WO2004046307A3 - Scanning of biological samples - Google Patents
Scanning of biological samples Download PDFInfo
- Publication number
- WO2004046307A3 WO2004046307A3 PCT/US2003/024068 US0324068W WO2004046307A3 WO 2004046307 A3 WO2004046307 A3 WO 2004046307A3 US 0324068 W US0324068 W US 0324068W WO 2004046307 A3 WO2004046307 A3 WO 2004046307A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- emitted
- sample
- biological sample
- scanning
- Prior art date
Links
- 239000012472 biological sample Substances 0.000 title abstract 4
- 239000000523 sample Substances 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003302138A AU2003302138A1 (en) | 2002-08-02 | 2003-07-31 | Scanning of biological samples |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/211,113 | 2002-08-02 | ||
US10/211,113 US6867851B2 (en) | 1999-11-04 | 2002-08-02 | Scanning of biological samples |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004046307A2 WO2004046307A2 (en) | 2004-06-03 |
WO2004046307A3 true WO2004046307A3 (en) | 2004-08-12 |
Family
ID=32324248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/024068 WO2004046307A2 (en) | 2002-08-02 | 2003-07-31 | Scanning of biological samples |
Country Status (3)
Country | Link |
---|---|
US (1) | US6867851B2 (en) |
AU (1) | AU2003302138A1 (en) |
WO (1) | WO2004046307A2 (en) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7232547B2 (en) * | 2002-03-22 | 2007-06-19 | Marshfield Clinic | Apparatus and method for testing and continuously reading low-volume samples |
US7154598B2 (en) | 2002-07-12 | 2006-12-26 | Decision Biomarkers, Inc. | Excitation and imaging of fluorescent arrays |
US7384742B2 (en) * | 2002-08-16 | 2008-06-10 | Decision Biomarkers, Inc. | Substrates for isolating reacting and microscopically analyzing materials |
US7285424B2 (en) * | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
DE50211264D1 (en) * | 2002-09-16 | 2008-01-03 | Pan Biotech Gmbh | DEVICE FOR CULTURING CELLS, ESPECIALLY HUMAN OR ANIMAL CELLS |
US7635575B2 (en) * | 2002-09-16 | 2009-12-22 | Pan-Biotech Gmbh | Method for cultivating cells, particularly human or animal cells |
WO2004059006A1 (en) * | 2002-12-25 | 2004-07-15 | Casio Computer Co., Ltd. | Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor |
US7107864B2 (en) * | 2003-01-15 | 2006-09-19 | General Motors Corporation | Quality control methods for gas diffusion media |
US20050116942A1 (en) * | 2003-09-26 | 2005-06-02 | Vander Jagt Peter G. | Color measurement instrument |
US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
US20050190286A1 (en) * | 2004-02-26 | 2005-09-01 | Gregory Kaduchak | Integrated array sensor for real time measurements of biological samples |
US7815854B2 (en) * | 2004-04-30 | 2010-10-19 | Kimberly-Clark Worldwide, Inc. | Electroluminescent illumination source for optical detection systems |
US7796266B2 (en) * | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
US20060019265A1 (en) * | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
US20050244953A1 (en) * | 2004-04-30 | 2005-11-03 | Kimberly-Clark Worldwide, Inc. | Techniques for controlling the optical properties of assay devices |
US8916348B2 (en) * | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
US20090141132A1 (en) * | 2004-07-26 | 2009-06-04 | Cellular Technology Ltd. | Instrumentation for image acquisition from biological and non-biological assays |
US7524672B2 (en) * | 2004-09-22 | 2009-04-28 | Sandia Corporation | Microfluidic microarray systems and methods thereof |
US7592139B2 (en) | 2004-09-24 | 2009-09-22 | Sandia National Laboratories | High temperature flow-through device for rapid solubilization and analysis |
US20070121113A1 (en) * | 2004-12-22 | 2007-05-31 | Cohen David S | Transmission-based optical detection systems |
US20060166305A1 (en) * | 2005-01-27 | 2006-07-27 | Genetix Limited | Animal cell confluence detection method and apparatus |
US20070097364A1 (en) * | 2005-05-09 | 2007-05-03 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
US7738086B2 (en) * | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
US7805081B2 (en) * | 2005-08-11 | 2010-09-28 | Pacific Biosciences Of California, Inc. | Methods and systems for monitoring multiple optical signals from a single source |
JP4441653B2 (en) * | 2005-08-31 | 2010-03-31 | シャープ株式会社 | Automated two-dimensional electrophoresis apparatus and apparatus components |
US8838210B2 (en) * | 2006-06-29 | 2014-09-16 | AccuView, Inc. | Scanned laser vein contrast enhancer using a single laser |
US8263360B2 (en) * | 2006-01-30 | 2012-09-11 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same |
US7995202B2 (en) * | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7715001B2 (en) * | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7692783B2 (en) * | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
GB2436870B (en) * | 2006-04-03 | 2009-12-09 | Custom Interconnect Ltd | Point source apparatus and method of manufacture thereof |
US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
EP3936857B1 (en) * | 2006-09-01 | 2023-06-21 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
JP4316596B2 (en) * | 2006-09-13 | 2009-08-19 | シャープ株式会社 | Sample analysis method and analyzer |
US20080080059A1 (en) * | 2006-09-28 | 2008-04-03 | Pacific Biosciences Of California, Inc. | Modular optical components and systems incorporating same |
US20080116255A1 (en) * | 2006-11-17 | 2008-05-22 | Fuji Xerox Co., Ltd. | Seamless screen labeling for branding, access control and content management |
US20100167413A1 (en) * | 2007-05-10 | 2010-07-01 | Paul Lundquist | Methods and systems for analyzing fluorescent materials with reduced autofluorescence |
US20080277595A1 (en) * | 2007-05-10 | 2008-11-13 | Pacific Biosciences Of California, Inc. | Highly multiplexed confocal detection systems and methods of using same |
DE102007045897A1 (en) * | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Method for the microscopic three-dimensional imaging of a sample |
EP2065752A1 (en) * | 2007-11-23 | 2009-06-03 | Koninklijke Philips Electronics N.V. | Optical illumination apparatus for illuminating a sample with a line beam |
JP5226352B2 (en) * | 2008-03-21 | 2013-07-03 | オリンパス株式会社 | Living body observation apparatus and living body observation method |
AU2009292629B2 (en) * | 2008-09-16 | 2014-03-20 | Pacific Biosciences Of California, Inc. | Substrates and optical systems and methods of use thereof |
EP2347252B1 (en) * | 2008-10-08 | 2014-07-16 | Sage Science, Inc. | Multichannel preparative electrophoresis system |
US8361299B2 (en) * | 2008-10-08 | 2013-01-29 | Sage Science, Inc. | Multichannel preparative electrophoresis system |
WO2010045400A2 (en) * | 2008-10-14 | 2010-04-22 | Tissuevision, Inc. | Devices and methods for direct sampling analog time-resolved detection |
DK200801722A (en) * | 2008-12-05 | 2010-06-06 | Unisensor As | Optical sectioning of a sample and detection of particles in a sample |
US20100184616A1 (en) * | 2009-01-20 | 2010-07-22 | Bio-Rad Laboratories, Inc. | Spatially controlled illumination of biological sample array through wedge-shaped support |
US8449842B2 (en) * | 2009-03-19 | 2013-05-28 | Thermo Scientific Portable Analytical Instruments Inc. | Molecular reader |
JP5387328B2 (en) * | 2009-08-31 | 2014-01-15 | ソニー株式会社 | Fluorescence image acquisition apparatus, fluorescence image acquisition method, and fluorescence image acquisition program |
US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
CN102713720B (en) | 2009-10-28 | 2016-05-11 | 阿兰蒂克微科学股份有限公司 | Microscopic imaging device and micro imaging method |
JP5878874B2 (en) | 2009-12-04 | 2016-03-08 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | System and method for time-related microscopy of biological organisms |
AU2011217862B9 (en) | 2010-02-19 | 2014-07-10 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
JP5769116B2 (en) | 2010-03-04 | 2015-08-26 | コーニンクレッカ フィリップス エヌ ヴェ | Flexible sample container |
US8974651B2 (en) | 2010-04-17 | 2015-03-10 | C.C. Imex | Illuminator for visualization of fluorophores |
TWI487914B (en) * | 2010-05-14 | 2015-06-11 | Univ Nat Taipei Technology | Handheld fluorescent protein spectral sensing system |
US8436321B2 (en) * | 2010-05-21 | 2013-05-07 | Li-Cor, Inc. | Optical background suppression systems and methods for fluorescence imaging |
US20110312654A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ptd | Apparatus for loading oligonucleotide spotting devices and spotting oligonucleotide probes |
US10682198B2 (en) | 2010-07-02 | 2020-06-16 | Intuitive Surgical Operations, Inc. | Method and system for fluorescent imaging with background surgical image composed of selective illumination spectra |
US9211058B2 (en) * | 2010-07-02 | 2015-12-15 | Intuitive Surgical Operations, Inc. | Method and system for fluorescent imaging with background surgical image composed of selective illumination spectra |
US8481282B2 (en) | 2010-07-23 | 2013-07-09 | Abbott Point Of Care, Inc. | Method for detecting the presence of anisotropic crystals in undiluted whole blood |
WO2012059784A1 (en) | 2010-11-03 | 2012-05-10 | Reametrix Inc | Method and device for fluorescent measurement of samples |
US9671345B2 (en) * | 2011-02-24 | 2017-06-06 | Reametrix, Inc. | Mapping volumes of interest in selected planes in liquid samples |
CN102955238A (en) * | 2011-08-22 | 2013-03-06 | 安鹏科技股份有限公司 | Handheld fluorescence microscope |
US9046473B2 (en) | 2011-09-28 | 2015-06-02 | Abbott Point Of Care, Inc. | Method and apparatus for detecting the presence of intraerythrocytic parasites |
AU2012352965B2 (en) | 2011-12-16 | 2014-08-21 | Li-Cor, Inc. | Luminescence imaging scanner |
US8906320B1 (en) | 2012-04-16 | 2014-12-09 | Illumina, Inc. | Biosensors for biological or chemical analysis and systems and methods for same |
JP5797870B2 (en) | 2012-04-23 | 2015-10-21 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | Biological assay sample analyzer |
CN104471379A (en) * | 2012-05-09 | 2015-03-25 | 生命技术公司 | Systems and method for fluorescence imaging |
US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
US8809811B2 (en) * | 2012-09-13 | 2014-08-19 | Prysm, Inc. | Reduction of intensity ringing in fluorescent displays |
US9619692B2 (en) | 2012-09-24 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Image capture-based predictive control device |
EP2906935B1 (en) | 2012-10-12 | 2018-04-04 | Sage Science, Inc. | Side-eluting molecular fractionator |
SG11201502782YA (en) * | 2012-10-17 | 2015-05-28 | Bio Rad Laboratories | Image capture for large analyte arrays |
EP4123294A1 (en) | 2012-12-18 | 2023-01-25 | Pacific Biosciences Of California, Inc. | An optical analytical device |
US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
US9624540B2 (en) | 2013-02-22 | 2017-04-18 | Pacific Biosciences Of California, Inc. | Integrated illumination of optical analytical devices |
US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
US11199498B2 (en) | 2013-05-09 | 2021-12-14 | University Of Central Florida Research Foundation, Inc. | Portable spectrometer for the presumptive identification of substances |
WO2014183026A1 (en) * | 2013-05-09 | 2014-11-13 | University Of Central Florida Research Foundation, Inc. | A portable spectrometer for the presumptive identification of illicit drugs and substances of abuse |
EP3000458B1 (en) * | 2013-05-22 | 2020-02-19 | PHC Holdings Corporation | Pill inspection device and pill inspection method |
EP3014330B1 (en) | 2013-06-26 | 2024-01-03 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
CN103344618B (en) * | 2013-06-27 | 2015-03-25 | 北京印刷学院 | Fluorescence excitation testing device |
EP3040697A4 (en) * | 2013-08-28 | 2017-07-19 | Mitsubishi Electric Corporation | Thermal image sensor and air conditioner |
EP3080585B1 (en) | 2013-12-10 | 2023-12-06 | Illumina, Inc. | Biosensors for biological or chemical analysis and methods of manufacturing the same |
US9835587B2 (en) | 2014-04-01 | 2017-12-05 | C.C. Imex | Electrophoresis running tank assembly |
CN114280023A (en) | 2014-08-27 | 2022-04-05 | 加利福尼亚太平洋生物科学股份有限公司 | Integrated analytical device array |
CA2964487C (en) | 2014-10-15 | 2024-03-19 | Sage Science, Inc. | Apparatuses, methods and systems for automated processing of nucleic acids and electrophoretic sample preparation |
WO2016118456A1 (en) * | 2015-01-19 | 2016-07-28 | Sri International | Measuring hiv reservoirs with optical scanning |
EP3271762B1 (en) | 2015-03-16 | 2023-01-04 | Pacific Biosciences of California, Inc. | Analytical system comprising integrated devices and systems for free-space optical coupling |
EP3290909B1 (en) * | 2015-05-01 | 2021-10-06 | Universal Bio Research Co., Ltd. | Parallel measurement device and parallel measurement method for multiple reactions |
CN107924027B (en) | 2015-06-12 | 2024-01-23 | 加利福尼亚太平洋生物科学股份有限公司 | Integrated target waveguide device and system for optical coupling |
US11542495B2 (en) | 2015-11-20 | 2023-01-03 | Sage Science, Inc. | Preparative electrophoretic method for targeted purification of genomic DNA fragments |
EP3420338B1 (en) * | 2016-02-26 | 2023-05-03 | Single Technologies AB | Method and apparatus for high throughput imaging |
CN109791108A (en) * | 2016-08-10 | 2019-05-21 | 阿提拉生物系统公司 | Device for the fluorescence signal that test sample issues |
CN109791277A (en) * | 2016-09-29 | 2019-05-21 | 奥林巴斯株式会社 | Observe device |
US10324041B2 (en) | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
US11047854B2 (en) | 2017-02-06 | 2021-06-29 | Abbott Japan Llc | Methods for reducing noise in signal-generating digital assays |
CA3055306A1 (en) | 2017-04-07 | 2018-10-11 | Sage Science, Inc. | Systems and methods for detection of genetic structural variation using integrated electrophoretic dna purification |
KR102466365B1 (en) | 2017-12-26 | 2022-11-14 | 일루미나, 인코포레이티드 | Sensor System |
NL2020636B1 (en) * | 2017-12-28 | 2019-07-08 | Illumina Inc | Light energy fluorescence excitation |
DE102018104693A1 (en) * | 2018-03-01 | 2019-09-05 | Carl Zeiss Microscopy Gmbh | Method for accelerated, high-resolution scanning microscopy |
WO2019226897A2 (en) * | 2018-05-25 | 2019-11-28 | Five Prime Therapeutics, Inc. | Enhanced cytometry for tissue characterization and screening |
US11460403B2 (en) | 2018-07-05 | 2022-10-04 | AhuraTech LLC | Electroluminescent methods and devices for characterization of biological specimens |
US11393387B2 (en) | 2018-07-05 | 2022-07-19 | AhuraTech LLC | Open-circuit electroluminescence |
US11428656B2 (en) | 2018-07-05 | 2022-08-30 | AhuraTech LLC | Electroluminescent methods and system for real-time measurements of physical properties |
US20210187503A1 (en) * | 2019-12-19 | 2021-06-24 | Personal Genomics Taiwan, Inc. | Apparatus and system for single-molecule nucleic acids detection |
JP2021140032A (en) * | 2020-03-05 | 2021-09-16 | ソニーグループ株式会社 | Signal acquisition device, signal acquisition system, and signal acquisition method |
AU2021236681A1 (en) * | 2020-03-19 | 2022-11-17 | The J. David Gladstone Institutes | Rapid field-deployable detection of SARS-CoV-2 virus |
CN113493857A (en) * | 2020-04-03 | 2021-10-12 | 中国科学院大连化学物理研究所 | Coronavirus fluorescence detector, coronavirus fluorescence detection kit and coronavirus fluorescence detection method |
DE102020131374B4 (en) | 2020-11-26 | 2024-02-08 | Dionex Softron Gmbh | Fluorescence detection |
US11604121B1 (en) * | 2022-01-19 | 2023-03-14 | Pantomics Inc. | Plate guided arrayer for construction of tissue array blocks |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140653A (en) * | 1998-03-27 | 2000-10-31 | Vysis, Inc. | Large-field fluorescence imaging apparatus |
US6448088B1 (en) * | 1998-03-07 | 2002-09-10 | Robert A. Levine | Method and apparatus for detecting insoluable constituents in a quiescent urine sample |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5293563A (en) * | 1988-12-29 | 1994-03-08 | Sharp Kabushiki Kaisha | Multi-level memory cell with increased read-out margin |
US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5378883A (en) * | 1991-07-19 | 1995-01-03 | Omniplanar Inc. | Omnidirectional wide range hand held bar code reader |
JP3067331B2 (en) * | 1991-10-30 | 2000-07-17 | 株式会社ニコン | microscope |
US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5556539A (en) * | 1993-02-26 | 1996-09-17 | Mitsubishi Chemical Corporation | Apparatus for separating a liquid mixture by pervaporation |
US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
US5858659A (en) * | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
US5861242A (en) * | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
JPH0798276A (en) * | 1993-09-28 | 1995-04-11 | Hitachi Electron Eng Co Ltd | Determining device for appangement of dna base |
US5631734A (en) * | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5578832A (en) * | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US5928905A (en) * | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US5571639A (en) * | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
DE69527585T2 (en) * | 1994-06-08 | 2003-04-03 | Affymetrix Inc | Method and device for packaging chips |
JP3068413B2 (en) * | 1994-07-13 | 2000-07-24 | 日立電子エンジニアリング株式会社 | DNA base sequencer |
US5459325A (en) * | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US5672881A (en) * | 1994-09-14 | 1997-09-30 | Glyko, Inc. | Charge-coupled device imaging apparatus |
US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
US5795716A (en) * | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5959098A (en) * | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US5599695A (en) * | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US5624711A (en) * | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5968740A (en) * | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
US5633724A (en) * | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
US5733729A (en) * | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
US5843655A (en) * | 1995-09-18 | 1998-12-01 | Affymetrix, Inc. | Methods for testing oligonucleotide arrays |
US5871628A (en) * | 1996-08-22 | 1999-02-16 | The University Of Texas System | Automatic sequencer/genotyper having extended spectral response |
US5856104A (en) * | 1996-10-28 | 1999-01-05 | Affymetrix, Inc. | Polymorphisms in the glucose-6 phosphate dehydrogenase locus |
DE19707227A1 (en) * | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Light scanner |
US6200752B1 (en) | 1998-01-14 | 2001-03-13 | Joseph R. Lakowicz | Method and composition for detecting the presence of a nucleic acid sequence in a sample |
DE69937126T2 (en) | 1998-07-17 | 2008-06-12 | Vertex Pharmaceuticals (San Diego) Llc, San Diego | Detector and sieve device for ion channels |
DE19940749A1 (en) | 1998-08-28 | 2000-05-18 | Febit Ferrarius Biotech Gmbh | Integrated synthesis and analysis method e.g. for polymers, comprises a carrier body provided with immobilized receptors to provide respective channels before contact with sample and subsequent analysis |
DE19914279C1 (en) | 1999-03-25 | 2000-09-07 | Jena Optronik Gmbh | Sensor for optical examination of stimulated sample pixels on e.g. nano-titration screening plates or bio-chips for gene analysis, employs e.g. a liquid crystal matrix shutter and fiber optics with photomultiplier detection |
WO2000068670A1 (en) | 1999-05-07 | 2000-11-16 | Anslyn Eric V | Method and system for remotely collecting and evaluating chemical/biochemical information |
-
2002
- 2002-08-02 US US10/211,113 patent/US6867851B2/en not_active Expired - Lifetime
-
2003
- 2003-07-31 WO PCT/US2003/024068 patent/WO2004046307A2/en not_active Application Discontinuation
- 2003-07-31 AU AU2003302138A patent/AU2003302138A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448088B1 (en) * | 1998-03-07 | 2002-09-10 | Robert A. Levine | Method and apparatus for detecting insoluable constituents in a quiescent urine sample |
US6140653A (en) * | 1998-03-27 | 2000-10-31 | Vysis, Inc. | Large-field fluorescence imaging apparatus |
Also Published As
Publication number | Publication date |
---|---|
US20030151735A1 (en) | 2003-08-14 |
AU2003302138A1 (en) | 2004-06-15 |
AU2003302138A8 (en) | 2004-06-15 |
US6867851B2 (en) | 2005-03-15 |
WO2004046307A2 (en) | 2004-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004046307A3 (en) | Scanning of biological samples | |
JP2513442B2 (en) | Coded code detector | |
DE69534719D1 (en) | DEVICE AND METHOD FOR ANALYZING SAMPLES | |
CA2415376A1 (en) | Scanning system and method for scanning a plurality of samples | |
EP1650548A3 (en) | Surface plasmon sensor | |
CA2285189A1 (en) | A system for acquiring an image of a multi-phase fluid by measuring backscattered light | |
WO2002048693A1 (en) | Fluorometric analyzer and fluorometric analysis | |
WO1998044330A3 (en) | Optical inspection module and method for detecting particles and defects on substrates in integrated process tools | |
EP1248132A3 (en) | Method and arrangement for depth resolving optical detection of a probe | |
WO2006132862A3 (en) | Opto-acoustic apparatus for acoustic imaging | |
WO1998052025A1 (en) | Surface inspection instrument and surface inspection method | |
US20050069090A1 (en) | Optical alignment of X-ray microanalyzers | |
WO2004090604A3 (en) | Microscope arrangement | |
ATE495476T1 (en) | LASER SCANNING DEVICE AND LASER SCANNING MICROSCOPE | |
CA2290575A1 (en) | High resolution confocal microscope | |
DE50211516D1 (en) | Sample carrier with integrated optics | |
ATE161636T1 (en) | OPTICAL NEAR FIELD SCANING MICROSCOPE | |
DE602006008717D1 (en) | Optical scanning device and image forming apparatus with it | |
KR100615040B1 (en) | Apparatus and method for measuring bio chips | |
TW200614815A (en) | System and method for detecting distortion | |
US6088104A (en) | Surface characterization apparatus | |
US20030095252A1 (en) | Method and apparatus for defect analysis of wafers | |
EP1293768A3 (en) | Sensor utilizing attenuated total reflection | |
US20050190365A1 (en) | Method and device for interrogating samples using laser scanning cytometry and other techniques | |
JPH0518901A (en) | Wafer-surface inspecting apparatus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |