WO2004032862A3 - Cyclodextrin-based materials, compositions and uses related thereto - Google Patents

Cyclodextrin-based materials, compositions and uses related thereto Download PDF

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Publication number
WO2004032862A3
WO2004032862A3 PCT/US2003/031991 US0331991W WO2004032862A3 WO 2004032862 A3 WO2004032862 A3 WO 2004032862A3 US 0331991 W US0331991 W US 0331991W WO 2004032862 A3 WO2004032862 A3 WO 2004032862A3
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WO
WIPO (PCT)
Prior art keywords
cyclodextrin
compositions
based materials
uses related
active agents
Prior art date
Application number
PCT/US2003/031991
Other languages
French (fr)
Other versions
WO2004032862A2 (en
Inventor
Nathalie C Bellocq
Mark E Davis
Suzie Hwang Pun
Original Assignee
Insert Therapeutics Inc
Nathalie C Bellocq
Mark E Davis
Suzie Hwang Pun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insert Therapeutics Inc, Nathalie C Bellocq, Mark E Davis, Suzie Hwang Pun filed Critical Insert Therapeutics Inc
Priority to AU2003295344A priority Critical patent/AU2003295344B2/en
Priority to JP2004543586A priority patent/JP4602085B2/en
Priority to BR0315198-0A priority patent/BR0315198A/en
Priority to CA002501132A priority patent/CA2501132A1/en
Priority to MXPA05003591A priority patent/MXPA05003591A/en
Priority to EP03786526A priority patent/EP1549269A4/en
Publication of WO2004032862A2 publication Critical patent/WO2004032862A2/en
Publication of WO2004032862A3 publication Critical patent/WO2004032862A3/en

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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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Abstract

The application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.
PCT/US2003/031991 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto WO2004032862A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003295344A AU2003295344B2 (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto
JP2004543586A JP4602085B2 (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and related applications
BR0315198-0A BR0315198A (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials and compositions and uses thereof
CA002501132A CA2501132A1 (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto
MXPA05003591A MXPA05003591A (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto.
EP03786526A EP1549269A4 (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41737302P 2002-10-09 2002-10-09
US60/417,373 2002-10-09

Publications (2)

Publication Number Publication Date
WO2004032862A2 WO2004032862A2 (en) 2004-04-22
WO2004032862A3 true WO2004032862A3 (en) 2004-07-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031991 WO2004032862A2 (en) 2002-10-09 2003-10-08 Cyclodextrin-based materials, compositions and uses related thereto

Country Status (13)

Country Link
US (3) US8357377B2 (en)
EP (1) EP1549269A4 (en)
JP (1) JP4602085B2 (en)
KR (1) KR20050051686A (en)
CN (1) CN1717209A (en)
AU (1) AU2003295344B2 (en)
BR (1) BR0315198A (en)
CA (1) CA2501132A1 (en)
MX (1) MXPA05003591A (en)
RU (1) RU2005114007A (en)
TW (1) TW200423960A (en)
WO (1) WO2004032862A2 (en)
ZA (1) ZA200502754B (en)

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US8110179B2 (en) 2002-09-06 2012-02-07 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutics delivery

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SG129240A1 (en) * 2003-01-23 2007-02-26 Agency Science Tech & Res Biodegradable copolymer and nucleic acid delivery system
US7605120B2 (en) * 2003-10-22 2009-10-20 Amgen Inc. Antagonists of the brandykinin B1 receptor
KR20070007076A (en) 2003-12-31 2007-01-12 사이덱스 인크 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER gamma;-CYCLODEXTRIN AND CORTICOSTEROID
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US20070020196A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension
ATE446581T1 (en) * 2004-03-12 2009-11-15 Trinity College Dublin MAGNETORRESISTIVE MEDIUM
CN1976708A (en) * 2004-07-01 2007-06-06 荷兰癌症研究所 Combination comprising a BCRP inhibitor and 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyridimin-2-ylamino)phenyl]-benzamide
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