WO2004026888A3 - Toll-like receptor 9 (tlr9) from various mammalian species - Google Patents

Toll-like receptor 9 (tlr9) from various mammalian species Download PDF

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Publication number
WO2004026888A3
WO2004026888A3 PCT/US2003/029577 US0329577W WO2004026888A3 WO 2004026888 A3 WO2004026888 A3 WO 2004026888A3 US 0329577 W US0329577 W US 0329577W WO 2004026888 A3 WO2004026888 A3 WO 2004026888A3
Authority
WO
WIPO (PCT)
Prior art keywords
tlr9
receptor
amino acid
toll
nucleotide sequences
Prior art date
Application number
PCT/US2003/029577
Other languages
French (fr)
Other versions
WO2004026888A2 (en
Inventor
Grayson B Lipford
Neeloffer Mookherjee
Lorne Babiuk
Robert Brownlie
Philip Griebel
George Mutwiri
Rolf Hecker
Original Assignee
Coley Pharm Gmbh
Univ Saskatchewan
Qiagen Gmbh
Grayson B Lipford
Neeloffer Mookherjee
Lorne Babiuk
Robert Brownlie
Philip Griebel
George Mutwiri
Rolf Hecker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Univ Saskatchewan, Qiagen Gmbh, Grayson B Lipford, Neeloffer Mookherjee, Lorne Babiuk, Robert Brownlie, Philip Griebel, George Mutwiri, Rolf Hecker filed Critical Coley Pharm Gmbh
Priority to AU2003278845A priority Critical patent/AU2003278845A1/en
Publication of WO2004026888A2 publication Critical patent/WO2004026888A2/en
Publication of WO2004026888A3 publication Critical patent/WO2004026888A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Abstract

Novel amino acid and nucleotide sequences for rat, pig (porcine), cow (bovine), horse (equine), and sheep (ovine) Toll-­like receptor 9 (TLR9) are provided. Also provided are amino acid and nucleotide sequences for dog (canine), cat (feline), mouse (murine), and human TLR9. Comparison of these sequences, especially in combination with functional assessment for species-specific CpG motif preferences, permits identification of specific regions and amino acid residues of interest in TLR9 ligand interaction. Novel chimeric TLR9 receptor molecules, cells expressing these molecules, and methods for their use in screening assays for TLR9 ligands are also provided.
PCT/US2003/029577 2002-09-19 2003-09-19 Toll-like receptor 9 (tlr9) from various mammalian species WO2004026888A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003278845A AU2003278845A1 (en) 2002-09-19 2003-09-19 Toll-like receptor 9 (tlr9) from various mammalian species

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41247902P 2002-09-19 2002-09-19
US60/412,479 2002-09-19

Publications (2)

Publication Number Publication Date
WO2004026888A2 WO2004026888A2 (en) 2004-04-01
WO2004026888A3 true WO2004026888A3 (en) 2005-01-06

Family

ID=32030880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029577 WO2004026888A2 (en) 2002-09-19 2003-09-19 Toll-like receptor 9 (tlr9) from various mammalian species

Country Status (2)

Country Link
AU (1) AU2003278845A1 (en)
WO (1) WO2004026888A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354522B2 (en) 2005-11-25 2013-01-15 Coley Pharmaceutical Gmbh Immunostimulatory oligoribonucleotides
US9382545B2 (en) 2006-09-27 2016-07-05 Coley Pharmaceutical Gmbh CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
IL139813A0 (en) 1998-05-22 2002-02-10 Loeb Health Res Inst At The Ot Methods and products for inducing mucosal immunity
EP2204186B1 (en) 1999-02-17 2016-04-06 CSL Limited Immunogenic complexes and methods relating thereto
NZ517929A (en) 1999-09-25 2004-02-27 Univ Iowa Res Found Immunostimulatory nucleic acids
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
CA2419894A1 (en) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Process for high throughput screening of cpg-based immuno-agonist/antagonist
WO2003015711A2 (en) 2001-08-17 2003-02-27 Coley Pharmaceutical Group, Inc. Combination motif immune stimulatory oligonucleotides with improved activity
CA2480775C (en) 2002-04-04 2016-05-31 Coley Pharmaceutical Gmbh Immunostimulatory g,u-containing oligoribonucleotides
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (en) 2002-08-19 2005-04-27 Coley Pharm Group Inc IMMUNE STIMULATING NUCLEIC ACIDS
CN1753687A (en) 2002-10-29 2006-03-29 科勒制药集团股份有限公司 Use of cpg oligonucleotides in the treatment of hepatitis c virus infection
WO2004053104A2 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
WO2005001116A1 (en) * 2003-06-17 2005-01-06 Meiji Dairies Corporation Utilization of cell forcibly expressing toll-like receptor
SG122973A1 (en) 2003-10-30 2006-06-29 Coley Pharm Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
AR091569A1 (en) 2012-06-28 2015-02-11 Intervet Int Bv TOLL TYPE RECEIVERS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEMMI H. ET AL: "A toll-like receptor recognizes bacterial DNA", NATURE, vol. 408, no. 6813, December 2000 (2000-12-01), pages 740 - 745, XP002944896 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354522B2 (en) 2005-11-25 2013-01-15 Coley Pharmaceutical Gmbh Immunostimulatory oligoribonucleotides
US9382545B2 (en) 2006-09-27 2016-07-05 Coley Pharmaceutical Gmbh CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity

Also Published As

Publication number Publication date
WO2004026888A2 (en) 2004-04-01
AU2003278845A1 (en) 2004-04-08
AU2003278845A8 (en) 2004-04-08

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