WO2004039427A3 - Transdermal delivery system for anti-emetic medication - Google Patents

Transdermal delivery system for anti-emetic medication Download PDF

Info

Publication number
WO2004039427A3
WO2004039427A3 PCT/IL2003/000902 IL0300902W WO2004039427A3 WO 2004039427 A3 WO2004039427 A3 WO 2004039427A3 IL 0300902 W IL0300902 W IL 0300902W WO 2004039427 A3 WO2004039427 A3 WO 2004039427A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
transdermal delivery
hydrophilic
emetic
emetic medication
Prior art date
Application number
PCT/IL2003/000902
Other languages
French (fr)
Other versions
WO2004039427A2 (en
Inventor
Galit Levin
Dorit Daniel
Original Assignee
Transpharma Medical Ltd
Galit Levin
Dorit Daniel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transpharma Medical Ltd, Galit Levin, Dorit Daniel filed Critical Transpharma Medical Ltd
Priority to JP2004547954A priority Critical patent/JP2006509739A/en
Priority to AU2003276656A priority patent/AU2003276656A1/en
Priority to EP03809829.9A priority patent/EP1556135B1/en
Publication of WO2004039427A2 publication Critical patent/WO2004039427A2/en
Publication of WO2004039427A3 publication Critical patent/WO2004039427A3/en
Priority to US11/116,065 priority patent/US7415306B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Abstract

The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof, the system comprises an apparatus that generates hydrophilic micro-channels in skin of a subject and a patch comprising a hydrophilic layer comprising a hydrophilic polymer and hydrophilic anti-emetic agent.
PCT/IL2003/000902 2002-10-31 2003-10-30 Transdermal delivery system for anti-emetic medication WO2004039427A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2004547954A JP2006509739A (en) 2002-10-31 2003-10-30 Anti-emetic transdermal delivery system
AU2003276656A AU2003276656A1 (en) 2002-10-31 2003-10-30 Transdermal delivery system for anti-emetic medication
EP03809829.9A EP1556135B1 (en) 2002-10-31 2003-10-30 Transdermal delivery system for anti-emetic medication
US11/116,065 US7415306B2 (en) 2002-10-31 2005-04-27 Transdermal delivery system for anti-emetic medication

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL152573A IL152573A (en) 2002-10-31 2002-10-31 Transdermal delivery system for anti-emetic medication
IL152573 2002-10-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/116,065 Continuation US7415306B2 (en) 2002-10-31 2005-04-27 Transdermal delivery system for anti-emetic medication

Publications (2)

Publication Number Publication Date
WO2004039427A2 WO2004039427A2 (en) 2004-05-13
WO2004039427A3 true WO2004039427A3 (en) 2004-09-23

Family

ID=29765102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000902 WO2004039427A2 (en) 2002-10-31 2003-10-30 Transdermal delivery system for anti-emetic medication

Country Status (6)

Country Link
US (1) US7415306B2 (en)
EP (1) EP1556135B1 (en)
JP (1) JP2006509739A (en)
AU (1) AU2003276656A1 (en)
IL (1) IL152573A (en)
WO (1) WO2004039427A2 (en)

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Also Published As

Publication number Publication date
IL152573A0 (en) 2003-05-29
AU2003276656A8 (en) 2004-05-25
EP1556135A2 (en) 2005-07-27
AU2003276656A1 (en) 2004-05-25
US20050260252A1 (en) 2005-11-24
EP1556135B1 (en) 2017-09-27
IL152573A (en) 2009-11-18
WO2004039427A2 (en) 2004-05-13
JP2006509739A (en) 2006-03-23
EP1556135A4 (en) 2011-03-30
US7415306B2 (en) 2008-08-19

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