid
US6008205A (en) * 1997-04-04 1999-12-28 The Brigham & Women's Hospital, Inc. Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6428990B1 (en) 1997-04-11 2002-08-06 Abbott Laboratories Human desaturase gene and uses thereof
US5878423A (en) * 1997-04-21 1999-03-02 Bellsouth Corporation Dynamically processing an index to create an ordered set of questions
US6030715A (en) * 1997-10-09 2000-02-29 The University Of Southern California Azlactone-related dopants in the emissive layer of an OLED
US6259699B1 (en) * 1997-12-30 2001-07-10 Nexabit Networks, Llc System architecture for and method of processing packets and/or cells in a common switch
JP3196714B2 (en) * 1998-03-05 2001-08-06 日本電気株式会社 Manufacturing method of semiconductor integrated circuit having triple well structure
EP1075252A2 (en) 1998-05-07 2001-02-14 ELAN CORPORATION, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
US6377937B1 (en) * 1998-05-28 2002-04-23 Paskowitz Associates Method and system for more effective communication of characteristics data for products and services
US6069109A (en) * 1998-07-01 2000-05-30 Union Carbide Chemicals & Plastics Technology Corporation Process for the production of half-sandwich transition metal based catalyst precursors
US6336138B1 (en) * 1998-08-25 2002-01-01 Hewlett-Packard Company Template-driven approach for generating models on network services
US6336105B1 (en) * 1998-11-16 2002-01-01 Trade Access Inc. System and method for representing data and providing electronic non-repudiation in a negotiations system
DE19855426A1 (en) 1998-12-02 2000-06-08 Wolfgang Langhoff Agents for the therapy and prophylaxis of rheumatic-arthritic diseases and for the prophylaxis of cardiovascular diseases
US6272474B1 (en) * 1999-02-08 2001-08-07 Crisostomo B. Garcia Method for monitoring and trading stocks via the internet displaying bid/ask trade bars
US6397212B1 (en) * 1999-03-04 2002-05-28 Peter Biffar Self-learning and self-personalizing knowledge search engine that delivers holistic results
CA2365204C (en) * 1999-03-18 2009-10-27 Brigham And Women's Hospital Lipoxin compounds and their use
ATE310512T1 (en) * 1999-03-18 2005-12-15 Brigham & Womens Hospital USE OF LIPOXINS TO INHIBIT TNF-ALPHA INITIATED COUNTERREACTION
US6271435B1 (en) * 1999-03-18 2001-08-07 Brigham & Women's Hospital, Inc. Leukotriene B4 receptor transgenic mice
EP2236140A1 (en) * 1999-03-18 2010-10-06 The Brigham and Women's Hospital, Inc. Regulation of phospholipase D activity
US6427132B1 (en) * 1999-08-31 2002-07-30 Accenture Llp System, method and article of manufacture for demonstrating E-commerce capabilities via a simulation on a network
US6415270B1 (en) * 1999-09-03 2002-07-02 Omnihub, Inc. Multiple auction coordination method and system
EP1296923B3 (en) * 2000-02-16 2012-04-11 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
EP1268393A2 (en) * 2000-03-20 2003-01-02 Trustees Of Boston University Lipoxin analogs and methods for the treatment of periodontal disease
DK1406698T3 (en) * 2001-03-02 2009-02-09 Brigham & Womens Hospital Lipoxin analogs as novel inhibitors of angiogenesis
US20040044028A1 (en) * 2001-03-30 2004-03-04 Obukowicz Mark G. Combinations of omega-3 fatty acids and cyclooxygenase-2 inhibitors for treatment or prevention of cardiovascular disease and treatment or prevention of cancer
CA2465117C (en) * 2001-11-06 2012-01-03 Brigham And Women's Hospital, Inc. Lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases
CA2467580C (en) * 2001-12-18 2012-10-30 Brigham And Women's Hospital Use of lipoxin analogs to promote cell defense against gram-negative infections
US7030159B2 (en) 2001-12-18 2006-04-18 The Brigham And Women's Hospital, Inc. Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs
EP2022775B1 (en) * 2002-04-01 2014-10-15 University of Southern California Trihydroxy polyunsaturated eicosanoids
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
AU2003238240A1 (en) 2002-06-17 2003-12-31 Resolvyx Pharmaceuticals ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE
US7759395B2 (en) * 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
EP2216318B1 (en) * 2002-08-12 2018-10-10 Brigham And Women's Hospital Resolvins: Biotemplates for therapeutic interventions
WO2004078143A2 (en) 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
WO2005013908A2 (en) * 2003-08-05 2005-02-17 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Neuroprotection protects against cellular apoptosis, neural stroke damage, alzheimer’s disease and retinal degeneration
US20050238589A1 (en) * 2004-04-14 2005-10-27 Van Dyke Thomas E Methods and compositions for preventing or treating periodontal diseases
US20060293288A1 (en) 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HONG, SONG ET AL: "Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells", JOURNAL OF BIOLOGICAL CHEMISTRY (2003), 278(17), 14677-14687, XP002267883 *
MARCHESELLI, VICTOR L. ET AL: "Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression", JOURNAL OF BIOLOGICAL CHEMISTRY (2003), 278(44), 43807-43817, XP002267882 *
SERHAN, CHARLES N. ET AL: "Novel Functional Sets of Lipid-derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2-Nonsteroidal Antiinflammatory Drugs and Transcellular Processing", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 8, 16 October 2000 (2000-10-16), pages 1197 - 1204, XP002267884 *
SERHAN, CHARLES N. ET AL: "Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals", JOURNAL OF EXPERIMENTAL MEDICINE (2002), 196(8), 1025-1037, XP002267881 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349896B2 (en) 2000-02-16 2013-01-08 The Brigham And Womens's Hospital, Inc. Aspirin-triggered lipid mediators

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