WO2004034970A3 - Macrocyclic lactams - Google Patents

Macrocyclic lactams Download PDF

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Publication number
WO2004034970A3
WO2004034970A3 PCT/US2003/030518 US0330518W WO2004034970A3 WO 2004034970 A3 WO2004034970 A3 WO 2004034970A3 US 0330518 W US0330518 W US 0330518W WO 2004034970 A3 WO2004034970 A3 WO 2004034970A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon
bond
substitution
alkyl
equal
Prior art date
Application number
PCT/US2003/030518
Other languages
French (fr)
Other versions
WO2004034970A2 (en
Inventor
Scott S Mitchell
Benjamin Nicholson
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Priority to AU2003296908A priority Critical patent/AU2003296908A1/en
Publication of WO2004034970A2 publication Critical patent/WO2004034970A2/en
Publication of WO2004034970A3 publication Critical patent/WO2004034970A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Compounds represented by Formula (I), acid-addition salts and pro-drugs are disclosed, wherein the ring structure includes no substitutions, one substitution, or more than one substitution; and wherein n is equal to an integer greater than 1, preferably 2, 3, or 4; m is equal to a positive integer, preferably 1, 2 or 3, and each separate Xn and X are each separately selected from a nucleophilic residue, preferably -H, -OH, -O-CO-alkyl, -O-alkyl, -NH2, a halogen and the like; and wherein the dashed line represents a C-C bond or a C-H bond, and the dashed and solid line represents either a carbon-carbon single bond or a carbon-carbon double bond.
PCT/US2003/030518 2002-09-27 2003-09-25 Macrocyclic lactams WO2004034970A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003296908A AU2003296908A1 (en) 2002-09-27 2003-09-25 Macrocyclic lactams

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41481702P 2002-09-27 2002-09-27
US60/414,817 2002-09-27

Publications (2)

Publication Number Publication Date
WO2004034970A2 WO2004034970A2 (en) 2004-04-29
WO2004034970A3 true WO2004034970A3 (en) 2004-11-18

Family

ID=32107877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030518 WO2004034970A2 (en) 2002-09-27 2003-09-25 Macrocyclic lactams

Country Status (3)

Country Link
US (1) US7112581B2 (en)
AU (1) AU2003296908A1 (en)
WO (1) WO2004034970A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007692A2 (en) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft New epothilone derivatives, method for producing same and their pharmaceutical use
WO2000037473A1 (en) * 1998-12-22 2000-06-29 Novartis Ag Epothilone derivatives and their use as antitumor agents

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (en) * 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr PHARMACEUTICAL FORMULATIONS
KR100221695B1 (en) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 Pharmaceutical spheroid formulation
US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
DE4231289A1 (en) * 1992-09-18 1994-03-24 Bayer Ag New natural product cyclamenol and chemical derivatives
ES2119996T3 (en) * 1992-11-27 1998-10-16 Napro Biotherapeutics Inc INJECTABLE COMPOSITION INCLUDING FACLITAXEL.
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
DE69434474T2 (en) * 1993-10-01 2006-05-18 Roche Palo Alto Llc, Palo Alto HIGHLY DOSED ORAL SUSPENSIONS CONTAIN MYCOPHENOLATE MOFETIL
US5707641A (en) * 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) * 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) * 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5874443A (en) * 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US5886210A (en) * 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
DE69842004D1 (en) * 1997-11-21 2010-12-30 Purdue Neuroscience Co SUBSTITUTED 2-AMINOACETAMIDES AND APPLICATION THEREOF
AU752005B2 (en) * 1998-03-26 2002-09-05 Shionogi & Co., Ltd. Indole derivatives with antiviral activity
US6509331B1 (en) * 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5992683A (en) 1998-08-31 1999-11-30 Kimberly-Clark Worldwide, Inc. Clip lift for sheet dispensing system
FR2784988B1 (en) * 1998-10-23 2002-09-20 Adir NOVEL DIHYDRO AND TETRAHYDROQUINOLEINIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007692A2 (en) * 1997-08-09 1999-02-18 Schering Aktiengesellschaft New epothilone derivatives, method for producing same and their pharmaceutical use
WO2000037473A1 (en) * 1998-12-22 2000-06-29 Novartis Ag Epothilone derivatives and their use as antitumor agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARAI H ET AL: "Absolute Stereochemistry of Vicenistatin, A Novel 20-Membered Macrocyclic Lactam Antitumor Antibiotic", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 20, 14 May 1998 (1998-05-14), pages 3181 - 3184, XP004116225, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
US20040132997A1 (en) 2004-07-08
US7112581B2 (en) 2006-09-26
WO2004034970A2 (en) 2004-04-29
AU2003296908A1 (en) 2004-05-04
AU2003296908A8 (en) 2004-05-04

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