WO2004037316A3 - Nanoparticle delivery system - Google Patents

Nanoparticle delivery system Download PDF

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Publication number
WO2004037316A3
WO2004037316A3 PCT/US2003/032355 US0332355W WO2004037316A3 WO 2004037316 A3 WO2004037316 A3 WO 2004037316A3 US 0332355 W US0332355 W US 0332355W WO 2004037316 A3 WO2004037316 A3 WO 2004037316A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
nanoparticle delivery
nanotubes
materials
delivery
Prior art date
Application number
PCT/US2003/032355
Other languages
French (fr)
Other versions
WO2004037316A2 (en
Inventor
Donn M Dennis
Charles R Martin
Richard J Rogers
Jon D Stewart
Original Assignee
Univ Florida
Donn M Dennis
Charles R Martin
Richard J Rogers
Jon D Stewart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Donn M Dennis, Charles R Martin, Richard J Rogers, Jon D Stewart filed Critical Univ Florida
Priority to AU2003290524A priority Critical patent/AU2003290524A1/en
Publication of WO2004037316A2 publication Critical patent/WO2004037316A2/en
Publication of WO2004037316A3 publication Critical patent/WO2004037316A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Abstract

The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials . The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.
PCT/US2003/032355 2002-10-21 2003-10-10 Nanoparticle delivery system WO2004037316A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003290524A AU2003290524A1 (en) 2002-10-21 2003-10-10 Nanoparticle delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/274,829 2002-10-21
US10/274,829 US7195780B2 (en) 2002-10-21 2002-10-21 Nanoparticle delivery system

Publications (2)

Publication Number Publication Date
WO2004037316A2 WO2004037316A2 (en) 2004-05-06
WO2004037316A3 true WO2004037316A3 (en) 2004-10-07

Family

ID=32093154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032355 WO2004037316A2 (en) 2002-10-21 2003-10-10 Nanoparticle delivery system

Country Status (3)

Country Link
US (1) US7195780B2 (en)
AU (1) AU2003290524A1 (en)
WO (1) WO2004037316A2 (en)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ518740A (en) 1999-11-08 2004-04-30 Univ Florida Marker detection method and apparatus to monitor drug compliance
EP1718971A2 (en) * 2000-11-08 2006-11-08 University Of Florida Research Foundation, Inc. System and method for real-time diagnosis, treatment, and therapeutic drug monitoring
US20040166152A1 (en) * 2002-02-14 2004-08-26 Andreas Hirsch Use of buckysome or carbon nanotube for drug delivery
US20080193490A1 (en) * 2002-02-14 2008-08-14 Andreas Hirsch Use of Carbon Nanotube for Drug Delivery
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
WO2003092763A1 (en) * 2002-05-03 2003-11-13 Duke University Carbon nanotubules for storage of nitric oxide
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
EP1565397A1 (en) * 2002-11-18 2005-08-24 Koninklijke Philips Electronics N.V. Dispersion of nanowires of semiconductor material
US7898005B2 (en) * 2002-12-09 2011-03-01 The Regents Of The University Of California Inorganic nanotubes and electro-fluidic devices fabricated therefrom
US7355216B2 (en) * 2002-12-09 2008-04-08 The Regents Of The University Of California Fluidic nanotubes and devices
EP1493714A1 (en) * 2003-03-14 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Encapsulation of biomolecules inside carbon nanotube
US20040186459A1 (en) * 2003-03-20 2004-09-23 Michael Shur Fluid delivery to cells and sensing properties of cells using nanotubes
US8993327B2 (en) * 2003-04-07 2015-03-31 Ut-Battelle, Llc Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures
US7056409B2 (en) * 2003-04-17 2006-06-06 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20050221072A1 (en) * 2003-04-17 2005-10-06 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7579077B2 (en) * 2003-05-05 2009-08-25 Nanosys, Inc. Nanofiber surfaces for use in enhanced surface area applications
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20060122596A1 (en) * 2003-04-17 2006-06-08 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
WO2005005679A2 (en) * 2003-04-28 2005-01-20 Nanosys, Inc. Super-hydrophobic surfaces, methods of their construction and uses therefor
WO2005010480A2 (en) * 2003-04-28 2005-02-03 Eikos, Inc. Sensor device utilizing carbon nanotubes
TWI427709B (en) * 2003-05-05 2014-02-21 Nanosys Inc Nanofiber surfaces for use in enhanced surface area applications
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7563451B2 (en) * 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
EP1680087A1 (en) * 2003-10-31 2006-07-19 Teva Pharmaceutical Industries Limited Nanoparticles for drug delivery
US7824660B2 (en) * 2003-12-05 2010-11-02 Buzatu Dan A Nanotubes for cancer therapy and diagnostics
US20110039690A1 (en) 2004-02-02 2011-02-17 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US8025960B2 (en) 2004-02-02 2011-09-27 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US20060163160A1 (en) * 2005-01-25 2006-07-27 Weiner Michael L Halloysite microtubule processes, structures, and compositions
DE102004017705A1 (en) * 2004-04-07 2005-11-03 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Ferromagnetic carbon nanotubes carrying biomolecules, methods of making them, and their use in diagnosis and therapy
DE102004026745B4 (en) * 2004-05-28 2013-06-20 Justus-Liebig-Universität Giessen Method and device for applying nanoscale polymer fibers as a carrier for agricultural active ingredients
WO2006028930A2 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
WO2007018562A2 (en) * 2004-09-22 2007-02-15 Nanolab, Inc. Nanospearing for molecular transportation into cells
DE602005010747D1 (en) * 2005-01-13 2008-12-11 Cinv Ag CARBON NANOPARTICLES CONTAINING COMPOSITE MATERIALS
WO2006078640A2 (en) * 2005-01-19 2006-07-27 International Technology Center Alterations utilizing nanoparticles
JP2008528722A (en) * 2005-01-24 2008-07-31 シンベンション アーゲー Metal-containing composite material
US7400490B2 (en) * 2005-01-25 2008-07-15 Naturalnano Research, Inc. Ultracapacitors comprised of mineral microtubules
US8119021B2 (en) * 2005-04-06 2012-02-21 Drexel University Functional nanoparticle filled carbon nanotubes and methods of their production
US20090311767A1 (en) * 2005-04-21 2009-12-17 Chiles Thomas C Method for molecular delivery into cells using naonotube spearing
US20070015179A1 (en) * 2005-04-26 2007-01-18 Trustees Of Boston University Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples
CA2646106C (en) 2005-05-06 2014-03-18 University Of Kentucky Research Foundation Nanotubes as mitochondrial uncouplers
US7928208B2 (en) * 2005-05-09 2011-04-19 University Of Florida Research Foundation, Inc. Template-synthesized DNA nanotubes
WO2007086923A2 (en) * 2005-05-23 2007-08-02 University Of South Florida Controlled and sustained gene transfer mediated by thiol-modified polymers
US8033501B2 (en) * 2005-06-10 2011-10-11 The Boeing Company Method and apparatus for attaching electrically powered seat track cover to through hole seat track design
JP2008545026A (en) * 2005-07-01 2008-12-11 シンベンション アーゲー Process for the preparation of porous reticulated composites
US20070111002A1 (en) * 2005-07-25 2007-05-17 University Of Washington Polymer hollow particles with controllable holes in their surfaces
US9629927B2 (en) * 2005-07-29 2017-04-25 Sloan-Kettering Institute For Cancer Research Single wall nanotube constructs and uses thereof
WO2007016466A2 (en) * 2005-07-29 2007-02-08 Sloan-Kettering Institute For Cancer Research Single wall nanotube constructs and uses therefor
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
US20070071790A1 (en) 2005-09-28 2007-03-29 Northwestern University Biodegradable nanocomposites with enhance mechanical properties for soft tissue
US8536324B2 (en) * 2005-10-21 2013-09-17 University Of South Florida Method of drug delivery by carbon nanotube-chitosan nanocomplexes
WO2007136404A2 (en) * 2005-11-03 2007-11-29 Clemson University Lysophospholipids solubilized single-walled carbon nanotubes
US8647644B1 (en) 2006-04-19 2014-02-11 Iowa State University Research Foundation, Inc. Methods of using capped mesoporous silicates
WO2007142316A1 (en) * 2006-06-08 2007-12-13 The University Of Tokushima Method for production of novel nano silica particle and use of the nano silica particle
US20120141543A1 (en) * 2007-01-11 2012-06-07 Sitharaman Balaji Carbon Nanotube Based Nanocomposites
US8076124B2 (en) * 2007-01-17 2011-12-13 Ut-Battelle, Llc Method and apparatus for sustaining viability of biological cells on a substrate
WO2008127508A2 (en) * 2007-02-21 2008-10-23 Northeastern University Titania nanotubes prepared by anodization in chloride-containing electrolytes
EP2164425B1 (en) * 2007-03-16 2015-10-28 The Regents of The University of California Nanostructure surface coated medical implants and methods of using the same
US8784866B2 (en) * 2007-03-26 2014-07-22 William Marsh Rice University Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
WO2008118960A2 (en) * 2007-03-26 2008-10-02 William Marsh Rice University Radiation protection using carbon nanotube derivatives
US20080292979A1 (en) * 2007-05-22 2008-11-27 Zhe Ding Transparent conductive materials and coatings, methods of production and uses thereof
US20090004231A1 (en) * 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
US20090056589A1 (en) * 2007-08-29 2009-03-05 Honeywell International, Inc. Transparent conductors having stretched transparent conductive coatings and methods for fabricating the same
WO2009032994A2 (en) * 2007-09-06 2009-03-12 Emory University Silica-based nanoparticles and methods of stimulating bone formation and suppressing bone resorption through modulation of nf-kb
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
US8319002B2 (en) 2007-12-06 2012-11-27 Nanosys, Inc. Nanostructure-enhanced platelet binding and hemostatic structures
JP5519524B2 (en) 2007-12-06 2014-06-11 ナノシス・インク． Absorbable nano-reinforced hemostatic structure and bandage material
US8551072B2 (en) 2007-12-12 2013-10-08 Boston Scientific Scimed, Inc. Methods, devices and compositions for controlled drug delivery to injured myocardium
US7727578B2 (en) 2007-12-27 2010-06-01 Honeywell International Inc. Transparent conductors and methods for fabricating transparent conductors
IL188647A0 (en) 2008-01-08 2008-11-03 Orina Gribova Adaptable structured drug and supplements administration system (for oral and/or transdermal applications)
US20100310465A1 (en) * 2008-01-23 2010-12-09 The Regents Of The University Of California Nano-devices having releasable seals for controlled release of molecules
WO2009094580A2 (en) * 2008-01-23 2009-07-30 The Regents Of The University Of California Nano-devices having releasable seals for controlled release of molecules
US7960027B2 (en) 2008-01-28 2011-06-14 Honeywell International Inc. Transparent conductors and methods for fabricating transparent conductors
US7642463B2 (en) * 2008-01-28 2010-01-05 Honeywell International Inc. Transparent conductors and methods for fabricating transparent conductors
US9737593B2 (en) 2008-03-19 2017-08-22 Yale University Carbon nanotube compositions and methods of use thereof
WO2009117616A2 (en) * 2008-03-19 2009-09-24 Yale University Carbon nanotube compositions and methods of use thereof
WO2009142340A1 (en) * 2008-05-19 2009-11-26 Vericom Co., Ltd. Dental composition containing organic nanotube
US20100022439A1 (en) * 2008-06-16 2010-01-28 Purdue Pharma L.P. Nanostructures with High Load of Active Agents
US20110177154A1 (en) * 2008-09-15 2011-07-21 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Tubular nanostructure targeted to cell membrane
US8945912B2 (en) 2008-09-29 2015-02-03 The Board Of Trustees Of The University Of Illinois DNA sequencing and amplification systems using nanoscale field effect sensor arrays
US20110217770A1 (en) * 2008-11-12 2011-09-08 Eran Bram Cell Piercing Device and Method of Using Same
US8540889B1 (en) 2008-11-19 2013-09-24 Nanosys, Inc. Methods of generating liquidphobic surfaces
HUE028642T2 (en) * 2009-04-20 2016-12-28 Galen Bio Inc Compositions for transfection of biomolecules into cells
US20100266694A1 (en) * 2009-04-21 2010-10-21 Jessica Amber Jennings Chitosan/Carbon Nanotube Composite Scaffolds for Drug Delivery
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
RU2528895C2 (en) 2009-07-09 2014-09-20 Ошади Драг Администрейшн Лтд. Matrix carrier compositions, methods and uses
US8236118B2 (en) 2009-08-07 2012-08-07 Guardian Industries Corp. Debonding and transfer techniques for hetero-epitaxially grown graphene, and products including the same
US8507797B2 (en) * 2009-08-07 2013-08-13 Guardian Industries Corp. Large area deposition and doping of graphene, and products including the same
US10167572B2 (en) * 2009-08-07 2019-01-01 Guardian Glass, LLC Large area deposition of graphene via hetero-epitaxial growth, and products including the same
US10164135B2 (en) * 2009-08-07 2018-12-25 Guardian Glass, LLC Electronic device including graphene-based layer(s), and/or method or making the same
US20110129424A1 (en) * 2009-09-16 2011-06-02 Cory Berkland Fluorinated polymers and associated methods
US9376713B2 (en) * 2009-09-23 2016-06-28 The Board Of Trustees Of The University Of Illinois Label free detection of nucleic acid amplification
WO2011044418A2 (en) * 2009-10-08 2011-04-14 Cornell Research Foundation, Inc. Fluid flow device containing nanotubes and method for cell trafficking using same
US9039969B2 (en) * 2009-10-14 2015-05-26 Raytheon Company Electrospun fiber pre-concentrator
WO2011087548A2 (en) * 2009-10-27 2011-07-21 William Marsh Rice University Therapeutic compositions and methods for targeted delivery of active agents
US8808810B2 (en) * 2009-12-15 2014-08-19 Guardian Industries Corp. Large area deposition of graphene on substrates, and products including the same
US8460747B2 (en) * 2010-03-04 2013-06-11 Guardian Industries Corp. Large-area transparent conductive coatings including alloyed carbon nanotubes and nanowire composites, and methods of making the same
US8604332B2 (en) * 2010-03-04 2013-12-10 Guardian Industries Corp. Electronic devices including transparent conductive coatings including carbon nanotubes and nanowire composites, and methods of making the same
US8518472B2 (en) * 2010-03-04 2013-08-27 Guardian Industries Corp. Large-area transparent conductive coatings including doped carbon nanotubes and nanowire composites, and methods of making the same
US20130143319A1 (en) * 2010-03-16 2013-06-06 The Board of Trustees of the University of Illinois et al Use of Functional Nanoelectrodes for Intracellular Delivery of Chemical and Biomolecular Species
US8557529B2 (en) 2010-04-09 2013-10-15 International Business Machines Corporation Nanopore capture system
US9664677B2 (en) * 2010-04-19 2017-05-30 Massachusetts Institute Of Technology Polymer-nanostructure composition for selective molecular recognition
US20120207795A1 (en) 2010-07-13 2012-08-16 The Regents Of The University Of California Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US20120134924A1 (en) * 2010-11-30 2012-05-31 Magnetus, Llc Micro-Vesicles Providing Contrast To Target Tissue Electrical Property Gradients
US9303171B2 (en) 2011-03-18 2016-04-05 Tesla Nanocoatings, Inc. Self-healing polymer compositions
US20140154269A1 (en) * 2011-04-26 2014-06-05 The Methodist Hospital Research Institute Targeted nanovectors and their use for treatment of brain tumors
WO2013066398A1 (en) 2011-04-26 2013-05-10 William Marsh Rice University Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
US10220004B2 (en) 2011-07-14 2019-03-05 The Regents Of The University Of California Method of controlled delivery using sub-micron-scale machines
WO2013033562A2 (en) 2011-08-31 2013-03-07 Jorma Virtanen Composition for corrosion prevention
WO2013043812A1 (en) 2011-09-22 2013-03-28 Board Of Regents Of The University Of Texas System Logical enzyme triggered (let) layer-by-layer nanocapsules for drug delivery system
CN104394853B (en) * 2012-02-19 2017-10-10 纳维基因股份有限公司 Purposes of the porous nanostructured in delivering
US10570296B2 (en) * 2012-03-19 2020-02-25 Tesla Nanocoatings, Inc. Self-healing polymer compositions
US20150033418A1 (en) * 2012-04-16 2015-01-29 North Carolina State University Nanotechnology system for agricultural applications
JP2015536319A (en) * 2012-10-16 2015-12-21 ウィリアム・マーシュ・ライス・ユニバーシティ Improved nanovector-based drug delivery system to overcome drug resistance
WO2014087410A1 (en) 2012-12-05 2014-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Recognition-release nanoporous substrate comprising active agents, methods of their preparation and uses
US10431354B2 (en) 2013-03-15 2019-10-01 Guardian Glass, LLC Methods for direct production of graphene on dielectric substrates, and associated articles/devices
US9593019B2 (en) 2013-03-15 2017-03-14 Guardian Industries Corp. Methods for low-temperature graphene precipitation onto glass, and associated articles/devices
JP6446030B2 (en) 2013-04-24 2018-12-26 フレゼニウス カービ ドイチュラント ゲーエムベーハー Method of operating a control device for controlling a drug injection device
US10364389B1 (en) 2013-09-12 2019-07-30 Adámas Nanotechnologies, lnc. Fluorescent diamond particles
EP3156076A4 (en) * 2014-06-12 2018-01-10 Seed Co., Ltd. Functional polymer gel containing organic nanotubes and method for producing same
EP3310342A4 (en) * 2015-06-16 2019-03-06 The Trustees of the University of Pennsylvania Inorganic controlled release particles with fast drug loading
US10145005B2 (en) 2015-08-19 2018-12-04 Guardian Glass, LLC Techniques for low temperature direct graphene growth on glass
US10350380B2 (en) 2015-12-17 2019-07-16 Soniphi Llc Systems and methods for distal control of health effectors
US11235976B2 (en) * 2017-01-26 2022-02-01 Sichuan Yingrui Pharmaceutical Technology Company Nanocarbon-iron composite system as well as composition, preparation method and use thereof
US11331019B2 (en) 2017-08-07 2022-05-17 The Research Foundation For The State University Of New York Nanoparticle sensor having a nanofibrous membrane scaffold
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
ES2821420B2 (en) * 2019-10-25 2022-09-15 Fund Centro De Innovacion Y Demostracion Tecnologica System for the encapsulation and controlled release of pyrethroids with prolonged efficacy over time against fruit flies
US11508498B2 (en) 2019-11-26 2022-11-22 Trimtabs Ltd Cables and methods thereof
KR20220132598A (en) 2020-01-28 2022-09-30 제넨테크, 인크. IL15/IL15R alpha heterodimer Fc-fusion protein for cancer treatment
WO2023245016A1 (en) 2022-06-13 2023-12-21 B.A.I. Laboratories, Llc Interleukin-13 binding cyclic oligopeptides and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879713A (en) * 1994-10-12 1999-03-09 Focal, Inc. Targeted delivery via biodegradable polymers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879713A (en) * 1994-10-12 1999-03-09 Focal, Inc. Targeted delivery via biodegradable polymers

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US7195780B2 (en) 2007-03-27

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