WO2004035754A3 - Microencapsulation and sustained release of biologically active polypeptides - Google Patents
Microencapsulation and sustained release of biologically active polypeptides Download PDFInfo
- Publication number
- WO2004035754A3 WO2004035754A3 PCT/US2003/033062 US0333062W WO2004035754A3 WO 2004035754 A3 WO2004035754 A3 WO 2004035754A3 US 0333062 W US0333062 W US 0333062W WO 2004035754 A3 WO2004035754 A3 WO 2004035754A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biologically active
- sustained release
- active polypeptides
- microencapsulation
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003286472A AU2003286472A1 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41938802P | 2002-10-17 | 2002-10-17 | |
US60/419,388 | 2002-10-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004035754A2 WO2004035754A2 (en) | 2004-04-29 |
WO2004035754A3 true WO2004035754A3 (en) | 2004-10-07 |
Family
ID=32108072
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/033198 WO2004035762A2 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
PCT/US2003/033168 WO2004036186A2 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
PCT/US2003/033062 WO2004035754A2 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/033198 WO2004035762A2 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
PCT/US2003/033168 WO2004036186A2 (en) | 2002-10-17 | 2003-10-17 | Microencapsulation and sustained release of biologically active polypeptides |
Country Status (3)
Country | Link |
---|---|
US (4) | US7462365B2 (en) |
AU (3) | AU2003282955A1 (en) |
WO (3) | WO2004035762A2 (en) |
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US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
WO2004035762A2 (en) * | 2002-10-17 | 2004-04-29 | Alkermes Controlled Therapeutics, Inc. Ii | Microencapsulation and sustained release of biologically active polypeptides |
US20040121009A1 (en) * | 2002-10-17 | 2004-06-24 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
EP2462923A3 (en) | 2003-07-18 | 2012-08-29 | Oakwood Laboratories L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
US20060057180A1 (en) * | 2004-02-20 | 2006-03-16 | Ashutosh Chilkoti | Tunable nonfouling surface of oligoethylene glycol |
US7456254B2 (en) * | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
PL1734971T3 (en) | 2004-04-15 | 2012-08-31 | Alkermes Pharma Ireland Ltd | Polymer-based sustained release device |
US20060110423A1 (en) * | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
CA2565980A1 (en) | 2004-05-12 | 2005-12-01 | Luca Technologies, Llc | Generation of hydrogen from hydrocarbon-bearing materials |
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US7597907B2 (en) * | 2004-11-05 | 2009-10-06 | Trustees Of The University Of Pennsylvania | Antioxidant polymer nanocarriers for use in preventing oxidative injury |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
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KR20080013878A (en) * | 2005-04-18 | 2008-02-13 | 노보 노르디스크 에이/에스 | Il-21 variants |
AU2006256802A1 (en) * | 2005-06-06 | 2006-12-14 | Novo Nordisk A/S | Stabilised IL-21 compositions |
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ES2736184T3 (en) | 2005-08-19 | 2019-12-26 | Amylin Pharmaceuticals Llc | Exendina for the treatment of diabetes and the reduction of body weight |
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US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
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US20110263496A1 (en) | 2008-05-21 | 2011-10-27 | Amylin Pharmaceuticals, Inc. | Exendins to lower cholesterol and triglycerides |
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BR112012012945A2 (en) | 2009-11-25 | 2020-12-29 | Arisgen Sa | MUCOSAL RELEASE COMPOSITION, ITS PRODUCTION METHOD, PRE-FORMED PEPTIDE COMPLEX, KIT AND USE OF AN ACTIVE PEPTIDE AGENT |
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US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5922253A (en) * | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
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-
2003
- 2003-10-17 WO PCT/US2003/033198 patent/WO2004035762A2/en not_active Application Discontinuation
- 2003-10-17 US US10/688,059 patent/US7462365B2/en active Active
- 2003-10-17 US US10/688,786 patent/US7164005B2/en not_active Expired - Lifetime
- 2003-10-17 WO PCT/US2003/033168 patent/WO2004036186A2/en not_active Application Discontinuation
- 2003-10-17 AU AU2003282955A patent/AU2003282955A1/en not_active Abandoned
- 2003-10-17 AU AU2003286472A patent/AU2003286472A1/en not_active Abandoned
- 2003-10-17 WO PCT/US2003/033062 patent/WO2004035754A2/en not_active Application Discontinuation
- 2003-10-17 AU AU2003277446A patent/AU2003277446A1/en not_active Abandoned
-
2006
- 2006-09-29 US US11/541,323 patent/US20070027085A1/en not_active Abandoned
-
2008
- 2008-11-06 US US12/289,857 patent/US8129339B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5922253A (en) * | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
Also Published As
Publication number | Publication date |
---|---|
WO2004035762A3 (en) | 2004-08-05 |
US20040228833A1 (en) | 2004-11-18 |
US7462365B2 (en) | 2008-12-09 |
US7164005B2 (en) | 2007-01-16 |
WO2004035762A2 (en) | 2004-04-29 |
US20090281034A1 (en) | 2009-11-12 |
WO2004036186A2 (en) | 2004-04-29 |
AU2003277446A8 (en) | 2004-05-04 |
US20040208929A1 (en) | 2004-10-21 |
AU2003286472A1 (en) | 2004-05-04 |
AU2003277446A1 (en) | 2004-05-04 |
AU2003286472A8 (en) | 2004-05-04 |
AU2003282955A8 (en) | 2004-05-04 |
WO2004035754A2 (en) | 2004-04-29 |
WO2004036186A3 (en) | 2004-12-23 |
US8129339B2 (en) | 2012-03-06 |
AU2003282955A1 (en) | 2004-05-04 |
US20070027085A1 (en) | 2007-02-01 |
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