WO2004034025A3 - Nano-chem-fet based biosensors - Google Patents

Nano-chem-fet based biosensors Download PDF

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Publication number
WO2004034025A3
WO2004034025A3 PCT/US2003/032063 US0332063W WO2004034025A3 WO 2004034025 A3 WO2004034025 A3 WO 2004034025A3 US 0332063 W US0332063 W US 0332063W WO 2004034025 A3 WO2004034025 A3 WO 2004034025A3
Authority
WO
WIPO (PCT)
Prior art keywords
chem
nano
nanosensors
based biosensors
fet based
Prior art date
Application number
PCT/US2003/032063
Other languages
French (fr)
Other versions
WO2004034025A2 (en
Inventor
Larry Bock
R Hugh Daniels
Stephen Empedocles
Chumming Niu
John C Owicki
Vijendra Sahi
Calvin Chow
George Pontis
Original Assignee
Nanosys Inc
Larry Bock
R Hugh Daniels
Stephen Empedocles
Chumming Niu
John C Owicki
Vijendra Sahi
Calvin Chow
George Pontis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosys Inc, Larry Bock, R Hugh Daniels, Stephen Empedocles, Chumming Niu, John C Owicki, Vijendra Sahi, Calvin Chow, George Pontis filed Critical Nanosys Inc
Priority to AU2003282548A priority Critical patent/AU2003282548A1/en
Publication of WO2004034025A2 publication Critical patent/WO2004034025A2/en
Publication of WO2004034025A3 publication Critical patent/WO2004034025A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Abstract

Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.
PCT/US2003/032063 2002-10-10 2003-10-09 Nano-chem-fet based biosensors WO2004034025A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003282548A AU2003282548A1 (en) 2002-10-10 2003-10-09 Nano-chem-fet based biosensors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41776102P 2002-10-10 2002-10-10
US60/417,761 2002-10-10

Publications (2)

Publication Number Publication Date
WO2004034025A2 WO2004034025A2 (en) 2004-04-22
WO2004034025A3 true WO2004034025A3 (en) 2005-03-24

Family

ID=32094080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032063 WO2004034025A2 (en) 2002-10-10 2003-10-09 Nano-chem-fet based biosensors

Country Status (3)

Country Link
US (2) US7303875B1 (en)
AU (1) AU2003282548A1 (en)
WO (1) WO2004034025A2 (en)

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