WO2004016805A3 - Immunostimulatory nucleic acids - Google Patents

Immunostimulatory nucleic acids Download PDF

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Publication number
WO2004016805A3
WO2004016805A3 PCT/US2003/025935 US0325935W WO2004016805A3 WO 2004016805 A3 WO2004016805 A3 WO 2004016805A3 US 0325935 W US0325935 W US 0325935W WO 2004016805 A3 WO2004016805 A3 WO 2004016805A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
immunostimulatory nucleic
soft
stimulating
semi
Prior art date
Application number
PCT/US2003/025935
Other languages
French (fr)
Other versions
WO2004016805A9 (en
WO2004016805A2 (en
Inventor
Arthur M Krieg
Ulrike Samulowitz
Joerg Vollmer
Eugen Uhlmann
Marion Jurk
Grayson Lipford
Robert Rankin
Original Assignee
Coley Pharm Group Inc
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES03788643.9T priority Critical patent/ES2600553T3/en
Priority to YUP-2005/0126A priority patent/RS20050126A/en
Priority to PL414814A priority patent/PL232260B1/en
Priority to CN03824039.4A priority patent/CN1688192B/en
Priority to BRPI0313414-8A priority patent/BR0313414A/en
Priority to PL375398A priority patent/PL227938B1/en
Priority to NZ538001A priority patent/NZ538001A/en
Application filed by Coley Pharm Group Inc, Coley Pharm Gmbh filed Critical Coley Pharm Group Inc
Priority to EP03788643.9A priority patent/EP1538904B1/en
Priority to CA2493753A priority patent/CA2493753C/en
Priority to JP2005502069A priority patent/JP5414961B2/en
Priority to MXPA05002014A priority patent/MXPA05002014A/en
Priority to DK03788643.9T priority patent/DK1538904T3/en
Priority to AU2003259916A priority patent/AU2003259916B2/en
Publication of WO2004016805A2 publication Critical patent/WO2004016805A2/en
Publication of WO2004016805A9 publication Critical patent/WO2004016805A9/en
Priority to IL166376A priority patent/IL166376A/en
Publication of WO2004016805A3 publication Critical patent/WO2004016805A3/en
Priority to TNP2005000052A priority patent/TNSN05052A1/en
Priority to NO20051469A priority patent/NO20051469L/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

Abstract

The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
PCT/US2003/025935 2002-08-19 2003-08-19 Immunostimulatory nucleic acids WO2004016805A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
AU2003259916A AU2003259916B2 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
PL414814A PL232260B1 (en) 2002-08-19 2003-08-19 Immunostimulating oligonucleotide and composition containing such oligonucleotide to be applied for stimulation of immunological response
CN03824039.4A CN1688192B (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
BRPI0313414-8A BR0313414A (en) 2002-08-19 2003-08-19 immunostimulatory nucleic acids
PL375398A PL227938B1 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
NZ538001A NZ538001A (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
JP2005502069A JP5414961B2 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acid
EP03788643.9A EP1538904B1 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
CA2493753A CA2493753C (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
ES03788643.9T ES2600553T3 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
MXPA05002014A MXPA05002014A (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids.
DK03788643.9T DK1538904T3 (en) 2002-08-19 2003-08-19 IMMUNSTIMULATING NUCLEIC ACIDS
YUP-2005/0126A RS20050126A (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids
IL166376A IL166376A (en) 2002-08-19 2005-01-18 Immunostimulatory nucleic acids
TNP2005000052A TNSN05052A1 (en) 2002-08-19 2005-02-18 Immunostimulatory nucleic acids
NO20051469A NO20051469L (en) 2002-08-19 2005-03-18 Immune-stimulating nucleic acids.

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US40482002P 2002-08-19 2002-08-19
US40447902P 2002-08-19 2002-08-19
US60/404,820 2002-08-19
US60/404,479 2002-08-19
US42970102P 2002-11-27 2002-11-27
US60/429,701 2002-11-27
US44737703P 2003-02-14 2003-02-14
US60/447,377 2003-02-14

Publications (3)

Publication Number Publication Date
WO2004016805A2 WO2004016805A2 (en) 2004-02-26
WO2004016805A9 WO2004016805A9 (en) 2004-08-19
WO2004016805A3 true WO2004016805A3 (en) 2005-02-17

Family

ID=31892263

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025935 WO2004016805A2 (en) 2002-08-19 2003-08-19 Immunostimulatory nucleic acids

Country Status (27)

Country Link
US (2) US8283328B2 (en)
EP (2) EP2290078B1 (en)
JP (2) JP5414961B2 (en)
KR (2) KR20080011247A (en)
AR (1) AR040996A1 (en)
AU (2) AU2003259916B2 (en)
BR (1) BR0313414A (en)
CA (1) CA2493753C (en)
DK (2) DK2290078T3 (en)
EC (1) ECSP055687A (en)
ES (2) ES2600553T3 (en)
HU (2) HUE030347T2 (en)
IL (1) IL166376A (en)
MA (1) MA27468A1 (en)
MX (1) MXPA05002014A (en)
NO (1) NO20051469L (en)
NZ (2) NZ538001A (en)
OA (1) OA12906A (en)
PE (2) PE20040900A1 (en)
PL (2) PL232260B1 (en)
PT (2) PT1538904T (en)
RS (1) RS20050126A (en)
SI (1) SI2290078T1 (en)
SV (1) SV2008001602A (en)
TW (1) TW200412981A (en)
UY (1) UY27945A1 (en)
WO (1) WO2004016805A2 (en)

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