WO2004040307A3 - Device and method for analyzing the structure of complex glycostructures and for detecting same - Google Patents

Device and method for analyzing the structure of complex glycostructures and for detecting same Download PDF

Info

Publication number
WO2004040307A3
WO2004040307A3 PCT/EP2003/011567 EP0311567W WO2004040307A3 WO 2004040307 A3 WO2004040307 A3 WO 2004040307A3 EP 0311567 W EP0311567 W EP 0311567W WO 2004040307 A3 WO2004040307 A3 WO 2004040307A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyzing
complex
glycostructures
detecting same
detecting
Prior art date
Application number
PCT/EP2003/011567
Other languages
German (de)
French (fr)
Other versions
WO2004040307A2 (en
Inventor
Simone Cartellieri
Juergen Kuballa
Bernd Niemeyer
Heike Helmholz
Original Assignee
Gkss Forschungszentrum
Galab Technologies Gmbh
Simone Cartellieri
Juergen Kuballa
Bernd Niemeyer
Heike Helmholz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gkss Forschungszentrum, Galab Technologies Gmbh, Simone Cartellieri, Juergen Kuballa, Bernd Niemeyer, Heike Helmholz filed Critical Gkss Forschungszentrum
Priority to AU2003301693A priority Critical patent/AU2003301693A1/en
Publication of WO2004040307A2 publication Critical patent/WO2004040307A2/en
Publication of WO2004040307A3 publication Critical patent/WO2004040307A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00635—Introduction of reactive groups to the surface by reactive plasma treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00727—Glycopeptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The invention concerns a microarray and a binding assay for detecting complex gylcoconjugates and for analyzing same, each gylcoconjugate interacting with at least two different lectins.
PCT/EP2003/011567 2002-10-18 2003-10-17 Device and method for analyzing the structure of complex glycostructures and for detecting same WO2004040307A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003301693A AU2003301693A1 (en) 2002-10-18 2003-10-17 Device and method for analyzing the structure of complex glycostructures and for detecting same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10249608.0 2002-10-18
DE2002149608 DE10249608A1 (en) 2002-10-18 2002-10-18 Device and method for structural analysis and detection of complex glycostructures

Publications (2)

Publication Number Publication Date
WO2004040307A2 WO2004040307A2 (en) 2004-05-13
WO2004040307A3 true WO2004040307A3 (en) 2004-08-19

Family

ID=32087168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011567 WO2004040307A2 (en) 2002-10-18 2003-10-17 Device and method for analyzing the structure of complex glycostructures and for detecting same

Country Status (3)

Country Link
AU (1) AU2003301693A1 (en)
DE (1) DE10249608A1 (en)
WO (1) WO2004040307A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1771733A2 (en) * 2004-06-24 2007-04-11 The Scripps Research Institute Arrays with cleavable linkers
EP2037274A1 (en) 2007-09-11 2009-03-18 GALAB Technologies GmbH Lectin based glycane assay

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049989A2 (en) * 1996-06-25 1997-12-31 Interactiva Biotechnologie Gmbh Broad specificity affinity arrays: a qualitative approach to complex sample discrimination
WO2001084147A1 (en) * 2000-05-04 2001-11-08 Procognia, Ltd. Method and composition for analyzing a carbohydrate polymer
US20020110933A1 (en) * 1998-07-14 2002-08-15 Peter Wagner Arrays of proteins and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH645728A5 (en) * 1979-01-30 1984-10-15 Otsuka Pharma Co Ltd PROCESS FOR DETERMINING THE CONTENT OF SUBSTANCES CONTAINING GLUCOSIDIC BONDS ASSOCIATED WITH TUMORS, APPLICATION OF THIS PROCESS AND NECESSARY FOR ITS IMPLEMENTATION.
EP0057236A4 (en) * 1980-07-25 1982-10-14 Otsuka Pharma Co Ltd Method for determining tumor-associated glucose side chain, method for diagnosing tumors, and kit for diagnosing tumors.
GB8726271D0 (en) * 1987-11-10 1987-12-16 Univ London Protein glycosylation assay
EP0399464A3 (en) * 1989-05-24 1992-03-25 Eiji Ishikawa Assay method for a substance with a specific sugar chain
DE69422692T2 (en) * 1993-11-16 2000-07-06 Wako Pure Chem Ind Ltd Method of separating and measuring glycoprotein
CA2133772A1 (en) * 1993-11-19 1995-05-20 Yuji Yamada Method for assaying glycoconjugate and reagent thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049989A2 (en) * 1996-06-25 1997-12-31 Interactiva Biotechnologie Gmbh Broad specificity affinity arrays: a qualitative approach to complex sample discrimination
US20020110933A1 (en) * 1998-07-14 2002-08-15 Peter Wagner Arrays of proteins and methods of use thereof
WO2001084147A1 (en) * 2000-05-04 2001-11-08 Procognia, Ltd. Method and composition for analyzing a carbohydrate polymer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERTL P ET AL: "Electrochemical biosensor array for the identification of microorganisms based on lectin-lipopolysaccharide recognition.", ANALYTICAL CHEMISTRY. UNITED STATES 1 SEP 2001, vol. 73, no. 17, 1 September 2001 (2001-09-01), pages 4241 - 4248, XP002280826, ISSN: 0003-2700 *
HOUSEMAN B T ET AL: "Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic Modification", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 9, April 2002 (2002-04-01), pages 443 - 454, XP002273879, ISSN: 1074-5521 *

Also Published As

Publication number Publication date
WO2004040307A2 (en) 2004-05-13
DE10249608A1 (en) 2004-05-06
AU2003301693A1 (en) 2004-05-25
AU2003301693A8 (en) 2004-05-25

Similar Documents

Publication Publication Date Title
AU2002300939A1 (en) Reagents and Methods for Detecting Analytes, and Devices Comprising Reagents for Detecting Analytes
DE60223635D1 (en) Reagents, methods and devices for detecting analytes
WO2009014787A3 (en) Multianalyte assay
HK1120568A1 (en) Biosensors for detecting macromolecules and other analytes
MXPA02005798A (en) Reagent test strip for analyte determination.
AP2787A (en) Methods, immunoassays and devices for detection ofanti-lipoidal antibodies
GB2389419B (en) Analyte testing device
IL162204A0 (en) Devices, systems and methods for ectracting bodilyfluid and monitoring an analyte therein
EP1622680A4 (en) System and method for detecting, diagnosing, and treating cardiovascular disease
AU2002338348A1 (en) Method for detecting chronic dementia diseases, and corresponding peptides and detection reagents
WO2002039083A3 (en) Fluorescence and fret based assays for biomolecules on beads
WO2005017646A3 (en) System, software and methods for biomarker identification
MXPA03006086A (en) Detection of analytes.
WO2004075713A3 (en) Multiple marker assay for detection of ovarian cancer
AU2003229544A1 (en) A method for testing the interaction between at least one liquid sample and a respective solid sample.
AU4323602A (en) Methods, devices, arrays and kits for detecting and analyzing biomolecules
AU2003243559A1 (en) Apparatus and methods for detecting cerebrospinal fluid
AU2003229455A1 (en) Rapid vaccinia antibody detection device, method and test kit
AU2005259012A1 (en) Analyte detection system
AU2002341488A1 (en) Method for detecting progredient chronic dementia, and associated peptides and detection reagents
AU2000264217A1 (en) Method for detecting serum and for determining the quality thereof, and corresponding devices
EP1310763A4 (en) Method and device for detecting crankshaft installation position, and program for detecting the installation position
WO2004010143A3 (en) Electrochemical lateral flow and flow-through devices
GB0117230D0 (en) Detecting analytes
WO2004040307A3 (en) Device and method for analyzing the structure of complex glycostructures and for detecting same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP